Research Topics | Ervin EpsteinSummaryAffiliation: Children's Hospital Oakland Research Institute Country: USA Publications
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Publications
Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesisPo Lin So
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Mol Cancer Ther 7:1275-84. 2008..Furthermore, inhibition of basal RAR signaling in the skin promoted BCC carcinogenesis, suggesting that endogenous RAR signaling restrains BCC growth...
Mommy - where do tumors come from?Ervin H Epstein
Children s Hospital of Oakland Research Institute, Oakland, California, USA
J Clin Invest 121:1681-3. 2011..Although these cells sustain oncogenic mutations while in the stem cell niche, they may have to leave that stem cell niche to become tumor cells...- Basal cell carcinomas: attack of the hedgehogErvin H Epstein
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, California 94609, USA
Nat Rev Cancer 8:743-54. 2008..Importantly, a phase 1 first-in-human trial of a Hedgehog inhibitor has shown real progress in halting and even reversing the growth of these tumours... - Novel investigational drugs for basal cell carcinomaPo Lin So
Children s Hospital Oakland Research Institute, Cancer Division, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Expert Opin Investig Drugs 19:1099-112. 2010..Therefore, concerted effects to identify novel preventive and therapeutic strategies are necessary... 
Case records of the Massachusetts General Hospital. Case 3-2008. An 80-year-old woman with cutaneous basal-cell carcinomas and cysts of the jawsErvin H Epstein
Children's Hospital of Oakland Research Institute, Oakland, CA, USA
N Engl J Med 358:393-401. 2008- Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- miceParastoo Davari
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Carcinogenesis 31:968-73. 2010..Despite the quantitative differences, there was no dramatic qualititative difference in the BCC or RMS tumors associated with the mutant Blm genotype... - Statin use and risk of basal cell carcinomaMaryam M Asgari
Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA
J Am Acad Dermatol 61:66-72. 2009..We examined the association between statin use and basal cell carcinoma (BCC) risk... - Topical thymidine dinucleotide treatment reduces development of ultraviolet-induced basal cell carcinoma in Ptch-1+/- miceSimin Arad
Department of Dermatology, Boston University School of Medicine, 609 Albany St, Boston, MA 02118, USA
Am J Pathol 172:1248-55. 2008..01). We conclude that topical pTT treatment during a prolonged period of intermittent UV exposure decreases the number and size of UV-induced BCCs through several anti-cancer mechanisms... - Long-term establishment, characterization and manipulation of cell lines from mouse basal cell carcinoma tumorsPo Lin So
Department of Dermatology, University of California, San Francisco, 94110, USA
Exp Dermatol 15:742-50. 2006.... - Identification of genetic loci for basal cell nevus syndrome and inflammatory bowel disease in a single large pedigreeCarolien I Panhuysen
Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
Hum Genet 120:31-41. 2006.... - CUSP/p63 expression in basal cell carcinomaRobert P Dellavalle
Department of Dermatology, University of Colorado School of Medicine, Denver, Colorado, USA
Exp Dermatol 11:203-8. 2002..Therefore, CUSP appears to be present, unmutated, and yet frequently undetectable by immunofluorescence in cutaneous lesions in both humans and mice that are associated with SHH pathway dysregulation (BCCs, BCNS, and nevus sebaceous)... - Anti-rejection drug treatment increases basal cell carcinoma burden in Ptch1+/- miceAnnika Vogt
Department of Dermatology, University of California, San Francisco, California 94110, USA
J Invest Dermatol 124:263-7. 2005..5-fold. Thus, these mice provide a good model for study of the effects of long-term administration of ARD on at least one type of non-melanoma skin cancer... - Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosisMohammad Athar
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
Cancer Res 64:7545-52. 2004.... - Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiationPo-Lin So
Department of Dermatology, University of California, San Francisco, California, USA
Cancer Res 64:4385-9. 2004..The ability of tazarotene to inhibit BCC formation in this mouse model provides encouragement for the use of tazarotene in skin cancer chemoprevention trials in humans... - Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approachesKathy P An
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Photochem Photobiol 76:73-80. 2002..In summary, enhanced COX-2 expression serves as a marker of epidermal UVB exposure for murine and human NMSC. These results suggest that COX-2 inhibitors could have potent anticarcinogenic effects in UVB-induced skin cancer... - Evidence for lack of enhanced hedgehog target gene expression in common extracutaneous tumorsZhilan Hu
The Cooperative Human Tissue Network, University of Alabama, Birmingham, AL 35294, USA
Cancer Res 63:923-8. 2003.... - Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting proteinAnnika Vogt
Department of Dermatology, University of California San Francisco, 94143, USA
J Exp Med 199:753-61. 2004.... - Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- miceXiuwei Tang
Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
J Clin Invest 113:867-75. 2004..These results demonstrate the crucial importance of ODC for the induction of BCCs and indicate that chemopreventive strategies directed at inhibiting this enzyme may be useful in reducing BCCs in human populations... - Novel Hedgehog pathway targets against basal cell carcinomaJean Y Tang
Department of Dermatology, San Francisco General Hospital, University of California, San Francisco, CA, USA
Toxicol Appl Pharmacol 224:257-64. 2007..Thus, sterols may be a new therapeutic target for the treatment of BCCs, and readily available agents such as statins (HMG-CoA reductase inhibitors) or vitamin D might be helpful in reducing BCC incidence... - Cancer. An anchor for tumor cell invasionStuart H Yuspa
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Science 307:1727-8. 2005
Research Grants
- Biology of Basal Cell CarcinomasErvin H Epstein; Fiscal Year: 2010..We are able to propose these studies because of our long-standing interest and expertise in BCC carcinogenesis and, especially, because new techniques and approaches just now for the first time make these studies possible. ..
- Vitamin D3 Inhibition of Hedgehog Signaling and Cancer ChemopreventionErvin H Epstein; Fiscal Year: 2010....
- Chemoprevention of Basal Cell Carcinomas with TazaroteneErvin Epstein; Fiscal Year: 2006..REVISED: April 22, 2004 (See Revision Note) ..
- Chemoprevention of Basal Cell Carcinomas with TazaroteneErvin Epstein; Fiscal Year: 2009..REVISED: April 22, 2004 (See Revision Note) ..