Alan H Jobe

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Maternal glucocorticoids increase endotoxin-induced lung inflammation in preterm lambs
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 284:L633-42. 2003
  2. ncbi Adrenal and thyroid axis function in preterm ventilated baboons
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Biol Neonate 83:208-16. 2003
  3. ncbi Animal models of antenatal corticosteroids: clinical implications
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Ohio 45229 3039, USA
    Clin Obstet Gynecol 46:174-89. 2003
  4. ncbi Antenatal factors and the development of bronchopulmonary dysplasia
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, 3333 Burnet Avenue, 45229 3039, Cincinnati, OH, USA
    Semin Neonatol 8:9-17. 2003
  5. doi Injury and inflammation from resuscitation of the preterm infant
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Neonatology 94:190-6. 2008
  6. ncbi Differential effects of maternal betamethasone and cortisol on lung maturation and growth in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, and the School of Women s and Infant s Health, University of Western Australia
    Am J Obstet Gynecol 188:22-8. 2003
  7. doi Lung maturation: the survival miracle of very low birth weight infants
    Alan H Jobe
    Division of Neonatology Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Pediatr neonatol 51:7-13. 2010
  8. pmc Long term consequences of oxygen therapy in the neonatal period
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Semin Fetal Neonatal Med 15:230-5. 2010
  9. ncbi Decreased indicators of lung injury with continuous positive expiratory pressure in preterm lambs
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 52:387-92. 2002
  10. ncbi Minimal lung and systemic responses to TNF-alpha in preterm sheep
    Machiko Ikegami
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L121-9. 2003

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. ncbi Maternal glucocorticoids increase endotoxin-induced lung inflammation in preterm lambs
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 284:L633-42. 2003
    ..These results have implications for lung inflammation and bronchopulmonary dysplasia in preterm infants exposed to chorioamnionitis and maternal glucocorticoids...
  2. ncbi Adrenal and thyroid axis function in preterm ventilated baboons
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Biol Neonate 83:208-16. 2003
    ..The hypothalamic-pituitary-adrenal (HPA) axis was unresponsive to standard dose stimulation tests until 11 days of age in preterm baboons, indicating HPA immaturity...
  3. ncbi Animal models of antenatal corticosteroids: clinical implications
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Ohio 45229 3039, USA
    Clin Obstet Gynecol 46:174-89. 2003
  4. ncbi Antenatal factors and the development of bronchopulmonary dysplasia
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, 3333 Burnet Avenue, 45229 3039, Cincinnati, OH, USA
    Semin Neonatol 8:9-17. 2003
    ..In this article, the hypothesis developed is that bronchopulmonary dysplasia occurs because of repetitive adverse lung exposures, or hits, and that the initial hits may be antenatal glucocorticoid exposure and/or antenatal inflammation...
  5. doi Injury and inflammation from resuscitation of the preterm infant
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Neonatology 94:190-6. 2008
    ..Ventilation strategies that minimize injury need to be developed...
  6. ncbi Differential effects of maternal betamethasone and cortisol on lung maturation and growth in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, and the School of Women s and Infant s Health, University of Western Australia
    Am J Obstet Gynecol 188:22-8. 2003
    ..We asked whether maternal or fetal cortisol treatments induced fetal lung maturation and growth restriction compared with betamethasone and whether medroxyprogesterone (MPA) influenced lung maturation...
  7. doi Lung maturation: the survival miracle of very low birth weight infants
    Alan H Jobe
    Division of Neonatology Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Pediatr neonatol 51:7-13. 2010
    ....
  8. pmc Long term consequences of oxygen therapy in the neonatal period
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Semin Fetal Neonatal Med 15:230-5. 2010
    ..Different infants probably have quite variable sensitivities to oxygen injury, but there are no biomarkers available to predict the risk of oxygen injury...
  9. ncbi Decreased indicators of lung injury with continuous positive expiratory pressure in preterm lambs
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 52:387-92. 2002
    ..05). In this model in preterm lambs CPAP results in lower indicators of acute lung injury than does mechanical ventilation during the first 2 h of life...
  10. ncbi Minimal lung and systemic responses to TNF-alpha in preterm sheep
    Machiko Ikegami
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 285:L121-9. 2003
    ..Therefore, the presence of a mediator such as TNF-alpha in a developing animal does not necessarily mean that it is causing the responses anticipated from previous results in adult animals...
