MARY JC HENDRIX

Summary

Affiliation: Children's Memorial Hospital
Country: USA

Publications

  1. pmc The epigenetic influence of tumor and embryonic microenvironments: how different are they?
    Daniel E Abbott
    Children s Memorial Research Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
    Cancer Microenviron 1:13-21. 2008
  2. pmc Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment
    Fabricio F Costa
    Cancer Biology and Epigenomics Program, Children s Memorial Research Center and Northwestern University s Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
    Epigenomics 1:387-98. 2009
  3. ncbi Reprogramming metastatic tumour cells with embryonic microenvironments
    Mary J C Hendrix
    Cancer Biology and Epigenomics Program, Children s Memorial Research Centre, Robert H Lurie Comprehensive Cancer Centre, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Nat Rev Cancer 7:246-55. 2007
  4. ncbi The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation
    Lisa M J Lee
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois 60614 3394, USA
    Dev Dyn 233:1560-70. 2005
  5. pmc ErbB/EGF signaling and EMT in mammary development and breast cancer
    Katharine M Hardy
    Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
    J Mammary Gland Biol Neoplasia 15:191-9. 2010
  6. ncbi Paradoxical roles for lysyl oxidases in cancer--a prospect
    Stacey L Payne
    Children s Memorial Research Center, Division of Cancer Biology and Epigenomics, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine at Northwestern University, Chicago, IL 60614, USA
    J Cell Biochem 101:1338-54. 2007
  7. ncbi p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas
    Jian Zhong Qin
    Department of Pathology, Loyola University of Chicago Medical Center, Chicago, IL, USA
    Mol Cancer Ther 3:895-902. 2004
  8. pmc IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    J Cell Biochem 105:208-18. 2008
  9. pmc Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma
    Luigi Strizzi
    Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    Cell Cycle 7:1931-5. 2008
  10. pmc Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression
    Luigi Strizzi
    Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Northwestern University s Feinberg School of Medicine, Chicago, IL 60614, USA
    Breast Dis 29:91-103. 2008

Collaborators

Detail Information

Publications72

  1. pmc The epigenetic influence of tumor and embryonic microenvironments: how different are they?
    Daniel E Abbott
    Children s Memorial Research Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
    Cancer Microenviron 1:13-21. 2008
    ....
  2. pmc Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironment
    Fabricio F Costa
    Cancer Biology and Epigenomics Program, Children s Memorial Research Center and Northwestern University s Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
    Epigenomics 1:387-98. 2009
    ..However, several other molecular mechanisms might be related directly and/or indirectly to these changes, including microRNA (miRNA) regulation and DNA methylation...
  3. ncbi Reprogramming metastatic tumour cells with embryonic microenvironments
    Mary J C Hendrix
    Cancer Biology and Epigenomics Program, Children s Memorial Research Centre, Robert H Lurie Comprehensive Cancer Centre, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Nat Rev Cancer 7:246-55. 2007
    ..This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration...
  4. ncbi The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formation
    Lisa M J Lee
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Chicago, Illinois 60614 3394, USA
    Dev Dyn 233:1560-70. 2005
    ..These results demonstrate the utility of the zebrafish embryonic model for the study of tumor cell plasticity and suggest that this experimental paradigm can be a powerful one in which to investigate tumor-microenvironment interactions...
  5. pmc ErbB/EGF signaling and EMT in mammary development and breast cancer
    Katharine M Hardy
    Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
    J Mammary Gland Biol Neoplasia 15:191-9. 2010
    ..How this information may contribute to the improvement of therapeutic approaches in breast cancer will also be addressed...
  6. ncbi Paradoxical roles for lysyl oxidases in cancer--a prospect
    Stacey L Payne
    Children s Memorial Research Center, Division of Cancer Biology and Epigenomics, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine at Northwestern University, Chicago, IL 60614, USA
    J Cell Biochem 101:1338-54. 2007
    ....
  7. ncbi p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas
    Jian Zhong Qin
    Department of Pathology, Loyola University of Chicago Medical Center, Chicago, IL, USA
    Mol Cancer Ther 3:895-902. 2004
    ....
  8. pmc IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    J Cell Biochem 105:208-18. 2008
    ..However, Maspin transfection of breast cancer cells partially sensitizes the cells to IFN-gamma's effect, thus providing new therapeutic implications...
