Eric Hoffman

Summary

Affiliation: Children's National Medical Center
Country: USA

Publications

  1. pmc Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model
    Vanessa E Jahnke
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC, USA
    Skelet Muscle 2:16. 2012
  2. pmc Genome-wide identification of significant aberrations in cancer genome
    Xiguo Yuan
    School of Computer Science and Technology, Xidian University, Xi an, P R China
    BMC Genomics 13:342. 2012
  3. pmc Alterations in osteopontin modify muscle size in females in both humans and mice
    Eric P Hoffman
    Department of Integrative Systems Biology, Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC 20010, USA
    Med Sci Sports Exerc 45:1060-8. 2013
  4. pmc Eps homology domain endosomal transport proteins differentially localize to the neuromuscular junction
    Suzanne E Mate
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Skelet Muscle 2:19. 2012
  5. pmc Novel approaches to corticosteroid treatment in Duchenne muscular dystrophy
    Eric P Hoffman
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC 20010, USA
    Phys Med Rehabil Clin N Am 23:821-8. 2012
  6. pmc Δ-9,11 modification of glucocorticoids dissociates nuclear factor-κB inhibitory efficacy from glucocorticoid response element-associated side effects
    Andreas R Baudy
    Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA
    J Pharmacol Exp Ther 343:225-32. 2012
  7. pmc AKT1 polymorphisms are associated with risk for metabolic syndrome
    Joseph M Devaney
    Department of Integrative Systems Biology, Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Hum Genet 129:129-39. 2011
  8. pmc Characterization of the ZBTB42 gene in humans and mice
    Stephanie A Devaney
    Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Hum Genet 129:433-41. 2011
  9. pmc NKG2A inhibits TH2 cell effector function in vitro
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, Washington, DC, USA
    BMC Pulm Med 7:14. 2007
  10. pmc PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
    Julieta Uthurralt
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 8:55. 2007

Detail Information

Publications108 found, 100 shown here

  1. pmc Metabolic remodeling agents show beneficial effects in the dystrophin-deficient mdx mouse model
    Vanessa E Jahnke
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC, USA
    Skelet Muscle 2:16. 2012
    ..abstract:..
  2. pmc Genome-wide identification of significant aberrations in cancer genome
    Xiguo Yuan
    School of Computer Science and Technology, Xidian University, Xi an, P R China
    BMC Genomics 13:342. 2012
    ....
  3. pmc Alterations in osteopontin modify muscle size in females in both humans and mice
    Eric P Hoffman
    Department of Integrative Systems Biology, Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC 20010, USA
    Med Sci Sports Exerc 45:1060-8. 2013
    ..An osteopontin (OPN; SPP1) gene promoter polymorphism modifies disease severity in Duchenne muscular dystrophy, and we hypothesized that it might also modify muscle phenotypes in healthy volunteers...
  4. pmc Eps homology domain endosomal transport proteins differentially localize to the neuromuscular junction
    Suzanne E Mate
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Skelet Muscle 2:19. 2012
    ..abstract:..
  5. pmc Novel approaches to corticosteroid treatment in Duchenne muscular dystrophy
    Eric P Hoffman
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC 20010, USA
    Phys Med Rehabil Clin N Am 23:821-8. 2012
    ..In parallel, there has been progress in the area of "dissociative steroids," drugs that are able to better separate efficacy and side effects, providing a broader therapeutic window...
  6. pmc Δ-9,11 modification of glucocorticoids dissociates nuclear factor-κB inhibitory efficacy from glucocorticoid response element-associated side effects
    Andreas R Baudy
    Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA
    J Pharmacol Exp Ther 343:225-32. 2012
    ..Accordingly, Δ-9,11 analogs may hold promise as a source of safer therapeutic agents for chronic inflammatory disorders...
  7. pmc AKT1 polymorphisms are associated with risk for metabolic syndrome
    Joseph M Devaney
    Department of Integrative Systems Biology, Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Hum Genet 129:129-39. 2011
    ..021). The 12-kb haplotype is a risk factor for metabolic syndrome and insulin resistance that needs to be explored in further populations...
  8. pmc Characterization of the ZBTB42 gene in humans and mice
    Stephanie A Devaney
    Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Hum Genet 129:433-41. 2011
    ..The genetic association data of metabolic syndrome, coupled with the molecular characterization of the ZBTB42 transcript unit and encoded protein presented here, suggests that ZBTB42 may be involved in metabolic syndrome phenotypes...
  9. pmc NKG2A inhibits TH2 cell effector function in vitro
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, Washington, DC, USA
    BMC Pulm Med 7:14. 2007
    ..Here we measured cytokine expression in human ex vivo TH2 cells upon activation with anti-CD3/28 and challenge with an NKG2A-specific agonist...
  10. pmc PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
    Julieta Uthurralt
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 8:55. 2007
    ..We hypothesized that the study of younger populations would mitigate many confounding variables, and allow us to better define genetic predisposition loci for metabolic syndrome...
  11. pmc INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men
    Funda E Orkunoglu-Suer
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 9:117. 2008
    ....
  12. pmc Sexual dimorphism in immune response genes as a function of puberty
    Rebecca Lamason
    Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    BMC Immunol 7:2. 2006
    ....
  13. pmc Skeletal muscle gene expression in response to resistance exercise: sex specific regulation
    Dongmei Liu
    Dept of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, USA
    BMC Genomics 11:659. 2010
    ..A logistic regression-based method (LRpath), following Bayesian moderated t-statistic (IMBT), was used to test gene functional groups and biological pathways enriched with differentially expressed genes...
