Janet A Englund
Affiliation: Children's Hospital and Regional Medical Center
- A comparison of 2 influenza vaccine schedules in 6- to 23-month-old childrenJanet A Englund
Division of Pediatric Infectious Diseases, Allergy, and Rheumatology, University of Washington and Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
Pediatrics 115:1039-47. 2005..Trivalent inactivated influenza vaccine (TIV) is recommended for all children ages 6 to 23 months. Delivering 2 doses of TIV at least 4 weeks apart to young children receiving this vaccine for the first time is challenging...
- Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipientsChristian Renaud
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Biol Blood Marrow Transplant 19:1220-6. 2013..Thus, HMPV lower respiratory tract disease is associated with high mortality in HCT recipients. Earlier detection in combination with new antiviral therapy is needed to reduce mortality among HCT recipients. ..
- Respiratory virus pneumonia after hematopoietic cell transplantation (HCT): associations between viral load in bronchoalveolar lavage samples, viral RNA detection in serum samples, and clinical outcomes of HCTAngela P Campbell
Department of Pediatrics, University of Washington, Seattle, Washington, USA
J Infect Dis 201:1404-13. 2010..Few data exist on respiratory virus quantitation in lower respiratory samples and detection in serum from hematopoietic cell transplant (HCT) recipients with respiratory virus-associated pneumonia...
- WU and KI polyomaviruses in respiratory samples from allogeneic hematopoietic cell transplant recipientsJane Kuypers
University of Washington, Seattle, Washington 98102, USA
Emerg Infect Dis 18:1580-8. 2012..There were no associations with polyomavirus detection and acute graft versus host disease, cytomegalovirus reactivation, neutropenia, lymphopenia, hospitalization, or death...
- Outcome of respiratory syncytial virus lower respiratory tract disease in hematopoietic cell transplant recipients receiving aerosolized ribavirin: significance of stem cell source and oxygen requirementSachiko Seo
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Biol Blood Marrow Transplant 19:589-96. 2013..These results may explain differences in outcomes reported from RSV infection over time and may guide the design of future interventional trials...
- Influenza viral RNA detection in blood as a marker to predict disease severity in hematopoietic cell transplant recipientsSu Mi Choi
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Infect Dis 206:1872-7. 2012..Among patients with LRD, viremia was associated with increased hazards of overall and influenza-associated death (hazard ratio 3.5, 1.1-12). Thus, influenza viremia may serve as marker for overall poor outcome...
- Self-collection of foam nasal swabs for respiratory virus detection by PCR among immunocompetent subjects and hematopoietic cell transplant recipientsAngela P Campbell
University of Washington, Seattle, Washington, USA
J Clin Microbiol 51:324-7. 2013..004), respectively, and those from 140 URI samples from hematopoietic cell transplantation recipients were 88% and 85% (P = 0.56), respectively...
- Molecular epidemiology of respiratory syncytial virus transmission in childcareHelen Y Chu
Department of Medicine, University of Washington, Seattle, WA, USA
J Clin Virol 57:343-50. 2013..No prior studies using molecular techniques to examine RSV transmission in the community childcare setting have been performed...
- Implementation of filmarray respiratory viral panel in a core laboratory improves testing turnaround time and patient careMin Xu
Dept of Laboratories, Seattle Children s Hospital, Seattle, WA 98105, USA
Am J Clin Pathol 139:118-23. 2013..Our results demonstrate that molecular technology can be successfully deployed in a nonspecialty, high-volume, multidisciplinary core laboratory...
- Combination therapy with amantadine, oseltamivir and ribavirin for influenza A infection: safety and pharmacokineticsSachiko Seo
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Antivir Ther 18:377-86. 2013..A triple-combination antiviral drug (TCAD) regimen consisting of amantadine (AMT), oseltamivir (OSL) and ribavirin (RBV) demonstrated good efficacy in an animal model...
- Antiviral therapy of respiratory viruses in haematopoietic stem cell transplant recipientsChristian Renaud
Seattle Children s Hospital, Seattle, WA, USA
Antivir Ther 17:175-91. 2012..Finally, new drugs have been developed to treat influenza virus, respiratory syncytial virus, parainfluenza virus and adenovirus with some promising results...
- Differences in clinical outcomes after 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipientsSu Mi Choi
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Blood 117:5050-6. 2011..Thus, our data suggest that infection with 2009 influenza A/H1N1 resulted in more severe respiratory disease in HCT recipients compared with seasonal influenza...
- Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirusEmily T Martin
Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
Diagn Microbiol Infect Dis 62:382-8. 2008..Our study has described a significant relationship between viral load and markers of disease severity for both RSV and hMPV in a large population of children evaluated for respiratory disease...
- Respiratory syncytial virus disease: prevention and treatmentHelen Y Chu
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA
Curr Top Microbiol Immunol 372:235-58. 2013....
- Frequent and prolonged shedding of bocavirus in young children attending daycareEmily T Martin
Center for Clinical and Translational Research, Seattle Children s Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA
J Infect Dis 201:1625-32. 2010..Little is known about human bocavirus (HBoV) persistence and shedding and the association between HBoV detection and the onset and resolution of respiratory symptoms...
- H275Y mutant pandemic (H1N1) 2009 virus in immunocompromised patientsChristian Renaud
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Emerg Infect Dis 17:653-60; quiz 765. 2011..Emergence of oseltamivir resistance is frequent in immunocompromised patients infected with pandemic (H1N1) 2009 virus and can be associated with a wide range of clinical disease and viral kinetics...
