Research Topics
Species | MARY JC HENDRIXSummaryAffiliation: Children's Memorial Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
The epigenetic influence of tumor and embryonic microenvironments: how different are they?Daniel E Abbott
Children s Memorial Research Center, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
Cancer Microenviron 1:13-21. 2008....- Epigenetically reprogramming metastatic tumor cells with an embryonic microenvironmentFabricio F Costa
Cancer Biology and Epigenomics Program, Children s Memorial Research Center and Northwestern University s Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
Epigenomics 1:387-98. 2009..However, several other molecular mechanisms might be related directly and/or indirectly to these changes, including microRNA (miRNA) regulation and DNA methylation... 
Reprogramming metastatic tumour cells with embryonic microenvironmentsMary J C Hendrix
Cancer Biology and Epigenomics Program, Children s Memorial Research Centre, Robert H Lurie Comprehensive Cancer Centre, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
Nat Rev Cancer 7:246-55. 2007..This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration...- The fate of human malignant melanoma cells transplanted into zebrafish embryos: assessment of migration and cell division in the absence of tumor formationLisa M J Lee
Children's Memorial Research Center, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, Illinois 60614-3394, USA
Dev Dyn 233:1560-70. 2005..These results demonstrate the utility of the zebrafish embryonic model for the study of tumor cell plasticity and suggest that this experimental paradigm can be a powerful one in which to investigate tumor-microenvironment interactions... - ErbB/EGF signaling and EMT in mammary development and breast cancerKatharine M Hardy
Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
J Mammary Gland Biol Neoplasia 15:191-9. 2010..How this information may contribute to the improvement of therapeutic approaches in breast cancer will also be addressed... - Paradoxical roles for lysyl oxidases in cancer--a prospectStacey L Payne
Children s Memorial Research Center, Division of Cancer Biology and Epigenomics, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine at Northwestern University, Chicago, IL 60614, USA
J Cell Biochem 101:1338-54. 2007.... - p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomasJian Zhong Qin
Department of Pathology, Loyola University of Chicago Medical Center, Chicago, IL, USA
Mol Cancer Ther 3:895-902. 2004.... - IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cellsZhila Khalkhali-Ellis
Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
J Cell Biochem 105:208-18. 2008..However, Maspin transfection of breast cancer cells partially sensitizes the cells to IFN-gamma's effect, thus providing new therapeutic implications... - Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanomaLuigi Strizzi
Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
Cell Cycle 7:1931-5. 2008.... - Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progressionLuigi Strizzi
Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Northwestern University s Feinberg School of Medicine, Chicago, IL 60614, USA
Breast Dis 29:91-103. 2008..Moreover, we emphasize the potential utility of this signaling pathway as a novel target for the treatment and diagnosis of breast cancer... - Elucidating the function of secreted maspin: inhibiting cathepsin D-mediated matrix degradationZhila Khalkhali-Ellis
Children s Memorial Research Center and Robert H Lurie Comprehensive Cancer Center at Northwestern University Feinberg School of Medicine, 2300 Children s Plaza, Chicago, IL 60614, USA
Cancer Res 67:3535-9. 2007..In addition, these findings could have a potential effect on future therapeutic intervention strategies for breast cancer... - Focal adhesion kinase promotes the aggressive melanoma phenotypeAngela R Hess
Children's Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614-3394, USA
Cancer Res 65:9851-60. 2005..Collectively, these data suggest a new mechanism involved in promoting the aggressive melanoma phenotype through FAK-mediated signal transduction pathways, thus providing new insights into possible therapeutic intervention strategies... - Hypoxia/reoxygenation: a dynamic regulator of lysyl oxidase-facilitated breast cancer migrationLynne Marie Postovit
Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60614, USA
J Cell Biochem 103:1369-78. 2008.... - Influence of the microenvironment on melanoma cell fate determination and phenotypeLynne-Marie Postovit
Children's Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H. Lurie Comprehensive Cancer Center, Northwestern University's Feinberg School of Medicine, Chicago, Illinois, USA
Cancer Res 66:7833-6. 2006..The microenvironment therefore presents a novel target for the treatment and ultimately the prevention of melanoma progression and metastasis... - Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent mannerCaleb M Bailey
Children s Memorial Research Center, 2300 Children s Plaza, Box 222, Chicago, IL 60614 3394, USA
Mol Cell Biol 28:2235-43. 2008..These data support a model in which IRF6, in collaboration with maspin, promotes mammary epithelial cell differentiation by facilitating entry into the G(0) phase of the cell cycle... - The epigenetic reprogramming of poorly aggressive melanoma cells by a metastatic microenvironmentElisabeth A Seftor
Children's Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
J Cell Mol Med 10:174-96. 2006.... - A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cellsLynne-Marie Postovit
Children's Memorial Research Center, Chicago, Illinois 60614, USA
Stem Cells 24:501-5. 2006..These findings demonstrate the utility of this 3D model for studying the unique factors deposited by hESCs and for investigating the epigenetic effects that stem cell microenvironments may have on tumor progression... - Epigenetic transdifferentiation of normal melanocytes by a metastatic melanoma microenvironmentElisabeth A Seftor
Children's Memorial Research Center and Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, IL 60614, USA
Cancer Res 65:10164-9. 2005..This novel approach identifies specific genes involved in the transdifferentiation of melanocytes to a more aggressive phenotype, which may offer significant therapeutic value... - EphA2 as a promoter of melanoma tumorigenicityNaira V Margaryan
The Children s Memorial Research Center, Chicago, IL, USA
Cancer Biol Ther 8:279-88. 2009.... - Reevaluating cathepsin D as a biomarker for breast cancer: serum activity levels versus histopathologyDaniel E Abbott
Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Cancer Biol Ther 9:23-30. 2010.... 
Role of nodal signaling and the microenvironment underlying melanoma plasticityLynne Marie Postovit
Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Northwestern University s Feinberg School of Medicine, Chicago, IL, USA
Pigment Cell Melanoma Res 21:348-57. 2008..Here, we review the concept of melanoma plasticity, with an emphasis on the emerging role of Nodal as a regulator of melanoma tumorigenesis and progression, and present findings related to epigenetic reprogramming...- IRF6 in development and disease: a mediator of quiescence and differentiationCaleb M Bailey
Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614 3394, USA
Cell Cycle 7:1925-30. 2008.... - Microgenomics profile the endogenous angiogenic phenotype in subpopulations of aggressive melanomaZoe N Demou
Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 4314, USA
J Cell Biochem 105:562-73. 2008..Identifying factors regulating tumor plasticity and heterogeneity at the molecular level is essential in designing effective anti-cancer therapies... - Temporal and spatial expression patterns for the tumor suppressor Maspin and its binding partner interferon regulatory factor 6 during breast developmentCaleb M Bailey
Children s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614 3394, USA
Dev Growth Differ 51:473-81. 2009..These results support the hypothesis that IRF6 and Maspin are important for mammary epithelial cell differentiation, and advance our understanding of the Maspin-IRF6 partnership during normal mammary gland development... - Lysyl oxidase regulates actin filament formation through the p130(Cas)/Crk/DOCK180 signaling complexStacey L Payne
Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60614, USA
J Cell Biochem 98:827-37. 2006..Elucidating the role of LOX in the regulation of cell motility will allow the development of more effective therapeutic strategies to treat invasive/metastatic breast cancer... - Exploiting the convergence of embryonic and tumorigenic signaling pathways to develop new therapeutic targetsDaniel E Abbott
Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60614, USA
Stem Cell Rev 3:68-78. 2007..Here we outline evidence that demonstrates the inductive influence of embryonic stem cells and their microenvironment to reprogram cancer cells to exhibit a more benign phenotype, with profound implications for differentiation therapy... - Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancerLuigi Strizzi
Children s Memorial Research Center, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 2300 Children s Plaza, Chicago, IL 60614, USA
Breast Cancer Res 14:R75. 2012.... - Focal adhesion kinase signaling and the aggressive melanoma phenotypeAngela R Hess
Children's Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614-3394, USA
Cell Cycle 5:478-80. 2006..Together these observations implicate FAK as a promoter of the aggressive melanoma phenotype, thereby identifying a rational target for therapeutic intervention of malignant melanoma... - Notch and NOXA-related pathways in melanoma cellsBrian J Nickoloff
Department of Pathology, Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University, Chicago, Illinois 60153 5385, USA
J Investig Dermatol Symp Proc 10:95-104. 2005..g. Notch signaling), and anti-cancer agents that achieve tumor selectivity (e.g., GSI-induced NOXA), this experimental approach provides a useful framework for future therapeutic strategies in cutaneous oncology... - Cancer hallmarks in induced pluripotent cells: new insightsSergey Malchenko
Children s Memorial Research Center, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60614, USA
J Cell Physiol 225:390-3. 2010..These data demonstrate cancer hallmarks expressed by hiPSCs, which will require further assessment for their impact on future therapies.... - VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: implications for vasculogenic mimicryAngela R Hess
Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Cancer Biol Ther 5:228-33. 2006.... - Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cellsLynne Marie Postovit
Program in Cancer Biology and Epigenomics, Children s Memorial Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60614, USA
Proc Natl Acad Sci U S A 105:4329-34. 2008..The tumor-suppressive effects of the hESC microenvironment, by neutralizing the expression of Nodal in aggressive tumor cells, provide previously unexplored therapeutic modalities for cancer treatment... - Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanismStacey L Payne
Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine at Northwestern University, Chicago, IL 60614, USA
Cancer Res 65:11429-36. 2005..These data show the need to target LOX for treatment of aggressive breast cancer... - Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: role of the Eph receptorsAngela R Hess
Children s Memorial Research Center, Program in Cancer Biology and Epigenomics, Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer, Chicago, Illinois 60614 3394, USA
Dev Dyn 236:3283-96. 2007..Specifically, this review will focus on the role of the Eph receptors and ligands in embryonic vasculogenesis, angiogenesis, and vasculogenic mimicry... - Targeting Nodal in malignant melanoma cellsLynne Marie Postovit
Children s Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H Lurie Comprehensive Cancer Center, Northwestern University s Feinberg School of Medicine, 2300 Children s Plaza, Box 222, Chicago, IL 60614, USA
Expert Opin Ther Targets 11:497-505. 2007..Hence, due to its restricted expression pattern and function as a melanoma-tumor-promoter, Nodal (and its signaling partners) present unique targets for both immunologic and pharmacologic therapies... - The commonality of plasticity underlying multipotent tumor cells and embryonic stem cellsLynne Marie Postovit
Program in Cancer Biology and Epigenomics, Children s Memorial Research Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
J Cell Biochem 101:908-17. 2007..These stem cell-derived mediators, as well as the genes they regulate, provide therapeutic targets designed to specifically differentiate and eradicate aggressive cancers... - Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cellsDaisy W J van der Schaft
Children's Memorial Research Center, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 60614-3394, USA
