Prasad Devarajan

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways
    Prasad Devarajan
    Division of Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Hear Res 174:45-54. 2002
  2. ncbi request reprint The death domain of kidney ankyrin interacts with Fas and promotes Fas-mediated cell death in renal epithelia
    Marcela Del Rio
    Department of Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA
    J Am Soc Nephrol 15:41-51. 2004
  3. ncbi request reprint Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways
    Moon Soo Park
    Pediatric Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, New York, NY, USA
    J Am Soc Nephrol 13:858-65. 2002
  4. ncbi request reprint Activation of mitochondrial apoptotic pathways in human renal allografts after ischemiareperfusion injury
    M Patricia Castaneda
    Division of Nephrology, Children s Hospital at Montefiore, Bronx, New York, USA
    Transplantation 76:50-4. 2003
  5. pmc Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery
    Ganesan Ramesh
    Division of Nephrology, H040, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Clin J Am Soc Nephrol 5:395-401. 2010
  6. ncbi request reprint Differential gene expression following early renal ischemia/reperfusion
    Suroj Supavekin
    Pediatric Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA
    Kidney Int 63:1714-24. 2003
  7. doi request reprint Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials
    Mark D Okusa
    Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908 0133, USA
    Clin J Am Soc Nephrol 7:851-5. 2012
  8. ncbi request reprint Angiotensin-converting enzyme inhibition induces death receptor apoptotic pathways in erythroid precursors following renal transplantation
    Ilya Glezerman
    Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Nephrol 23:195-201. 2003
  9. ncbi request reprint Dissociation of spectrin-ankyrin complex as a basis for loss of Na-K-ATPase polarity after ischemia
    Robert Woroniecki
    Division of Pediatric Nephrology, Albert Einstein College of Medicine, New York, New York 10467, USA
    Am J Physiol Renal Physiol 284:F358-64. 2003
  10. ncbi request reprint Estradiol reverses TGF-beta1-induced mesangial cell apoptosis by a casein kinase 2-dependent mechanism
    Olivia Negulescu
    Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Kidney Int 62:1989-98. 2002

Research Grants

  1. ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES
    Prasad Devarajan; Fiscal Year: 2000
  2. RESEARCH TRAINING IN PEDIATRIC NEPHROLOGY
    Prasad Devarajan; Fiscal Year: 2007
  3. Implications of the ASK1/JNK pathway in ARF
    Prasad Devarajan; Fiscal Year: 2007
  4. Implications of the ASK1/JNK pathway in ARF
    Prasad Devarajan; Fiscal Year: 2006
  5. NGAL: A novel early biomarker of acute renal injury
    Prasad Devarajan; Fiscal Year: 2005
  6. ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES
    Prasad Devarajan; Fiscal Year: 2003
  7. ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES
    Prasad Devarajan; Fiscal Year: 2002
  8. ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES
    Prasad Devarajan; Fiscal Year: 2002
  9. ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES
    Prasad Devarajan; Fiscal Year: 2001
  10. Implications of the ASK1/JNK pathway in ARF
    Prasad Devarajan; Fiscal Year: 2009

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Cisplatin-induced apoptosis in auditory cells: role of death receptor and mitochondrial pathways
    Prasad Devarajan
    Division of Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY 10467, USA
    Hear Res 174:45-54. 2002
    ..Our results indicate the involvement of both the death receptor mechanisms as well as mitochondrial pathways in cisplatin-induced apoptosis of auditory cells in an in vitro model system...
  2. ncbi request reprint The death domain of kidney ankyrin interacts with Fas and promotes Fas-mediated cell death in renal epithelia
    Marcela Del Rio
    Department of Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA
    J Am Soc Nephrol 15:41-51. 2004
    ..The results identify a novel tethering interaction between ankyrin and Fas in kidney epithelia and suggest that AnkG190 may play a role as an adapter molecule in renal tubule cell death...
  3. ncbi request reprint Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways
    Moon Soo Park
    Pediatric Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, New York, NY, USA
    J Am Soc Nephrol 13:858-65. 2002
    ..Inhibition of this specific pathway may provide a strategy to minimize cisplatin-induced nephrotoxicity...
  4. ncbi request reprint Activation of mitochondrial apoptotic pathways in human renal allografts after ischemiareperfusion injury
    M Patricia Castaneda
    Division of Nephrology, Children s Hospital at Montefiore, Bronx, New York, USA
    Transplantation 76:50-4. 2003
    ..We tested the hypothesis that activation of specific apoptotic pathways represents a mechanism for tubular cell death after CAD kidney transplantation...