  14. pmc Membrane sealant Poloxamer P188 protects against isoproterenol induced cardiomyopathy in dystrophin deficient mice
    Christopher F Spurney
    Children s National Heart Institute, Division of Cardiology, Children s National Medical Center, Washington, DC, USA
    BMC Cardiovasc Disord 11:20. 2011
    ..The absence of dystrophin leads to loss of membrane integrity, cell death and fibrosis in cardiac muscle. Treatment of cardiomyocyte membrane instability could help prevent cardiomyopathy...
  15. pmc Motif-guided sparse decomposition of gene expression data for regulatory module identification
    Ting Gong
    Bradley Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA 22203, USA
    BMC Bioinformatics 12:82. 2011
    ..However, traditional gene clustering often yields unsatisfactory results for regulatory module identification because the resulting gene clusters are co-expressed but not necessarily co-regulated...
  16. pmc Probe set algorithms: is there a rational best bet?
    Jinwook Seo
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington DC 20010, USA
    BMC Bioinformatics 7:395. 2006
    ..We argue that "background" is an enormously complex variable that can only be vaguely quantified, and thus the "best" probe set algorithm will vary from project to project...
  17. pmc Motif-directed network component analysis for regulatory network inference
    Chen Wang
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 9:S21. 2008
    ..We propose a new approach, motif-directed NCA (mNCA), to integrate motif information and gene expression data to infer regulatory networks...
  18. pmc Knowledge-guided gene ranking by coordinative component analysis
    Chen Wang
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 11:162. 2010
    ..However, current integration strategies are often heuristic and fail to incorporate fully the true interplay between biological knowledge and gene expression data...
  19. pmc Development and production of an oligonucleotide MuscleChip: use for validation of ambiguous ESTs
    Rehannah H A Borup
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue N W, Washington, DC 20010, USA
    BMC Bioinformatics 3:33. 2002
    ..The 120,000 oligonucleotides were synthesized by photolithography and light-activated chemistry on each microarray...
  20. pmc Knowledge-guided multi-scale independent component analysis for biomarker identification
    Li Chen
    Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA, USA
    BMC Bioinformatics 9:416. 2008
    ..In this paper, we develop a novel strategy, namely knowledge-guided multi-scale independent component analysis (ICA), to first infer regulatory signals and then identify biologically relevant biomarkers from microarray data...
  21. pmc caBIG VISDA: modeling, visualization, and discovery for cluster analysis of genomic data
    Yitan Zhu
    Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Arlington, VA 22203, USA
    BMC Bioinformatics 9:383. 2008
    ....
  22. pmc Proteomic profiling of glucocorticoid-exposed myogenic cells: Time series assessment of protein translocation and transcription of inactive mRNAs
    Erica Km Reeves
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington DC, 20010, USA
    Proteome Sci 7:26. 2009
    ....
  23. pmc Translating mighty mice into neuromuscular therapeutics: is bigger muscle better?
    Eric P Hoffman
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Am J Pathol 168:1775-8. 2006
  24. pmc Restoring dystrophin expression in duchenne muscular dystrophy muscle progress in exon skipping and stop codon read through
    Eric P Hoffman
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Am J Pathol 179:12-22. 2011
    ..We discuss the status of these two methods aimed at inducing de novo dystrophin production from mutant genes and review implications for other disorders...
  25. pmc Integrated genomics and proteomics of the Torpedo californica electric organ: concordance with the mammalian neuromuscular junction
    Suzanne E Mate
    Department of Biochemistry and Molecular Genetics, IBS, George Washington University, Washington DC, USA
    Skelet Muscle 1:20. 2011
    ..abstract:..
  26. ncbi request reprint Clarifying the boundaries between the inflammatory and dystrophic myopathies: insights from molecular diagnostics and microarrays
    Eric P Hoffman
    Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Rheum Dis Clin North Am 28:743-57. 2002
    ..It is hoped that novel approaches for treating the inflammatory myopathies and dystrophies can be derived from intimate knowledge of the pathways involved in each disease, and the key molecules that provide cross-talk between pathways...
  27. ncbi request reprint New molecular research technologies in the study of muscle disease
    Eric P Hoffman
    Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Curr Opin Rheumatol 15:698-707. 2003
    ....
  28. ncbi request reprint Expression profiling and pharmacogenomics of muscle and muscle disease
    Eric P Hoffman
    Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Curr Opin Pharmacol 3:309-16. 2003
    ..Muscle is also important in drug metabolism and adverse events, and the application of single nucleotide polymorphism association studies in muscle pharmacogenomics is a field of expected future growth...
  29. doi request reprint Antisense oligo-mediated multiple exon skipping in a dog model of duchenne muscular dystrophy
    Toshifumi Yokota
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue, NW, Washington, DC, USA
    Methods Mol Biol 709:299-312. 2011
    ....
  30. ncbi request reprint Interactively optimizing signal-to-noise ratios in expression profiling: project-specific algorithm selection and detection p-value weighting in Affymetrix microarrays
    Jinwook Seo
    Research Center for Genetic Medicine, Children s National Medical Center, MD, USA
    Bioinformatics 20:2534-44. 2004
    ..Also, we hypothesized that use of the Microarray Suite (MAS) 5.0 probe set detection p-value as a weighting function would improve the performance of all probe set algorithms...
  31. ncbi request reprint IGF-II gene region polymorphisms related to exertional muscle damage
    Joseph M Devaney
    Children s National Medical Center, Washington, District of Columbia, USA
    J Appl Physiol (1985) 102:1815-23. 2007
    ..In women, fewer significant associations appeared...