  9. pmc Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma
    Luigi Strizzi
    Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    Cell Cycle 7:1931-5. 2008
    ....
  10. pmc Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression
    Luigi Strizzi
    Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Northwestern University s Feinberg School of Medicine, Chicago, IL 60614, USA
    Breast Dis 29:91-103. 2008
    ..Moreover, we emphasize the potential utility of this signaling pathway as a novel target for the treatment and diagnosis of breast cancer...
  11. pmc Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradation
    Zhila Khalkhali-Ellis
    Children s Memorial Research Center and Robert H Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
    Cancer Res 67:3535-9. 2007
    ..In addition, these findings could have a potential effect on future therapeutic intervention strategies for breast cancer...
  12. ncbi Focal adhesion kinase promotes the aggressive melanoma phenotype
    Angela R Hess
    Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614 3394, USA
    Cancer Res 65:9851-60. 2005
    ..Collectively, these data suggest a new mechanism involved in promoting the aggressive melanoma phenotype through FAK-mediated signal transduction pathways, thus providing new insights into possible therapeutic intervention strategies...
  13. ncbi Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migration
    Lynne Marie Postovit
    Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60614, USA
    J Cell Biochem 103:1369-78. 2008
    ....
  14. ncbi Influence of the microenvironment on melanoma cell fate determination and phenotype
    Lynne Marie Postovit
    Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Northwestern University s Feinberg School of Medicine, Chicago, Illinois, USA
    Cancer Res 66:7833-6. 2006
    ..The microenvironment therefore presents a novel target for the treatment and ultimately the prevention of melanoma progression and metastasis...
  15. pmc Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner
    Caleb M Bailey
    Children s Memorial Research Center, 2300 Children s Plaza, Box 222, Chicago, IL 60614 3394, USA
    Mol Cell Biol 28:2235-43. 2008
    ..These data support a model in which IRF6, in collaboration with maspin, promotes mammary epithelial cell differentiation by facilitating entry into the G(0) phase of the cell cycle...
  16. ncbi The epigenetic reprogramming of poorly aggressive melanoma cells by a metastatic microenvironment
    Elisabeth A Seftor
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    J Cell Mol Med 10:174-96. 2006
    ....
  17. ncbi A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells
    Lynne Marie Postovit
    Children s Memorial Research Center, Chicago, Illinois 60614, USA
    Stem Cells 24:501-5. 2006
    ..These findings demonstrate the utility of this 3D model for studying the unique factors deposited by hESCs and for investigating the epigenetic effects that stem cell microenvironments may have on tumor progression...
  18. ncbi Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironment
    Elisabeth A Seftor
    Children s Memorial Research Center and Robert H Lurie Comprehensive Cancer Center at Northwestern University, Chicago, IL 60614, USA
    Cancer Res 65:10164-9. 2005
    ..This novel approach identifies specific genes involved in the transdifferentiation of melanocytes to a more aggressive phenotype, which may offer significant therapeutic value...
  19. pmc EphA2 as a promoter of melanoma tumorigenicity
    Naira V Margaryan
    The Children s Memorial Research Center, Chicago, IL, USA
    Cancer Biol Ther 8:279-88. 2009
    ....
  20. pmc Reevaluating cathepsin D as a biomarker for breast cancer: serum activity levels versus histopathology
    Daniel E Abbott
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Cancer Biol Ther 9:23-30. 2010
    ....
  21. doi Role of nodal signaling and the microenvironment underlying melanoma plasticity
    Lynne Marie Postovit
    Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
    Pigment Cell Melanoma Res 21:348-57. 2008
    ..Here, we review the concept of melanoma plasticity, with an emphasis on the emerging role of Nodal as a regulator of melanoma tumorigenesis and progression, and present findings related to epigenetic reprogramming...
  22. pmc IRF6 in development and disease: a mediator of quiescence and differentiation
    Caleb M Bailey
    Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614 3394, USA
    Cell Cycle 7:1925-30. 2008
    ....
  23. pmc Microgenomics profile the endogenous angiogenic phenotype in subpopulations of aggressive melanoma
    Zoe N Demou
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 4314, USA
    J Cell Biochem 105:562-73. 2008
    ..Identifying factors regulating tumor plasticity and heterogeneity at the molecular level is essential in designing effective anti-cancer therapies...
