Alejandro Hoberman

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. pmc Factors that influence parental decisions to participate in clinical research: consenters vs nonconsenters
    Alejandro Hoberman
    University of Pittsburgh, Pittsburgh, PA, USA
    JAMA Pediatr 167:561-6. 2013
  2. ncbi request reprint Large dosage amoxicillin/clavulanate, compared with azithromycin, for the treatment of bacterial acute otitis media in children
    Alejandro Hoberman
    Children s Hospital of Pittsburgh, PA 15213, USA
    Pediatr Infect Dis J 24:525-32. 2005
  3. ncbi request reprint Penicillin susceptibility of pneumococcal isolates causing acute otitis media in children: seasonal variation
    Alejandro Hoberman
    Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Pediatr Infect Dis J 24:115-20. 2005
  4. pmc Treatment of acute otitis media in children under 2 years of age
    Alejandro Hoberman
    Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    N Engl J Med 364:105-15. 2011
  5. doi request reprint Pneumococcal resistance and serotype 19A in Pittsburgh-area children with acute otitis media before and after introduction of 7-valent pneumococcal polysaccharide vaccine
    Alejandro Hoberman
    Division of General Academic Pediatrics, Children s Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Pittsburgh, PA 15201, USA
    Clin Pediatr (Phila) 50:114-20. 2011
  6. ncbi request reprint Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children: a randomized controlled trial
    Alejandro Hoberman
    Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    JAMA 290:1608-16. 2003
  7. ncbi request reprint Imaging studies after a first febrile urinary tract infection in young children
    Alejandro Hoberman
    Department of Pediatrics, University of Pittsburgh School of Medicine and Children s Hospital of Pittsburgh, Pittsburgh 15213 2583, USA
    N Engl J Med 348:195-202. 2003
  8. doi request reprint Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators
    Russell W Chesney
    University of Tennessee Health Science Center, Department of Pediatrics, Memphis, TN 38103, USA
    Pediatrics 122:S233-9. 2008
  9. pmc Parental perspectives on influenza vaccination of children with chronic medical conditions
    Chyongchiou J Lin
    Department of Pediatrics, University of Pittsburgh School of Medicine Pittsburgh, PA 15261, USA
    J Natl Med Assoc 98:148-53. 2006
  10. pmc Changes in parents' perceptions of infant influenza vaccination over two years
    Mary Patricia Nowalk
    Department of Family Medicine and Clinical Epidemiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Natl Med Assoc 99:636-41. 2007