J Natl Cancer Inst 96:1473-7. 2004..These findings may contribute to the development of new antivascular therapeutic agents that target both angiogenesis and tumor cell vasculogenic mimicry... - Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironmentPaul M Kulesa
Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
Proc Natl Acad Sci U S A 103:3752-7. 2006..This model has the potential to provide insights into the regulation of tumor cell plasticity by an embryonic milieu, which may hold significant therapeutic promise... - Biological functions of maspinCaleb M Bailey
Department of Anatomy and Cell Biology, The Carver College of Medicine, University of Iowa, Iowa City, IA, USA
J Cell Physiol 209:617-24. 2006.... - A requirement for dimerization of HP1Hsalpha in suppression of breast cancer invasionLaura E Norwood
Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
J Biol Chem 281:18668-76. 2006..Taken together, these data demonstrate that modulation of HP1(Hsalpha) alters the invasive potential of breast cancer cells through mechanisms requiring HP1 dimerization, but not interactions with PXVXL-containing proteins... - Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressivenessJolanta M Topczewska
Program in Developmental Biology, Children s Memorial Research Center, Feinberg School of Medicine Northwestern University, 2300 Children s Plaza, Box 222, Chicago Illinois, 60614, USA
Nat Med 12:925-32. 2006..These data suggest that Nodal signaling has a key role in melanoma cell plasticity and tumorigenicity, thereby providing a previously unknown molecular target for regulating tumor progression... - Prostatic tumor cell plasticity involves cooperative interactions of distinct phenotypic subpopulations: role in vasculogenic mimicryNavesh Sharma
Department of Anatomy and Cell Biology, The University of Iowa College of Medicine, Iowa City, Iowa 52242-1109, USA
Prostate 50:189-201. 2002..These results reflect the plasticity of aggressive prostatic tumor cells and may provide new prognostic markers for clinical diagnosis and new therapeutic intervention strategies... - Transendothelial function of human metastatic melanoma cells: role of the microenvironment in cell-fate determinationMary J C Hendrix
Department of Anatomy and Cell Biology, University of Iowa, 51 Newton Road, 1 100 BSB, Iowa City, IA 52242, USA
Cancer Res 62:665-8. 2002.... - Tyrosine phosphorylation of maspin in normal mammary epithelia and breast cancer cellsValerie A Odero-Marah
Department of Anatomy and Cell Biology, The Roy J and Lucille A Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
Biochem Biophys Res Commun 295:800-5. 2002..These novel observations suggest that maspin, which deviates from the classical serpin, may be an important signal transduction molecule in its phosphorylated form... - The paradoxical expression of maspin in ovarian carcinomaAnil K Sood
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1109, USA
Clin Cancer Res 8:2924-32. 2002..These paradoxical results may offer new insights regarding the role of maspin in ovarian cancer progression that may also impact diagnosis and treatment strategies... - Expression of multiple molecular phenotypes by aggressive melanoma tumor cells: role in vasculogenic mimicryElisabeth A Seftor
Department of Anatomy and Cell Biology, The University of Iowa, 51 Newton Road, 1-100 BSB, Iowa City, IA 52242-1109, USA
Crit Rev Oncol Hematol 44:17-27. 2002.... - Nitric oxide regulation of maspin expression in normal mammary epithelial and breast cancer cellsZhila Khalkhali-Ellis
Department of Anatomy and Cell Biology and the Holden Comprehensive Cancer Center at The University of Iowa, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA
Am J Pathol 162:1411-7. 2003..Targeted delivery of NO within the tumor microenvironment could provide a feasible noninvasive approach for effective treatment... - Remodeling of the microenvironment by aggressive melanoma tumor cellsMary J C Hendrix
Department of Anatomy and Cell Biology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242 1109, USA
Ann N Y Acad Sci 995:151-61. 2003..These observations illustrate the remarkable influence of the microenvironment on the phenotype of melanoma cells and may provide new perspectives on tumor cell plasticity and unique treatment strategies... - Maspin regulates different signaling pathways for motility and adhesion in aggressive breast cancer cellsValerie A Odero-Marah
