Zhila Khalkhali-Ellis

Summary

Affiliation: Children's Memorial Hospital
Country: USA

Publications

  1. pmc IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    J Cell Biochem 105:208-18. 2008
  2. pmc Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center and Robert H Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
    Cancer Res 67:3535-9. 2007
  3. pmc Maspin: the new frontier
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    Clin Cancer Res 12:7279-83. 2006
  4. pmc Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner
    Caleb M Bailey
    Children s Memorial Research Center, 2300 Children s Plaza, Box 222, Chicago, IL 60614 3394, USA
    Mol Cell Biol 28:2235-43. 2008
  5. pmc New insights into cathepsin D in mammary tissue development and remodeling
    Naira V Margaryan
    Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois USA
    Cancer Biol Ther 10:457-66. 2010
  6. pmc Reevaluating cathepsin D as a biomarker for breast cancer: serum activity levels versus histopathology
    Daniel E Abbott
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Cancer Biol Ther 9:23-30. 2010
  7. pmc Temporal and spatial expression patterns for the tumor suppressor Maspin and its binding partner interferon regulatory factor 6 during breast development
    Caleb M Bailey
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    Dev Growth Differ 51:473-81. 2009
  8. doi request reprint Maspin: molecular mechanisms and therapeutic implications
    Thomas M Bodenstine
    Children s Hospital of Chicago Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 225 E Chicago Avenue, Box 222, Chicago, IL 60611, USA
    Cancer Metastasis Rev 31:529-51. 2012
  9. ncbi request reprint Biological functions of maspin
    Caleb M Bailey
    Department of Anatomy and Cell Biology, The Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    J Cell Physiol 209:617-24. 2006
  10. pmc Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership
    Caleb M Bailey
    Department of Anatomy and Cell Biology and Pediatrics, Roy A and Lucille J Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, USA
    J Biol Chem 280:34210-7. 2005

Collaborators

  • Stephen L Gluck
  • Jacqueline S Jeruss
  • Anil Sood
  • MARY JC HENDRIX
  • Caleb M Bailey
  • Naira V Margaryan
  • Elisabeth A Seftor
  • Daniel E Abbott
  • Richard E B Seftor
  • Sumaira Amir
  • Valerie A Odero-Marah
  • Thomas M Bodenstine
  • Jirapat Chunthapong
  • Brian C Schutte
  • Joanne K Tobacman
  • Philip A Pemberton
  • Nora Hansen
  • David J Winchester
  • Alina Lipavsky
  • Virginia Kaklamani
  • Seema Khan
  • Dawn A Kirschmann
  • Alfred Rademaker
  • Baoli Yang
  • Michael R Pins
  • Valerie Odero-Marah
  • Shinji Kondo
  • William W Wheaton
  • David M Lubaroff
  • Paul M Heidger
  • John G Koland
  • Galen B Schneider
  • Marilyn Hinkhouse

