Research Topics
Species | Prasad DevarajanSummaryAffiliation: Children's Hospital Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathwaysPrasad Devarajan
Division of Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA
Hear Res 174:45-54. 2002..Our results indicate the involvement of both the death receptor mechanisms as well as mitochondrial pathways in cisplatin-induced apoptosis of auditory cells in an in vitro model system...- The death domain of kidney ankyrin interacts with Fas and promotes Fas-mediated cell death in renal epitheliaMarcela Del Rio
Department of Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA
J Am Soc Nephrol 15:41-51. 2004..The results identify a novel tethering interaction between ankyrin and Fas in kidney epithelia and suggest that AnkG190 may play a role as an adapter molecule in renal tubule cell death... - Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathwaysMoon Soo Park
Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, New York, NY, USA
J Am Soc Nephrol 13:858-65. 2002..Inhibition of this specific pathway may provide a strategy to minimize cisplatin-induced nephrotoxicity... - Activation of mitochondrial apoptotic pathways in human renal allografts after ischemiareperfusion injuryM Patricia Castaneda
Division of Nephrology, Children's Hospital at Montefiore, Bronx, New York, USA
Transplantation 76:50-4. 2003..CONCLUSIONS: Ischemia-reperfusion injury in CAD kidney transplants is associated with a duration-dependent increase in tubular cell apoptosis, mediated at least in part by activation of mitochondrial pathways... 
Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgeryGanesan Ramesh
Division of Nephrology, H040, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Clin J Am Soc Nephrol 5:395-401. 2010..Here, we determined the utility of urinary netrin-1 levels to predict AKI in humans undergoing cardiopulmonary bypass (CPB)...- Differential gene expression following early renal ischemia/reperfusionSuroj Supavekin
Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA
Kidney Int 63:1714-24. 2003.... 
Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trialsMark D Okusa
Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908 0133, USA
Clin J Am Soc Nephrol 7:851-5. 2012..The workgroups detailed primary and secondary endpoints for studies in these groups, and explored the use of adaptive clinical trial designs for trials of novel preventive strategies to improve outcomes of patients with AKI...- Angiotensin-converting enzyme inhibition induces death receptor apoptotic pathways in erythroid precursors following renal transplantationIlya Glezerman
Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY, USA
Am J Nephrol 23:195-201. 2003..CONCLUSIONS: Our results suggest that ACEI therapy induces apoptosis in erythrocyte progenitor cells of renal transplant patients at least in part via induction of death receptor apoptotic cascades... - Dissociation of spectrin-ankyrin complex as a basis for loss of Na-K-ATPase polarity after ischemiaRobert Woroniecki
Division of Pediatric Nephrology, Albert Einstein College of Medicine, New York, New York 10467, USA
Am J Physiol Renal Physiol 284:F358-64. 2003.... - Estradiol reverses TGF-beta1-induced mesangial cell apoptosis by a casein kinase 2-dependent mechanismOlivia Negulescu
Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA
Kidney Int 62:1989-98. 2002..The ability of estradiol to reverse TGF-beta1-induced apoptosis may contribute to the protective effects of female gender on the course of chronic renal disease... - Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injuryJaya Mishra
Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA
J Am Soc Nephrol 14:2534-43. 2003..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury... - Microarray analysis of focal segmental glomerulosclerosisKristopher Schwab
Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
Am J Nephrol 24:438-47. 2004..The genes and genetic pathways identified in this study can be compared to results of similar studies of other diseases to examine specificity and used to study the pathogenesis of FSGS... - Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritisMichiko Suzuki
Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Pediatr Nephrol 23:403-12. 2008..3 +/- 6.2 or 21%; renal disease activity: 20.2 +/- 6.0 or 51%; both p = not significant]. In conclusion, NGAL in urine but not in plasma represents a novel biomarker for renal disease activity in pSLE... - Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort studyCatherine L Dent
Department of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
Crit Care 11:R127. 2007..In this study we tested whether a point-of-care NGAL device can predict AKI after CPB in a larger cohort... - Proteomics for biomarker discovery in acute kidney injuryPrasad Devarajan
Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
Semin Nephrol 27:637-51. 2007..Such studies will be facilitated markedly by the development of commercial tools for the reproducible measurement of biomarkers across different laboratories... - NGAL is an early predictive biomarker of contrast-induced nephropathy in childrenRussel Hirsch
Division of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Pediatr Nephrol 22:2089-95. 2007..52, p < 0.0001) and plasma (R (2) = 0.72, p < 0.0001) were found to be powerful independent predictors of CIN. Patient demographics and contrast volume were not predictive of CIN... - Biomarkers in acute and chronic kidney diseaseThomas L Nickolas
Renal Division, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA
Curr Opin Nephrol Hypertens 17:127-32. 2008..The paucity of early, predictive, noninvasive biomarkers has impaired our ability to institute potentially effective therapies for acute kidney injury and chronic kidney disease in a timely manner... - Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective studyMichael Bennett
Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
Clin J Am Soc Nephrol 3:665-73. 2008..In this study, whether an NGAL immunoassay developed for a standardized clinical platform (ARCHITECT analyzer, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL) can predict AKI after CPB was tested... - Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shockDerek S Wheeler
Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Crit Care Med 36:1297-303. 2008..To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury in critically ill children with septic shock... - Induction of proapoptotic Daxx following ischemic acute kidney injuryQing Ma
Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
Kidney Int 74:310-8. 2008..Antisense oligonucleotides to Daxx and specific JNK inhibitors blunted the apoptotic response to ATP depletion. These studies indicate that Daxx may play an unrecognized role in the early apoptotic response to ischemic renal injury... - Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injuryThomas L Nickolas
Columbia University, New York, New York 10032, USA
Ann Intern Med 148:810-9. 2008..A single serum creatinine measurement cannot distinguish acute kidney injury from chronic kidney disease or prerenal azotemia... - Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney diseasePrasad Devarajan
Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 2029, USA
Scand J Clin Lab Invest Suppl 241:89-94. 2008..Such studies will be facilitated by the anticipated widespread availability of standardized commercial tools in the near future... - NGAL in acute kidney injury: from serendipity to utilityPrasad Devarajan
Am J Kidney Dis 52:395-9. 2008 - Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort studyMichael Zappitelli
Texas Children s Hospital, Fannin Street, Houston, Texas 77030, USA
Crit Care 11:R84. 2007..It is unknown whether uNGAL predicts AKI in the general critical care setting. We assessed the ability of uNGAL to predict AKI development and severity in critically ill children... - Emerging biomarkers of acute kidney injuryPrasad Devarajan
Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
Contrib Nephrol 156:203-12. 2007..Acute kidney injury (AKI) is a major clinical problem with a rising incidence and high mortality rate. The lack of early biomarkers has resulted in an unacceptable delay in initiating therapies... - Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cellsElif Erkan
Department of Pediatrics, University of Rochester, School of Medicine, Rochester, New York, USA
J Am Soc Nephrol 18:1199-208. 2007..It is concluded that albumin induces apoptosis in human proximal tubule cells by stimulating mitochondrial apoptotic pathway independent of ROS production... - Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicityJaya Mishra
Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA
Am J Nephrol 24:307-15. 2004..CONCLUSION: The results indicate that NGAL represents an early and quantitative urinary biomarker for cisplatin nephrotoxicity... - Low renal toxicity of lipoplatin compared to cisplatin in animalsPrasad Devarajan
Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Anticancer Res 24:2193-200. 2004..This is proposed as one mechanism to explain the low renal toxicity of Lipoplatin... - Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injuryKiyoshi Mori
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
J Clin Invest 115:610-21. 2005..We reveal what we believe to be a novel pathway of iron traffic that is activated in human and mouse renal diseases, and it provides a unique method for their treatment... - Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgeryJaya Mishra
Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3039, USA
Lancet 365:1231-8. 2005..00, and specificity was 0.98 for a cutoff value of 50 microg/L. INTERPRETATION: Concentrations in urine and serum of NGAL represent sensitive, specific, and highly predictive early biomarkers for acute renal injury after cardiac surgery... - Induction of Zf9 in the kidney following early ischemia/reperfusionRidwan Tarabishi
Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
Kidney Int 68:1511-9. 2005..An improved understanding of the early cell injury mechanisms is critical for effective therapy of acute renal failure (ARF)... - Single and combination toxic metal exposures induce apoptosis in cultured murine podocytes exclusively via the extrinsic caspase 8 pathwayTad Eichler
Pediatric Nephrology Division, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, Michigan 48109, USA
Toxicol Sci 90:392-9. 2006.... - Kidney NGAL is a novel early marker of acute injury following transplantationJaya Mishra
Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Pediatr Nephrol 21:856-63. 2006..We conclude that NGAL staining intensity in early protocol biopsies represents a novel predictive biomarker of acute kidney injury following transplantation... - Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: a novel marker of renal injuryHoward Trachtman
Department of Pediatrics Division of Nephrology, Schneider Children s Hospital of the North Shore Long Island Jewish Medical Center, New Hyde Park, New York, NY, USA
Pediatr Nephrol 21:989-94. 2006..Diarrhea-associated hemolytic uremic syndrome (D+HUS) causes acute renal failure. Neutrophil gelatinase-associated lipocalcin (NGAL) is an early indicator of kidney injury... - Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epitheliaKai M Schmidt-Ott
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Curr Opin Nephrol Hypertens 15:442-9. 2006..The data have implications for the diagnosis and treatment of acute renal injury... - Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney diseaseMark M Mitsnefes
Divisions of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
Pediatr Nephrol 22:101-8. 2007..62), followed by cystatin C (r=0.41). We conclude that (a) both serum NGAL and cystatin C may prove useful in the quantitation of CKD, and (b) by correlation analysis, NGAL outperforms cystatin C and eGFR at lower levels of measured GFR... - Hypoxia/re-oxygenation injury induces apoptosis of LLC-PK1 cells by activation of caspase-2Moon Soo Park
Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
Pediatr Nephrol 22:202-8. 2007..These results indicate that hypoxia/re-oxygenation injury in cultured proximal tubule cells induced apoptosis by activation of caspase-2, which is required for the mitochondrial translocation of Bax... - Dual action of neutrophil gelatinase-associated lipocalinKai M Schmidt-Ott
Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
J Am Soc Nephrol 18:407-13. 2007..This review summarizes the current knowledge about the dual effects of NGAL as a siderophore:iron-binding protein and as a growth factor and examines the role of these effects in renal injury... - Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosusHermine I Brunner
Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Arthritis Rheum 54:2577-84. 2006..We undertook this study to determine the relationship between urinary NGAL excretion and SLE disease activity or damage, with a focus on nephritis...
Research Grants
- RESEARCH TRAINING IN PEDIATRIC NEPHROLOGYPrasad Devarajan; Fiscal Year: 2007....
- Implications of the ASK1/JNK pathway in ARFPrasad Devarajan; Fiscal Year: 2007..The long term goal is to identify novel ASK1- and JNK-based pharmacologic interventions aimed at ameliorating renal cell damage and preventing renal failure secondary to ischemia-reperfusion injury. ..
- NGAL: A novel early biomarker of acute renal injuryPrasad Devarajan; Fiscal Year: 2005..The long-term goal is to identify novel biomarkers for the early diagnosis of human ARF, to facilitate the early institution of therapy ..
- ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADESPrasad Devarajan; Fiscal Year: 2003..The results will provide important insights into apoptotic cell death that accompanies ischemia and several other renal pathophysiologic states, and reveal critical clues for potential therapeutic interventions. ..
- Implications of the ASK1/JNK pathway in ARFPrasad Devarajan; Fiscal Year: 2009..The long term goal is to identify novel ASK1- and JNK-based pharmacologic interventions aimed at ameliorating renal cell damage and preventing renal failure secondary to ischemia-reperfusion injury. ..