Affiliation: Children's Hospital and Regional Medical Center
- Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosisJulia Emerson
Division of Pulmonary Medicine, Department of Pediatrics, University of Washington, Seattle, USA
Pediatr Pulmonol 34:91-100. 2002..These findings confirm reports from previous smaller studies of outcomes among young children with CF, and highlight the potential to decrease the morbidity and mortality of young patients with CF through early intervention...
- Early anti-pseudomonal acquisition in young patients with cystic fibrosis: rationale and design of the EPIC clinical trial and observational study'Miriam M Treggiari
Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA 98104, USA
Contemp Clin Trials 30:256-68. 2009..Risk factors for and clinical impact of early Pa infection in young CF patients are less well understood...
- Baseline characteristics and factors associated with nutritional and pulmonary status at enrollment in the cystic fibrosis EPIC observational cohortMargaret Rosenfeld
Department of Pediatrics, Seattle Children s Hospital and University of Washington, Seattle, Washington, USA
Pediatr Pulmonol 45:934-44. 2010..The EPIC Observational Study is an ongoing prospective cohort study investigating risk factors for and clinical outcomes associated with early Pseudomonas aeruginosa (Pa) acquisition in young children with cystic fibrosis (CF)...
- Impact of Pseudomonas and Staphylococcus infection on inflammation and clinical status in young children with cystic fibrosisScott D Sagel
Department of Pediatrics, The Children s Hospital and University of Colorado Health Sciences Center, Aurora, CO 80045, USA
J Pediatr 154:183-8. 2009..To assess the effects of Pseudomonas aeruginosa and Staphylococcus aureus infection on lower airway inflammation and clinical status in young children with cystic fibrosis (CF)...
- Risk factors for age at initial Pseudomonas acquisition in the cystic fibrosis epic observational cohortMargaret Rosenfeld
Department of Pediatrics, Seattle Children s Hospital and University of Washington, Seattle, WA 98105, USA
J Cyst Fibros 11:446-53. 2012..We aimed to identify such risk factors in order to inform prevention strategies and identify high-risk populations...
- Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progressionLucas R Hoffman
Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA
J Cyst Fibros 8:66-70. 2009..Pseudomonas aeruginosa with mutations in the transcriptional regulator LasR chronically infect the airways of people with cystic fibrosis (CF), yet the prevalence and clinical implications of lasR mutant infection are unknown...
- Duration of treatment effect after tobramycin solution for inhalation in young children with cystic fibrosisRonald L Gibson
Department of Pediatrics, University of Washington Children s Hospital and Regional Medical Center, Seattle, WA 98105 0371, USA
Pediatr Pulmonol 42:610-23. 2007..Early intervention strategies include tobramycin solution for inhalation (TSI), which can eradicate lower airway Pa from cultures obtained at the end of 28 days of treatment in young children...
- Changes in cystic fibrosis sputum microbiology in the United States between 1995 and 2008Julia Emerson
Seattle Children s Hospital, Seattle, Washington 98101, USA
Pediatr Pulmonol 45:363-70. 2010..The study objective was to identify changes in cystic fibrosis (CF) sputum microbiology over 13 years...
- Prevalence of cystic fibrosis pathogens in the oropharynx of healthy children and implications for cystic fibrosis careMargaret Rosenfeld
Division of Pulmonary Medicine, Seattle Children s Hospital, Seattle, WA 98105, USA
J Cyst Fibros 11:456-7. 2012..To describe the prevalence of the CF pathogens Pseudomonas aeruginosa, Staphylococcus aureus and Haemophilus influenzae in OP cultures from healthy children...
- Significant microbiological effect of inhaled tobramycin in young children with cystic fibrosisRonald L Gibson
Department of Pediatrics, Children s Hospital and Regional Medical Center University of Washington, Seattle, Washington 98105 0371, USA
Am J Respir Crit Care Med 167:841-9. 2003..We conclude that 28 days of tobramycin solution for inhalation of 300 mg twice daily is safe and effective for significant reduction of lower airway Pa density in young children with cystic fibrosis...
- Respiratory viruses in children with cystic fibrosis: viral detection and clinical findingsJane L Burns
Department of Pediatrics, Division of Infectious Diseases, University of Washington and Seattle Children s Hospital, USA
Influenza Other Respi Viruses 6:218-23. 2012..In addition, associations between viral detection and respiratory symptoms are not well described...
- Clinically feasible biofilm susceptibility assay for isolates of Pseudomonas aeruginosa from patients with cystic fibrosisSamuel M Moskowitz
Department of Pediatrics, University of Washington School of Medicine, and Division of Pulmonary Medicine, Children's Hospital and Regional Medical Center, Seattle, USA
J Clin Microbiol 42:1915-22. 2004....
- Prevalence of neutralizing antibodies against adeno-associated virus (AAV) types 2, 5, and 6 in cystic fibrosis and normal populations: Implications for gene therapy using AAV vectorsChristine L Halbert
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA
Hum Gene Ther 17:440-7. 2006..AAV5-positive sera were lower both in titers and rates than those seen for AAV6. The results indicate that AAV type 2, 5 or 6 exposure is low in CF and control populations and even lower in CF children...
- Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosisMary J Emond
Department of Biostatistics, University of Washington, Seattle, Washington, USA
Nat Genet 44:886-9. 2012..aeruginosa airway infection, chronic P. aeruginosa infection and mucoid P. aeruginosa in individuals with cystic fibrosis...
- Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosaLucas R Hoffman
Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 103:19890-5. 2006....
- Use of real-time PCR with multiple targets to identify Pseudomonas aeruginosa and other nonfermenting gram-negative bacilli from patients with cystic fibrosisXuan Qin
Department of Laboratory Medicine, Therapeutics Development Network Resource Center for Microbiology, Children's Hospital and Regional Medical Center, University of Washington, Seattle, Washington, USA
J Clin Microbiol 41:4312-7. 2003..Given the diversity of these CF isolates, real-time PCR with a combination of two target sequences appears to be the optimum choice for identification of atypical P. aeruginosa and for non-P. aeruginosa gram-negative isolates...
- Developing cystic fibrosis lung transplant referral criteria using predictors of 2-year mortalityNicole Mayer-Hamblett
Department of Pediatrics, University of Washington, Seattle, Washington 98105 0371, USA
Am J Respir Crit Care Med 166:1550-5. 2002..Better clinical predictors of short-term mortality among patients with CF are needed...
- Standardized procedure for measurement of nasal potential difference: an outcome measure in multicenter cystic fibrosis clinical trialsThomas A Standaert
University of Washington, Seattle, Washington, USA
Pediatr Pulmonol 37:385-92. 2004..Valid and consistent results can be attained with trained operators and attention to technical details. These data demonstrate the procedure to be sufficient for multicenter studies in the CF Foundation network...
- Oral corticosteroid therapy in cystic fibrosis patients hospitalized for pulmonary exacerbation: a pilot studyMark Dovey
Section of Pediatric Pulmonology and Allergy, St Christopher s Hospital For Children, Philadelphia, PA, USA
Chest 132:1212-8. 2007..We hypothesized that adding 5 days of prednisone to standard therapy for acute pulmonary exacerbations in patients with cystic fibrosis (CF) would result in a more rapid and greater increase in lung function...