Allison A Eddy

Summary

Affiliation: Children's Hospital and Regional Medical Center
Country: USA

Publications

  1. ncbi request reprint Plasminogen activator inhibitor-1 and the kidney
    Allison A Eddy
    Children s Hospital and Regional Medical Center, University of Washington, Seattle, Washington 98105, USA
    Am J Physiol Renal Physiol 283:F209-20. 2002
  2. ncbi request reprint An introduction to frontiers in nephrology
    Allison A Eddy
    Deputy Editor, Journal of the American Society of Nephrology
    J Am Soc Nephrol 13:2185. 2002
  3. ncbi request reprint Endogenous urokinase lacks antifibrotic activity during progressive renal injury
    Ikuyo Yamaguchi
    Department of Pediatrics, Children s Hospital and Regional Medical Center, University of Washington, Seattle, WA 98105 0371, USA
    Am J Physiol Renal Physiol 293:F12-9. 2007
  4. pmc Vitronectin accumulates in the interstitium but minimally impacts fibrogenesis in experimental chronic kidney disease
    Jesus M Lopez-Guisa
    Seattle Children s Research Institute, Department of Pediatrics, University of Washington, USA
    Am J Physiol Renal Physiol 300:F1244-54. 2011
  5. ncbi request reprint Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals
    Guoqiang Zhang
    Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Division of Nephrology, Mail Stop M1 5, Seattle, WA 98105, USA
    J Am Soc Nephrol 18:846-59. 2007
  6. pmc Mannose receptor 2 attenuates renal fibrosis
    Jesus M Lopez-Guisa
    Seattle Children s Research Institute and Department of Pediatrics, University of Washington, Seattle, WA 98101 1309, USA
    J Am Soc Nephrol 23:236-51. 2012
  7. pmc CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD
    Daryl M Okamura
    Department of Pediatrics, Seattle Children s Research Institute, Division of Nephrology, Seattle, WA 98105, USA
    J Am Soc Nephrol 20:495-505. 2009
  8. pmc A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis
    Guoqiang Zhang
    Division of Nephrology, Immunology, Seattle Children s Hospital Research Institute, Seattle, Washington 98101, USA
    J Biol Chem 284:29050-64. 2009
  9. ncbi request reprint Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury
    Daryl M Okamura
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, 4800 Sand Point Way NE, Seattle WA 98015, USA
    Am J Physiol Renal Physiol 293:F575-85. 2007
  10. ncbi request reprint Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice
    Sarah J Collins
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Wash, USA
    Nephron Exp Nephrol 104:e23-34. 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Plasminogen activator inhibitor-1 and the kidney
    Allison A Eddy
    Children s Hospital and Regional Medical Center, University of Washington, Seattle, Washington 98105, USA
    Am J Physiol Renal Physiol 283:F209-20. 2002
    ..An active area of present research interest, untold stories are likely to be uncovered soon...
  2. ncbi request reprint An introduction to frontiers in nephrology
    Allison A Eddy
    Deputy Editor, Journal of the American Society of Nephrology
    J Am Soc Nephrol 13:2185. 2002
  3. ncbi request reprint Endogenous urokinase lacks antifibrotic activity during progressive renal injury
    Ikuyo Yamaguchi
    Department of Pediatrics, Children s Hospital and Regional Medical Center, University of Washington, Seattle, WA 98105 0371, USA
    Am J Physiol Renal Physiol 293:F12-9. 2007
    ..Finally, these results highlight a significant organ-specific difference in basic fibrogenic pathways, as enhanced uPA activity has been reported to attenuate pulmonary and hepatic fibrosis...
  4. pmc Vitronectin accumulates in the interstitium but minimally impacts fibrogenesis in experimental chronic kidney disease
    Jesus M Lopez-Guisa
    Seattle Children s Research Institute, Department of Pediatrics, University of Washington, USA
    Am J Physiol Renal Physiol 300:F1244-54. 2011
    ..These data are remarkable given Vtn's strong affinity for the potent fibrogenic molecule PAI-1...