  32. ncbi request reprint Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb-MyoD pathways in muscle regeneration
    Marina Bakay
    Research Center for Genetic Medicine, Children s National Medical Center, Washington DC 20010, USA
    Brain 129:996-1013. 2006
    ..Our data is consistent with mutations of nuclear lamina components leading to destabilization of the transcriptome in differentiated cells...
  33. pmc Sources of variability and effect of experimental approach on expression profiling data interpretation
    Marina Bakay
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue, NW Washington, DC 20010 USA
    BMC Bioinformatics 3:4. 2002
    ....
  34. ncbi request reprint Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis
    Zivana Tezak
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    J Immunol 168:4154-63. 2002
    ..We hypothesize that these data support a model of Ag (?viral) induction of an apparent autoimmune disease based on dynamic interaction between the muscle, vascular, and immune systems in the genetically susceptible (DQA1*0501(+)) child...
  35. pmc Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset
    Akanchha Kesari
    Research Center for Genetic Medicine, Children s National Medical Center, Washington DC 20010, USA
    Am J Pathol 173:1476-87. 2008
    ....
  36. pmc Inflammasome up-regulation and activation in dysferlin-deficient skeletal muscle
    Rashmi Rawat
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Am J Pathol 176:2891-900. 2010
    ..These data indicate that skeletal muscle is an active contributor of IL-1beta and strategies that interfere with this pathway may be therapeutically useful for patients with limb girdle muscular dystrophy type 2B...
  37. pmc The PEPR GeneChip data warehouse, and implementation of a dynamic time series query tool (SGQT) with graphical interface
    Josephine Chen
    Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Nucleic Acids Res 32:D578-81. 2004
    ..cnmcresearch.org/pgadatatable.asp)...
  38. ncbi request reprint A web-accessible complete transcriptome of normal human and DMD muscle
    Marina Bakay
    Research Center for Genetic Medicine, George Washington University School of Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Neuromuscul Disord 12:S125-41. 2002
    ..org/pga). These data enumerate the full range of molecular changes associated downstream of dystrophin deficiency, and provide a web-accessible platform to study the specificity of transcriptional pathway alterations in muscle disease...
  39. ncbi request reprint Gene expression profiling of experimental traumatic spinal cord injury as a function of distance from impact site and injury severity
    Andrea De Biase
    Children s National Medical Center, Center for Genetic Medicine, Georgetown University School of Medicine, Washington, District of Columbia 20057, USA
    Physiol Genomics 22:368-81. 2005
    ..The results underscore the power of microarray approaches to reveal global genomic responses as well as changes in particular gene clusters and/or families that may be important in the secondary injury cascade...
  40. ncbi request reprint Murine cytomegalovirus infection increases aortic expression of proatherosclerotic genes
    Mary Susan Burnett
    Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Circulation 109:893-7. 2004
    ..Additionally, in cholesterol-fed C57BL/6J mice, we examined the effects of MCMV infection on aortic lesion area...
  41. ncbi request reprint Constitutive activation of MAPK cascade in acute quadriplegic myopathy
    Simone Di Giovanni
    Center for Genetic Medicine, Children s National Medical Center and Genetics Program, George Washington University, Washington, DC 20010, USA
    Ann Neurol 55:195-206. 2004
    ..The acute stimulation of the TGF-beta/MAPK pathway, coupled with the inactivity-induced atrogin-1/proteosome pathway, leads to the acute muscle loss seen in AQM patients...
  42. ncbi request reprint GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle
    Jung Jun Park
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Physiol Genomics 27:114-21. 2006
    ..Thus our data provide a possible regulatory pathway involved in the development of insulin resistance in the morbidly obese state, and improvement of insulin resistance with weight loss...
  43. ncbi request reprint Efficacy of systemic morpholino exon-skipping in Duchenne dystrophy dogs
    Toshifumi Yokota
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Ann Neurol 65:667-76. 2009
    ..We sought to test efficacy and toxicity of intravenous oligonucleotide (morpholino)-induced exon skipping in the DMD dog model...
  44. ncbi request reprint Proteomics and systems biology in exercise and sport sciences research
    Dustin S Hittel
    Research Center for Genetic Medicine, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
    Exerc Sport Sci Rev 35:5-11. 2007
    ..In this review, we describe recent advances in mass spectrometry-based proteomics and their application toward interpreting the physiological adaptations of skeletal muscle with exercise and obesity...
  45. pmc NKG2A and CD56 are coexpressed on activated TH2 but not TH1 lymphocytes
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, and Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20010 2970, USA
    Hum Immunol 66:1223-34. 2005
    ..This would likely result in less effector inhibition and a relatively robust TH2 response...
  46. pmc Dystrophin-deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart
    Christopher F Spurney
    Center for Genetic Medicine Research, Children s National Medical Center, 111 Michigan Avenue, NW, Washington, DC 20010, USA
    Neuromuscul Disord 18:371-81. 2008
    ..This is the first report of an altered profibrotic gene expression profile in cardiac tissue of dystrophic mice showing echocardiographic evidence of cardiomyopathy...
  47. ncbi request reprint Musculin isoforms and repression of MyoD in muscle regeneration
    Po Zhao
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Biochem Biophys Res Commun 342:835-42. 2006
    ....