Research Grants

Detail Information

Publications41

  1. pmc Factors that influence parental decisions to participate in clinical research: consenters vs nonconsenters
    Alejandro Hoberman
    University of Pittsburgh, Pittsburgh, PA, USA
    JAMA Pediatr 167:561-6. 2013
    ..This study identified that nonconsenting parents were better educated, had private insurance, showed lower levels of altruism, and less understanding of study design...
  2. ncbi request reprint Large dosage amoxicillin/clavulanate, compared with azithromycin, for the treatment of bacterial acute otitis media in children
    Alejandro Hoberman
    Children s Hospital of Pittsburgh, PA 15213, USA
    Pediatr Infect Dis J 24:525-32. 2005
    ....
  3. ncbi request reprint Penicillin susceptibility of pneumococcal isolates causing acute otitis media in children: seasonal variation
    Alejandro Hoberman
    Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Pediatr Infect Dis J 24:115-20. 2005
    ..The purpose of this study was to determine whether seasonal variation in resistance exists among pneumococcal isolates from children with AOM...
  4. pmc Treatment of acute otitis media in children under 2 years of age
    Alejandro Hoberman
    Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    N Engl J Med 364:105-15. 2011
    ..Recommendations vary regarding immediate antimicrobial treatment versus watchful waiting for children younger than 2 years of age with acute otitis media...
  5. doi request reprint Pneumococcal resistance and serotype 19A in Pittsburgh-area children with acute otitis media before and after introduction of 7-valent pneumococcal polysaccharide vaccine
    Alejandro Hoberman
    Division of General Academic Pediatrics, Children s Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Pittsburgh, PA 15201, USA
    Clin Pediatr (Phila) 50:114-20. 2011
    ....
  6. ncbi request reprint Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children: a randomized controlled trial
    Alejandro Hoberman
    Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    JAMA 290:1608-16. 2003
    ..Acute otitis media (AOM) frequently complicates influenza infection. Previous studies have found influenza vaccine effective in reducing the occurrence of AOM in children mainly older than 2 years...
  7. ncbi request reprint Imaging studies after a first febrile urinary tract infection in young children
    Alejandro Hoberman
    Department of Pediatrics, University of Pittsburgh School of Medicine and Children s Hospital of Pittsburgh, Pittsburgh 15213 2583, USA
    N Engl J Med 348:195-202. 2003
    ..We investigated whether imaging studies altered management or improved outcomes in young children with a first febrile urinary tract infection...
  8. doi request reprint Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators
    Russell W Chesney
    University of Tennessee Health Science Center, Department of Pediatrics, Memphis, TN 38103, USA
    Pediatrics 122:S233-9. 2008
    ..Such recommendations should be evidence-based...
  9. pmc Parental perspectives on influenza vaccination of children with chronic medical conditions
    Chyongchiou J Lin
    Department of Pediatrics, University of Pittsburgh School of Medicine Pittsburgh, PA 15261, USA
    J Natl Med Assoc 98:148-53. 2006
    ..Minorities and those living in the inner city have a higher respiratory disease burden than other groups. Yet, influenza vaccination rates among all children with chronic medical conditions remain low...
  10. pmc Changes in parents' perceptions of infant influenza vaccination over two years
    Mary Patricia Nowalk
    Department of Family Medicine and Clinical Epidemiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Natl Med Assoc 99:636-41. 2007
    ..Inner-city health centers serving large proportions of low-income and minority children participated in a study to introduce influenza vaccination among healthy infants in 2002-2003 and 2003-2004...
  11. ncbi request reprint Are nasopharyngeal cultures useful in diagnosis of acute bacterial sinusitis in children?
    Nader Shaikh
    1University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Pediatr (Phila) 52:1118-21. 2013
    ..Absence of pathogens in the nasopharynx was not helpful in identifying this low-risk subgroup. ..
  12. pmc Improving influenza vaccination rates of high-risk inner-city children over 2 intervention years
    Richard K Zimmerman
    Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh School of Medicine, 3518 Fifth Ave, Pittsburgh, PA 15261, USA
    Ann Fam Med 4:534-40. 2006
    ..We wanted to determine whether interventions tailored to individual practice sites improve influenza immunization rates among high-risk children in inner-city health centers over 2 years...
  13. doi request reprint Responsiveness and construct validity of a symptom scale for acute otitis media
    Nader Shaikh
    Division of General Academic Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Pediatr Infect Dis J 28:9-12. 2009
    ..We have developed a scale for measuring symptoms of AOM in young children (AOM-SOS), and we present data on its construct validity and responsiveness...
  14. doi request reprint Mastering diagnostic skills: Enhancing Proficiency in Otitis Media, a model for diagnostic skills training
    Phillip H Kaleida
    Children s Hospital of Pittsburgh of UPMC, One Children s Hospital Dr, 4401 Penn Ave, General Academic Pediatrics, CHOB 3rd Floor, Pittsburgh, PA 15224, USA
    Pediatrics 124:e714-20. 2009
    ....
  15. pmc Predicting response to antimicrobial therapy in children with acute sinusitis
    Nader Shaikh
    Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA Electronic address
    J Pediatr 164:536-41. 2014
    ..To determine prognostic factors that independently predict response to antimicrobial therapy in children with acute sinusitis...
  16. doi request reprint Development of an algorithm for the diagnosis of otitis media
    Nader Shaikh
    Children s Hospital of Pittsburgh of UPMC, One Children s Hospital Drive, 4401 Penn Ave, Pittsburgh, PA 15224, USA
    Acad Pediatr 12:214-8. 2012
    ..This has led to a large degree of variation in the criteria used to diagnose otitis media, which has resulted in inconsistencies in clinical care and discrepant research findings...
  17. doi request reprint Development and preliminary evaluation of a parent-reported outcome instrument for clinical trials in acute otitis media
    Nader Shaikh
    University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Division of General Academic Pediatrics, Pittsburgh, PA
    Pediatr Infect Dis J 28:5-8. 2009
    ..The goal of the present study was to develop and evaluate a parent-reported symptom scale for children with AOM (AOM-SOS) for use as an outcome measure in AOM treatment trials...
  18. pmc Rationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study
    Ron Keren
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 122:S240-50. 2008
    ....
  19. doi request reprint Pain management in young children undergoing diagnostic tympanocentesis
    Nader Shaikh
    University of Pittsburgh School of Medicine, and General Academic Pediatrics, Children s Hospital of Pittsburgh, 3414 Fifth Ave, Pittsburgh, PA 15213, USA
    Clin Pediatr (Phila) 50:231-6. 2011
    ..To describe the pain associated with diagnostic tympanocentesis and to gather preliminary data comparing the efficacy of 3 methods of pain reduction for tympanocentesis...
  20. doi request reprint Development of a patient-reported outcome measure for children with streptococcal pharyngitis
    Nader Shaikh
    Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 124:e557-63. 2009
    ....
  21. pmc Beliefs and attitudes about influenza immunization among parents of children with chronic medical conditions over a two-year period
    Chyongchiou J Lin
    Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Urban Health 83:874-83. 2006
    ....
  22. ncbi request reprint Parental perspectives on influenza immunization of children aged 6 to 23 months
    Mary Patricia Nowalk
    Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh School of Medicine, PA 15261, USA
    Am J Prev Med 29:210-4. 2005
    ..Participating inner-city health centers designed interventions to introduce influenza vaccination among this group of children. The study was designed to assess parents' attitudes toward the vaccine...
  23. doi request reprint Otoscopic signs of otitis media
    Nader Shaikh
    Division of General Academic Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Pediatr Infect Dis J 30:822-6. 2011
    ..The objective of this study was to examine findings that expert otoscopists use when diagnosing AOM...
  24. pmc Signs and symptoms that differentiate acute sinusitis from viral upper respiratory tract infection
    Nader Shaikh
    From the Division of General Academic Pediatrics, University of Pittsburgh School of Medicine University of Pittsburgh, Graduate School of Public Health, Biostatistics Division of Pediatric Radiology, Children s Hospital of Pittsburgh, Pittsburgh, PA and University of Wisconsin School of Medicine and Public Health, Madison, WI
    Pediatr Infect Dis J 32:1061-5. 2013
    ..The objective of this study was to determine which signs and symptoms could be used to identify the subgroup of children who meet current clinical criteria for sinusitis but who nevertheless have a viral URI...
  25. pmc Development and impact of an intervention to boost recruitment in a multicenter pediatric randomized clinical trial
    Sonika Bhatnagar
    1University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Pediatr (Phila) 53:151-7. 2014
    ..Our primary objective was to develop and evaluate an intervention to increase recruitment in a multicenter pediatric randomized clinical trial (RCT). Our secondary objective was to assess the impact beyond 120 days...
  26. pmc How do parents of preverbal children with acute otitis media determine how much ear pain their child is having?
    Nader Shaikh
    Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Pain 11:1291-4. 2010
    ....
  27. ncbi request reprint Does this child have a urinary tract infection?
    Nader Shaikh
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    JAMA 298:2895-904. 2007
    ..Urinary tract infection (UTI) is a frequently occurring pediatric illness that, if left untreated, can lead to permanent renal injury. Accordingly, accurate diagnosis of UTI is important...
  28. ncbi request reprint Spectral gradient acoustic reflectometry compared with tympanometry in diagnosing middle ear effusion in children aged 6 to 24 months
    Jennifer Chianese
    Division of General Academic Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213 2583, USA
    Arch Pediatr Adolesc Med 161:884-8. 2007
    ..To evaluate the accuracy of spectral gradient acoustic reflectometry (SGAR) in children aged 6 to 24 months, and to compare SGAR with tympanometry...
  29. ncbi request reprint Dysfunctional elimination syndrome: is it related to urinary tract infection or vesicoureteral reflux diagnosed early in life?
    Nader Shaikh
    Department of Pediatrics, University of Pittsburgh School of Medicine and Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213 2583, USA
    Pediatrics 112:1134-7. 2003
