Robert J Freishtat

Summary

Affiliation: Children's National Medical Center
Country: USA

Publications

  1. pmc Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade
    Matthew Sharron
    Division of Critical Care Medicine, Children s National Medical Center, Washington, DC, United States of America
    PLoS ONE 7:e41549. 2012
  2. pmc Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray
    Rajit K Basu
    Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45223, USA
    Crit Care 15:R273. 2011
  3. pmc Identification of pediatric septic shock subclasses based on genome-wide expression profiling
    Hector R Wong
    Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    BMC Med 7:34. 2009
  4. pmc Asthmatic airway epithelium is intrinsically inflammatory and mitotically dyssynchronous
    Robert J Freishtat
    Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA
    Am J Respir Cell Mol Biol 44:863-9. 2011
  5. pmc High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC
    Robert J Freishtat
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC 20010, USA
    J Pediatr 156:948-52. 2010
  6. pmc Glucocorticoid efficacy in asthma: is improved tissue remodeling upstream of anti-inflammation
    Robert J Freishtat
    Children s National Medical Center, Washington, DC 20010, USA
    J Investig Med 58:19-22. 2010
  7. pmc Delineation of a gene network underlying the pulmonary response to oxidative stress in asthma
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, The George Washington University, 111 Michigan Avenue NW, Washington, DC 20010, USA
    J Investig Med 57:756-64. 2009
  8. pmc Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Am J Respir Crit Care Med 179:467-73. 2009
  9. pmc Toward early identification of acute lung injury in the emergency department
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, Washington, DC 20010, USA
    J Investig Med 55:423-9. 2007
  10. pmc Understanding genomics: implications for the emergency medicine physician and the treatment of asthma
    Robert J Freishtat
    Research Center for Genetic Medicine, Division of Emergency Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Emerg Care 22:71-5; quiz 76-8. 2006

Research Grants

Collaborators

  • Eric P Hoffman
  • Mary C Rose
  • James M Chamberlain
  • Kanneboyina Nagaraju
  • S J Teach
  • Laura L Tosi
  • Joanna S Cohen
  • Pavan P Zaveri
  • David J Mathison
  • Thomas P Shanley
  • Catherine J Klein
  • Leticia M Ryan
  • Angela S Benton
  • Alan M Watson
  • Hector R Wong
  • Jennifer Lerner
  • Geoffrey L Allen
  • Neal J Thomas
  • Richard Lin
  • Nick Anas
  • Natalie Cvijanovich
  • Asha S Payne
  • Matthew Sharron
  • Erik J Stemmy
  • Andrew A Wiles
  • Rajit K Basu
  • Sabah Fatima Iqbal
  • Dinesh K Pillai
  • Matthew Foerster
  • Keith Meyer
  • Paul A Checchia
  • Heather Gordish-Dressman
  • Marie Monaco
  • Lindsay M Garvin
  • Claire E Hoptay
  • Mayya Geha
  • Andrew Wiles
  • Stuart L Goldstein
  • Stephen W Standage
  • Michael T Bigham
  • Natalie Z Cvijanovich
  • Stephanie L Constant
  • Sarah Alcala
  • Sabah F Iqbal
  • Prasad Devarajan
  • Tugba Ozedirne
  • Henry P Holbrook
  • Derek S Wheeler
  • Perry W Payne
  • Nikila Kumar
  • Kelli Odom
  • Wai Man Ngor
  • Douglas F Willson
  • Gwenn McLaughlin
  • Paul Checchia
  • Julie Simon
  • Margaret Winkler
  • Bhuvaneswari Sakthivel
  • Gary Kohn
  • Kelli Odoms
  • Meena Kalyanarman
  • Allan Doctor
  • Nancy M Tofil
  • Joseph Hess
  • Scott Penfil
  • Cheri Landers
  • Douglas Willson