  5. pmc Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery
    Ganesan Ramesh
    Division of Nephrology, H040, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Clin J Am Soc Nephrol 5:395-401. 2010
    ..Here, we determined the utility of urinary netrin-1 levels to predict AKI in humans undergoing cardiopulmonary bypass (CPB)...
  6. ncbi request reprint Differential gene expression following early renal ischemia/reperfusion
    Suroj Supavekin
    Pediatric Nephrology, Children s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA
    Kidney Int 63:1714-24. 2003
    ..The purpose of this study was to identify apoptosis-related genes that are differentially expressed in the early periods following renal ischemia...
  7. doi request reprint Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials
    Mark D Okusa
    Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908 0133, USA
    Clin J Am Soc Nephrol 7:851-5. 2012
    ..The workgroups detailed primary and secondary endpoints for studies in these groups, and explored the use of adaptive clinical trial designs for trials of novel preventive strategies to improve outcomes of patients with AKI...
  8. ncbi request reprint Angiotensin-converting enzyme inhibition induces death receptor apoptotic pathways in erythroid precursors following renal transplantation
    Ilya Glezerman
    Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Nephrol 23:195-201. 2003
    ..We have previously shown that ACEI induce apoptosis in the peripheral erythroid precursors from patients with PTE. In the current study we elucidate the molecular mechanisms of ACEI-induced apoptosis...
  9. ncbi request reprint Dissociation of spectrin-ankyrin complex as a basis for loss of Na-K-ATPase polarity after ischemia
    Robert Woroniecki
    Division of Pediatric Nephrology, Albert Einstein College of Medicine, New York, New York 10467, USA
    Am J Physiol Renal Physiol 284:F358-64. 2003
    ....
  10. ncbi request reprint Estradiol reverses TGF-beta1-induced mesangial cell apoptosis by a casein kinase 2-dependent mechanism
    Olivia Negulescu
    Division of Nephrology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA
    Kidney Int 62:1989-98. 2002
    ..We hypothesized that estradiol would reverse TGF-beta1-induced mesangial cell apoptosis by antagonizing the stimulatory effects of TGF-beta1 on casein kinase 2 activity, thereby preventing p53 activation...
  11. ncbi request reprint Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Am Soc Nephrol 14:2534-43. 2003
    ..The results indicate that NGAL may represent an early, sensitive, noninvasive urinary biomarker for ischemic and nephrotoxic renal injury...
  12. ncbi request reprint Microarray analysis of focal segmental glomerulosclerosis
    Kristopher Schwab
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Nephrol 24:438-47. 2004
    ..Here we use oligonucleotide microarrays to obtain a global gene expression profile of kidney biopsy specimens from patients with FSGS in order to better understand the pathogenesis of this disease...
  13. doi request reprint Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis
    Michiko Suzuki
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Pediatr Nephrol 23:403-12. 2008
    ..3 +/- 6.2 or 21%; renal disease activity: 20.2 +/- 6.0 or 51%; both p = not significant]. In conclusion, NGAL in urine but not in plasma represents a novel biomarker for renal disease activity in pSLE...
  14. pmc Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study
    Catherine L Dent
    Department of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
    Crit Care 11:R127. 2007
    ..In this study we tested whether a point-of-care NGAL device can predict AKI after CPB in a larger cohort...
  15. pmc Proteomics for biomarker discovery in acute kidney injury
    Prasad Devarajan
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Semin Nephrol 27:637-51. 2007
    ..Such studies will be facilitated markedly by the development of commercial tools for the reproducible measurement of biomarkers across different laboratories...
  16. ncbi request reprint NGAL is an early predictive biomarker of contrast-induced nephropathy in children
    Russel Hirsch
    Division of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Nephrol 22:2089-95. 2007
    ..52, p < 0.0001) and plasma (R (2) = 0.72, p < 0.0001) were found to be powerful independent predictors of CIN. Patient demographics and contrast volume were not predictive of CIN...
  17. doi request reprint Biomarkers in acute and chronic kidney disease
    Thomas L Nickolas
    Renal Division, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York, USA
    Curr Opin Nephrol Hypertens 17:127-32. 2008
    ..The paucity of early, predictive, noninvasive biomarkers has impaired our ability to institute potentially effective therapies for acute kidney injury and chronic kidney disease in a timely manner...
  18. pmc Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study
    Michael Bennett
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
    Clin J Am Soc Nephrol 3:665-73. 2008
    ..In this study, whether an NGAL immunoassay developed for a standardized clinical platform (ARCHITECT analyzer, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL) can predict AKI after CPB was tested...