    ..This study evaluated the relationship between early UTI, vesicoureteral reflux (VUR), and DES by comparing two cohorts of school-aged children...
  30. ncbi request reprint Feasibility of influenza immunization for inner-city children aged 6 to 23 months
    Richard K Zimmerman
    Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Am J Prev Med 27:397-403. 2004
    ..This study tested the feasibility of vaccinating 6- to 23-month-old children against influenza and assessed the effect on timely receipt of other vaccines...
  31. doi request reprint Risk of renal scarring in children with a first urinary tract infection: a systematic review
    Nader Shaikh
    Children s Hospital of Pittsburgh, Division of General Academic Pediatrics, 3414 Fifth Ave, Pittsburgh, PA 15213 2583, USA
    Pediatrics 126:1084-91. 2010
    ..To our knowledge, the risk of renal scarring in children with a urinary tract infection (UTI) has not been systematically studied...
  32. ncbi request reprint Tailored interventions to introduce influenza vaccination among 6- to 23-month-old children at inner-city health centers
    Mary Patricia Nowalk
    Department of Family Medicine and Clinical Epidemiology, School of Medicine, University of Pittsburgh, 3518 Fifth Avenue, Pittsburgh, PA 15261, USA
    Am J Manag Care 11:717-24. 2005
    ....
  33. doi request reprint Identifying children with vesicoureteral reflux: a comparison of 2 approaches
    Nader Shaikh
    Division of General Academic Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    J Urol 188:1895-9. 2012
    ..We compared the sensitivities of the top-down ((99m)technetium dimercaptosuccinic acid renal scan to screen) and biomarker based (C-reactive protein level at presentation) approaches in identifying children with vesicoureteral reflux...
  34. doi request reprint Enhanced versus automated urinalysis for screening of urinary tract infections in children in the emergency department
    Ami P Shah
    From the Department of Pediatrics, Division of Pediatric Emergency Medicine, Wayne State University School of Medicine, Detroit, MI University of Pittsburgh School of Medicine, Pittsburgh, PA Department of Pathology, UPMC Presbyterian Shadyside Department of Pediatrics, University of Pittsburgh School of Medicine Laboratory Services, Children s Hospital of Pittsburgh, Pittsburgh, PA Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI Department of Pathology and Department of Pediatrics, Division of Pediatric Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Pediatr Infect Dis J 33:272-5. 2014
    ..UA can be performed manually or using automated techniques. We sought to compare manual versus automated UA for urine specimens obtained via catheterization in the pediatric emergency department...
  35. ncbi request reprint Treatment of acute otitis media consensus recommendations
    Alejandro Hoberman
    University of Pittsburgh School of Medicine and Children s Hospital of Pittsburgh, PA 15213 2583, USA
    Clin Pediatr (Phila) 41:373-90. 2002
    ....
  36. ncbi request reprint Validation of a decision rule identifying febrile young girls at high risk for urinary tract infection
    Marc H Gorelick
    Section of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Pediatr Emerg Care 19:162-4. 2003
    ..To validate a previously published clinical decision rule to predict risk of urinary tract infection in febrile young girls...
  37. pmc Study design questions in treatment of children with acute otitis media
    Alejandro Hoberman
    Antimicrob Agents Chemother 48:2784; author reply 2785-6. 2004
  38. ncbi request reprint A multicenter, open label, double tympanocentesis study of high dose cefdinir in children with acute otitis media at high risk of persistent or recurrent infection
    Adriano Arguedas
    Instituto de AtenciĆ³n PediĆ”trica, Neeman ICIC, Hospital Nacional de Ninos, San Jose, Costa Rica
    Pediatr Infect Dis J 25:211-8. 2006
    ....
  39. ncbi request reprint Vesicoureteral reflux: the RIVUR study and the way forward
    Saul P Greenfield
    J Urol 179:405-7. 2008
  40. ncbi request reprint Clinical practice guideline: Otitis media with effusion
    Richard M Rosenfeld
    SUNY HSC Brooklyn, Department of Pediatric Otolaryngology, NY 11201, USA
    Otolaryngol Head Neck Surg 130:S95-118. 2004
    ..It is not intended to replace clinical judgment or establish a protocol for all children with this condition, and may not provide the only appropriate approach to diagnosing and managing this problem...
  41. ncbi request reprint Antimicrobial guidelines for the treatment of acute bacterial rhinosinusitis in immunocompetent children
    Michael D Poole
    Department of Otolaryngology, University of Texas Health Science Center at Houston, 6431 Fannin Suite 6132, Houston, TX 77030, USA
    Int J Pediatr Otorhinolaryngol 63:1-13. 2002
    ..The purpose of this paper is to review the rationale behind the development of these guidelines and how they apply to the management of acute bacterial rhinosinusitis in children...

Research Grants3

  1. Efficacy of Prophylactic Antimicrobials in Children with Vesicoureteral Reflux
    Alejandro Hoberman; Fiscal Year: 2007
    ..subspecialties, which has 2) a strong record of clinical research accomplishments in pediatric UTI and VUR, and 3) extensive expertise in research methods and in recruiting and retaining a large number of children in clinical trials ..
  2. Efficacy of Antimicrobials in Young Children with AOM
    Alejandro Hoberman; Fiscal Year: 2007
    ..This earlier and more complete improvement may constitute the most important benefit of antimicrobial treatment. ..