Detail Information

Publications25

  1. pmc Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade
    Matthew Sharron
    Division of Critical Care Medicine, Children s National Medical Center, Washington, DC, United States of America
    PLoS ONE 7:e41549. 2012
    ..We previously reported an acute sepsis-induced cytotoxic platelet phenotype expressing serine protease granzyme B. We now aim to define the site(s) of and mechanism(s) by which platelet granzyme B induces end-organ apoptosis in sepsis...
  2. pmc Identification of candidate serum biomarkers for severe septic shock-associated kidney injury via microarray
    Rajit K Basu
    Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45223, USA
    Crit Care 15:R273. 2011
    ..The objective of our study was to determine whether microarray data from children with septic shock could be used to derive a panel of candidate biomarkers for predicting SSAKI...
  3. pmc Identification of pediatric septic shock subclasses based on genome-wide expression profiling
    Hector R Wong
    Cincinnati Children s Hospital Medical Center and Cincinnati Children s Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    BMC Med 7:34. 2009
    ..Herein we tested the hypothesis that pediatric septic shock subclasses can be discovered through genome-wide expression profiling...
  4. pmc Asthmatic airway epithelium is intrinsically inflammatory and mitotically dyssynchronous
    Robert J Freishtat
    Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA
    Am J Respir Cell Mol Biol 44:863-9. 2011
    ..These data, generated in an airway model lacking inflammatory cells, support the concept that epithelium contributes to asthmatic inflammation...
  5. pmc High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC
    Robert J Freishtat
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC 20010, USA
    J Pediatr 156:948-52. 2010
    ..The goal of this study was to examine the prevalence of vitamin D insufficiency and deficiency among urban African-American (AA) youth with asthma compared with control subjects without asthma...
  6. pmc Glucocorticoid efficacy in asthma: is improved tissue remodeling upstream of anti-inflammation
    Robert J Freishtat
    Children s National Medical Center, Washington, DC 20010, USA
    J Investig Med 58:19-22. 2010
    ..Herein, we present an alternative paradigm, where GC efficacy is mediated through more successful tissue remodeling, with reduction in inflammation secondary to successful regeneration...
  7. pmc Delineation of a gene network underlying the pulmonary response to oxidative stress in asthma
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, The George Washington University, 111 Michigan Avenue NW, Washington, DC 20010, USA
    J Investig Med 57:756-64. 2009
    ..These analyses identified key relationships and primary hypothetical targets for future studies of cigarette smoke-induced oxidative stress in asthma...
  8. pmc Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Am J Respir Crit Care Med 179:467-73. 2009
    ..Sepsis-related mortality results in part from immunodeficiency secondary to profound lymphoid apoptosis. The biological mechanisms responsible are not understood...
  9. pmc Toward early identification of acute lung injury in the emergency department
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, Washington, DC 20010, USA
    J Investig Med 55:423-9. 2007
    ..The purpose of this study was to describe the epidemiology of the ALI precursor acute hypoxemic respiratory failure (AHRF) in the ED...
  10. pmc Understanding genomics: implications for the emergency medicine physician and the treatment of asthma
    Robert J Freishtat
    Research Center for Genetic Medicine, Division of Emergency Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Pediatr Emerg Care 22:71-5; quiz 76-8. 2006
  11. pmc NKG2A inhibits TH2 cell effector function in vitro
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, Washington, DC, USA
    BMC Pulm Med 7:14. 2007
    ..Here we measured cytokine expression in human ex vivo TH2 cells upon activation with anti-CD3/28 and challenge with an NKG2A-specific agonist...
  12. pmc NKG2A and CD56 are coexpressed on activated TH2 but not TH1 lymphocytes
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, and Department of Pediatrics, George Washington University School of Medicine and Health Sciences, Washington, DC 20010 2970, USA
    Hum Immunol 66:1223-34. 2005
    ..This would likely result in less effector inhibition and a relatively robust TH2 response...
  13. pmc Associations between genetic variants in vitamin D metabolism and asthma characteristics in young African Americans: a pilot study
    Dinesh K Pillai
    Division of Pulmonary Medicine, Children s National Medical Center, Washington, DC, USA
    J Investig Med 59:938-46. 2011