  19. pmc Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock
    Derek S Wheeler
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Crit Care Med 36:1297-303. 2008
    ..To validate serum neutrophil gelatinase-associated lipocalin (NGAL) as an early biomarker for acute kidney injury in critically ill children with septic shock...
  20. doi request reprint Induction of proapoptotic Daxx following ischemic acute kidney injury
    Qing Ma
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Kidney Int 74:310-8. 2008
    ..Antisense oligonucleotides to Daxx and specific JNK inhibitors blunted the apoptotic response to ATP depletion. These studies indicate that Daxx may play an unrecognized role in the early apoptotic response to ischemic renal injury...
  21. pmc Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury
    Thomas L Nickolas
    Columbia University, New York, New York 10032, USA
    Ann Intern Med 148:810-9. 2008
    ..A single serum creatinine measurement cannot distinguish acute kidney injury from chronic kidney disease or prerenal azotemia...
  22. pmc Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease
    Prasad Devarajan
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 2029, USA
    Scand J Clin Lab Invest Suppl 241:89-94. 2008
    ..Such studies will be facilitated by the anticipated widespread availability of standardized commercial tools in the near future...
  23. doi request reprint NGAL in acute kidney injury: from serendipity to utility
    Prasad Devarajan
    Am J Kidney Dis 52:395-9. 2008
  24. pmc Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study
    Michael Zappitelli
    Texas Children s Hospital, Fannin Street, Houston, Texas 77030, USA
    Crit Care 11:R84. 2007
    ..It is unknown whether uNGAL predicts AKI in the general critical care setting. We assessed the ability of uNGAL to predict AKI development and severity in critically ill children...
  25. ncbi request reprint Emerging biomarkers of acute kidney injury
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Contrib Nephrol 156:203-12. 2007
    ..Acute kidney injury (AKI) is a major clinical problem with a rising incidence and high mortality rate. The lack of early biomarkers has resulted in an unacceptable delay in initiating therapies...
  26. ncbi request reprint Mitochondria are the major targets in albumin-induced apoptosis in proximal tubule cells
    Elif Erkan
    Department of Pediatrics, University of Rochester, School of Medicine, Rochester, New York, USA
    J Am Soc Nephrol 18:1199-208. 2007
    ..It is concluded that albumin induces apoptosis in human proximal tubule cells by stimulating mitochondrial apoptotic pathway independent of ROS production...
  27. ncbi request reprint Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Am J Nephrol 24:307-15. 2004
    ..In this study, we have explored the expression and urinary excretion of neutrophil gelatinase-associated lipocalin (NGAL) in a mouse model of cisplatin-induced nephrotoxic injury...
  28. ncbi request reprint Low renal toxicity of lipoplatin compared to cisplatin in animals
    Prasad Devarajan
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Anticancer Res 24:2193-200. 2004
    ..This is proposed as one mechanism to explain the low renal toxicity of Lipoplatin...
  29. pmc Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    Kiyoshi Mori
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:610-21. 2005
    ..We reveal what we believe to be a novel pathway of iron traffic that is activated in human and mouse renal diseases, and it provides a unique method for their treatment...
  30. ncbi request reprint Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    Jaya Mishra
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Lancet 365:1231-8. 2005
    ..We tested the hypothesis that neutrophil gelatinase-associated lipocalin (NGAL) is an early biomarker for ischaemic renal injury after cardiopulmonary bypass...
  31. ncbi request reprint Induction of Zf9 in the kidney following early ischemia/reperfusion
    Ridwan Tarabishi
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Kidney Int 68:1511-9. 2005
    ..An improved understanding of the early cell injury mechanisms is critical for effective therapy of acute renal failure (ARF)...
  32. ncbi request reprint Single and combination toxic metal exposures induce apoptosis in cultured murine podocytes exclusively via the extrinsic caspase 8 pathway
    Tad Eichler
    Pediatric Nephrology Division, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan 48109, USA
    Toxicol Sci 90:392-9. 2006
    ....
  33. ncbi request reprint Kidney NGAL is a novel early marker of acute injury following transplantation
    Jaya Mishra
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Pediatr Nephrol 21:856-63. 2006
    ..We conclude that NGAL staining intensity in early protocol biopsies represents a novel predictive biomarker of acute kidney injury following transplantation...
  34. ncbi request reprint Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: a novel marker of renal injury
    Howard Trachtman
    Department of Pediatrics Division of Nephrology, Schneider Children s Hospital of the North Shore Long Island Jewish Medical Center, New Hyde Park, New York, NY, USA
    Pediatr Nephrol 21:989-94. 2006
    ..Diarrhea-associated hemolytic uremic syndrome (D+HUS) causes acute renal failure. Neutrophil gelatinase-associated lipocalcin (NGAL) is an early indicator of kidney injury...