  11. pmc IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 179:955-61. 2009
    ..However, chorioamnionitis is also associated with a paradoxical reduction in the incidence of surfactant deficiency-related respiratory distress syndrome in preterm infants...
  12. pmc Modulation of lipopolysaccharide-induced chorioamnionitis in fetal sheep by maternal betamethasone
    Katherine B Wolfe
    1Division of Maternal Fetal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Reprod Sci 20:1447-54. 2013
    ..We tested the hypothesis that the order of exposure to maternal betamethasone and intra-amniotic (IA) lipopolysaccharide (LPS) will differentially modulate inflammation in the chorioamnion...
  13. ncbi Oxidative stress in fetal lambs exposed to intra-amniotic endotoxin in a chorioamnionitis model
    Fook Choe Cheah
    Department of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Res 63:274-9. 2008
    ..Surfactant protein A and B mRNAs were highest at 2 d, suggesting that oxidative stress did not contribute to the lung maturation response. A modest lung oxidative stress in chorioamnionitis could contribute to bronchopulmonary dysplasia...
  14. pmc IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L512-9. 2009
    ..Inhibition of CXCR2 did not change IA LPS-induced lung maturation. IL-8 signaling does not mediate LPS-induced lung inflammation and lung maturation...
  15. pmc Interleukin-1 in lipopolysaccharide induced chorioamnionitis in the fetal sheep
    Clare A Berry
    Division of Pulmonary Biology Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Reprod Sci 18:1092-102. 2011
    ..We conclude that IL-1 and LPS both can cause chorioamnionitis, but IL-1 is not an important mediator of LPS-induced chorioamnionitis in fetal sheep...
  16. ncbi Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    J Immunol 179:8491-9. 2007
    ..The findings have implications for preterm infants exposed to chorioamnionitis for both responses to lung injury and postnatal nosocomial infections...
  17. doi High and low body temperature during the initiation of ventilation for near-term lambs
    Molly K Ball
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Resuscitation 80:133-7. 2009
    ..Recent literature suggests hypothermia may protect against lung injury. We evaluated body temperature as a variable in lung inflammation due to oxygenation and mechanical ventilation following delivery of near-term lambs...
  18. pmc Airway inflammatory cell responses to intra-amniotic lipopolysaccharide in a sheep model of chorioamnionitis
    Fook Choe Cheah
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 296:L384-93. 2009
    ..Intra-amniotic LPS recruits leukocytes to the fetal air space that have a persistent activation. These results have implications for the pathogenesis of lung inflammatory disorders in the preterm...
  19. pmc Pulmonary and systemic expression of monocyte chemotactic proteins in preterm sheep fetuses exposed to lipopolysaccharide-induced chorioamnionitis
    Tushar A Shah
    Divisions of Neonatology and Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Res 68:210-5. 2010
    ..LPS or IL-1 can induce robust expression of MCP-1 or MCP-2 in the fetal lung. LPS induction of MCP-1 is not IL-1 dependent in fetal sheep. MCP-1 and MCP-2 may be significant contributors to fetal inflammation...
  20. pmc Modulation of lipopolysaccharide-induced chorioamnionitis by Ureaplasma parvum in sheep
    Candice C Snyder
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Am J Obstet Gynecol 208:399.e1-8. 2013
    ..We hypothesized that Ureaplasma colonization of amniotic fluid would modulate chorioamnionitis induced by Escherichia coli lipopolysaccharide (LPS)...
  21. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
    ..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support...
  22. ncbi Chronic endotoxin exposure does not cause sustained structural abnormalities in the fetal sheep lungs
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Div of Pulmonary Biology, University of Cincinnati College of Medicine, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 288:L966-74. 2005
    ..Contrary to our hypothesis, a prolonged fetal exposure to intra-amniotic endotoxin caused mild persistent inflammation but did not lead to progressive structural abnormalities in lungs of near-term gestation lambs...
  23. pmc Chorioamnionitis-induced fetal gut injury is mediated by direct gut exposure of inflammatory mediators or by lung inflammation
    Tim G A M Wolfs
    Division of Neonatology, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio
    Am J Physiol Gastrointest Liver Physiol 306:G382-93. 2014
    ..Our results indicate that the detrimental consequences of chorioamnionitis on fetal gut development are the combined result of local gut and lung-mediated inflammatory responses. ..
