Shabaana A Khader

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. pmc Lipocalin 2 regulates inflammation during pulmonary mycobacterial infections
    Lokesh Guglani
    Division of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e50052. 2012
  2. pmc Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis
    R Gopal
    Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mucosal Immunol 6:972-84. 2013
  3. pmc Profiling early lung immune responses in the mouse model of tuberculosis
    Dongwan D Kang
    Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e16161. 2011
  4. pmc IL-17 in protective immunity to intracellular pathogens
    Shabaana A Khader
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Virulence 1:423-7. 2010
  5. pmc IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung
    Shabaana A Khader
    Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    J Immunol 187:5402-7. 2011
  6. pmc IL-10 restrains IL-17 to limit lung pathology characteristics following pulmonary infection with Francisella tularensis live vaccine strain
    Samantha R Slight
    Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Am J Pathol 183:1397-404. 2013
  7. pmc IL-23-dependent IL-17 drives Th1-cell responses following Mycobacterium bovis BCG vaccination
    Radha Gopal
    Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Eur J Immunol 42:364-73. 2012
  8. pmc CXCR5⁺ T helper cells mediate protective immunity against tuberculosis
    Samantha R Slight
    Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Clin Invest 123:712-26. 2013
  9. pmc Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis
    Yinyao Lin
    Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Immunity 31:799-810. 2009
  10. pmc Francisella tularensis LVS-induced Interleukin-12 p40 cytokine production mediates dendritic cell migration through IL-12 Receptor β1
    Samantha R Slight
    Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Cytokine 55:372-9. 2011

Collaborators

  • Jay K Kolls
  • Troy D Randall
  • John F Alcorn
  • Deepak Kaushal
  • T D Connell
  • Tim D Oury
  • Yvonne R Chan
  • Sarah L Gaffen
  • Moises Selman
  • Tak W Mak
  • Pawel Kalinski
  • UMA NAGARAJAN
  • Derek A Pociask
  • Radha Gopal
  • Samantha R Slight
  • Yinyao Lin
  • Javier Rangel-Moreno
  • Lokesh Guglani
  • Todd A Reinhart
  • Beth A Fallert Junecko
  • Samantha Slight
  • Leticia Monin
  • R Gopal
  • Dongwan D Kang
  • Anupa Kudva
  • Michelle Messmer
  • Uzodinma Uche
  • Ted M Ross
  • Kong Chen
  • Rosalío Ramos-Payán
  • Emmeline Blanchard
  • Daniel J Mallon
  • Christina L Stallings
  • Hillary Cleveland
  • Y Lin
  • Javier Baquera-Heredia
  • Enrique Becerril-Villanueva
  • B A Fallert Junecko
  • H F Nawar
  • Marci Davis
  • T A Reinhart
  • J Rangel-Moreno
  • Lyndsay Avery
  • Smriti Mehra
  • S Slight
  • Lenin Pavon
  • Mushtaq Ahmed
  • Natasa Obermajer
  • Beth Fallert Junecko
  • Nikhil Nuthalapati
  • Thorsten Berger
  • Erich V Scheller
  • Keven M Robinson
  • Patricia J Dubin
  • Chris R Crowe
  • Javier Rangel Moreno
  • Sun Mi Choi
  • Richard I Enelow
  • Reiko Onishi
  • Heather Strawbridge
  • Michael J Walter
  • Shane Ritchea
  • Sang Mi Park
  • Yoichiro Iwakura
  • Alison Logar
  • Nikki Nyugen

