WILLIAM GAILLARD

Summary

Affiliation: Children's National Medical Center
Country: USA

Publications

  1. ncbi request reprint Structural and functional imaging in children with partial epilepsy
    W D Gaillard
    Department of Neurology, Children s National Medical Center, The George Washington University School of Medicine, Washington, DC 20010, USA
    Ment Retard Dev Disabil Res Rev 6:220-6. 2000
  2. pmc fMRI language dominance and FDG-PET hypometabolism
    W D Gaillard
    Center for Neuroscience, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Neurology 76:1322-9. 2011
  3. doi request reprint Guidelines for imaging infants and children with recent-onset epilepsy
    William D Gaillard
    Department of Neuroscience, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
    Epilepsia 50:2147-53. 2009
  4. pmc Epilepsy imaging study guideline criteria: commentary on diagnostic testing study guidelines and practice parameters
    William D Gaillard
    Center for Neuroscience, Children s National Medical Center, George Washington University, Washington, District of Columbia 20010, USA
    Epilepsia 52:1750-6. 2011
  5. ncbi request reprint Atypical language in lesional and nonlesional complex partial epilepsy
    W D Gaillard
    Department of Neuroscience, Children s National Medical Center, George Washington University School of Medicine, 111 Michigan Ave NW, Washington, DC 20010, USA
    Neurology 69:1761-71. 2007
  6. ncbi request reprint Prognosis of children with partial epilepsy: MRI and serial 18FDG-PET
    W D Gaillard
    Clinical Epilepsy Section, NINDS, Division of Intramural Research, Washington, DC, USA
    Neurology 68:655-9. 2007
  7. pmc The fMRI success rate of children and adolescents: typical development, epilepsy, attention deficit/hyperactivity disorder, and autism spectrum disorders
    Benjamin E Yerys
    Department of Neurosciences, Children s National Medical Center, George Washington University School of Medicine, Washington, DC, USA
    Hum Brain Mapp 30:3426-35. 2009
  8. pmc Functional connectivity of the inferior frontal cortex changes with age in children with autism spectrum disorders: a fcMRI study of response inhibition
    Philip S Lee
    Department of Psychology, Georgetown University, Washington, DC 20057, USA
    Cereb Cortex 19:1787-94. 2009
  9. doi request reprint Utility of functional MRI in pediatric neurology
    Emily R Freilich
    Department of Neurosciences, Children s National Medical Center, 111 Michigan Avenue Northwest, Washington, DC, 20010, USA
    Curr Neurol Neurosci Rep 10:40-6. 2010
  10. doi request reprint Treatment of refractory status epilepticus in childhood
    John M Schreiber
    Department of Neurology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Curr Neurol Neurosci Rep 11:195-204. 2011

