David W Killilea

Summary

Affiliation: Children's Hospital Oakland Research Institute
Country: USA

Publications

  1. pmc A connection between magnesium deficiency and aging: new insights from cellular studies
    David W Killilea
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA, USA
    Magnes Res 21:77-82. 2008
  2. pmc Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts
    David W Killilea
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 105:5768-73. 2008
  3. pmc N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration
    Ludmila A Voloboueva
    Children s Hospital Oakland Research Institute, Nutrition and Metabolism Center, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    FASEB J 21:4077-86. 2007
  4. ncbi request reprint Iron accumulation during cellular senescence
    David W Killilea
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Ann N Y Acad Sci 1019:365-7. 2004
  5. doi request reprint Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts
    Ashutosh Lal
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Redox Rep 13:2-10. 2008
  6. ncbi request reprint Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging
    Bruce N Ames
    Nutrition, Metabolisms and Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, U States
    Mol Aspects Med 26:363-78. 2005
  7. pmc Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging
    Hani Atamna
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 99:14807-12. 2002
  8. pmc Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease
    Patrick B Walter
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Br J Haematol 135:254-63. 2006
  9. ncbi request reprint Iron accumulation during cellular senescence in human fibroblasts in vitro
    David W Killilea
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Antioxid Redox Signal 5:507-16. 2003
  10. pmc Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid
    Jiankang Liu
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:1876-81. 2002

Collaborators

Detail Information

Publications12

  1. pmc A connection between magnesium deficiency and aging: new insights from cellular studies
    David W Killilea
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA, USA
    Magnes Res 21:77-82. 2008
    ....
  2. pmc Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts
    David W Killilea
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 105:5768-73. 2008
    ....
  3. pmc N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration
    Ludmila A Voloboueva
    Children s Hospital Oakland Research Institute, Nutrition and Metabolism Center, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    FASEB J 21:4077-86. 2007
    ..NtBHA might be useful in AMD due to its potential to reduce oxidative stress, mitochondrial damage, and age-related iron accumulation, which may damage normal RPE function and lead to loss of vision...
  4. ncbi request reprint Iron accumulation during cellular senescence
    David W Killilea
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Ann N Y Acad Sci 1019:365-7. 2004
    ..Thus, iron accumulation is not a cause, but a consequence of normal cellular senescence in vitro. Senescence-associated iron accumulation may contribute to the increased oxidative stress and cellular dysfunction seen in senescent cells...
  5. doi request reprint Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts
    Ashutosh Lal
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Redox Rep 13:2-10. 2008
    ..We conclude that LA is highly effective in reversing oxidative stress arising from iron overload and that its antioxidant efficacy is further enhanced in combination with ALCAR...
  6. ncbi request reprint Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging
    Bruce N Ames
    Nutrition, Metabolisms and Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, U States
    Mol Aspects Med 26:363-78. 2005
    ..An optimum intake of micronutrients could tune up metabolism and give a marked increase in health, particularly for the poor, elderly, and obese, at little cost...
  7. pmc Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging
    Hani Atamna
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 99:14807-12. 2002
    ..Thus, heme deficiency or dysregulation may be an important and preventable component of the neurodegenerative process...
  8. pmc Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease
    Patrick B Walter
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Br J Haematol 135:254-63. 2006
    ..This supports the hypothesis that the biology of SCD may show increased inflammation and increased levels of protective antioxidants compared with thalassaemia...
  9. ncbi request reprint Iron accumulation during cellular senescence in human fibroblasts in vitro
    David W Killilea
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Antioxid Redox Signal 5:507-16. 2003
    ..These data indicate that iron accumulation occurs during normal cellular senescence in vitro. This accumulation of iron may contribute to the increased oxidative stress and cellular dysfunction seen in senescent cells...
  10. pmc Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid
    Jiankang Liu
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:1876-81. 2002
    ..Thus, feeding old rats high levels of key mitochondrial metabolites can ameliorate oxidative damage, enzyme activity, substrate-binding affinity, and mitochondrial dysfunction...
  11. ncbi request reprint Zinc deficiency reduces paclitaxel efficacy in LNCaP prostate cancer cells
    Alison N Killilea
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
    Cancer Lett 258:70-9. 2007
    ..Given the prevalence of zinc deficiency, determining how chemotherapeutic action is modulated by zinc adequacy may have clinical importance...
  12. pmc Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
    Gawain McColl
    Buck Institute for Age Research, Novato, CA 94945, USA
    J Biol Chem 283:350-7. 2008
    ..2), a histone demethylase; knockdown by RNA interference of T08D10.2 is sufficient to extend longevity ( approximately 25% median increase), suggesting Li(+) regulates survival by modulating histone methylation and chromatin structure...