  24. pmc Airway injury from initiating ventilation in preterm sheep
    Noah H Hillman
    Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 67:60-5. 2010
    ..HSP70 protein decreased in the lung tissue and increased in BALF with ventilation. Initiation of ventilation induced a stress response and inflammatory cytokines in small and medium-sized airways...
  25. pmc Betamethasone for lung maturation: testing dose and formulation in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Am J Obstet Gynecol 197:523.e1-6. 2007
    ..We evaluated lung maturation responses to the mixture of betamethasone phosphate (Beta-PO4) + betamethasone acetate (Beta-Ac) in comparison to Beta-PO4 or Beta-Ac in fetal sheep...
  26. pmc Recruited inflammatory cells mediate endotoxin-induced lung maturation in preterm fetal lambs
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 172:1315-21. 2005
    ..In preterm lambs, intraamniotic endotoxin and interleukin 1 (IL-1) induce lung inflammation followed by lung maturation...
  27. doi Toll-like receptors and agonist responses in the developing fetal sheep lung
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 63:388-93. 2008
    ..We conclude that TLR2 and TLR4 mRNAs increase through gestation and expression of TLR2 and TLR4 are induced by LPS in the fetal sheep lung...
  28. pmc Pulmonary and systemic inflammatory responses to intra-amniotic IL-1α in fetal sheep
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, Univ of Cincinnati, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 301:L285-95. 2011
    ..IL-1α is a potent mediator of the fetal inflammatory response syndrome...
  29. ncbi Increased IP-10 and MIG expression after intra-amniotic endotoxin in preterm lamb lung
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 167:779-86. 2003
    ..IP-10 and MIG are potent angiostatic chemokines that may contribute to lung injury and altered pulmonary vascular development in the preterm exposed to chorioamnionitis...
  30. ncbi Initial responses to ventilation of premature lambs exposed to intra-amniotic endotoxin 4 days before delivery
    Machiko Ikegami
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 286:L573-9. 2004
    ..After lung inflammation was induced by intra-amniotic endotoxin injection, ventilation did not increase lung injury...
  31. pmc Positive end-expiratory pressure and surfactant decrease lung injury during initiation of ventilation in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 301:L712-20. 2011
    ..The use of PEEP during initiation of ventilation at birth decreased early mediators of lung injury. Surfactant administration changed the distribution of injury and had a moderate additive protective effect...
  32. pmc Betamethasone dose and formulation for induced lung maturation in fetal sheep
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Am J Obstet Gynecol 201:611.e1-7. 2009
    ..We hypothesized that maternal treatments with betamethasone acetate induce fetal lung maturation comparably to the betamethasone phosphate+betamethasone acetate used clinically...
  33. ncbi Surfactant and physiologic responses of preterm lambs to continuous positive airway pressure
    Neil Mulrooney
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati School of Medicine, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 171:488-93. 2005
    ..A small amount of endogenous Sat PC is required for preterm lambs to breathe successfully with CPAP. CPAP 8 improves early newborn respiratory transition relative to CPAP 5...
  34. pmc Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 11:151. 2010
    ..Increased pro-inflammatory cytokines in tracheal aspirates correlate with the development of BPD in preterm infants. Ventilation of preterm lambs increases pro-inflammatory cytokines and causes lung inflammation...
  35. pmc Chronic fetal exposure to Ureaplasma parvum suppresses innate immune responses in sheep
    Suhas G Kallapur
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    J Immunol 187:2688-95. 2011
    ..parvum. The findings increase our understanding of how chorioamnionitis-exposed preterm infants may respond to lung injury and postnatal nosocomial infections...
  36. pmc Inflammation and lung maturation from stretch injury in preterm fetal sheep
    Noah H Hillman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 300:L232-41. 2011
    ..We conclude that a brief period of high V(T) ventilation causes a proinflammatory cascade, a maturation of lung monocytic cells, and an induction of surfactant protein mRNA...
  37. ncbi Effects of high PCO2 on ventilated preterm lamb lungs
    Marya Strand
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 53:468-72. 2003
    ..Preterm lambs tolerated a very high PCO(2) without physiologic compromise for 6 h. The high PCO(2) may attenuate ventilator-induced lung injury in the preterm...