  48. ncbi request reprint Collaborative translational research leading to multicenter clinical trials in Duchenne muscular dystrophy: the Cooperative International Neuromuscular Research Group (CINRG)
    Diana M Escolar
    Research Center for Genetic Medicine CRI III, Children s National Medical Center, George Washington University, 111 Michigan Avenue, NW, Washington, DC 20010, USA
    Neuromuscul Disord 12:S147-154. 2002
    ....
  49. pmc MC4R variant is associated with BMI but not response to resistance training in young females
    Funda E Orkunoglu-Suer
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Obesity (Silver Spring) 19:662-6. 2011
    ..in a cohort (n = 796) that undertook a 12-week resistance-training program. Females with a copy of the rare allele (C) for rs17782313 (MC4R) had significantly higher BMIs (..
  50. ncbi request reprint CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage
    Monica J Hubal
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    J Appl Physiol (1985) 108:1651-8. 2010
    ..In summary, we found that SNPs in CCL2 and CCR2 are associated with exercise-induced muscle damage and that the presence of certain variants may result in an exaggerated damage response to strenuous exercise...
  51. ncbi request reprint Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome
    Dustin S Hittel
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    J Appl Physiol 98:168-79. 2005
    ..These biochemical adaptations complement existing molecular models for improved glucose tolerance with exercise intervention in prediabetic individuals...
  52. pmc Glucocorticoid efficacy in asthma: is improved tissue remodeling upstream of anti-inflammation
    Robert J Freishtat
    Children s National Medical Center, Washington, DC 20010, USA
    J Investig Med 58:19-22. 2010
    ..Herein, we present an alternative paradigm, where GC efficacy is mediated through more successful tissue remodeling, with reduction in inflammation secondary to successful regeneration...
  53. pmc Delineation of a gene network underlying the pulmonary response to oxidative stress in asthma
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, The George Washington University, 111 Michigan Avenue NW, Washington, DC 20010, USA
    J Investig Med 57:756-64. 2009
    ..These analyses identified key relationships and primary hypothetical targets for future studies of cigarette smoke-induced oxidative stress in asthma...
  54. ncbi request reprint Nondisease genetic testing: reporting of muscle SNPs shows effects on self-concept and health orientation scales
    Erynn S Gordon
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Eur J Hum Genet 13:1047-54. 2005
    ..This study is limited by the ability to determine the direction of the impact of nondisease genetic information presented to participants...
  55. ncbi request reprint The genetics of muscle atrophy and growth: the impact and implications of polymorphisms in animals and humans
    Erynn S Gordon
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Int J Biochem Cell Biol 37:2064-74. 2005
    ..As a society, most accept testing for genetic diseases or susceptibility, but do we as easily accept testing to determine one's athletic potential to be an Olympic endurance runner, or quarterback on the high school football team...
  56. pmc Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures
    Christopher F Spurney
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Muscle Nerve 39:591-602. 2009
    ..These data provide an experimental basis upon which standardization of preclinical drug testing can be developed. Muscle Nerve, 2008...
  57. pmc Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Am J Respir Crit Care Med 179:467-73. 2009
    ..Sepsis-related mortality results in part from immunodeficiency secondary to profound lymphoid apoptosis. The biological mechanisms responsible are not understood...
  58. pmc Dysferlin deficiency enhances monocyte phagocytosis: a model for the inflammatory onset of limb-girdle muscular dystrophy 2B
    Kanneboyina Nagaraju
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Am J Pathol 172:774-85. 2008
    ..Therefore, we hypothesize that mild myofiber damage in dysferlin-deficient muscle stimulates an inflammatory cascade that may initiate, exacerbate, and possibly perpetuate the underlying myofiber-specific dystrophic process...
  59. ncbi request reprint Loss of emerin at the nuclear envelope disrupts the Rb1/E2F and MyoD pathways during muscle regeneration
    Gisela Melcon
    Research Center for Genetic Medicine, Children s National Medical Center, Washington DC, USA
    Hum Mol Genet 15:637-51. 2006
    ..We suggest that the dominant LMNA mutations seen in many clinically disparate laminopathies may similarly alter Rb function, with regard to either the timing of exit from the cell cycle or terminal differentiation programs or both...
  60. ncbi request reprint An interactive power analysis tool for microarray hypothesis testing and generation
    Jinwook Seo
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Bioinformatics 22:808-14. 2006
    ..5 software package. We then sought to determine if probe set algorithms or organism type strongly influenced power analysis results...
  61. pmc Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular Dystrophy
    Alfredo D Guerron
    Center for Genetic Medicine Research, Children s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA
    PLoS ONE 5:e11220. 2010
    ..One of the proposed strategies is to use drugs that are known to act by multiple different mechanisms including inducing of homologous fetal form of adult genes, for example utrophin in place of dystrophin...
  62. pmc Gene expression profiling of astrocytes from hyperammonemic mice reveals altered pathways for water and potassium homeostasis in vivo
    Uta Lichter-Konecki
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC 20010, USA
    Glia 56:365-77. 2008
    ..Our results suggest that alterations in astrocyte-mediated water and potassium homeostasis in brain may be key to the development of the brain edema...
  63. pmc A robust in vitro screening assay to identify NF-kappaB inhibitors for inflammatory muscle diseases
    Andreas R Baudy
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Int Immunopharmacol 9:1209-14. 2009
    ....
  64. ncbi request reprint Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowth
    Simone Di Giovanni
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    FASEB J 19:153-4. 2005
    ..Finally, in vitro transfection experiments in primary dorsal root ganglion cells showed that cluster members act synergistically to drive neurite outgrowth...