  35. ncbi request reprint Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia
    Kai M Schmidt-Ott
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Curr Opin Nephrol Hypertens 15:442-9. 2006
    ..Here, we review the expression, siderophore-dependent biological activities and clinical significance of NGAL in epithelial development and in kidney disease...
  36. ncbi request reprint Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease
    Mark M Mitsnefes
    Divisions of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, MLC 7022, 3333 Burnet Avenue, Cincinnati, OH, 45229 3039, USA
    Pediatr Nephrol 22:101-8. 2007
    ..62), followed by cystatin C (r=0.41). We conclude that (a) both serum NGAL and cystatin C may prove useful in the quantitation of CKD, and (b) by correlation analysis, NGAL outperforms cystatin C and eGFR at lower levels of measured GFR...
  37. ncbi request reprint Hypoxia/re-oxygenation injury induces apoptosis of LLC-PK1 cells by activation of caspase-2
    Moon Soo Park
    Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Pediatr Nephrol 22:202-8. 2007
    ..These results indicate that hypoxia/re-oxygenation injury in cultured proximal tubule cells induced apoptosis by activation of caspase-2, which is required for the mitochondrial translocation of Bax...
  38. ncbi request reprint Dual action of neutrophil gelatinase-associated lipocalin
    Kai M Schmidt-Ott
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Am Soc Nephrol 18:407-13. 2007
    ..This review summarizes the current knowledge about the dual effects of NGAL as a siderophore:iron-binding protein and as a growth factor and examines the role of these effects in renal injury...
  39. ncbi request reprint Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus
    Hermine I Brunner
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Arthritis Rheum 54:2577-84. 2006
    ..We undertook this study to determine the relationship between urinary NGAL excretion and SLE disease activity or damage, with a focus on nephritis...

Research Grants12

  1. ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES
    Prasad Devarajan; Fiscal Year: 2000
    ..The results will provide important insights into apoptotic cell death that accompanies ischemia and several other renal pathophysiologic states, and reveal critical clues for potential therapeutic interventions. ..
  2. RESEARCH TRAINING IN PEDIATRIC NEPHROLOGY
    Prasad Devarajan; Fiscal Year: 2007
    ....
  3. Implications of the ASK1/JNK pathway in ARF
    Prasad Devarajan; Fiscal Year: 2007
    ..The long term goal is to identify novel ASK1- and JNK-based pharmacologic interventions aimed at ameliorating renal cell damage and preventing renal failure secondary to ischemia-reperfusion injury. ..
  4. Implications of the ASK1/JNK pathway in ARF
    Prasad Devarajan; Fiscal Year: 2006
    ..The long term goal is to identify novel ASK1- and JNK-based pharmacologic interventions aimed at ameliorating renal cell damage and preventing renal failure secondary to ischemia-reperfusion injury. ..
  5. NGAL: A novel early biomarker of acute renal injury
    Prasad Devarajan; Fiscal Year: 2005
    ..The long-term goal is to identify novel biomarkers for the early diagnosis of human ARF, to facilitate the early institution of therapy ..
  6. ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES
    Prasad Devarajan; Fiscal Year: 2003
    ..The results will provide important insights into apoptotic cell death that accompanies ischemia and several other renal pathophysiologic states, and reveal critical clues for potential therapeutic interventions. ..
  7. ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES
    Prasad Devarajan; Fiscal Year: 2002
    ..The results will provide important insights into apoptotic cell death that accompanies ischemia and several other renal pathophysiologic states, and reveal critical clues for potential therapeutic interventions. ..
  8. ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES
    Prasad Devarajan; Fiscal Year: 2002
    ..The results will provide important insights into apoptotic cell death that accompanies ischemia and several other renal pathophysiologic states, and reveal critical clues for potential therapeutic interventions. ..
  9. ANKYRIN: CRUCIAL LINKER IN RENAL CELL APOPTOTIC CASCADES
    Prasad Devarajan; Fiscal Year: 2001
    ..The results will provide important insights into apoptotic cell death that accompanies ischemia and several other renal pathophysiologic states, and reveal critical clues for potential therapeutic interventions. ..
  10. Implications of the ASK1/JNK pathway in ARF
    Prasad Devarajan; Fiscal Year: 2009
    ..The long term goal is to identify novel ASK1- and JNK-based pharmacologic interventions aimed at ameliorating renal cell damage and preventing renal failure secondary to ischemia-reperfusion injury. ..