Detail Information

Publications15

  1. pmc Lipocalin 2 regulates inflammation during pulmonary mycobacterial infections
    Lokesh Guglani
    Division of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e50052. 2012
    ..Importantly, despite a common role for Lcn2 in regulating chemokines during mycobacterial pulmonary infections, Lcn2 deficient mice are more susceptible to acute M.bovis BCG, but not low dose M.tuberculosis pulmonary infection...
  2. pmc Interleukin-17-dependent CXCL13 mediates mucosal vaccine-induced immunity against tuberculosis
    R Gopal
    Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Mucosal Immunol 6:972-84. 2013
    ..Our studies highlight the potential value of targeting the IL-17-CXCL13 pathway rather than the IFNγ pathway as a new strategy to improve mucosal vaccines against TB...
  3. pmc Profiling early lung immune responses in the mouse model of tuberculosis
    Dongwan D Kang
    Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e16161. 2011
    ..These data suggest that the recruitment of Gr1+ neutrophils is an early event that leads to production of chemokines that regulate the accumulation of Th1 cells in the M.tuberculosis-infected lungs...
  4. pmc IL-17 in protective immunity to intracellular pathogens
    Shabaana A Khader
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Virulence 1:423-7. 2010
    ..The current outlook on the role of IL-23-IL-17 pathway in protective immunity to intracellular pathogens is discussed here...
  5. pmc IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung
    Shabaana A Khader
    Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    J Immunol 187:5402-7. 2011
    ..Further, although IL-17 and IL-22 can both contribute to Cxcl13 production and B cell follicle formation, it is IL-23 that is critical in this regard...
  6. pmc IL-10 restrains IL-17 to limit lung pathology characteristics following pulmonary infection with Francisella tularensis live vaccine strain
    Samantha R Slight
    Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Am J Pathol 183:1397-404. 2013
    ..These data suggest a critical role for IL-10 in maintaining the delicate balance between host immunity and pathology during pulmonary infection with F. tularensis live vaccine strain. ..
  7. pmc IL-23-dependent IL-17 drives Th1-cell responses following Mycobacterium bovis BCG vaccination
    Radha Gopal
    Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Eur J Immunol 42:364-73. 2012
    ....
  8. pmc CXCR5⁺ T helper cells mediate protective immunity against tuberculosis
    Samantha R Slight
    Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Clin Invest 123:712-26. 2013
    ..These data demonstrate that CD4+CXCR5+ T cells play a protective role in the immune response against TB and highlight their potential use for future TB vaccine design and therapy...
  9. pmc Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis
    Yinyao Lin
    Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Immunity 31:799-810. 2009
    ..Together, these findings illustrate a biological function for IL-17A in regulating IL-12-Th1 cell immunity and host responses to an intracellular pathogen...
  10. pmc Francisella tularensis LVS-induced Interleukin-12 p40 cytokine production mediates dendritic cell migration through IL-12 Receptor β1
    Samantha R Slight
    Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Cytokine 55:372-9. 2011
    ..Together, these findings illustrate that IL-12p40 is induced rapidly in response to F. tularensis LVS and is required for DC migration through an IL-12Rβ1-IL-12(p40)(2) dependent mechanism...
  11. pmc Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection
    Radha Gopal
    Department of Pediatrics, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS Pathog 10:e1004099. 2014
    ..In addition, our data changes the existing paradigm that IL-17 is dispensable for primary immunity against Mtb infection, and instead suggests a differential role for IL-17 in early protective immunity against emerging Mtb strains. ..
  12. pmc Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology after influenza infection
    Radha Gopal
    Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Am J Pathol 184:55-63. 2014
    ....
  13. doi request reprint Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice
    Anupa Kudva
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    J Immunol 186:1666-74. 2011
    ..These data indicate a novel mechanism by which influenza A-induced type I IFNs inhibit Th17 immunity and increase susceptibility to secondary bacterial pneumonia...
  14. pmc Chemokines shape the immune responses to tuberculosis
    Samantha R Slight
    Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Cytokine Growth Factor Rev 24:105-13. 2013
    ..This review highlights our recent advances in understanding the role of chemokines and chemokine receptors in cellular recruitment of immune cells to the lung, role in granuloma formation and host defense against Mtb infection...
  15. pmc Th17 cytokines in mucosal immunity and inflammation
    Lokesh Guglani
    Division of Pulmonary Medicine, Allergy and Immunology, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Curr Opin HIV AIDS 5:120-7. 2010
    ..Most importantly, it is becoming apparent that there is a fine balance between protective and pathological manifestation of Th17 responses at mucosal sites that defines immunity or inflammation...

Research Grants1