  38. ncbi Lung inflammatory responses to intratracheal interleukin-1alpha in ventilated preterm lambs
    Neil Mulrooney
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatr Res 55:682-7. 2004
    ..The i.v. IL-1alpha caused no lung inflammation or injury but did result in severe neutropenia and hypotension leading to early death. IT IL-1alpha can cause intense lung inflammation and systemic shock in ventilated preterm lungs...
  39. ncbi Postnatal lung inflammation increased by ventilation of preterm lambs exposed antenatally to Escherichia coli endotoxin
    Machiko Ikegami
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 52:356-62. 2002
    ..An antenatal exposure of the fetal lung to endotoxin enhanced the subsequent inflammatory response of the ventilated preterm lung...
  40. ncbi Pulmonary and systemic induction of SAA3 after ventilation and endotoxin in preterm lambs
    Teicha C Wilson
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Division of Pulmonary Biology, OH 45229, USA
    Pediatr Res 58:1204-9. 2005
    ..Our experiments show rapid induction of an APR gene in lung in response to proinflammatory stimuli...
  41. ncbi Vascular changes after intra-amniotic endotoxin in preterm lamb lungs
    Suhas G Kallapur
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1178-85. 2004
    ..Exposure to antenatal inflammation may cause vascular remodeling and contribute to the development of BPD...
  42. ncbi Injury, inflammation, and remodeling in fetal sheep lung after intra-amniotic endotoxin
    Boris W Kramer
    Division of Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229, USA
    Am J Physiol Lung Cell Mol Physiol 283:L452-9. 2002
    ..Intra-amniotic endotoxin caused surfactant secretion, inflammation, cell death, and remodeling as indications of lung injury. The recovery phase was accompanied by maturational changes in the fetal lung...
  43. ncbi Intratracheal endotoxin causes systemic inflammation in ventilated preterm lambs
    Boris W Kramer
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Crit Care Med 165:463-9. 2002
    ..Inflammation in the lungs was more severe in preterm animals. Mechanical ventilation of the endotoxin-exposed preterm lung resulted in systemic effects at a low endotoxin dose and without high tidal volume ventilation...
  44. pmc Intra-amniotic IL-1β induces fetal inflammation in rhesus monkeys and alters the regulatory T cell/IL-17 balance
    Suhas G Kallapur
    Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    J Immunol 191:1102-9. 2013
    ..Boosting regulatory T cells and/or controlling IL-17 may provide a means to ameliorate these abnormalities...
  45. pmc Moderate tidal volumes and oxygen exposure during initiation of ventilation in preterm fetal sheep
    Noah H Hillman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Ohio, USA
    Pediatr Res 72:593-9. 2012
    ..Exposure to large tidal volumes (V(T)s) at birth causes lung inflammation, and oxygen may amplify the injury. We hypothesized that normal V(T) ventilation at birth causes lung injury that is exacerbated by 95% oxygen...
  46. ncbi Monocyte function in preterm, term, and adult sheep
    Boris W Kramer
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
    Pediatr Res 54:52-7. 2003
    ..The reduced phagocytosis of apoptotic cells by monocytes from the preterm may contribute to prolonged inflammation in diseases such as bronchopulmonary dysplasia...
  47. ncbi Surfactant protein B inhibits endotoxin-induced lung inflammation
    Ralph Epaud
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Respir Cell Mol Biol 28:373-8. 2003
    ....
  48. pmc Antenatal and postnatal corticosteroid and resuscitation induced lung injury in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 10:124. 2009
    ..Antenatal corticosteroids mature the lungs of preterm infants and postnatal corticosteroids are used to treat bronchopulmonary dysplasia...
  49. doi "Miracle" extremely low birth weight neonates: examples of developmental plasticity
    Alan H Jobe
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Obstet Gynecol 116:1184-90. 2010
    ..The adaptations that permit survival after very preterm birth may have adverse effects in later life. The biology of multiple organ system plasticities resulting from very preterm birth remains to be extensively explored...
  50. doi Repeated exposure to intra-amniotic LPS partially protects against adverse effects of intravenous LPS in preterm lambs
    Tate Gisslen
    1Division of Neonatology Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Innate Immun 20:214-24. 2014
    ..The different compartments of exposure to LPS (i.a. vs i.v.) are unique to the fetal to newborn transition. Intra-amniotic LPS incompletely tolerized fetal lambs to postnatal i.v. LPS...
