Ervin Epstein

Summary

Affiliation: Children's Hospital Oakland Research Institute
Country: USA

Publications

  1. doi request reprint Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis
    Po Lin So
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Mol Cancer Ther 7:1275-84. 2008
  2. pmc Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis
    Grace Ying Wang
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Invest Dermatol 131:2298-305. 2011
  3. ncbi request reprint PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis
    Po Lin So
    Jr, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 and Po Lin So
    Cancer Prev Res (Phila) 7:407-17. 2014
  4. doi request reprint Tazarotene: randomized, double-blind, vehicle-controlled, and open-label concurrent trials for basal cell carcinoma prevention and therapy in patients with basal cell nevus syndrome
    Jean Y Tang
    Children s Hospital of Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609
    Cancer Prev Res (Phila) 7:292-9. 2014
  5. pmc Mommy - where do tumors come from?
    Ervin H Epstein
    Children s Hospital of Oakland Research Institute, Oakland, California, USA
    J Clin Invest 121:1681-3. 2011
  6. doi request reprint Basal cell carcinomas: attack of the hedgehog
    Ervin H Epstein
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, California 94609, USA
    Nat Rev Cancer 8:743-54. 2008
  7. pmc Novel investigational drugs for basal cell carcinoma
    Po Lin So
    Children s Hospital Oakland Research Institute, Cancer Division, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Expert Opin Investig Drugs 19:1099-112. 2010
  8. doi request reprint Case records of the Massachusetts General Hospital. Case 3-2008. An 80-year-old woman with cutaneous basal-cell carcinomas and cysts of the jaws
    Ervin H Epstein
    Children s Hospital of Oakland Research Institute, Oakland, CA, USA
    N Engl J Med 358:393-401. 2008
  9. pmc Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice
    Parastoo Davari
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Carcinogenesis 31:968-73. 2010
  10. pmc Statin use and risk of basal cell carcinoma
    Maryam M Asgari
    Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA
    J Am Acad Dermatol 61:66-72. 2009