  65. pmc Skeletal muscle dictates the fibrinolytic state after exercise training in overweight men with characteristics of metabolic syndrome
    Dustin S Hittel
    Research Center for Genetic Medicine, Children s National Medical Center and George Washington University, Washington, DC, USA
    J Physiol 548:401-10. 2003
    ..We conclude that aerobic exercise training induces both local and systemic changes in fibrinolysis and vascular homeostasis that are probably protective against cardiovascular disease...
  66. ncbi request reprint DNA microarray analysis of neonatal mouse lung connects regulation of KDR with dexamethasone-induced inhibition of alveolar formation
    Linda Biadasz Clerch
    Department of Pediatrics, Georgetown University School of Medicine, 3900 Reservoir Rd, NW, Washington, DC 20057, USA
    Am J Physiol Lung Cell Mol Physiol 286:L411-9. 2004
    ....
  67. ncbi request reprint Molecular responses of human muscle to eccentric exercise
    Yi Wen Chen
    Center for Genetic Medicine, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
    J Appl Physiol (1985) 95:2485-94. 2003
    ....
  68. ncbi request reprint Intracellular expression profiling by laser capture microdissection: three novel components of the neuromuscular junction
    Javad Nazarian
    The Institute for Biomedical Sciences, George Washington University, Washington, District of Columbia, USA
    Physiol Genomics 21:70-80. 2005
    ..Our LCM-based mRNA expression profiling provided us with new means of identification of specific genes potentially responsible for NMJ stability and function and new candidates for involvement in disease pathogenesis...
  69. pmc Rapid genotyping of common MeCP2 mutations with an electronic DNA microchip using serial differential hybridization
    William A Thistlethwaite
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, District of Columbia 20010, USA
    J Mol Diagn 5:121-6. 2003
    ..This novel method displayed the same level of specificity and accuracy as the single amplimer reactions, and proved to be faster and more economical...
  70. ncbi request reprint Gene profiling in spinal cord injury shows role of cell cycle in neuronal death
    Simone Di Giovanni
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Ann Neurol 53:454-68. 2003
    ..These findings suggest that cell cycle-related genes, induced after spinal cord injury, are involved in neuronal damage and subsequent cell death...
  71. ncbi request reprint Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration
    Po Zhao
    Research Center for Genetic Medicine, Children s National Medical Center, and Genetics Program, George Washington University, Washington, D C 20010, USA
    J Biol Chem 277:30091-101. 2002
    ....
  72. ncbi request reprint Moderate-intensity aerobic training program improves insulin sensitivity and inflammatory markers in a pilot study of morbidly obese minority teens
    Gina Many
    Children s National Medical Center, Research Center for Genetics Medicine, Washington, DC, USA
    Pediatr Exerc Sci 25:12-26. 2013
    ..The effects of training on insulin sensitivity (SI), inflammation and other metabolic syndrome features were examined...
  73. ncbi request reprint Secreted proteome profiling in human RPE cell cultures derived from donors with age related macular degeneration and age matched healthy donors
    Eunkyung An
    Center for Genetic Medicine, Children s National Medical Center, and Program in Biochemistry and Molecular Genetics, Institute of Biomedical Science, The George Washington University, Washington, DC, USA
    J Proteome Res 5:2599-610. 2006
    ..Overall, these data strongly suggest that RPE cells are involved in the biogenesis of drusen and the pathology of AMD...
  74. pmc Global gene profiling of VCP-associated inclusion body myopathy
    Angele Nalbandian
    Department of Pediatrics, Division of Genetics and Metabolism, University of California, Irvine, California, USA
    Clin Transl Sci 5:226-34. 2012
    ..In this report, we present data from the first global microarray analyzing IBMPFD patient muscles and elucidating dysregulated pathways to further understand the pathogenesis of the disease and discover potential therapeutics...
  75. pmc Response of rat muscle to acute resistance exercise defined by transcriptional and translational profiling
    Yi Wen Chen
    Research Center for Genetic Medicine, Children s National Medical Center and George Washington University, Washington DC, USA
    J Physiol 545:27-41. 2002
    ..This novel finding of p53 induction following exercise also demonstrates the power of expression profiling for identification of novel pathways involved in the response to muscle contraction...
  76. pmc Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse
    Christopher F Spurney
    Division of Cardiology, Children s National Medical Center, Washington, District of Columbia, United States of America
    PLoS ONE 5:e8976. 2010
    ....
  77. ncbi request reprint Embryonic myogenesis pathways in muscle regeneration
    Po Zhao
    Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Dev Dyn 229:380-92. 2004
    ....
  78. ncbi request reprint In vivo filtering of in vitro expression data reveals MyoD targets
    Po Zhao
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    C R Biol 326:1049-65. 2003
    ..This approach provided strong support that 18 targets including of MyoD are biologically relevant during myoblast differentiation...
  79. ncbi request reprint Expression of two temporally distinct microglia-related gene clusters after spinal cord injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    Glia 53:420-33. 2006
    ....
  80. ncbi request reprint Clinical and molecular study in congenital muscular dystrophy with partial laminin alpha 2 (LAMA2) deficiency
    Zivana Tezak
    Research Center for Genetic Medicine, Children s Research Hospital, Washington, DC, USA
    Hum Mutat 21:103-11. 2003
    ..The clinical presentation and disease progression was homogeneous in the laminin alpha2-mutation positive and negative CMD patients...