  24. pmc Temporal and spatial expression patterns for the tumor suppressor Maspin and its binding partner interferon regulatory factor 6 during breast development
    Caleb M Bailey
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
    Dev Growth Differ 51:473-81. 2009
    ..These results support the hypothesis that IRF6 and Maspin are important for mammary epithelial cell differentiation, and advance our understanding of the Maspin-IRF6 partnership during normal mammary gland development...
  25. ncbi Lysyl oxidase regulates actin filament formation through the p130(Cas)/Crk/DOCK180 signaling complex
    Stacey L Payne
    Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60614, USA
    J Cell Biochem 98:827-37. 2006
    ..Elucidating the role of LOX in the regulation of cell motility will allow the development of more effective therapeutic strategies to treat invasive/metastatic breast cancer...
  26. ncbi Exploiting the convergence of embryonic and tumorigenic signaling pathways to develop new therapeutic targets
    Daniel E Abbott
    Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
    Stem Cell Rev 3:68-78. 2007
    ..Here we outline evidence that demonstrates the inductive influence of embryonic stem cells and their microenvironment to reprogram cancer cells to exhibit a more benign phenotype, with profound implications for differentiation therapy...
  27. pmc Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer
    Luigi Strizzi
    Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 2300 Children s Plaza, Chicago, IL 60614, USA
    Breast Cancer Res 14:R75. 2012
    ....
  28. ncbi Focal adhesion kinase signaling and the aggressive melanoma phenotype
    Angela R Hess
    Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614 3394, USA
    Cell Cycle 5:478-80. 2006
    ..Together these observations implicate FAK as a promoter of the aggressive melanoma phenotype, thereby identifying a rational target for therapeutic intervention of malignant melanoma...
  29. ncbi Notch and NOXA-related pathways in melanoma cells
    Brian J Nickoloff
    Department of Pathology, Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois 60153 5385, USA
    J Investig Dermatol Symp Proc 10:95-104. 2005
    ..g. Notch signaling), and anti-cancer agents that achieve tumor selectivity (e.g., GSI-induced NOXA), this experimental approach provides a useful framework for future therapeutic strategies in cutaneous oncology...
  30. pmc Cancer hallmarks in induced pluripotent cells: new insights
    Sergey Malchenko
    Children s Memorial Research Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60614, USA
    J Cell Physiol 225:390-3. 2010
    ..These data demonstrate cancer hallmarks expressed by hiPSCs, which will require further assessment for their impact on future therapies....
  31. ncbi VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: implications for vasculogenic mimicry
    Angela R Hess
    Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Cancer Biol Ther 5:228-33. 2006
    ....
  32. pmc Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells
    Lynne Marie Postovit
    Program in Cancer Biology and Epigenomics, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
    Proc Natl Acad Sci U S A 105:4329-34. 2008
    ..The tumor-suppressive effects of the hESC microenvironment, by neutralizing the expression of Nodal in aggressive tumor cells, provide previously unexplored therapeutic modalities for cancer treatment...
  33. ncbi Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism
    Stacey L Payne
    Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine at Northwestern University, Chicago, IL 60614, USA
    Cancer Res 65:11429-36. 2005
    ..These data show the need to target LOX for treatment of aggressive breast cancer...
  34. ncbi Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: role of the Eph receptors
    Angela R Hess
    Children s Memorial Research Center, Program in Cancer Biology and Epigenomics, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer, Chicago, Illinois 60614 3394, USA
    Dev Dyn 236:3283-96. 2007
    ..Specifically, this review will focus on the role of the Eph receptors and ligands in embryonic vasculogenesis, angiogenesis, and vasculogenic mimicry...
  35. ncbi Targeting Nodal in malignant melanoma cells
    Lynne Marie Postovit
    Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Northwestern University s Feinberg School of Medicine, 2300 Children s Plaza, Box 222, Chicago, IL 60614, USA
    Expert Opin Ther Targets 11:497-505. 2007
    ..Hence, due to its restricted expression pattern and function as a melanoma-tumor-promoter, Nodal (and its signaling partners) present unique targets for both immunologic and pharmacologic therapies...
  36. ncbi The commonality of plasticity underlying multipotent tumor cells and embryonic stem cells
    Lynne Marie Postovit
    Program in Cancer Biology and Epigenomics, Children s Memorial Research Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
    J Cell Biochem 101:908-17. 2007
    ..These stem cell-derived mediators, as well as the genes they regulate, provide therapeutic targets designed to specifically differentiate and eradicate aggressive cancers...