- Safety and immunogenicity of trivalent inactivated influenza vaccine in infants: a randomized double-blind placebo-controlled studyJanet A Englund
Department of Pediatrics, Division of Infectious Diseases, Children s Hospital Research Institute, University of Washington, Seattle, WA, USA
Pediatr Infect Dis J 29:105-10. 2010..Infants less than 6 months of age are at high risk for influenza disease and influenza-related complications, but no vaccine is licensed for this population...
- Immunization with trivalent inactivated influenza vaccine in partially immunized toddlersJanet A Englund
Pediatric ID, Children s Hospital and Regional Medical Center, 4800 Sand Point Way, NE W8851, Seattle, Washington 98105, USA
Pediatrics 118:e579-85. 2006....
- Emerging oseltamivir resistance in seasonal and pandemic influenza A/H1N1Christian Renaud
Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
J Clin Virol 52:70-8. 2011..However, immunocompromised patients infected with oseltamivir-resistant H1N1 experience potentially more risks of complication and transmissibility with few therapeutic options...
- Hospital-based influenza vaccination of children: an opportunity to prevent subsequent hospitalizationDanielle M Zerr
Children s Research Institute, and Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
Pediatrics 121:345-8. 2008..We performed this study to determine the frequency of previous hospitalization among children hospitalized with influenza...
- Development of a symptom score for clinical studies to identify children with a documented viral upper respiratory tract infectionJames A Taylor
Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
Pediatr Res 68:252-7. 2010..9%, and accuracy of 73.3%. Parental impression is only a moderately accurate predictor of viral URI in children. Our URI symptom score provided a more accurate method for identifying children with viral URIs for clinical studies...
- Emergence of oseltamivir-resistant pandemic H1N1 in an immunocompetent child with severe status asthmaticusChristian Renaud
Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
J Asthma 48:572-5. 2011..Pandemic influenza A (H1N1) may cause severe illness in pediatric patient with chronic lung disease...
- Multiple viral respiratory pathogens in children with bronchiolitisHilary E Stempel
Seattle Children s Hospital Research Institute, University of Washington, Seattle, WA, USA
Acta Paediatr 98:123-6. 2009..The aim of the study was to describe the frequency of viral pathogens and relative frequency of co-infections in nasal specimens obtained from young children with bronchiolitis receiving care at a children's hospital...
- Outcomes and duration of Pneumocystis jiroveci pneumonia therapy in infants with severe combined immunodeficiencyIngrid S Lundgren
Division of Infectious Diseases, Seattle Children s Hospital, Seattle, WA 98105, USA
Pediatr Infect Dis J 31:95-7. 2012..We found that 80% of patients receiving only 21 days of antibiotics survived to 12 months beyond hematopoietic cell transplant, whereas only 25% of patients who required longer treatment for PCP survived to stem cell engraftment...
- Influenza-associated morbidity in children with cancerSarah K Tasian
Department of Pediatrics, University of Washington and Children s Hospital and Regional Medical Center, Seattle, Washington 98105, USA
Pediatr Blood Cancer 50:983-7. 2008..The clinical impact of influenza in children undergoing therapy for cancer is not well-described in the literature...
- Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipientsFilippo Milano
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Blood 115:2088-94. 2010..HRV and HCoV infections are common in the first 100 days after HCT, viral shedding lasts more than 3 weeks in half, and lower respiratory infection is rare...
- Prevalence and mechanisms of broad-spectrum beta-lactam resistance in Enterobacteriaceae: a children's hospital experienceXuan Qin
Department of Laboratory Medicine, Microbiology Laboratory, Children s Hospital and Regional Medical Center, NE, Seattle, WA 98105 0371, USA
Antimicrob Agents Chemother 52:3909-14. 2008..These data have important implications for empirical antimicrobial strategies targeting serious pediatric infections. Further study of this problem is warranted...
- BK nephropathy in pediatric hematopoietic stem cell transplant recipientsPriya S Verghese
Department of Pediatrics, University of Washington and Seattle Children s Hospital, Seattle, WA 98105, USA
Pediatr Transplant 13:913-8. 2009....
- Maternal immunization with inactivated influenza vaccine: rationale and experienceJanet A Englund
Department of Pediatrics, Children s Hospital and Regional Medical Center, University of Washington, 4800 Sand Point Way NE 8G, Seattle, WA 98105, USA
Vaccine 21:3460-4. 2003..Increased influenza vaccine use during pregnancy has the potential to benefit both the woman and her infant...
- Effectiveness of school-based influenza vaccinationJames C King
Department of Pediatrics, University of Maryland School of Medicine, 737 W Lombard St, Baltimore, MD 21201, USA
N Engl J Med 355:2523-32. 2006..Vaccination of children in school is one strategy to reduce the spread of influenza in households and communities...
- Influenza vaccine for young children: two doses are better than oneKathleen Maletic Neuzil
J Pediatr 149:737-8. 2006
- Influenza vaccine immunogenicity in 6- to 23-month-old children: are identical antigens necessary for priming?Emmanuel B Walter
Duke Clinical Research Institute, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
Pediatrics 118:e570-8. 2006....
- Pertussis immunization in the global pertussis initiative North American region: recommended strategies and implementation considerationsTina Tan
Division of Infectious Diseases, Northwestern University s Feinberg School of Medicine, The Children s Memorial Hospital, Chicago, IL 60614, USA
Pediatr Infect Dis J 24:S83-6. 2005....
- Antiviral therapy of influenzaJanet A Englund
Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
Semin Pediatr Infect Dis 13:120-8. 2002..No direct comparisons of any of these antiviral agents has been performed; all result in clinical improvement approximately 1 to 2 days earlier in otherwise healthy children when therapy is initiated within 48 hours of onset of symptoms...