The Department of Anatomy and Cell Biology at The University of Iowa, Carver College of Medicine; Iowa City, Iowa USA
Cancer Biol Ther 2:398-403. 2003.... - Regulating the tumor suppressor gene maspin in breast cancer cells: a potential mechanism for the anticancer properties of tamoxifenZhila Khalkhali-Ellis
Department of Anatomy and Cell Biology and the Holden Comprehensive Cancer Center at The University of Iowa, Iowa City, Iowa 52242 1109, USA
Clin Cancer Res 10:449-54. 2004..Specifically, our hypothesis tested the clinical efficacy of tamoxifen to regulate maspin expression... - Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasionAnil K Sood
Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Am J Pathol 165:1087-95. 2004..These data indicate that FAK is overexpressed in most invasive ovarian cancers and plays a functionally significant role in ovarian cancer migration and invasion. Thus, FAK may be an important therapeutic target in ovarian carcinoma... - Maspin regulates hypoxia-mediated stimulation of uPA/uPAR complex in invasive breast cancer cellsSumaira Amir
The Department of Anatomy and Cell Biology, Carver College of Medicine, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa, USA
Cancer Biol Ther 4:400-6. 2005..These results indicate that maspin inhibits hypoxia-induced invasion of metastatic breast cancer cells by blocking the uPA system, thus illuminating an important molecular pathway for therapeutic consideration... - Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnershipCaleb M Bailey
Department of Anatomy and Cell Biology and Pediatrics, Roy A and Lucille J Carver College of Medicine, University of Iowa, Iowa City, Iowa, 52242, USA
J Biol Chem 280:34210-7. 2005..These findings help to elucidate the molecular mechanisms of maspin and suggest an interactive role between maspin and IRF6 in regulating cellular phenotype, the loss of which can lead to neoplastic transformation... - Aberrant methylation of the maspin promoter is an early event in human breast cancerBernard W Futscher
Bone Marrow Transplant Program, Arizona Cancer Center, and Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
Neoplasia 6:380-9. 2004..Taken together, these results indicate that aberrant methylation of the maspin promoter is an early event in human breast cancer... - Dual roles of E-cadherin in prostate cancer invasionJirapat Chunthapong
Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242 1109, USA
J Cell Biochem 91:649-61. 2004..These results suggest that E-cadherin plays an important role in regulating the invasive potential of prostate cancer cells through an unique paracrine mechanism... - Preoperative serum vascular endothelial growth factor levels: significance in ovarian cancerBrian C Cooper
Division of Gynecologic Oncology, Departments of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Clin Cancer Res 8:3193-7. 2002..004) were significant. CONCLUSIONS: Preoperative VEGF levels may be useful in differentiating benign adnexal masses from malignancy. Preoperative VEGF levels >380 pg/ml are an independent risk factor for death because of disease... - Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cellsJian-Zhong Qin
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153-5385, USA
Cancer Res 65:6282-93. 2005.... - Apoptosis in colorectal tumors: does it help tumors metastasize?Mary J C Hendrix
Cancer Biol Ther 1:64. 2002 - A molecular role for lysyl oxidase in breast cancer invasionDawn A Kirschmann
Department of Anatomy and Cell Biology, Holden Comprehensive Cancer Center, The University of Iowa, The Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242 1109, USA
Cancer Res 62:4478-83. 2002..These results provide substantial new evidence that LOX is involved in cancer cell invasion... - Molecular determinants of human uveal melanoma invasion and metastasisElisabeth A Seftor
Department of Anatomy and Cell Biology, College of Medicine and The Holden Comprehensive Cancer Center, University of Iowa, Iowa City 52242-1109, USA
Clin Exp Metastasis 19:233-46. 2002..This study provides a molecular profile that will hopefully lead to the development of new molecular targets for therapeutic intervention and possible diagnostic markers to predict the clinical outcome of patients with uveal melanoma... - Targeting the tumor microenvironment with chemically modified tetracyclines: inhibition of laminin 5 gamma2 chain promigratory fragments and vasculogenic mimicryRichard E B Seftor
Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa 52242-1109, USA
Mol Cancer Ther 1:1173-9. 2002.... - p53 null mutations are associated with a telomerase negative phenotype in ovarian carcinomaAnil K Sood
Department of Gynecologic Oncology, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 440, Houston, TX 77030 USA
Cancer Biol Ther 1:511-7. 2002..03). Ovarian cancers with a p53 null mutation are more likely to lack telomerase activity. This may have implications for therapeutic approaches based on telomerase... - Editorial: potential clinical use of exploiting metastasis suppressor genes to regulate prostatic cancerMary J C Hendrix
J Urol 169:1134. 2003 - Functional role of matrix metalloproteinases in ovarian tumor cell plasticityAnil K Sood
Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Am J Obstet Gynecol 190:899-909. 2004..We also investigated the clinical relevance of matrix metalloproteinase-2 and -9 and membrane type 1-matrix metalloproteinase in human ovarian cancers with evidence of tumor cell-lined vasculature... - Conserved properties of HP1(Hsalpha)Laura E Norwood
The Department of Biochemistry, The University of Iowa, 3136 MERF, Iowa City, IA 52242, USA
Gene 336:37-46. 2004..Taken together, these results demonstrate the participation of HP1(Hsalpha) in silent chromatin formation and that HP1(Hsalpha) is a functional homologue of Drosophila HP1... - Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicryWolfram Ruf
Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
Cancer Res 63:5381-9. 2003..Thus, TFPI-2 contributes to VM plasticity, whereas TFPI-1 has anticoagulant functions of relevance for perfusion of VM channels formed by TF-expressing melanoma cells... - Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicryAngela R Hess
The Department of Anatomy and Cell Biology, The University of Iowa, Iowa City, Iowa 52242-1109, USA
Cancer Res 63:4757-62. 2003..PI3K may represent an excellent target for therapeutic intervention of a novel signaling cascade underlying VM... - The complexity of tumor vascularityAnil K Sood
Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Biol Ther 2:257-8. 2003 - Molecular plasticity of human melanoma cellsMary J C Hendrix
The Holden Comprehensive Cancer Center at The University of Iowa, Roy J and Lucille A Carver College of Medicine, Bowen Science Building, 51 Newton Road, Iowa City, IA 52242 1109, USA
Oncogene 22:3070-5. 2003.... - Vasculogenic mimicry and tumour-cell plasticity: lessons from melanomaMary J C Hendrix
Department of Anatomy and Cell Biology, Carver College of Medicine and the Holden Comprehensive Cancer Center at The University of Iowa, 375 Newton Road, Iowa City, Iowa 52242, USA
Nat Rev Cancer 3:411-21. 2003..This ability has been termed 'vasculogenic mimicry'. How does vasculogenic mimicry contribute to tumour progression, and can it be targeted by therapeutic agents?.. - Plasmalemmal vacuolar H+-ATPase is decreased in microvascular endothelial cells from a diabetic modelJose D Rojas
Department of Physiology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
J Cell Physiol 201:190-200. 2004..These novel observations suggest that the angiogenic abnormalities in diabetes involve a decrease in pmV-ATPase in microvascular endothelial cells... - Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxiaDaisy W J van der Schaft
Angiogenesis Laboratory, Research Institute for Growth and Development, Department of Pathology, Maastricht University and University Hospital Maastricht, The Netherlands
Cancer Res 65:11520-8. 2005..The results suggest that optimal tumor treatment may require targeting of these structures in combination with prevention of angiogenesis...
Research Grants
- PROSTATIC VASCULOGENIC MIMICRY: A NEW METASTATIC PATHWAYMary Hendrix; Fiscal Year: 2003..abstract_text> ..
- Epigenetic Effect of the Microenvironment on Stem Cell Plasticity and FunctionMary Hendrix; Fiscal Year: 2007....
- Endothelial Transdifferentiation of Invasive Tumor CellsMary Hendrix; Fiscal Year: 2007..The data generated from these novel studies will provide new molecular markers for clinical diagnosis and new concepts regarding the trarisendothelial differentiation of aggressive melanoma tumor cells and their stem cell plasticity. ..