  37. ncbi Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells
    Daisy W J van der Schaft
    Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Chicago, IL 60614 3394, USA
    J Natl Cancer Inst 96:1473-7. 2004
    ..These findings may contribute to the development of new antivascular therapeutic agents that target both angiogenesis and tumor cell vasculogenic mimicry...
  38. pmc Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment
    Paul M Kulesa
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 103:3752-7. 2006
    ..This model has the potential to provide insights into the regulation of tumor cell plasticity by an embryonic milieu, which may hold significant therapeutic promise...
  39. ncbi Biological functions of maspin
    Caleb M Bailey
    Department of Anatomy and Cell Biology, The Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    J Cell Physiol 209:617-24. 2006
    ....
  40. ncbi A requirement for dimerization of HP1Hsalpha in suppression of breast cancer invasion
    Laura E Norwood
    Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 281:18668-76. 2006
    ..Taken together, these data demonstrate that modulation of HP1(Hsalpha) alters the invasive potential of breast cancer cells through mechanisms requiring HP1 dimerization, but not interactions with PXVXL-containing proteins...
  41. ncbi Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness
    Jolanta M Topczewska
    Program in Developmental Biology, Children s Memorial Research Center, Feinberg School of Medicine Northwestern University, 2300 Children s Plaza, Box 222, Chicago Illinois, 60614, USA
    Nat Med 12:925-32. 2006
    ..These data suggest that Nodal signaling has a key role in melanoma cell plasticity and tumorigenicity, thereby providing a previously unknown molecular target for regulating tumor progression...
  42. ncbi Prostatic tumor cell plasticity involves cooperative interactions of distinct phenotypic subpopulations: role in vasculogenic mimicry
    Navesh Sharma
    Department of Anatomy and Cell Biology, The University of Iowa College of Medicine, Iowa City, Iowa 52242 1109, USA
    Prostate 50:189-201. 2002
    ..In the current investigation, we examined whether there is evidence for vasculogenic mimicry in heterogeneous prostatic neoplasms...
  43. ncbi Transendothelial function of human metastatic melanoma cells: role of the microenvironment in cell-fate determination
    Mary J C Hendrix
    Department of Anatomy and Cell Biology, University of Iowa, 51 Newton Road, 1 100 BSB, Iowa City, IA 52242, USA
    Cancer Res 62:665-8. 2002
    ....
  44. ncbi Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cells
    Valerie A Odero-Marah
    Department of Anatomy and Cell Biology, The Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Biochem Biophys Res Commun 295:800-5. 2002
    ..These novel observations suggest that maspin, which deviates from the classical serpin, may be an important signal transduction molecule in its phosphorylated form...
  45. ncbi The paradoxical expression of maspin in ovarian carcinoma
    Anil K Sood
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1109, USA
    Clin Cancer Res 8:2924-32. 2002
    ..These paradoxical results may offer new insights regarding the role of maspin in ovarian cancer progression that may also impact diagnosis and treatment strategies...
  46. ncbi Expression of multiple molecular phenotypes by aggressive melanoma tumor cells: role in vasculogenic mimicry
    Elisabeth A Seftor
    Department of Anatomy and Cell Biology, The University of Iowa, 51 Newton Road, 1 100 BSB, Iowa City, IA 52242 1109, USA
    Crit Rev Oncol Hematol 44:17-27. 2002
    ....
  47. pmc Nitric oxide regulation of maspin expression in normal mammary epithelial and breast cancer cells
    Zhila Khalkhali-Ellis
    Department of Anatomy and Cell Biology and the Holden Comprehensive Cancer Center at The University of Iowa, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
    Am J Pathol 162:1411-7. 2003
    ..Targeted delivery of NO within the tumor microenvironment could provide a feasible noninvasive approach for effective treatment...
  48. ncbi Remodeling of the microenvironment by aggressive melanoma tumor cells
    Mary J C Hendrix
    Department of Anatomy and Cell Biology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242 1109, USA
    Ann N Y Acad Sci 995:151-61. 2003
    ..These observations illustrate the remarkable influence of the microenvironment on the phenotype of melanoma cells and may provide new perspectives on tumor cell plasticity and unique treatment strategies...