  5. ncbi request reprint Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals
    Guoqiang Zhang
    Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Division of Nephrology, Mail Stop M1 5, Seattle, WA 98105, USA
    J Am Soc Nephrol 18:846-59. 2007
    ..Plasmin-induced ERK phosphorylation was enhanced in PAR-1-overexpressing tubular cells. These findings support important profibrotic roles for plasmin that include PAR-1-dependent ERK signaling and EMT induction...
  6. pmc Mannose receptor 2 attenuates renal fibrosis
    Jesus M Lopez-Guisa
    Seattle Children s Research Institute and Department of Pediatrics, University of Washington, Seattle, WA 98101 1309, USA
    J Am Soc Nephrol 23:236-51. 2012
    ..Taken together, these data establish an important fibrosis-attenuating role for Mrc2-expressing renal interstitial cells and suggest the involvement of a lysosomal collagen turnover pathway...
  7. pmc CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD
    Daryl M Okamura
    Department of Pediatrics, Seattle Children s Research Institute, Division of Nephrology, Seattle, WA 98105, USA
    J Am Soc Nephrol 20:495-505. 2009
    ..These data suggest that CD36 is a key modulator of proinflammatory and oxidative pathways that promote fibrogenesis in CKD...
  8. pmc A novel signaling pathway: fibroblast nicotinic receptor alpha1 binds urokinase and promotes renal fibrosis
    Guoqiang Zhang
    Division of Nephrology, Immunology, Seattle Children s Hospital Research Institute, Seattle, Washington 98101, USA
    J Biol Chem 284:29050-64. 2009
    ..This new fibrosis-promoting pathway may also be relevant to disorders that extend beyond chronic kidney disease...
  9. ncbi request reprint Atherogenic scavenger receptor modulation in the tubulointerstitium in response to chronic renal injury
    Daryl M Okamura
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, 4800 Sand Point Way NE, Seattle WA 98015, USA
    Am J Physiol Renal Physiol 293:F575-85. 2007
    ..01). Strong tubular expression suggests that in addition to inflammatory interstitial cells, renal tubular scavenger receptors may help to orchestrate the inflammatory and fibrogenic pathways that are activated by oxLDL...
  10. ncbi request reprint Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice
    Sarah J Collins
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, Wash, USA
    Nephron Exp Nephrol 104:e23-34. 2006
    ..Although increased intrarenal expression of PAI-1 is also a feature of diabetic nephropathy, evidence that PAI-1 plays a primary pathogenetic role in the renal pathology is lacking...
  11. pmc Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis
    Daryl M Okamura
    Department of Pediatrics, Seattle Children s Research Institute, University of Washington, Division of Nephrology, 4800 Sand Point Way NE, A7931, Seattle, WA 98105, USA
    Am J Physiol Renal Physiol 300:F245-53. 2011
    ..Taken together, these results suggested that Gal-3 not only protects renal tubules from chronic injury by limiting apoptosis but that it may lead to enhanced matrix remodeling and fibrosis attenuation...
  12. pmc Serine proteases, inhibitors and receptors in renal fibrosis
    Allison A Eddy
    University of Washington, Head, Division of Pediatric Nephrology, Seattle Children s Hospital and Research Institute, USA
    Thromb Haemost 101:656-64. 2009
    ..Molecular pathways activated by serine proteases and their inhibitor, PAI-1, are promising targets for future anti-fibrotic therapeutic agents...
  13. pmc Cysteamine modulates oxidative stress and blocks myofibroblast activity in CKD
    Daryl M Okamura
    Seattle Children s Hospital Research Institute, University of Washington, Seattle, Washington
    J Am Soc Nephrol 25:43-54. 2014
    ....
  14. ncbi request reprint Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice
    Shunya Matsuo
    Children s Hospital and Regional Medical Center and Department of Pediatrics, University of Washington, Seattle, Washington 98105, USA
    Kidney Int 67:2221-38. 2005
    ..PAI-1 is a multifunctional protein and the mechanisms that account for its profibrotic effects have not been fully elucidated...
