Diana Escolar

Summary

Affiliation: Children's National Medical Center
Country: USA

Publications

  1. pmc Translating mighty mice into neuromuscular therapeutics: is bigger muscle better?
    Eric P Hoffman
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Am J Pathol 168:1775-8. 2006
  2. ncbi request reprint Collaborative translational research leading to multicenter clinical trials in Duchenne muscular dystrophy: the Cooperative International Neuromuscular Research Group (CINRG)
    Diana M Escolar
    Research Center for Genetic Medicine CRI III, Children s National Medical Center, George Washington University, 111 Michigan Avenue, NW, Washington, DC 20010, USA
    Neuromuscul Disord 12:S147-154. 2002
  3. ncbi request reprint CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy
    Diana M Escolar
    Children s National Medical Center, George Washington University, Washington, DC, USA
    Ann Neurol 58:151-5. 2005
  4. ncbi request reprint Reliable surrogate outcome measures in multicenter clinical trials of Duchenne muscular dystrophy
    Jill E Mayhew
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Muscle Nerve 35:36-42. 2007
  5. pmc Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular Dystrophy
    Alfredo D Guerron
    Center for Genetic Medicine Research, Children s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA
    PLoS ONE 5:e11220. 2010
  6. ncbi request reprint Challenges in drug development for muscle disease: a stakeholders' meeting
    Jerry R Mendell
    Columbus Children s Research Institute, and Ohio State University, 700 Children s Drive, Columbus, OH 43235, USA
    Muscle Nerve 35:8-16. 2007
  7. ncbi request reprint CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy
    Gunnar M Buyse
    University Hospitals KU Leuven, Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Paediatr Neurol 11:337-40. 2007

Research Grants

Collaborators

Detail Information

Publications7

  1. pmc Translating mighty mice into neuromuscular therapeutics: is bigger muscle better?
    Eric P Hoffman
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Ave NW, Washington, DC 20010, USA
    Am J Pathol 168:1775-8. 2006
  2. ncbi request reprint Collaborative translational research leading to multicenter clinical trials in Duchenne muscular dystrophy: the Cooperative International Neuromuscular Research Group (CINRG)
    Diana M Escolar
    Research Center for Genetic Medicine CRI III, Children s National Medical Center, George Washington University, 111 Michigan Avenue, NW, Washington, DC 20010, USA
    Neuromuscul Disord 12:S147-154. 2002
    ....
  3. ncbi request reprint CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy
    Diana M Escolar
    Children s National Medical Center, George Washington University, Washington, DC, USA
    Ann Neurol 58:151-5. 2005
    ..Creatine and glutamine were well tolerated...
  4. ncbi request reprint Reliable surrogate outcome measures in multicenter clinical trials of Duchenne muscular dystrophy
    Jill E Mayhew
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    Muscle Nerve 35:36-42. 2007
    ..61). These data suggest that primary surrogate outcome measures in large multicenter clinical trials in DMD should use QMT, FVC, or time function tests to obtain maximum power and greatest sensitivity...
  5. pmc Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular Dystrophy
    Alfredo D Guerron
    Center for Genetic Medicine Research, Children s National Medical Center, Department of Integrative Systems Biology, George Washington University School of Medicine and Health Sciences, Washington, DC, USA
    PLoS ONE 5:e11220. 2010
    ..One of the proposed strategies is to use drugs that are known to act by multiple different mechanisms including inducing of homologous fetal form of adult genes, for example utrophin in place of dystrophin...
  6. ncbi request reprint Challenges in drug development for muscle disease: a stakeholders' meeting
    Jerry R Mendell
    Columbus Children s Research Institute, and Ohio State University, 700 Children s Drive, Columbus, OH 43235, USA
    Muscle Nerve 35:8-16. 2007
    ..The meeting provided a format for communication for diverse disciplines that usually have no common meeting ground, helping to lay the foundation for bringing products to market in a timely fashion...
  7. ncbi request reprint CINRG pilot trial of oxatomide in steroid-naïve Duchenne muscular dystrophy
    Gunnar M Buyse
    University Hospitals KU Leuven, Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Eur J Paediatr Neurol 11:337-40. 2007
    ..A modest mitigation of strength deterioration over time cannot be excluded...

Research Grants5

  1. Mentored Patient Oriented Research Career Development
    Diana Escolar; Fiscal Year: 2005
    ..Future studies will test several other drugs with potential to improve muscle strength in DMD. ..