  49. ncbi Maspin regulates different signaling pathways for motility and adhesion in aggressive breast cancer cells
    Valerie A Odero-Marah
    The Department of Anatomy and Cell Biology at The University of Iowa, Carver College of Medicine Iowa City, Iowa USA
    Cancer Biol Ther 2:398-403. 2003
    ....
  50. ncbi Regulating the tumor suppressor gene maspin in breast cancer cells: a potential mechanism for the anticancer properties of tamoxifen
    Zhila Khalkhali-Ellis
    Department of Anatomy and Cell Biology and the Holden Comprehensive Cancer Center at The University of Iowa, Iowa City, Iowa 52242 1109, USA
    Clin Cancer Res 10:449-54. 2004
    ..Specifically, our hypothesis tested the clinical efficacy of tamoxifen to regulate maspin expression...
  51. pmc Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion
    Anil K Sood
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Pathol 165:1087-95. 2004
    ..These data indicate that FAK is overexpressed in most invasive ovarian cancers and plays a functionally significant role in ovarian cancer migration and invasion. Thus, FAK may be an important therapeutic target in ovarian carcinoma...
  52. pmc Maspin regulates hypoxia-mediated stimulation of uPA/uPAR complex in invasive breast cancer cells
    Sumaira Amir
    The Department of Anatomy and Cell Biology, Carver College of Medicine, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa, USA
    Cancer Biol Ther 4:400-6. 2005
    ..These results indicate that maspin inhibits hypoxia-induced invasion of metastatic breast cancer cells by blocking the uPA system, thus illuminating an important molecular pathway for therapeutic consideration...
  53. pmc Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership
    Caleb M Bailey
    Department of Anatomy and Cell Biology and Pediatrics, Roy A and Lucille J Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, USA
    J Biol Chem 280:34210-7. 2005
    ..These findings help to elucidate the molecular mechanisms of maspin and suggest an interactive role between maspin and IRF6 in regulating cellular phenotype, the loss of which can lead to neoplastic transformation...
  54. pmc Aberrant methylation of the maspin promoter is an early event in human breast cancer
    Bernard W Futscher
    Bone Marrow Transplant Program, Arizona Cancer Center, and Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
    Neoplasia 6:380-9. 2004
    ..Taken together, these results indicate that aberrant methylation of the maspin promoter is an early event in human breast cancer...
  55. ncbi Dual roles of E-cadherin in prostate cancer invasion
    Jirapat Chunthapong
    Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242 1109, USA
    J Cell Biochem 91:649-61. 2004
    ..These results suggest that E-cadherin plays an important role in regulating the invasive potential of prostate cancer cells through an unique paracrine mechanism...
  56. ncbi Preoperative serum vascular endothelial growth factor levels: significance in ovarian cancer
    Brian C Cooper
    Division of Gynecologic Oncology, Departments of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Clin Cancer Res 8:3193-7. 2002
    ..VEGF levels were determined using an ELISA (R&D Systems, Minneapolis, MN)...
  57. ncbi Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells
    Jian Zhong Qin
    Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153 5385, USA
    Cancer Res 65:6282-93. 2005
    ....
  58. ncbi Apoptosis in colorectal tumors: does it help tumors metastasize?
    Mary J C Hendrix
    Cancer Biol Ther 1:64. 2002
  59. ncbi A molecular role for lysyl oxidase in breast cancer invasion
    Dawn A Kirschmann
    Department of Anatomy and Cell Biology, Holden Comprehensive Cancer Center, The University of Iowa, The Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242 1109, USA
    Cancer Res 62:4478-83. 2002
    ..These results provide substantial new evidence that LOX is involved in cancer cell invasion...
  60. ncbi Molecular determinants of human uveal melanoma invasion and metastasis
    Elisabeth A Seftor
    Department of Anatomy and Cell Biology, College of Medicine and The Holden Comprehensive Cancer Center, University of Iowa, Iowa City 52242 1109, USA
    Clin Exp Metastasis 19:233-46. 2002
    ..This study provides a molecular profile that will hopefully lead to the development of new molecular targets for therapeutic intervention and possible diagnostic markers to predict the clinical outcome of patients with uveal melanoma...