Research Grants

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Structural and functional imaging in children with partial epilepsy
    W D Gaillard
    Department of Neurology, Children s National Medical Center, The George Washington University School of Medicine, Washington, DC 20010, USA
    Ment Retard Dev Disabil Res Rev 6:220-6. 2000
    ..fMRI is a valuable tool for elucidating the impact of chronic neurologic disease states on the functional organization of language networks during development...
  2. pmc fMRI language dominance and FDG-PET hypometabolism
    W D Gaillard
    Center for Neuroscience, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Neurology 76:1322-9. 2011
    ..Atypical language dominance is common in patients with temporal lobe epilepsy. We examined the association of left temporal hypometabolism with laterality of fMRI activation in a language task in a cross-sectional study...
  3. doi request reprint Guidelines for imaging infants and children with recent-onset epilepsy
    William D Gaillard
    Department of Neuroscience, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
    Epilepsia 50:2147-53. 2009
    ..When available, MRI is preferred to CT because of its superior resolution, versatility, and lack of radiation...
  4. pmc Epilepsy imaging study guideline criteria: commentary on diagnostic testing study guidelines and practice parameters
    William D Gaillard
    Center for Neuroscience, Children s National Medical Center, George Washington University, Washington, District of Columbia 20010, USA
    Epilepsia 52:1750-6. 2011
    ..We review the limitations of current guidelines and propose elements for imaging studies that can contribute meaningfully to the epilepsy literature...
  5. ncbi request reprint Atypical language in lesional and nonlesional complex partial epilepsy
    W D Gaillard
    Department of Neuroscience, Children s National Medical Center, George Washington University School of Medicine, 111 Michigan Ave NW, Washington, DC 20010, USA
    Neurology 69:1761-71. 2007
    ..We investigated the relationship between partial epilepsy, MRI findings, and atypical language representation...
  6. ncbi request reprint Prognosis of children with partial epilepsy: MRI and serial 18FDG-PET
    W D Gaillard
    Clinical Epilepsy Section, NINDS, Division of Intramural Research, Washington, DC, USA
    Neurology 68:655-9. 2007
    ..To study the evolution of cerebral glucose metabolism after partial seizure onset in children, and its relation to clinical variables...
  7. pmc The fMRI success rate of children and adolescents: typical development, epilepsy, attention deficit/hyperactivity disorder, and autism spectrum disorders
    Benjamin E Yerys
    Department of Neurosciences, Children s National Medical Center, George Washington University School of Medicine, Washington, DC, USA
    Hum Brain Mapp 30:3426-35. 2009
    ..Studies with 4- to 6-year-olds may require 20-40% additional participants; studies with 10- to 18-year-olds may require 10-15% additional participants...
  8. pmc Functional connectivity of the inferior frontal cortex changes with age in children with autism spectrum disorders: a fcMRI study of response inhibition
    Philip S Lee
    Department of Psychology, Georgetown University, Washington, DC 20057, USA
    Cereb Cortex 19:1787-94. 2009
    ..This discrepancy suggests an atypical developmental trajectory in ASD for right IFC connectivity with other neural regions supporting response inhibition...
  9. doi request reprint Utility of functional MRI in pediatric neurology
    Emily R Freilich
    Department of Neurosciences, Children s National Medical Center, 111 Michigan Avenue Northwest, Washington, DC, 20010, USA
    Curr Neurol Neurosci Rep 10:40-6. 2010
    ..This article reviews the background of fMRI in pediatrics and highlights the most recent literature and clinical applications...
  10. doi request reprint Treatment of refractory status epilepticus in childhood
    John M Schreiber
    Department of Neurology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Curr Neurol Neurosci Rep 11:195-204. 2011
    ..We review the current treatment strategies for RSE, focusing on patient selection, monitoring, optimal dosing and administration of medications, efficacy, adverse effects, and treatment duration...
  11. doi request reprint Parenting stress and childhood epilepsy: the impact of depression, learning, and seizure-related factors
    Sandra Cushner-Weinstein
    Center for Neuroscience and Behavioral Medicine, Children s National Medical Center, Department of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC 20010 2970, USA
    Epilepsy Behav 13:109-14. 2008
    ..The purpose of this study was to evaluate stress in parents of children with epilepsy relative to the impact of childhood depression, learning disorders, and seizure-related risk factors...