    ..Our objective was to determine associations between variants in vitamin D metabolism genes and asthma characteristics in a pilot study of young urban AAs...
  14. pmc Genetic influences on vitamin D status and forearm fracture risk in African American children
    Leticia Manning Ryan
    Division of Emergency Medicine, Children s National Medical Center, Washington, DC 20010, USA
    J Investig Med 60:902-6. 2012
    ..Additional research is required to discover the genetics of fracture risk in blacks...
  15. pmc Cigarette smoke alters tissue inhibitor of metalloproteinase 1 and matrix metalloproteinase 9 levels in the basolateral secretions of human asthmatic bronchial epithelium in vitro
    Alan M Watson
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    J Investig Med 58:725-9. 2010
    ..Cigarette smoke (CS) significantly impacts the development of asthma and is strongly associated with increased asthma-related morbidity...
  16. pmc MUC7 polymorphisms are associated with a decreased risk of a diagnosis of asthma in an African American population
    Alan M Watson
    Research Center for Genetic Medicine, Children s National Medical Center CNMC, George Washington University, Washington, DC 20010, USA
    J Investig Med 57:882-6. 2009
    ..Occurrence of the rs9982010 and MUC7 allelic frequencies was evaluated in inner-city African Americans to test their association with a diagnosis of asthma...
  17. pmc Airway platelet activation is associated with airway eosinophilic inflammation in asthma
    Angela S Benton
    Center for Genetic Medicine Research, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    J Investig Med 58:987-90. 2010
    ....
  18. doi request reprint P-glycoprotein transporter expression on a549 respiratory epithelial cells is positively correlated with intracellular dexamethasone levels
    Joanna S Cohen
    Center for Genetic Medicine Research, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    J Investig Med 58:991-4. 2010
    ..This study was undertaken to determine the effect of P-gp expression on glucocorticoid efflux from airway epithelial cells...
  19. ncbi request reprint Extracellular cyclophilin levels associate with parameters of asthma in phenotypic clusters
    Erik J Stemmy
    Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA
    J Asthma 48:986-93. 2011
    ..The goals of this study were to determine whether Cyps are present in asthma patients during the chronic phase of the disease and to investigate whether levels of Cyps associate with clinical parameters of disease severity...
  20. pmc Mechanism of action of vitamin D in the asthmatic lung
    Sabah Fatima Iqbal
    Division of Emergency Medicine, Children s National Medical Center, Washington, DC, USA
    J Investig Med 59:1200-2. 2011
    ..Put together, there is compelling evidence for the role of vitamin D in asthma...
  21. pmc Conserved steroid hormone homology converges on nuclear factor κB to modulate inflammation in asthma
    Asha S Payne
    Division of Emergency Medicine, Children s National Medical Center, Washington, DC, USA
    J Investig Med 60:13-7. 2012
    ....
  22. pmc Prevalence of vitamin D insufficiency in African American children with forearm fractures: a preliminary study
    Leticia Manning Ryan
    Division of Emergency Medicine, Children s National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA
    J Pediatr Orthop 30:106-9. 2010
    ..The relationship between vitamin D status and childhood forearm fracture has not been investigated...
  23. ncbi request reprint Admission predictor modeling in pediatric interhospital transport
    Robert J Freishtat
    Division of Emergency Medicine, Children s National Medical Center, The George Washington University School of Medicine and Health Sciences, Washington, DC 20010 2970, USA
    Pediatr Emerg Care 20:443-7. 2004
    ....
  24. doi request reprint Overweight children: are they at increased risk for severe injury in motor vehicle collisions?
    Pavan P Zaveri
    Division of Emergency Medicine, Children s National Medical Center, USA
    Accid Anal Prev 41:959-62. 2009
    ..We hypothesized that overweight children suffer more severe injuries, different distributions of injuries and improper use of restraints in motor vehicle collisions...
  25. pmc Validating the genomic signature of pediatric septic shock
    Natalie Cvijanovich
    Children s Hospital and Research Center Oakland, Oakland, California, USA
    Physiol Genomics 34:127-34. 2008
    ..These data demonstrate that the previously reported genome-wide expression signature of pediatric septic shock is applicable to a validation cohort of patients...

Research Grants2

  1. Mentored Patient-Oriented Research Careeer Development Award
    ROBERT FREISHTAT; Fiscal Year: 2007
    ..Functionally important changes in gene expression will be confirmed in the entire cohort on the protein level by flow cytometry, and/or ELISA of proteins in peripheral blood and pulmonary edema fluid. ..