  61. ncbi Targeting the tumor microenvironment with chemically modified tetracyclines: inhibition of laminin 5 gamma2 chain promigratory fragments and vasculogenic mimicry
    Richard E B Seftor
    Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa 52242 1109, USA
    Mol Cancer Ther 1:1173-9. 2002
    ....
  62. ncbi p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinoma
    Anil K Sood
    Department of Gynecologic Oncology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 440, Houston, TX 77030 USA
    Cancer Biol Ther 1:511-7. 2002
    ..03). Ovarian cancers with a p53 null mutation are more likely to lack telomerase activity. This may have implications for therapeutic approaches based on telomerase...
  63. ncbi Editorial: potential clinical use of exploiting metastasis suppressor genes to regulate prostatic cancer
    Mary J C Hendrix
    J Urol 169:1134. 2003
  64. ncbi Functional role of matrix metalloproteinases in ovarian tumor cell plasticity
    Anil K Sood
    Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Obstet Gynecol 190:899-909. 2004
    ..We also investigated the clinical relevance of matrix metalloproteinase-2 and -9 and membrane type 1-matrix metalloproteinase in human ovarian cancers with evidence of tumor cell-lined vasculature...
  65. ncbi Conserved properties of HP1(Hsalpha)
    Laura E Norwood
    The Department of Biochemistry, The University of Iowa, 3136 MERF, Iowa City, IA 52242, USA
    Gene 336:37-46. 2004
    ..Taken together, these results demonstrate the participation of HP1(Hsalpha) in silent chromatin formation and that HP1(Hsalpha) is a functional homologue of Drosophila HP1...
  66. ncbi Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry
    Wolfram Ruf
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cancer Res 63:5381-9. 2003
    ..Thus, TFPI-2 contributes to VM plasticity, whereas TFPI-1 has anticoagulant functions of relevance for perfusion of VM channels formed by TF-expressing melanoma cells...
  67. ncbi Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry
    Angela R Hess
    The Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa 52242 1109, USA
    Cancer Res 63:4757-62. 2003
    ..PI3K may represent an excellent target for therapeutic intervention of a novel signaling cascade underlying VM...
  68. ncbi The complexity of tumor vascularity
    Anil K Sood
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 2:257-8. 2003
  69. ncbi Molecular plasticity of human melanoma cells
    Mary J C Hendrix
    The Holden Comprehensive Cancer Center at The University of Iowa, Roy J and Lucille A Carver College of Medicine, Bowen Science Building, 51 Newton Road, Iowa City, IA 52242 1109, USA
    Oncogene 22:3070-5. 2003
    ....
  70. ncbi Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma
    Mary J C Hendrix
    Department of Anatomy and Cell Biology, Carver College of Medicine and the Holden Comprehensive Cancer Center at The University of Iowa, 375 Newton Road, Iowa City, Iowa 52242, USA
    Nat Rev Cancer 3:411-21. 2003
    ..This ability has been termed 'vasculogenic mimicry'. How does vasculogenic mimicry contribute to tumour progression, and can it be targeted by therapeutic agents?..
  71. ncbi Plasmalemmal vacuolar H+-ATPase is decreased in microvascular endothelial cells from a diabetic model
    Jose D Rojas
    Department of Physiology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Cell Physiol 201:190-200. 2004
    ..These novel observations suggest that the angiogenic abnormalities in diabetes involve a decrease in pmV-ATPase in microvascular endothelial cells...
  72. ncbi Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia
    Daisy W J van der Schaft
    Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology, Maastricht University and University Hospital Maastricht, The Netherlands
    Cancer Res 65:11520-8. 2005
    ..The results suggest that optimal tumor treatment may require targeting of these structures in combination with prevention of angiogenesis...

Research Grants4

  1. PROSTATIC VASCULOGENIC MIMICRY: A NEW METASTATIC PATHWAY
    Mary Hendrix; Fiscal Year: 2003
    ..abstract_text> ..
  2. Epigenetic Effect of the Microenvironment on Stem Cell Plasticity and Function
    Mary Hendrix; Fiscal Year: 2007
    ....
  3. Endothelial Transdifferentiation of Invasive Tumor Cells
    Mary Hendrix; Fiscal Year: 2007
    ..The data generated from these novel studies will provide new molecular markers for clinical diagnosis and new concepts regarding the trarisendothelial differentiation of aggressive melanoma tumor cells and their stem cell plasticity. ..