Research Topics
| Alejandro HobermanSummaryAffiliation: Children's Hospital of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Pneumococcal resistance and serotype 19A in Pittsburgh-area children with acute otitis media before and after introduction of 7-valent pneumococcal polysaccharide vaccineAlejandro Hoberman
Division of General Academic Pediatrics, Children s Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Pittsburgh, PA 15201, USA
Clin Pediatr (Phila) 50:114-20. 2011....
Large dosage amoxicillin/clavulanate, compared with azithromycin, for the treatment of bacterial acute otitis media in childrenAlejandro Hoberman
Children s Hospital of Pittsburgh, PA 15213, USA
Pediatr Infect Dis J 24:525-32. 2005....- Imaging studies after a first febrile urinary tract infection in young childrenAlejandro Hoberman
Department of Pediatrics, University of Pittsburgh School of Medicine and Children s Hospital of Pittsburgh, Pittsburgh 15213 2583, USA
N Engl J Med 348:195-202. 2003..We investigated whether imaging studies altered management or improved outcomes in young children with a first febrile urinary tract infection... - Penicillin susceptibility of pneumococcal isolates causing acute otitis media in children: seasonal variationAlejandro Hoberman
Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
Pediatr Infect Dis J 24:115-20. 2005..The purpose of this study was to determine whether seasonal variation in resistance exists among pneumococcal isolates from children with AOM... - Effectiveness of inactivated influenza vaccine in preventing acute otitis media in young children: a randomized controlled trialAlejandro Hoberman
Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
JAMA 290:1608-16. 2003..Acute otitis media (AOM) frequently complicates influenza infection. Previous studies have found influenza vaccine effective in reducing the occurrence of AOM in children mainly older than 2 years... 
Treatment of acute otitis media in children under 2 years of ageAlejandro Hoberman
Department of Pediatrics, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
N Engl J Med 364:105-15. 2011..Recommendations vary regarding immediate antimicrobial treatment versus watchful waiting for children younger than 2 years of age with acute otitis media...- Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigatorsRussell W Chesney
University of Tennessee Health Science Center, Department of Pediatrics, Memphis, TN 38103, USA
Pediatrics 122:S233-9. 2008..Such recommendations should be evidence-based... - Changes in parents' perceptions of infant influenza vaccination over two yearsMary Patricia Nowalk
Department of Family Medicine and Clinical Epidemiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
J Natl Med Assoc 99:636-41. 2007..Inner-city health centers serving large proportions of low-income and minority children participated in a study to introduce influenza vaccination among healthy infants in 2002-2003 and 2003-2004... - Mastering diagnostic skills: Enhancing Proficiency in Otitis Media, a model for diagnostic skills trainingPhillip H Kaleida
Children s Hospital of Pittsburgh of UPMC, One Children s Hospital Dr, 4401 Penn Ave, General Academic Pediatrics, CHOB 3rd Floor, Pittsburgh, PA 15224, USA
Pediatrics 124:e714-20. 2009.... - Improving influenza vaccination rates of high-risk inner-city children over 2 intervention yearsRichard K Zimmerman
Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh School of Medicine, 3518 Fifth Ave, Pittsburgh, PA 15261, USA
Ann Fam Med 4:534-40. 2006..We recommend this strategy for faith-based practices and residencies with 1 practice site, but further research is needed on multisite practices and to achieve higher influenza vaccination rates... - Parental perspectives on influenza vaccination of children with chronic medical conditionsChyongchiou J Lin
Department of Pediatrics, University of Pittsburgh School of Medicine Pittsburgh, PA 15261, USA
J Natl Med Assoc 98:148-53. 2006.... - Responsiveness and construct validity of a symptom scale for acute otitis mediaNader Shaikh
Division of General Academic Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA
Pediatr Infect Dis J 28:9-12. 2009..We have developed a scale for measuring symptoms of AOM in young children (AOM-SOS), and we present data on its construct validity and responsiveness... - Development and preliminary evaluation of a parent-reported outcome instrument for clinical trials in acute otitis mediaNader Shaikh
University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Division of General Academic Pediatrics, Pittsburgh, PA
Pediatr Infect Dis J 28:5-8. 2009..The goal of the present study was to develop and evaluate a parent-reported symptom scale for children with AOM (AOM-SOS) for use as an outcome measure in AOM treatment trials... - Development of an algorithm for the diagnosis of otitis mediaNader Shaikh
Children s Hospital of Pittsburgh of UPMC, One Children s Hospital Drive, 4401 Penn Ave, Pittsburgh, PA 15224, USA
Acad Pediatr 12:214-8. 2012..This has led to a large degree of variation in the criteria used to diagnose otitis media, which has resulted in inconsistencies in clinical care and discrepant research findings... - Beliefs and attitudes about influenza immunization among parents of children with chronic medical conditions over a two-year periodChyongchiou J Lin
Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Urban Health 83:874-83. 2006.... - Development of a patient-reported outcome measure for children with streptococcal pharyngitisNader Shaikh
Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Pediatrics 124:e557-63. 2009.... - Pain management in young children undergoing diagnostic tympanocentesisNader Shaikh
University of Pittsburgh School of Medicine, and General Academic Pediatrics, Children s Hospital of Pittsburgh, 3414 Fifth Ave, Pittsburgh, PA 15213, USA
Clin Pediatr (Phila) 50:231-6. 2011..To describe the pain associated with diagnostic tympanocentesis and to gather preliminary data comparing the efficacy of 3 methods of pain reduction for tympanocentesis... - Otoscopic signs of otitis mediaNader Shaikh
Division of General Academic Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Pediatr Infect Dis J 30:822-6. 2011..The objective of this study was to examine findings that expert otoscopists use when diagnosing AOM... - Rationale and design issues of the Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) studyRon Keren
Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatrics 122:S240-50. 2008.... - Does this child have a urinary tract infection?Nader Shaikh
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
JAMA 298:2895-904. 2007..Urinary tract infection (UTI) is a frequently occurring pediatric illness that, if left untreated, can lead to permanent renal injury. Accordingly, accurate diagnosis of UTI is important... - Parental perspectives on influenza immunization of children aged 6 to 23 monthsMary Patricia Nowalk
Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh School of Medicine, PA 15261, USA
Am J Prev Med 29:210-4. 2005..Participating inner-city health centers designed interventions to introduce influenza vaccination among this group of children. The study was designed to assess parents' attitudes toward the vaccine... - How do parents of preverbal children with acute otitis media determine how much ear pain their child is having?Nader Shaikh
Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Pain 11:1291-4. 2010..Interpretation of symptoms, however, appears to be influenced by socioeconomic status. Thus, we question the utility of using a 1-item parental pain scale in clinical trials that include preverbal children... - Spectral gradient acoustic reflectometry compared with tympanometry in diagnosing middle ear effusion in children aged 6 to 24 monthsJennifer Chianese
Division of General Academic Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213 2583, USA
Arch Pediatr Adolesc Med 161:884-8. 2007..To evaluate the accuracy of spectral gradient acoustic reflectometry (SGAR) in children aged 6 to 24 months, and to compare SGAR with tympanometry... - Dysfunctional elimination syndrome: is it related to urinary tract infection or vesicoureteral reflux diagnosed early in life?Nader Shaikh
Department of Pediatrics, University of Pittsburgh School of Medicine and Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213 2583, USA
Pediatrics 112:1134-7. 2003..This study evaluated the relationship between early UTI, vesicoureteral reflux (VUR), and DES by comparing two cohorts of school-aged children... - Tailored interventions to introduce influenza vaccination among 6- to 23-month-old children at inner-city health centersMary Patricia Nowalk
Department of Family Medicine and Clinical Epidemiology, School of Medicine, University of Pittsburgh, 3518 Fifth Avenue, Pittsburgh, PA 15261, USA
Am J Manag Care 11:717-24. 2005.... - Risk of renal scarring in children with a first urinary tract infection: a systematic reviewNader Shaikh
Children s Hospital of Pittsburgh, Division of General Academic Pediatrics, 3414 Fifth Ave, Pittsburgh, PA 15213 2583, USA
Pediatrics 126:1084-91. 2010..To our knowledge, the risk of renal scarring in children with a urinary tract infection (UTI) has not been systematically studied... - Identifying children with vesicoureteral reflux: a comparison of 2 approachesNader Shaikh
Division of General Academic Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
J Urol 188:1895-9. 2012..We compared the sensitivities of the top-down ((99m)technetium dimercaptosuccinic acid renal scan to screen) and biomarker based (C-reactive protein level at presentation) approaches in identifying children with vesicoureteral reflux... - Feasibility of influenza immunization for inner-city children aged 6 to 23 monthsRichard K Zimmerman
Department of Family Medicine and Clinical Epidemiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Am J Prev Med 27:397-403. 2004..This study tested the feasibility of vaccinating 6- to 23-month-old children against influenza and assessed the effect on timely receipt of other vaccines... - Validation of a decision rule identifying febrile young girls at high risk for urinary tract infectionMarc H Gorelick
Section of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Pediatr Emerg Care 19:162-4. 2003..To validate a previously published clinical decision rule to predict risk of urinary tract infection in febrile young girls... - Vesicoureteral reflux: the RIVUR study and the way forwardSaul P Greenfield
J Urol 179:405-7. 2008 - A multicenter, open label, double tympanocentesis study of high dose cefdinir in children with acute otitis media at high risk of persistent or recurrent infectionAdriano Arguedas
Instituto de Atención Pediátrica, Neeman ICIC, Hospital Nacional de Ninos, San Jose, Costa Rica
Pediatr Infect Dis J 25:211-8. 2006.... - Study design questions in treatment of children with acute otitis mediaAlejandro Hoberman
Antimicrob Agents Chemother 48:2784; author reply 2785-6. 2004 - Treatment of acute otitis media consensus recommendationsAlejandro Hoberman
University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, PA 15213-2583, USA
Clin Pediatr (Phila) 41:373-90. 2002.... - Clinical practice guideline: Otitis media with effusionRichard M Rosenfeld
SUNY HSC Brooklyn, Department of Pediatric Otolaryngology, NY 11201, USA
Otolaryngol Head Neck Surg 130:S95-118. 2004..It is not intended to replace clinical judgment or establish a protocol for all children with this condition, and may not provide the only appropriate approach to diagnosing and managing this problem... - Antimicrobial guidelines for the treatment of acute bacterial rhinosinusitis in immunocompetent childrenMichael D Poole
Department of Otolaryngology, University of Texas Health Science Center at Houston, 6431 Fannin Suite 6132, Houston, TX 77030, USA
Int J Pediatr Otorhinolaryngol 63:1-13. 2002..The purpose of this paper is to review the rationale behind the development of these guidelines and how they apply to the management of acute bacterial rhinosinusitis in children...
Research Grants
- Efficacy of Prophylactic Antimicrobials in Children with Vesicoureteral RefluxAlejandro Hoberman; Fiscal Year: 2007..subspecialties, which has 2) a strong record of clinical research accomplishments in pediatric UTI and VUR, and 3) extensive expertise in research methods and in recruiting and retaining a large number of children in clinical trials ..
- Efficacy of Antimicrobials in Young Children with AOMAlejandro Hoberman; Fiscal Year: 2007..This earlier and more complete improvement may constitute the most important benefit of antimicrobial treatment. ..