  51. pmc Ureaplasma and BPD
    Suhas G Kallapur
    Divisions of Neonatology and Pulmonary Biology, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, University of Cincinnati, OH 45229, USA
    Semin Perinatol 37:94-101. 2013
    ..We will review epidemiological studies of Ureaplasma and BPD in preterm infants and efficacy of antibiotics in preventing preterm labor and BPD...
  52. ncbi Choice and dose of corticosteroid for antenatal treatments
    Alan H Jobe
    Division of Neonatology Pulmonary Biology, Cincinnati Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Am J Obstet Gynecol 190:878-81. 2004
    ..However, a change from current practice will require further randomized controlled trials...
  53. ncbi Injury responses to different surfactants in ventilated premature lamb lungs
    Machiko Ikegami
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45229 3039, USA
    Pediatr Res 51:689-95. 2002
    ....
  54. pmc Neutrophil recruitment and activation in decidua with intra-amniotic IL-1beta in the preterm rhesus macaque
    Pietro Presicce
    Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio
    Biol Reprod 92:56. 2015
    ..These results help to understand the contribution of neutrophils to the pathogenesis of chorioamnionitis-induced preterm labor. ..
  55. pmc Intra-amniotic LPS and antenatal betamethasone: inflammation and maturation in preterm lamb lungs
    Elke Kuypers
    Department of Pediatrics, School for Oncology and Developmental Biology, Maastricht University Medical Center, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 302:L380-9. 2012
    ..We conclude that the order of exposures of intra-amniotic LPS or maternal betamethasone had large effects on fetal lung inflammation and maturation...
  56. ncbi Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep
    Jodi K Regan
    Division of Maternal Fetal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Reprod Sci . 2015
    ..Collagen expression was nonhomogeneous by histochemical staining, and there was a trend toward decreased mRNA expression of collagen subunit COL5A1 after IA LPS...
  57. pmc Oral, nasal and pharyngeal exposure to lipopolysaccharide causes a fetal inflammatory response in sheep
    Gunlawadee Maneenil
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio, United States of America Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Thailand
    PLoS ONE 10:e0119281. 2015
    ..The oral, nasal, and pharyngeal cavities (ONP) contain lymphoid tissue and epithelium that are in contact with the amniotic fluid. The ability of the ONP epithelium and lymphoid tissue to initiate a FIR is unknown...
  58. pmc Physiology of transition from intrauterine to extrauterine life
    Noah H Hillman
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML 7029, Cincinnati, OH 45229 3039, USA
    Clin Perinatol 39:769-83. 2012
    ..Abnormalities in adaptation are frequently found following preterm birth or cesarean delivery at term, and many of these infants need delivery room resuscitation to assist in this transition...
  59. pmc Effects of chorioamnionitis on the fetal lung
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML 7029, Cincinnati, OH 45229 3039, USA
    Clin Perinatol 39:441-57. 2012
    ..In experimental models, chorioamnionitis can both injure and mature the fetal lung and cause immune nodulation. Postnatal care strategies also change how chorioamnionitis relates to clinical outcomes such as bronchopulmonary dysplasia...
  60. ncbi Antenatal associations with lung maturation and infection
    Alan H Jobe
    Division Pulmonary Biology, Cincinnati Children s Hospital, OH 45229, USA
    J Perinatol 25:S31-5. 2005
    ..These experimental observations contribute to explanations of why preterm infants have variable degrees of lung maturation at birth and unpredictably develop bronchopulmonary dysplasia BPD...
  61. ncbi Mechanisms to explain surfactant responses
    Alan H Jobe
    Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, Ohio, USA
    Biol Neonate 89:298-302. 2006
    ..Prenatal corticosteroids complement surfactant to further enhance lung function. The magic of surfactant therapy results from the multiple interactions between surfactant and the preterm lung...
  62. pmc Intra-amniotic LPS modulates expression of antimicrobial peptides in the fetal sheep lung
    Augusto F Schmidt
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio
    Pediatr Res 76:441-7. 2014
    ..We hypothesized that DAMPs and AMPs would increase in response to fetal pulmonary inflammation caused by chorioamnionitis in a time-dependent manner...
  63. pmc Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates
    Cesar M Rueda
    Division of Immunobiology, Cincinnati Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Hum Immunol 76:65-73. 2015
    ..Lower Treg activity may contribute to inflammation in newborns that is often associated with chorioamnionitis. ..
