Eric S Goetzman
Affiliation: Children's Hospital of Pittsburgh
Uppala R, McKinney R, Brant K, Fabisiak J, Goetzman E. Nickel inhibits mitochondrial fatty acid oxidation. Biochem Biophys Res Commun. 2015;463:806-10 pubmed publisher
..In conclusion, inhibition of fatty acid oxidation by nickel, concurrent with increased glucose metabolism, represents a form of metabolic reprogramming that may contribute to nickel-induced carcinogenesis. ..
Shinde A, Luo J, Bharathi S, Shi H, Beck M, McHugh K, et al
. Increased mortality from influenza infection in long-chain acyl-CoA dehydrogenase knockout mice. Biochem Biophys Res Commun. 2018;497:700-704 pubmed publisher
..We conclude that LCAD-/- mice succumb to influenza from bioenergetic starvation, likely due to increased reliance upon glucose for energy. ..
Otsubo C, Bharathi S, Uppala R, Ilkayeva O, Wang D, McHugh K, et al
. Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant. J Biol Chem. 2015;290:23897-904 pubmed publisher
..Finally, acylcarnitines are detectable in normal human lavage fluid. Thus, long-chain acylcarnitines may represent a risk factor for lung injury in humans with dysfunctional fatty acid oxidation. ..
Uppala R, Dudiak B, Beck M, Bharathi S, Zhang Y, Stolz D, et al
. Aspirin increases mitochondrial fatty acid oxidation. Biochem Biophys Res Commun. 2017;482:346-351 pubmed publisher
..These studies provide insight into the pathophysiology of Reye Syndrome, which is known to be triggered by aspirin ingestion in patients with fatty acid oxidation disorders. ..
Zhang Y, Bharathi S, Rardin M, Lu J, Maringer K, Sims Lucas S, et al
. Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. J Biol Chem. 2017;292:10239-10249 pubmed publisher
..Our findings suggest that SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin to promote respiratory chain function. ..
Goetzman E, Gong Z, Schiff M, Wang Y, Muzumdar R. Metabolic pathways at the crossroads of diabetes and inborn errors. J Inherit Metab Dis. 2018;41:5-17 pubmed publisher
..This highlights the need for future studies to determine whether certain inborn errors may confer increased risk for diabetes as the patients age. ..