  15. pmc Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy
    Guoqiang Zhang
    Division of Nephrology, Seattle Children s Hospital Research Institute, Department of Pediatrics, University of Washington, Seattle, WA 98101, USA
    Lab Invest 91:106-23. 2011
    ..This new proinflammatory pathway may also be relevant to other disorders beyond hyperlipidemic nephropathy...
  16. pmc Vascular endothelial cadherin modulates renal interstitial fibrosis
    Ikuyo Yamaguchi
    Department of Pediatrics, University of Washington, Seattle, WA 98101 1309, USA
    Nephron Exp Nephrol 120:e20-31. 2012
    ..We hypothesized that VE-cadherin modulates the renal microcirculation during fibrogenesis and ultimately affects renal fibrosis...
  17. pmc Urokinase and its receptors in chronic kidney disease
    Guoqiang Zhang
    University of Washington and Children s Hospital and Regional Medical Center, Division of Nephrology, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Front Biosci 13:5462-78. 2008
    ..Vitronectin and high molecular weight kininogen are alternate uPAR ligands, and receptors in addition to uPAR may also bind directly to uPA and activate cell signaling pathways...
  18. ncbi request reprint Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action
    Allison A Eddy
    Children s Hospital and Regional Medical Center, Department of Pediatrics, University of Washington, Seattle, WA 98105, USA
    J Am Soc Nephrol 17:2999-3012. 2006
  19. pmc Investigating mechanisms of chronic kidney disease in mouse models
    Allison A Eddy
    Center for Tissue and Cell Sciences, Seattle Children s Research Institute, 1900 Ninth Avenue, M S C9S 5, Seattle, WA 98101 1309, USA
    Pediatr Nephrol 27:1233-47. 2012
    ....
  20. ncbi request reprint Progression in chronic kidney disease
    Allison A Eddy
    Division of Nephrology, University of Washington and Children s Hospital and Regional Medical Center, Seattle, WA 98105, USA
    Adv Chronic Kidney Dis 12:353-65. 2005
    ..Development of new therapeutic agents for CKD looks promising, but several agents that target different components of the fibrogenic cascade will almost certainly be necessary...
  21. pmc Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2
    Alice M Chang
    University of Washington, and Seattle Children s Hospital and Research Institute, Seattle, WA, USA
    Nephrol Dial Transplant 27:1330-43. 2012
    ..Given its location, PECs are constantly exposed to low levels of filtered albumin, which is increased in nephrotic states. We tested the hypothesis that PECs internalize albumin and increased uptake results in apoptosis...
  22. ncbi request reprint Chronic kidney disease progression
    Allison A Eddy
    Department of Pediatric, University of Washington, Seattle, WA 98105, USA
    J Am Soc Nephrol 17:2964-6. 2006
  23. ncbi request reprint Mitogenic signaling of urokinase receptor-deficient kidney fibroblasts: actions of an alternative urokinase receptor and LDL receptor-related protein
    Guoqiang Zhang
    University of Washington, Children s Hospital and Regional Medical Center, Division of Nephrology, Seattle, WA 98105, USA
    J Am Soc Nephrol 15:2090-102. 2004
    ..Enhanced proliferation of uPAR-/- fibroblasts seems to be mediated by uPA-dependent ERK signaling via an alternative urokinase receptor...
  24. ncbi request reprint Exogenous bone morphogenetic protein-7 fails to attenuate renal fibrosis in rats with overload proteinuria
    Yukiko Ikeda
    Children s Hospital and Regional Medical Center, University of Washington, Seattle, Wash 98105, USA
    Nephron Exp Nephrol 97:e123-35. 2004
    ..The present study was designed to investigate the effect of BMP-7 on interstitial fibrosis in the rat protein-overloaded model...
  25. ncbi request reprint Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy
    Guoqiang Zhang
    Children s Hospital and Regional Medical Center, Division of Nephrology, University of Washington, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    J Am Soc Nephrol 14:1234-53. 2003
    ....
  26. ncbi request reprint Can renal fibrosis be reversed?
    Allison A Eddy
    Pediatr Nephrol 20:1369-75. 2005
    ..A powerful new molecular tool-box is at our disposal that can be used to begin to translate recent discoveries into the clinical research arena with the goal of reversing renal fibrosis in a functionally meaningful way...