  81. ncbi request reprint Rapid onset of gene expression in lung, supportive of formation of alveolar septa, induced by refeeding mice after calorie restriction
    Donald Massaro
    Lung Regeneration Laboratory, Department of 1Medicine, Georgetown University School of Medicine, Children s National Medical Center, Washington, District of Columbia 20057 1481, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1313-26. 2007
    ..These findings identify the first hour after providing calorie-restricted mice ad libitum access to food as the onset of gene expression in this model that supports processes needed for alveolar regeneration...
  82. pmc Somatic mosaicism for Duchenne dystrophy: evidence for genetic normalization mitigating muscle symptoms
    Akanchha Kesari
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Am J Med Genet A 149:1499-503. 2009
    ..Somatic mosaicism for DMD should be considered in acute heart failure with dilated cardiomyopathy, as genetic normalization in heart is unlikely to occur...
  83. pmc Differences in fat and muscle mass associated with a functional human polymorphism in a post-transcriptional BMP2 gene regulatory element
    Joseph M Devaney
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, District of Columbia 20010, USA
    J Cell Biochem 107:1073-82. 2009
    ..Furthermore, understanding the mechanisms by which regulatory polymorphisms influence BMP2 synthesis will reveal novel pharmaceutical targets for these disabling conditions...
  84. pmc Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway
    Po Zhao
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    J Biol Chem 281:429-38. 2006
    ..This activation was greatly reduced when the two E-boxes were mutated. Our data suggest a novel MyoD-Tead2-Fgfr4 pathway important for effective muscle regeneration...
  85. pmc A renaissance for antisense oligonucleotide drugs in neurology: exon skipping breaks new ground
    Toshifumi Yokota
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Arch Neurol 66:32-8. 2009
    ....
  86. pmc Delayed inflammatory mRNA and protein expression after spinal cord injury
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, NW, Washington, DC 20057, USA
    J Neuroinflammation 8:130. 2011
    ..Here we extend the microarray analysis of these gene clusters up to 6 months post-SCI...
  87. doi request reprint Genetic and clinical heterogeneity in eIF2B-related disorder
    Jelena Maletkovic
    Children s National Medical Center, Children s Research Institute, Center for Genetic Medicine, Washington, DC 20010, USA
    J Child Neurol 23:205-15. 2008
    ....
  88. ncbi request reprint Patterns of global gene expression in rat skeletal muscle during unloading and low-intensity ambulatory activity
    Lionel Bey
    Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri Columbia, Missouri 65211, USA
    Physiol Genomics 13:157-67. 2003
    ..This study reveals genes that are the most sensitive to loading/activity in rat skeletal muscle and indicates new targets that may initiate muscle alterations during inactivity...
  89. ncbi request reprint Microarray analysis of the temporal response of skeletal muscle to methylprednisolone: comparative analysis of two dosing regimens
    Richard R Almon
    Department of Pharmaceutical Sciences State University of New York at Buffalo, Buffalo, New York 14260, USA
    Physiol Genomics 30:282-99. 2007
    ..However, many genes did not exhibit steroid tolerance, indicating that present perspectives on the mechanism of glucocorticoid action cannot entirely explain all temporal profiles...
  90. doi request reprint Mathematical modeling of corticosteroid pharmacogenomics in rat muscle following acute and chronic methylprednisolone dosing
    Zhenling Yao
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York 14260, USA
    Mol Pharm 5:328-39. 2008
    ..Pharmacokinetic/pharmacodynamic (PK/PD) modeling provides a quantitative tool for elucidating the complexities of CS pharmacogenomics in skeletal muscle...
  91. ncbi request reprint Definition of the unique human extraocular muscle allotype by expression profiling
    M Dominik Fischer
    Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6085, USA
    Physiol Genomics 22:283-91. 2005
    ..Taken together, this study provides insight into how human EOMs achieve their unique structural, metabolic, and pathophysiological properties...
  92. ncbi request reprint Functional characteristics of dystrophic skeletal muscle: insights from animal models
    Jon F Watchko
    Department of Pediatrics, Magee Women s Research Institute, Duchenne Muscular Dystrophy Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Appl Physiol (1985) 93:407-17. 2002
    ..It is likely that changes in muscle structure and function, downstream of the specific, primary biochemical deficiency, may alter muscle contractile properties...
  93. pmc Integrin alpha 7 beta 1 in muscular dystrophy/myopathy of unknown etiology
    Elena Pegoraro
    Neuromuscular Center, Department of Neurological and Psychiatric Sciences, University of Padova, Padova, Italy
    Am J Pathol 160:2135-43. 2002
    ..We conclude that secondary integrin alpha 7 deficiency is rather common in muscular dystrophy/myopathy of unknown etiology, emphasizing the multiple mechanisms that may modulate integrin function and stability...
  94. ncbi request reprint Phenotypic-specific gene module discovery using a diagnostic tree and caBIG VISDA
    Yitan Zhu
    Dept of Electr and Comput Eng, Virginia Polytech Inst and State Univ, Arlington, VA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:5767-70. 2006
    ..We then superimpose existing knowledge of gene regulation and gene function (ingenuity pathway analysis) to analyze the clustering results and generate novel hypotheses for further research on muscular dystrophies...
  95. ncbi request reprint Expression profiling reveals metabolic and structural components of extraocular muscles
    M Dominik Fischer
    Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Physiol Genomics 9:71-84. 2002
    ..Characterization of the EOM expression profile begins to define gene transcription patterns associated with the unique anatomical, metabolic, and pathophysiological properties of EOM...