  12. doi request reprint Misidentification of vagus nerve stimulator for intravenous access and other major adverse events
    Phillip L Pearl
    Department of Neurology and Department of Neurosurgery, Children s National Medical Center, Washington, DC 20010 1970, USA
    Pediatr Neurol 38:248-51. 2008
    ..Unanticipated adverse events included misidentification of the wire for intravenous access, clipping of the wire during surgical dissection, and cervical dysesthesias associated with head-turning...
  13. ncbi request reprint The benefits of a camp designed for children with epilepsy: evaluating adaptive behaviors over 3 years
    Sandra Cushner-Weinstein
    Children s National Medical Center, Division of Neurosciences and Behavioral Medicine, Department of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC 20010 2970, USA
    Epilepsy Behav 10:170-8. 2007
    ..Children with epilepsy attending a condition-specific overnight camp were evaluated for behavioral changes over 3 consecutive years, using a modification of the Vineland Adaptive Behavioral Scale...
  14. ncbi request reprint Clinical experience with anticonvulsant medication in pediatric epilepsy and comorbid bipolar spectrum disorder
    Jay A Salpekar
    Department of Psychiatry and Behavioral Sciences, Children s National Medical Center, The George Washington University School of Medicine, Washington, DC, USA
    Epilepsy Behav 9:327-34. 2006
    ..01). Results suggest that in many cases, selected anticonvulsants appeared to simultaneously treat both epilepsy and mood disorder. Controlled trials are necessary to further ascertain optimal anticonvulsant usage...
  15. pmc Novel SCN1A mutation in a proband with malignant migrating partial seizures of infancy
    Emily R Freilich
    Department of Neurology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010 2970, USA
    Arch Neurol 68:665-71. 2011
    ..To characterize a novel SCN1A mutation in a proband with malignant migrating partial seizures of infancy...
  16. doi request reprint Infantile spasms: a U.S. consensus report
    John M Pellock
    Division of Child Neurology, Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Epilepsia 51:2175-89. 2010
    ..Differences of opinion among ISWG members occurred in areas where data were lacking; however, this article represents a consensus of the U.S. approach to the diagnostic evaluation and treatment of IS...
  17. pmc A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy
    Kelly M McVearry
    Department of Neurology, Georgetown University Medical Center, Washington, DC 20007, USA
    Epilepsy Behav 16:609-16. 2009
    ..To investigate the differential effects of fetal exposure to antiepileptic drugs (AEDs) on cognitive fluency and flexibility in a prospective sample of children...
  18. doi request reprint Diagnostic value of lumbar puncture in afebrile infants with suspected new-onset seizures
    Tarannum M Lateef
    Department of Neurology, Children s National Medical Center and George Washington University School of Medicine, Washington, DC, USA
    J Pediatr 153:140-2. 2008
    ..We analyzed cerebrospinal fluid results in infants and found that lumbar puncture adds little diagnostic value to the evaluation of young, well-appearing infants presenting with possible new-onset seizures...
  19. pmc Atypical neural substrates of Embedded Figures Task performance in children with Autism Spectrum Disorder
    Philip S Lee
    Department of Psychology, Georgetown University, Washington, DC 20057, USA
    Neuroimage 38:184-93. 2007
    ..ASD children performed the EFT at the same level as controls but with reduced cortical involvement, suggesting that disembedded visual processing is accomplished parsimoniously by ASD relative to typically developing brains...
  20. ncbi request reprint Developmental aspects of language processing: fMRI of verbal fluency in children and adults
    William D Gaillard
    Department of Neurology, Children s National Medical Center, George Washington University School of Medicine, Washington, DC 20010, USA
    Hum Brain Mapp 18:176-85. 2003
    ..15). The brain areas that process semantic verbal fluency are similar in children and adults. The laterality of activation does not change appreciably with age and appears to be strongly lateralized by age 7 years...
  21. doi request reprint Pediatric functional magnetic resonance imaging (fMRI): issues and applications
    Elizabeth Stief O'Shaughnessy
    Department of Neurosciences, Children s National Medical Center, George Washington University, Washington, District of Columbia 20010, USA
    J Child Neurol 23:791-801. 2008
    ..The focus is specifically on language studies to review strengths, limitations, and practical applications of this technology with children. Future directions for functional magnetic resonance imaging are presented...
