Janet A Englund

..Trivalent inactivated influenza vaccine (TIV) is recommended for all children ages 6 to 23 months. Delivering 2 doses of TIV at least 4 weeks apart to young children receiving this vaccine for the first time is challenging...

..Few data exist on respiratory virus quantitation in lower respiratory samples and detection in serum from hematopoietic cell transplant (HCT) recipients with respiratory virus-associated pneumonia...

..004), respectively, and those from 140 URI samples from hematopoietic cell transplantation recipients were 88% and 85% (P = 0.56), respectively...

..There were no associations with polyomavirus detection and acute graft versus host disease, cytomegalovirus reactivation, neutropenia, lymphopenia, hospitalization, or death...

..Finally, new drugs have been developed to treat influenza virus, respiratory syncytial virus, parainfluenza virus and adenovirus with some promising results...

..Our study has described a significant relationship between viral load and markers of disease severity for both RSV and hMPV in a large population of children evaluated for respiratory disease...

..Thus, our data suggest that infection with 2009 influenza A/H1N1 resulted in more severe respiratory disease in HCT recipients compared with seasonal influenza...

..Emergence of oseltamivir resistance is frequent in immunocompromised patients infected with pandemic (H1N1) 2009 virus and can be associated with a wide range of clinical disease and viral kinetics...

..Little is known about human bocavirus (HBoV) persistence and shedding and the association between HBoV detection and the onset and resolution of respiratory symptoms...

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..Infants less than 6 months of age are at high risk for influenza disease and influenza-related complications, but no vaccine is licensed for this population...

..However, immunocompromised patients infected with oseltamivir-resistant H1N1 experience potentially more risks of complication and transmissibility with few therapeutic options...

..9%, and accuracy of 73.3%. Parental impression is only a moderately accurate predictor of viral URI in children. Our URI symptom score provided a more accurate method for identifying children with viral URIs for clinical studies...

..Pandemic influenza A (H1N1) may cause severe illness in pediatric patient with chronic lung disease...

..We performed this study to determine the frequency of previous hospitalization among children hospitalized with influenza...

..The aim of the study was to describe the frequency of viral pathogens and relative frequency of co-infections in nasal specimens obtained from young children with bronchiolitis receiving care at a children's hospital...

..We found that 80% of patients receiving only 21 days of antibiotics survived to 12 months beyond hematopoietic cell transplant, whereas only 25% of patients who required longer treatment for PCP survived to stem cell engraftment...

..HRV and HCoV infections are common in the first 100 days after HCT, viral shedding lasts more than 3 weeks in half, and lower respiratory infection is rare...

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..These data have important implications for empirical antimicrobial strategies targeting serious pediatric infections. Further study of this problem is warranted...

..The clinical impact of influenza in children undergoing therapy for cancer is not well-described in the literature...

..Increased influenza vaccine use during pregnancy has the potential to benefit both the woman and her infant...

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..Vaccination of children in school is one strategy to reduce the spread of influenza in households and communities...

..No direct comparisons of any of these antiviral agents has been performed; all result in clinical improvement approximately 1 to 2 days earlier in otherwise healthy children when therapy is initiated within 48 hours of onset of symptoms...