Detail Information

Publications18

  1. pmc IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    J Cell Biochem 105:208-18. 2008
    ..However, Maspin transfection of breast cancer cells partially sensitizes the cells to IFN-gamma's effect, thus providing new therapeutic implications...
  2. pmc Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center and Robert H Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
    Cancer Res 67:3535-9. 2007
    ..In addition, these findings could have a potential effect on future therapeutic intervention strategies for breast cancer...
  3. pmc Maspin: the new frontier
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    Clin Cancer Res 12:7279-83. 2006
    ..This perspective briefly outlines the past and present strides in deciphering this unique molecule and speculates on new frontiers in maspin research and prospects of maspin as a diagnostic/prognostic indicator in cancer...
  4. pmc Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner
    Caleb M Bailey
    Children s Memorial Research Center, 2300 Children s Plaza, Box 222, Chicago, IL 60614 3394, USA
    Mol Cell Biol 28:2235-43. 2008
    ..These data support a model in which IRF6, in collaboration with maspin, promotes mammary epithelial cell differentiation by facilitating entry into the G(0) phase of the cell cycle...
  5. pmc New insights into cathepsin D in mammary tissue development and remodeling
    Naira V Margaryan
    Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois USA
    Cancer Biol Ther 10:457-66. 2010
    ..Thus, identifying the role of CatD in a dynamic normal tissue undergoing highly regulated cycles of remodeling could provide valuable information illuminating the deregulation of CatD associated with cancer development and metastasis...
  6. pmc Reevaluating cathepsin D as a biomarker for breast cancer: serum activity levels versus histopathology
    Daniel E Abbott
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Cancer Biol Ther 9:23-30. 2010
    ....
  7. pmc Temporal and spatial expression patterns for the tumor suppressor Maspin and its binding partner interferon regulatory factor 6 during breast development
    Caleb M Bailey
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    Dev Growth Differ 51:473-81. 2009
    ..These results support the hypothesis that IRF6 and Maspin are important for mammary epithelial cell differentiation, and advance our understanding of the Maspin-IRF6 partnership during normal mammary gland development...
  8. doi request reprint Maspin: molecular mechanisms and therapeutic implications
    Thomas M Bodenstine
    Children s Hospital of Chicago Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 225 E Chicago Avenue, Box 222, Chicago, IL 60611, USA
    Cancer Metastasis Rev 31:529-51. 2012
    ..We provide insight into the immense therapeutic potential of Maspin and the challenges related to its successful clinical translation...
  9. ncbi request reprint Biological functions of maspin
    Caleb M Bailey
    Department of Anatomy and Cell Biology, The Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    J Cell Physiol 209:617-24. 2006
    ....
  10. pmc Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership
    Caleb M Bailey
    Department of Anatomy and Cell Biology and Pediatrics, Roy A and Lucille J Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, USA
    J Biol Chem 280:34210-7. 2005
    ..These findings help to elucidate the molecular mechanisms of maspin and suggest an interactive role between maspin and IRF6 in regulating cellular phenotype, the loss of which can lead to neoplastic transformation...
  11. pmc Maspin regulates hypoxia-mediated stimulation of uPA/uPAR complex in invasive breast cancer cells
    Sumaira Amir
    The Department of Anatomy and Cell Biology, Carver College of Medicine, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa, USA
    Cancer Biol Ther 4:400-6. 2005
    ..These results indicate that maspin inhibits hypoxia-induced invasion of metastatic breast cancer cells by blocking the uPA system, thus illuminating an important molecular pathway for therapeutic consideration...
  12. ncbi request reprint Regulating the tumor suppressor gene maspin in breast cancer cells: a potential mechanism for the anticancer properties of tamoxifen
    Zhila Khalkhali-Ellis
    Department of Anatomy and Cell Biology and the Holden Comprehensive Cancer Center at The University of Iowa, Iowa City, Iowa 52242 1109, USA
    Clin Cancer Res 10:449-54. 2004
    ..Specifically, our hypothesis tested the clinical efficacy of tamoxifen to regulate maspin expression...
  13. ncbi request reprint Maspin regulates different signaling pathways for motility and adhesion in aggressive breast cancer cells
    Valerie A Odero-Marah
    The Department of Anatomy and Cell Biology at The University of Iowa, Carver College of Medicine Iowa City, Iowa USA
    Cancer Biol Ther 2:398-403. 2003
    ....
  14. pmc Nitric oxide regulation of maspin expression in normal mammary epithelial and breast cancer cells
    Zhila Khalkhali-Ellis
    Department of Anatomy and Cell Biology and the Holden Comprehensive Cancer Center at The University of Iowa, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Am J Pathol 162:1411-7. 2003
    ..Targeted delivery of NO within the tumor microenvironment could provide a feasible noninvasive approach for effective treatment...
  15. ncbi request reprint The paradoxical expression of maspin in ovarian carcinoma
    Anil K Sood
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1109, USA
    Clin Cancer Res 8:2924-32. 2002
    ..These paradoxical results may offer new insights regarding the role of maspin in ovarian cancer progression that may also impact diagnosis and treatment strategies...
  16. ncbi request reprint Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells
    Valerie A Odero-Marah
    Department of Anatomy and Cell Biology, The Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Biochem Biophys Res Commun 295:800-5. 2002
    ..These novel observations suggest that maspin, which deviates from the classical serpin, may be an important signal transduction molecule in its phosphorylated form...
  17. ncbi request reprint Dual roles of E-cadherin in prostate cancer invasion
    Jirapat Chunthapong
    Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242 1109, USA
    J Cell Biochem 91:649-61. 2004
    ..These results suggest that E-cadherin plays an important role in regulating the invasive potential of prostate cancer cells through an unique paracrine mechanism...
  18. ncbi request reprint Steroid sulfatase activity and expression in mammary myoepithelial cells
    Joanne K Tobacman
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242 1081, USA
    J Steroid Biochem Mol Biol 81:65-8. 2002
    ..This investigation examined mRNA expression and enzymatic activity of steroid sulfatase (STS) in human mammary myoepithelial cells (MMECs) and MCF-7 cells and assessed the effects of 17-beta estradiol on the activity of STS...