  22. doi request reprint Bilateral and independent Broca areas confirmed by Wada test and functional magnetic resonance imaging
    Timothy J Biega
    Department of Radiology, George Washington University Hospital, Washington, DC, USA
    J Comput Assist Tomogr 33:560-1. 2009
    ..We present a patient with right temporal lobe epilepsy who presented with bilateral and functionally independent Broca areas, as confirmed by Wada testing and functional magnetic resonance imaging...
  23. ncbi request reprint Status epilepticus in children
    Rani K Singh
    Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Curr Neurol Neurosci Rep 9:137-44. 2009
    ..It also reviews the recommended medications for first-line treatment of status epilepticus and refractory status epilepticus. Emphasis is placed on future pharmacotherapies and consideration of neurosurgical intervention when indicated...
  24. ncbi request reprint The utility of functional magnetic resonance imaging in epilepsy and language
    Lyn M Balsamo
    Department of Neurology, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Curr Neurol Neurosci Rep 2:142-9. 2002
    ..Paradigm selection, data analysis techniques, and considerations specific to imaging children are discussed. Utility of fMRI for studying neural plasticity as a result of brain insult (e.g., epilepsy) is also considered...
  25. ncbi request reprint A functional magnetic resonance imaging study of left hemisphere language dominance in children
    Lyn M Balsamo
    Department of Neurology, Children s National Medical Center, George Washington University School of Medicine, 111 Michigan Ave NW, Washington, DC 20010, USA
    Arch Neurol 59:1168-74. 2002
    ..Functional magnetic resonance imaging is a noninvasive method of assessing language dominance in a pediatric population...
  26. pmc Usefulness of pulsed arterial spin labeling MR imaging in mesial temporal lobe epilepsy
    Young Min Lim
    Clinical Epilepsy Section, NINDS, NIH, Bethesda, MD 20892, USA
    Epilepsy Res 82:183-9. 2008
    ..ASL-derived CBF measurements were compared with those derived from H(2)(15)O positron emission tomography (PET)...
  27. doi request reprint Cerebral MRI abnormalities associated with vigabatrin therapy
    Phillip L Pearl
    Department of Neurology, Children s National Medical Center, Washington DC, USA
    Epilepsia 50:184-94. 2009
    ..Investigate whether patients on vigabatrin demonstrated new-onset and reversible T(2)-weighted magnetic resonance imaging (MRI) abnormalities...
  28. pmc Human herpes virus 6B: a possible role in epilepsy?
    William H Theodore
    Clinical Epilepsy Section, NINDS, NIH, Bethesda, MD, USA
    Epilepsia 49:1828-37. 2008
    ....
  29. ncbi request reprint Neuroimaging and the progression of epilepsy
    William H Theodore
    Clinical Epilepsy Section, National Institutes of Health, Building 10, Room 5N 250, Bethesda, MD 20892, USA
    Prog Brain Res 135:305-13. 2002
    ....
  30. ncbi request reprint A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardation
    Yong Won Cho
    Department of Neurology, Georgetown University Hospital, Washington, D C 20007, USA
    Arch Neurol 60:1625-32. 2003
    ..A Korean family had distinctive clinical and neuroimaging features and carried the same genetic mutation that was found in a previously described Japanese kindred with autosomal dominant nocturnal frontal lobe epilepsy...
  31. ncbi request reprint Epilepsy duration, febrile seizures, and cerebral glucose metabolism
    William H Theodore
    NIH, Clinical Epilepsy Section, Bethesda, Maryland 20892, USA
    Epilepsia 45:276-9. 2004
    ..It is uncertain whether these factors have the same influence on functional as on structural measures of the integrity of the epileptogenic zone...
  32. doi request reprint Intact implicit learning of spatial context and temporal sequences in childhood autism spectrum disorder
    Kelly Anne Barnes
    Department of Psychology, Georgetown University, Washington DC 20057, USA
    Neuropsychology 22:563-70. 2008
    ..The present findings provide evidence for the integrity of learning processes dependent on integration of spatial and sequential contextual information in high-functioning children with ASD...
  33. doi request reprint New incidence, prevalence, and survival of Aicardi syndrome from 408 cases
    Barbara L Kroner
    RTI International, Rockville, MD 20852, USA
    J Child Neurol 23:531-5. 2008
    ..The longer life expectancy found in our study hints at a higher functioning capacity in Aicardi syndrome and may inform counseling to families...

Research Grants6

  1. Plasticity of Language Networks in Childhood Epilepsy
    WILLIAM GAILLARD; Fiscal Year: 2006
    ..Furthermore, patients may be identified and evaluated at the outset of the disease process so that the neuronal response and degree of plasticity may be assessed and monitored. ..