  64. pmc Ventilation-induced increases in EGFR ligand mRNA are not altered by intra-amniotic LPS or ureaplasma in preterm lambs
    Noah H Hillman
    Division of Neonatology, Saint Louis University, Saint Louis, Missouri, United States of America Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e96087. 2014
    ..The alterations seen in ACE with IA exposures and EGFR pathways with mechanical ventilation may contribute to the development of BPD in preterm infants. ..
  65. ncbi Early bubble CPAP and outcomes in ELBW preterm infants
    Vivek Narendran
    Division of Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45267 0541, USA
    J Perinatol 23:195-9. 2003
    ..To test whether the introduction of early bubble continuous positive airway pressure (CPAP) results in improved respiratory outcomes in extremely low birth-weight infants...
  66. ncbi Recruitment and development of academic pediatricians: departmental commitments to promote success
    Alan H Jobe
    Division of Pulmonary Biology, Children s Hospital, Cincinnati, Ohio 45229 3039, USA
    Pediatr Res 51:662-4. 2002
  67. pmc Fetal immune response to chorioamnionitis
    Suhas G Kallapur
    Division of Neonatology Pulmonary Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati
    Semin Reprod Med 32:56-67. 2014
    ..As chorioamnionitis disproportionately affects preterm infants, we discuss the relevant developmental context for the immune system. We also provide a clinical context for the fetal responses. ..
  68. doi An MRI system for imaging neonates in the NICU: initial feasibility study
    Jean A Tkach
    Imaging Research Center, Department of Radiology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 5033, Cincinnati, OH 45229, USA
    Pediatr Radiol 42:1347-56. 2012
    ..Transporting premature infants from a neonatal intensive care unit (NICU) to a radiology department for MRI has medical risks and logistical challenges...
  69. doi Obesity and the developmental origins of health and disease
    Matthew W Kemp
    School of Women s and Infants Health, The University of Western Australia, Subiaco, Western Australia, Australia
    J Paediatr Child Health 48:86-90. 2012
    ..Here, we review the evolution of 'the developmental origins of health and disease' as a concept and discuss recent advances in the association of specific stimuli to obesity, an epidemic cause of human morbidity and mortality...
  70. pmc Postnatal corticosteroids for bronchopulmonary dysplasia
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Clin Perinatol 36:177-88. 2009
    ..An approach to minimizing risk is to use low-dose, short-duration treatments in the highest risk ventilator-dependent patients. Questions remain about which corticosteroid is the safest and how to dose that corticosteroid...
  71. pmc The new bronchopulmonary dysplasia
    Alan H Jobe
    Cincinnati Children s Hospital, Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Curr Opin Pediatr 23:167-72. 2011
    ..Bronchopulmonary dysplasia (BPD) remains the most common severe complication of preterm birth. A number of recent animal models and clinical studies provide new information about pathophysiology and treatment...
  72. ncbi The multiple negative randomized controlled trials in perinatology--why?
    Marya Strand
    Division of Pulmonary Biology Neonatology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Semin Perinatol 27:343-50. 2003
    ....
  73. ncbi Indications for and questions about antenatal steroids
    Alan H Jobe
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Adv Pediatr 49:227-43. 2002
    ..Antenatal glucocorticoid therapy is very effective, and no adverse effects of a single treatment course have been identified...
  74. ncbi Fetal surgery for myelomeningocele
    Alan H Jobe
    Cincinnati Children s Hospital, Cincinnati, OH 45229 3039, USA
    N Engl J Med 347:230-1. 2002
  75. doi Clinical algorithms for the identification of sick newborns in community-based settings
    Beena D Kamath-Rayne
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Acta Paediatr 101:344-51. 2012
    ..Based on a comparison of relevant studies, we then identified the common, important clinical signs shown to be useful for the identification of at-risk newborns by health workers in community-based and low-resource settings...
  76. ncbi An unanticipated benefit of the treatment of preterm infants with CuZn superoxide dismutase
    Alan H Jobe
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Pediatrics 111:680. 2003
  77. ncbi Drug pricing in pediatrics: the egregious example of indomethacin
    Alan H Jobe
    Cincinnati Children s Hospital, Division of Pulmonary Biology, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Pediatrics 119:1197-8. 2007
  78. ncbi The clever fetus: responding to inflammation to minimize lung injury
    Boris W Kramer
    Universitäts Kinderklinik, Wurzburg, Germany
    Biol Neonate 88:202-7. 2005
    ..Both exposures can either increase or decrease fetal inflammatory responses depending on the timing of the exposures. The immunomodulatory ability of the fetus to fetal exposures remains an unexplored research field...