Research Grants

Collaborators

Detail Information

Publications23

  1. doi request reprint Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis
    Po Lin So
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Mol Cancer Ther 7:1275-84. 2008
    ..Furthermore, inhibition of basal RAR signaling in the skin promoted BCC carcinogenesis, suggesting that endogenous RAR signaling restrains BCC growth...
  2. pmc Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis
    Grace Ying Wang
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Invest Dermatol 131:2298-305. 2011
    ..Therefore, the allograft model provides a practical model for (i) studying BCC carcinogenesis and (ii) initial preclinical screening for anti-HH pathway and other anti-BCC drugs...
  3. ncbi request reprint PI3K-AKT signaling is a downstream effector of retinoid prevention of murine basal cell carcinogenesis
    Po Lin So
    Jr, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 and Po Lin So
    Cancer Prev Res (Phila) 7:407-17. 2014
    ..These data identify PI3K/AKT/mTOR signaling as a highly attractive target for BCC chemoprevention and indicate more generally that this pathway may be, in some contexts, an important mediator of retinoid anticancer effects...
  4. doi request reprint Tazarotene: randomized, double-blind, vehicle-controlled, and open-label concurrent trials for basal cell carcinoma prevention and therapy in patients with basal cell nevus syndrome
    Jean Y Tang
    Children s Hospital of Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609
    Cancer Prev Res (Phila) 7:292-9. 2014
    ..Our studies provide no evidence for either chemopreventive or chemotherapeutic effect of tazarotene against BCCs in patients with BCNS...
  5. pmc Mommy - where do tumors come from?
    Ervin H Epstein
    Children s Hospital of Oakland Research Institute, Oakland, California, USA
    J Clin Invest 121:1681-3. 2011
    ..Although these cells sustain oncogenic mutations while in the stem cell niche, they may have to leave that stem cell niche to become tumor cells...
  6. doi request reprint Basal cell carcinomas: attack of the hedgehog
    Ervin H Epstein
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, California 94609, USA
    Nat Rev Cancer 8:743-54. 2008
    ..Importantly, a phase 1 first-in-human trial of a Hedgehog inhibitor has shown real progress in halting and even reversing the growth of these tumours...
  7. pmc Novel investigational drugs for basal cell carcinoma
    Po Lin So
    Children s Hospital Oakland Research Institute, Cancer Division, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Expert Opin Investig Drugs 19:1099-112. 2010
    ..Therefore, concerted effects to identify novel preventive and therapeutic strategies are necessary...
  8. doi request reprint Case records of the Massachusetts General Hospital. Case 3-2008. An 80-year-old woman with cutaneous basal-cell carcinomas and cysts of the jaws
    Ervin H Epstein
    Children s Hospital of Oakland Research Institute, Oakland, CA, USA
    N Engl J Med 358:393-401. 2008
  9. pmc Loss of Blm enhances basal cell carcinoma and rhabdomyosarcoma tumorigenesis in Ptch1+/- mice
    Parastoo Davari
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Carcinogenesis 31:968-73. 2010
    ..Despite the quantitative differences, there was no dramatic qualititative difference in the BCC or RMS tumors associated with the mutant Blm genotype...
  10. pmc Statin use and risk of basal cell carcinoma
    Maryam M Asgari
    Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA
    J Am Acad Dermatol 61:66-72. 2009
    ..We examined the association between statin use and basal cell carcinoma (BCC) risk...
  11. pmc Topical thymidine dinucleotide treatment reduces development of ultraviolet-induced basal cell carcinoma in Ptch-1+/- mice
    Simin Arad
    Department of Dermatology, Boston University School of Medicine, 609 Albany St, Boston, MA 02118, USA
    Am J Pathol 172:1248-55. 2008
    ..01). We conclude that topical pTT treatment during a prolonged period of intermittent UV exposure decreases the number and size of UV-induced BCCs through several anti-cancer mechanisms...
  12. ncbi request reprint CUSP/p63 expression in basal cell carcinoma
    Robert P Dellavalle
    Department of Dermatology, University of Colorado School of Medicine, Denver, Colorado, USA
    Exp Dermatol 11:203-8. 2002
    ..Therefore, CUSP appears to be present, unmutated, and yet frequently undetectable by immunofluorescence in cutaneous lesions in both humans and mice that are associated with SHH pathway dysregulation (BCCs, BCNS, and nevus sebaceous)...
  13. ncbi request reprint Long-term establishment, characterization and manipulation of cell lines from mouse basal cell carcinoma tumors
    Po Lin So
    Department of Dermatology, University of California, San Francisco, 94110, USA
    Exp Dermatol 15:742-50. 2006
    ....
  14. ncbi request reprint Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation
    Po Lin So
    Department of Dermatology, University of California, San Francisco, California, USA
    Cancer Res 64:4385-9. 2004
    ..The ability of tazarotene to inhibit BCC formation in this mouse model provides encouragement for the use of tazarotene in skin cancer chemoprevention trials in humans...
  15. ncbi request reprint Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Cancer Res 64:7545-52. 2004
    ....
  16. ncbi request reprint Anti-rejection drug treatment increases basal cell carcinoma burden in Ptch1+/- mice
    Annika Vogt
    Department of Dermatology, University of California, San Francisco, California 94110, USA
    J Invest Dermatol 124:263-7. 2005
    ..5-fold. Thus, these mice provide a good model for study of the effects of long-term administration of ARD on at least one type of non-melanoma skin cancer...
  17. ncbi request reprint Identification of genetic loci for basal cell nevus syndrome and inflammatory bowel disease in a single large pedigree
    Carolien I Panhuysen
    Genetics Program, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Hum Genet 120:31-41. 2006
    ....
  18. ncbi request reprint Cancer. An anchor for tumor cell invasion
    Stuart H Yuspa
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 307:1727-8. 2005
  19. pmc Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice
    Xiuwei Tang
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:867-75. 2004
    ..These results demonstrate the crucial importance of ODC for the induction of BCCs and indicate that chemopreventive strategies directed at inhibiting this enzyme may be useful in reducing BCCs in human populations...
  20. pmc Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein
    Annika Vogt
    Department of Dermatology, University of California San Francisco, 94143, USA
    J Exp Med 199:753-61. 2004
    ....
  21. ncbi request reprint Evidence for lack of enhanced hedgehog target gene expression in common extracutaneous tumors
    Zhilan Hu
    The Cooperative Human Tissue Network, University of Alabama, Birmingham, AL 35294, USA
    Cancer Res 63:923-8. 2003
    ....
  22. ncbi request reprint Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches
    Kathy P An
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Photochem Photobiol 76:73-80. 2002
    ..In summary, enhanced COX-2 expression serves as a marker of epidermal UVB exposure for murine and human NMSC. These results suggest that COX-2 inhibitors could have potent anticarcinogenic effects in UVB-induced skin cancer...
  23. pmc Novel Hedgehog pathway targets against basal cell carcinoma
    Jean Y Tang
    Department of Dermatology, San Francisco General Hospital, University of California, San Francisco, CA, USA
    Toxicol Appl Pharmacol 224:257-64. 2007
    ..Thus, sterols may be a new therapeutic target for the treatment of BCCs, and readily available agents such as statins (HMG-CoA reductase inhibitors) or vitamin D might be helpful in reducing BCC incidence...

Research Grants9

  1. Biology of Basal Cell Carcinomas
    Ervin H Epstein; Fiscal Year: 2010
    ..We are able to propose these studies because of our long-standing interest and expertise in BCC carcinogenesis and, especially, because new techniques and approaches just now for the first time make these studies possible. ..
  2. Vitamin D3 Inhibition of Hedgehog Signaling and Cancer Chemoprevention
    Ervin H Epstein; Fiscal Year: 2010
    ....
  3. Chemoprevention of Basal Cell Carcinomas with Tazarotene
    Ervin Epstein; Fiscal Year: 2004
    ..REVISED: April 22, 2004 (See Revision Note) ..
  4. Chemoprevention of Basal Cell Carcinomas with Tazarotene
    Ervin Epstein; Fiscal Year: 2005
    ..REVISED: April 22, 2004 (See Revision Note) ..
  5. Chemoprevention of Basal Cell Carcinomas with Tazarotene
    Ervin Epstein; Fiscal Year: 2006
    ..REVISED: April 22, 2004 (See Revision Note) ..
  6. Biology of Basal Cell Carcinomas
    Ervin Epstein; Fiscal Year: 2009
    ..We are able to propose these studies because of our long-standing interest and expertise in BCC carcinogenesis and, especially, because new techniques and approaches just now for the first time make these studies possible. ..
  7. Chemoprevention of Basal Cell Carcinomas with Tazarotene
    Ervin Epstein; Fiscal Year: 2009
    ..REVISED: April 22, 2004 (See Revision Note) ..