  96. ncbi request reprint Application of scaling factors in simultaneous modeling of microarray data from diverse chips
    Zhenling Yao
    Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 565 Hochstetter Hall, Buffalo, NY 14260, USA
    Pharm Res 24:643-9. 2007
    ..However, differences in intensities of signals for different probe sets that represent the same gene on various types of Affymetrix chips make comparison of datasets complicated...
  97. ncbi request reprint A ground truth based comparative study on clustering of gene expression data
    Yitan Zhu
    Department of Electrical and Computer Engineering, Virginia Polytechnic and State University, Arlington, VA 22203, USA
    Front Biosci 13:3839-49. 2008
    ....
  98. ncbi request reprint Deficiency of different nitric oxide synthase isoforms activates divergent transcriptional programs in cardiac hypertrophy
    Thomas P Cappola
    National Heart, Lung, and Blood Institute Program in Genomic Applications HopGene, Philadelphia, Pennsylvania 19104, USA
    Physiol Genomics 14:25-34. 2003
    ..These findings suggest that the transcriptional basis for LVH varies depending on the inciting biochemical stimulus. In addition, NOS isoforms appear to play distinct roles in modulating cardiac structure...
  99. ncbi request reprint ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women
    Priscilla M Clarkson
    Dept of Exercise Science, Univ of Massachusetts, Amherst, MA 01003, USA
    J Appl Physiol (1985) 99:154-63. 2005
    ..01), suggesting that ACTN3 is one of many genes contributing to genetic variation in muscle performance and adaptation to exercise...
  100. ncbi request reprint Variability in muscle size and strength gain after unilateral resistance training
    Monica J Hubal
    Department of Exercise Science, Totman Building, University of Massachusetts, Amherst, MA 01003, USA
    Med Sci Sports Exerc 37:964-72. 2005
    ..A secondary purpose was to assess sex differences in size and strength changes after training...
  101. ncbi request reprint Differential expression of immunoregulatory genes in male and female Norway rats following infection with Seoul virus
    Sabra L Klein
    W Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Med Virol 74:180-90. 2004
    ..g., hsp70) suggesting that cellular stress is elevated in males. These data provide candidate genes and cellular pathways that may underlie sex differences in responses to Seoul virus and possibly other hemorrhagic fever viruses...

Research Grants38

  1. Functional SNPs Associated with Human Muscle Size and Strength
    Eric Hoffman; Fiscal Year: 2007
    ..In addition, the understanding of genetic variation also will impact our knowledge of basic biochemical pathways dictating muscle structure and function. ..
  2. Functional SNPs Associated with Human Muscle Size and Strength
    Eric Hoffman; Fiscal Year: 2009
    ..In addition, the understanding of genetic variation also will impact our knowledge of basic biochemical pathways dictating muscle structure and function. ..
  3. Functional SNPs Associated with Human Muscle Size and Strength
    Eric P Hoffman; Fiscal Year: 2010
    ..In addition, the understanding of genetic variation also will impact our knowledge of basic biochemical pathways dictating muscle structure and function. ..
  4. Improved Diagnostic of the Muscular Dystrophies
    Eric Hoffman; Fiscal Year: 2005
    ..Wang, Xuan, Miller). Importantly, all data will be released to the public via a highly evolved web database portal developed by the PI's lab (PEPR), including web-based dynamic data analysis tools. ..
  5. A FUNCTIONAL GENOMICS HEART & LUNG DEVELOP. PROGRAM
    Eric Hoffman; Fiscal Year: 2003
    Drs. Eric Hoffman and Dietrich Stephan (whose primary interests are focused on muscle disease and leukemia) are PI and Co-PI on the Program's Expression Array Core and have extensive experience with all aspects of array use and data ..
  6. Functional SNP's Assoc with Human Muscle Size & Strength
    Eric Hoffman; Fiscal Year: 2001
    ..The increase in understanding of normal human variation in muscle structure and function will have implications for both health (sports performance) and disease (sarcopenia during aging, atrophy during space flight). ..
  7. MOLECULAR GENETICS OF RETT SYNDROME
    Eric Hoffman; Fiscal Year: 2000
    ..Detailed physical mapping to define physical rearrangements in Xq28 will serve as a basis for testing candidate expressed sequence tags (ESTs) from within the critical region and for eventual gene and protein characterization. ..
  8. MOLECULAR GENETIC STUDIES OF RECURRENT PREGNANCY LOSS
    Eric Hoffman; Fiscal Year: 2000
    ..This proposal represents a synergistic collaboration between a laboratory well versed in molecular analysis of inherited traits, and clinicians and epidemiologists with considerable expertise in women's health issues. ..
  9. Improved Diagnostic of the Muscular Dystrophies
    Eric Hoffman; Fiscal Year: 2007
    ..Wang, Xuan, Miller). Importantly, all data will be released to the public via a highly evolved web database portal developed by the PI's lab (PEPR), including web-based dynamic data analysis tools. ..
  10. Integrated Molecular Core for Rehabilitation Medicine
    Eric Hoffman; Fiscal Year: 2007
    ..Pre-existing NICHD- and NCRR-funded core facilities that would be synergistic with the proposed Analytical Core include a MRDDRC Genetics Core, MRDDRC Proteomics Core, CRC Genetics Core, and CHDRCA Genetics Training Core. ..
  11. Wellstone Muscular Dystrophy Center: Children's Nat'l Med Ctr
    Eric Hoffman; Fiscal Year: 2007
    ....