  79. ncbi Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is associated with changes in surfactant pool size and morphometry
    J Jane Pillow
    Centre for Child Health Research, The University of Western Australia, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 287:L992-8. 2004
    ..Despite the complex cascade of events initiated by antenatal endotoxin exposure, variability in lung tissue mechanics is associated primarily with changes in alveolar Sat PC pool and lung morphology...
  80. ncbi Transition/adaptation in the delivery room and less RDS: "Don't just do something, stand there!"
    Alan H Jobe
    J Pediatr 147:284-6. 2005
  81. ncbi The effects of intra-amniotic injection of periodontopathic lipopolysaccharides in sheep
    John P Newnham
    The School of Women s and Infants Health, The University of Western Australia at King Edward Memorial Hospital, Perth, Western Australia
    Am J Obstet Gynecol 193:313-21. 2005
    ..The outcomes that were studied included the rates of fetal death and the features of inflammation and lung maturation in survivors...
  82. ncbi Endotoxin-induced chorioamnionitis modulates innate immunity of monocytes in preterm sheep
    Boris W Kramer
    University Children s Hospital, Josef Schneider Str 2, 97080 Wuerzburg, Germany
    Am J Respir Crit Care Med 171:73-7. 2005
    ..Modulation of fetal innate immune responses by exposure to inflammation may alter subsequent immune adaptation after birth...
  83. ncbi Prenatal glucocorticoid exposure and postnatal adaptation in premature newborn baboons ventilated for six days
    Lynne M Smith
    Department of Pediatrics, Harbor UCLA Research and Education Institute, University of California, Los Angeles School of Medicine, Harbor UCLA Medical Center, Torrance, Calif, USA
    Am J Obstet Gynecol 191:1688-94. 2004
    ..Study design Pregnant baboons received saline or BETA (6 mg) 48 and 24 hours before preterm delivery at 125 days' gestation. The newborn baboons were ventilated for 6 days, and assessed for renal, cardiovascular, and endocrine function...
  84. ncbi Experimental intrauterine Ureaplasma infection in sheep
    Timothy J M Moss
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Am J Obstet Gynecol 192:1179-86. 2005
    ..We hypothesized that intra-amniotic ureaplasmas would cause lung inflammation and alter fetal lung development...
  85. ncbi Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung
    Karen E Willet
    Division of Clinical Sciences, Center for Child Health Research, Perth, Australia
    Am J Physiol Lung Cell Mol Physiol 282:L411-20. 2002
    ..Lung compliance, lung volume, and alveolar Sat PC were positively correlated with residual alveolar wash leukocyte numbers 7 days after IL-1 treatment, suggesting a link between lung inflammation and maturation...
  86. ncbi Antenatal betamethasone changes cord blood monocyte responses to endotoxin in preterm lambs
    Boris W Kramer
    University Children s Hospital, 97080 Wurzburg, Germany
    Pediatr Res 55:764-8. 2004
    ..The time-dependent changes in maternal betamethasone modulation of the responses of fetal monocytes may influence immune function of the preterm lamb after delivery...
  87. ncbi Postnatal corticosteroids for preterm infants--do what we say, not what we do
    Alan H Jobe
    N Engl J Med 350:1349-51. 2004
  88. ncbi Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry
    Timothy J M Moss
    School of Women s and Infants Health and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 165:805-11. 2002
    ....
  89. ncbi Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia
    Richard A Ehrenkranz
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 116:1353-60. 2005
    ..The objective of this study was to determine the predictive validity of the severity-based, consensus definition of BPD...
  90. ncbi The fetal maturational and inflammatory responses to different routes of endotoxin infusion in sheep
    John P Newnham
    Department of Obstetrics and Gynaecology, University of Western Australia at King Edward Memorial Hospital, Subiaco, Perth, Australia
    Am J Obstet Gynecol 186:1062-8. 2002
    ..This study aimed to explore the mechanisms by which endotoxin matures the lungs by determining whether the route of administration influenced the maturational responses of the fetus...
