Jörg Köhl

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Drug evaluation: the C5a receptor antagonist PMX-53
    Jörg Köhl
    Cincinnati Children s Hospital Research Foundation, Division of Molecular Immunology, MLC 7021, Cincinnati, OH 45229, USA
    Curr Opin Mol Ther 8:529-38. 2006
  2. ncbi A dual role for complement in allergic asthma
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Curr Opin Pharmacol 7:283-9. 2007
  3. pmc A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:783-96. 2006
  4. ncbi The role of complement in danger sensing and transmission
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Immunol Res 34:157-76. 2006
  5. ncbi Self, non-self, and danger: a complementary view
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, MLC 7021, Cincinnati, OH 45229, USA
    Adv Exp Med Biol 586:71-94. 2006
  6. doi A critical role for C5L2 in the pathogenesis of experimental allergic asthma
    Xun Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 185:6741-52. 2010
  7. pmc CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
    Ian P Lewkowich
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 202:1549-61. 2005
  8. pmc A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells
    Xun Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 182:5123-30. 2009
  9. ncbi The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma
    Heiko Hawlisch
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 41:123-31. 2004
  10. ncbi Complement regulates inhalation tolerance at the dendritic cell/T cell interface
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 44:44-56. 2007

Collaborators

Detail Information

Publications18

  1. ncbi Drug evaluation: the C5a receptor antagonist PMX-53
    Jörg Köhl
    Cincinnati Children s Hospital Research Foundation, Division of Molecular Immunology, MLC 7021, Cincinnati, OH 45229, USA
    Curr Opin Mol Ther 8:529-38. 2006
    ..Peptech is developing PMX-53, a complement C5a inhibitor for the potential treatment of inflammatory disorders, including rheumatoid arthritis and psoriasis. Phase Ib/IIa clinical trials have been completed for both indications...
  2. ncbi A dual role for complement in allergic asthma
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Curr Opin Pharmacol 7:283-9. 2007
    ..As such, selective targeting of pro-allergic complement pathways appears an attractive therapeutic option in allergic asthma...
  3. pmc A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:783-96. 2006
    ..e., protection from the development of maladaptive type 2 immune responses during allergen sensitization at the DC/T cell interface but enhancement of airway inflammation and AHR in an established inflammatory environment...
  4. ncbi The role of complement in danger sensing and transmission
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Immunol Res 34:157-76. 2006
    ..Furthermore, I will discuss recent findings that support a concept of intense cross-talk between the complement system and TLRs, which defines the quality and the magnitude of immune responses in vivo...
  5. ncbi Self, non-self, and danger: a complementary view
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation, MLC 7021, Cincinnati, OH 45229, USA
    Adv Exp Med Biol 586:71-94. 2006
    ..Given the importance of complement as a sensor and effector system of innate and adaptive immune responses, a complement-related view of the immune system might help to unravel some enigmas of autoimmunity, allergy, and transplantation...
  6. doi A critical role for C5L2 in the pathogenesis of experimental allergic asthma
    Xun Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 185:6741-52. 2010
    ..Furthermore, it drives Th2 immune responses independent of mDCs, suggesting a complex role for C5L2 in the development of experimental allergic asthma...
  7. pmc CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
    Ian P Lewkowich
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 202:1549-61. 2005
    ..These data suggest that resistance to allergen-driven AHR is mediated in part by CD4+CD25+ T reg cell suppression of DC activation and that the absence of this regulatory pathway contributes to susceptibility...
  8. pmc A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells
    Xun Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 182:5123-30. 2009
    ..Ex vivo targeting of B7-H1 and B7-DC increased Th2 cytokine production from T cells of wild-type but not of C5aR-targeted mice, suggesting a protective role for C5a through regulation of B7 molecule expression on plasmacytoid DCs...
  9. ncbi The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma
    Heiko Hawlisch
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 41:123-31. 2004
    ..During the effector phase, both anaphylatoxins trigger the inflammatory response and contribute to bronchoconstriction...
  10. ncbi Complement regulates inhalation tolerance at the dendritic cell/T cell interface
    Jörg Köhl
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 44:44-56. 2007
    ..The emerging paradigm is that constitutive local generation of C5a and C5aR signaling in airway DCs controls inhalation tolerance directly as well as indirectly through sensitization of airway DCs for T(Reg)-mediated immunosuppression...
  11. pmc C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells
    Donald J Weaver
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Eur J Immunol 40:710-21. 2010
    ..Our data suggest critical roles for C5aR in Treg and Th17-cell differentiation through regulation of DC function...
  12. pmc C5a regulates NKT and NK cell functions in sepsis
    Michael E Fusakio
    Division of Immunobiology, Cincinnati Children s Hospital, Cincinnati, OH 45229, USA
    J Immunol 187:5805-12. 2011
    ..Our results identify C5aR activation as a novel pathway driving detrimental effects of NKT and NK cells during early experimental sepsis...
  13. pmc A complex role for complement in allergic asthma
    Xun Zhang
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, OH 45229, USA
    Expert Rev Clin Immunol 6:269-77. 2010
    ..In this article, we will review the recent findings in the field to judge the benefit of complement targeting in allergic asthma...
  14. pmc MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice
    Richard T Strait
    Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 208:2525-44. 2011
    ..These observations have important implications for the prevention and treatment of TRALI...
  15. pmc Peanuts can contribute to anaphylactic shock by activating complement
    Marat Khodoun
    Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Allergy Clin Immunol 123:342-51. 2009
    ..Resistance to digestion and dendritic cell activation by the major peanut allergen Ara h 1 are reported to contribute to its allergenicity...
  16. ncbi Complement and Toll-like receptors: key regulators of adaptive immune responses
    Heiko Hawlisch
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Mol Immunol 43:13-21. 2006
    ..Such cross-talk is likely to affect the outcome of infections with intracellular pathogens, as well as the initiation and maintenance of aberrant immune responses leading to autoimmunity and atopy...
  17. ncbi Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis
    Erin Addis-Lieser
    Division of Immunobiology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA
    J Immunol 175:1894-902. 2005
    ..Furthermore, these findings provide insight into the development of new therapeutic strategies for idiopathic pulmonary fibrosis patients...
  18. ncbi C5a negatively regulates toll-like receptor 4-induced immune responses
    Heiko Hawlisch
    Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Immunity 22:415-26. 2005
    ..Our findings identify the negative impact of C5a on IL-12 family cytokines as an important mechanism for regulating Th1 polarization in response to innate and adaptive immune network activation...