  12. Genetics and Genomic Approaches to Lung Diseases and Disorders in Washington, DC
    Eric Hoffman; Fiscal Year: 2007
    ..The Center is well-recognized for training, research, and technological innovations in genetics/genomics. Dr. Eric Hoffman serves as both the Director of the Research Center for Genetic Medicine and as Program Director for the ..
  13. Wellstone Muscular Dystrophy Center: Children's Nat'l Med Ctr
    Eric Hoffman; Fiscal Year: 2007
    ..abstract_text> ..
  14. Improved Diagnostic of the Muscular Dystrophies
    Eric Hoffman; Fiscal Year: 2009
    ..Wang, Xuan, Miller). Importantly, all data will be released to the public via a highly evolved web database portal developed by the PI's lab (PEPR), including web-based dynamic data analysis tools. ..
  15. Improved Diagnostic of the Muscular Dystorphies
    Eric Hoffman; Fiscal Year: 2006
    ..Wang, Xuan, Miller). Importantly, all data will be released to the public via a highly evolved web database portal developed by the PI's lab (PEPR), including web-based dynamic data analysis tools. ..
  16. Contractures: Molecular Remodeling of MTJ and Muscle
    Eric Hoffman; Fiscal Year: 2005
    ..All profiles with the MTJ expression signatures will be released to the public via our existing Oracle Web database. The MTJs will be isolated by laser capture microscopy well established in the laboratory. ..
  17. IMPROVED DIAGNOSIS OF THE MUSCULAR DYSTROPHIES
    Eric Hoffman; Fiscal Year: 2000
    ..The results will enable genetic counseling of patients and their families, and should facilitate efforts directed towards rational therapies. ..
  18. MOLECULAR GENETIC STUDIES OF RECURRENT PREGNANCY LOSS
    Eric Hoffman; Fiscal Year: 2001
    ..This proposal represents a synergistic collaboration between a laboratory well versed in molecular analysis of inherited traits, and clinicians and epidemiologists with considerable expertise in women's health issues. ..
  19. MOLECULAR GENETICS OF RETT SYNDROME
    Eric Hoffman; Fiscal Year: 2000
    ..Detailed physical mapping to define physical rearrangements in Xq28 will serve as a basis for testing candidate expressed sequence tags (ESTs) from within the critical region and for eventual gene and protein characterization. ..
  20. MOLECULAR GENETICS OF RETT SYNDROME
    Eric Hoffman; Fiscal Year: 2001
    ..Detailed physical mapping to define physical rearrangements in Xq28 will serve as a basis for testing candidate expressed sequence tags (ESTs) from within the critical region and for eventual gene and protein characterization. ..
  21. IMPROVED DIAGNOSIS OF THE MUSCULAR DYSTROPHIES
    Eric Hoffman; Fiscal Year: 2002
    ..The results will enable genetic counseling of patients and their families, and should facilitate efforts directed towards rational therapies. ..
  22. MOLECULAR GENETIC STUDIES OF RECURRENT PREGNANCY LOSS
    Eric Hoffman; Fiscal Year: 2002
    ..This proposal represents a synergistic collaboration between a laboratory well versed in molecular analysis of inherited traits, and clinicians and epidemiologists with considerable expertise in women's health issues. ..
  23. Functional SNP's Assoc with Human Muscle Size & Strength
    Eric Hoffman; Fiscal Year: 2002
    ..The increase in understanding of normal human variation in muscle structure and function will have implications for both health (sports performance) and disease (sarcopenia during aging, atrophy during space flight). ..
  24. IMPROVED DIAGNOSIS OF THE MUSCULAR DYSTROPHIES
    Eric Hoffman; Fiscal Year: 2003
    ..The results will enable genetic counseling of patients and their families, and should facilitate efforts directed towards rational therapies. ..
  25. MOLECULAR GENETIC STUDIES OF RECURRENT PREGNANCY LOSS
    Eric Hoffman; Fiscal Year: 1999
    ..This proposal represents a synergistic collaboration between a laboratory well versed in molecular analysis of inherited traits, and clinicians and epidemiologists with considerable expertise in women's health issues. ..
  26. Functional SNP's Assoc with Human Muscle Size & Strength
    Eric Hoffman; Fiscal Year: 2003
    ..The increase in understanding of normal human variation in muscle structure and function will have implications for both health (sports performance) and disease (sarcopenia during aging, atrophy during space flight). ..
  27. Integrated Standardized Express. Analytical Tools
    Eric Hoffman; Fiscal Year: 2003
    ..abstract_text> ..
  28. Functional SNP's Assoc with Human Muscle Size & Strength
    Eric Hoffman; Fiscal Year: 2004
    ..The increase in understanding of normal human variation in muscle structure and function will have implications for both health (sports performance) and disease (sarcopenia during aging, atrophy during space flight). ..
  29. MOLECULAR GENETICS OF RETT SYNDROME
    Eric Hoffman; Fiscal Year: 1999
    ..Detailed physical mapping to define physical rearrangements in Xq28 will serve as a basis for testing candidate expressed sequence tags (ESTs) from within the critical region and for eventual gene and protein characterization. ..
  30. IMPROVED DIAGNOSIS OF THE MUSCULAR DYSTROPHIES
    Eric Hoffman; Fiscal Year: 1999
    ..The results will enable genetic counseling of patients and their families, and should facilitate efforts directed towards rational therapies. ..
  31. IMPROVED DIAGNOSIS OF THE MUSCULAR DYSTROPHIES
    Eric Hoffman; Fiscal Year: 2001
    ..The results will enable genetic counseling of patients and their families, and should facilitate efforts directed towards rational therapies. ..