  91. ncbi Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep
    John P Newnham
    School of Women s and Infants Health, University of Western Australia, King Edward Memorial Hospital, Bagot Road, Subiaco, Perth, WA 6008, Australia
    Am J Obstet Gynecol 189:1458-66. 2003
    ..We describe the effects of intra-amniotic endotoxin on cytokines and white cell responses in the membranes and amniotic fluid and investigate the hypothesis that betamethasone treatment suppresses these responses...
  92. doi Maternal betamethasone and chorioamnionitis induce different collagenases during lung maturation in fetal sheep
    David G Sweet
    Department of Child Health, The Queen s University of Belfast, UK
    Neonatology 94:79-86. 2008
    ..The effectors of this antenatally-induced lung maturation are not understood. Matrix metalloproteinases (MMPs) 2 and 9 are type-IV collagenases that can degrade alveolar basement membranes...
  93. ncbi IL-1 alpha causes lung inflammation and maturation by direct effects on preterm fetal lamb lungs
    Ilene R S Sosenko
    Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33106, USA
    Pediatr Res 60:294-8. 2006
    ..IL-1alpha induced large increases in alveolar surfactant saturated phosphatidylcholine and increased lung gas volumes. Lung inflammation and maturation result from direct exposure of the fetal lung to a single cytokine - IL-1alpha...
  94. ncbi Intraamniotic endotoxin increases lung antioxidant enzyme activity in preterm lambs
    Ilene R S Sosenko
    Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Florida 33101, USA
    Pediatr Res 53:679-83. 2003
    ..Thus, mechanisms involving proinflammatory stimulation, unrelated to glucocorticoid hormones, can induce maturation of the AOE system of the fetal lung...
  95. ncbi Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs
    Graeme R Polglase
    School of Women s and Infants Health, The University of Western Australia, Crawley, Western Australia, 6009, Australia
    Pediatr Res 62:32-6. 2007
    ..Similar structural changes induced by intra-amniotic corticosteroids and maternal intramuscular betamethasone were associated with improvements in lung function at 2 and 7 d...
  96. ncbi Endotoxin-induced maturation of monocytes in preterm fetal sheep lung
    Boris W Kramer
    University Hospital Maastricht, Maastricht, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 293:L345-53. 2007
    ..Intra-amniotic endotoxin induced lung monocytes to develop into functionally mature cells consistent with macrophages. These findings have implications for lung immune responses after exposure to chorioamnionitis...
  97. ncbi Single and multiple prenatal glucocorticoid exposures improve preterm newborn lamb cardiovascular and renal function similarly
    Lynne M Smith
    Department of Pediatrics, University of California, Los Angeles School of Medicine, Harbor UCLA Medical Center, Torrance 90502, USA
    Am J Obstet Gynecol 188:444-53. 2003
    ..Renal and cardiovascular function improves in preterm newborn lambs after a single prenatal betamethasone treatment. We hypothesized that multiple betamethasone exposures would further improve renal and cardiovascular adaptation...
  98. pmc Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambs
    J Jane Pillow
    School of Women s and Infants Health, The University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 176:63-9. 2007
    ..The technique used to provide continuous positive airway pressure (CPAP) to the newborn may influence lung function and breathing efficiency...
  99. ncbi An unknown: lung growth and development after very preterm birth
    Alan H Jobe
    Am J Respir Crit Care Med 166:1529-30. 2002
  100. ncbi Surfactant phosphatidylcholine half-life and pool size measurements in premature baboons developing bronchopulmonary dysplasia
    Daphne J M T Janssen
    Department of Pediatrics Neonatology, Sophia s Children s Hospital Erasmus University Rotterdam, Rotterdam, The Netherlands
    Pediatr Res 52:724-9. 2002
    ..Measurements with stable isotopes are comparable to measurements with radioactive tracers and measurements at autopsy...
  101. ncbi Intra-amniotic endotoxin induces lung maturation by direct effects on the developing respiratory tract in preterm sheep
    Timothy J M Moss
    School of Women s and Infants Health, University of Western Australia, 35 Stirling Highway, Crawley WA, Perth, Australia
    Am J Obstet Gynecol 187:1059-65. 2002
    ..Our purpose was to determine whether improved preterm lung function caused by intraamniotic endotoxin treatment requires endotoxin entry into the respiratory tract...