Jay L Degen

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Fibrin and fibrinolysis in infection and host defense
    J L Degen
    Division of Developmental Biology, Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Thromb Haemost 5:24-31. 2007
  2. pmc Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair
    Kumar Shanmukhappa
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Biol Chem 284:12917-23. 2009
  3. pmc Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif
    Matthew J Flick
    Cincinnati Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 117:3224-35. 2007
  4. ncbi request reprint Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury
    V L Ng
    Divisions of Gastroenterology, Hepatology, and Nutrition, Children's Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229-3039, USA
    J Hepatol 35:781-9. 2001
  5. pmc Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia
    Matthew J Flick
    Division of Experimental Hematology and Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 121:1783-94. 2013
  6. ncbi request reprint Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency
    T H Bugge
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Cell 87:709-19. 1996
  7. pmc Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury
    J F Pohl
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA
    Am J Pathol 159:2179-86. 2001
  8. pmc Fibrinogen deficiency is compatible with the development of atherosclerosis in mice
    Q Xiao
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Clin Invest 101:1184-94. 1998
  9. pmc The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A
    Matthew J Flick
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Blood 117:6326-37. 2011
  10. ncbi request reprint Mechanisms linking hemostatic factors to tumor growth in mice
    Jay L Degen
    Division of Developmental Biology, Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Pathophysiol Haemost Thromb 33:31-5. 2003

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Fibrin and fibrinolysis in infection and host defense
    J L Degen
    Division of Developmental Biology, Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Thromb Haemost 5:24-31. 2007
    ..Detailed studies of the inflammatory response in mice with genetically-imposed modifications in coagulation and fibrinolytic factors underscore the regulatory crosstalk between the hemostatic and immune systems...
  2. pmc Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair
    Kumar Shanmukhappa
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Biol Chem 284:12917-23. 2009
    ..These findings support a fibrinolysis-unrelated role for Plg in modulating cell proliferation and migration by activation of Hgf...
  3. pmc Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif
    Matthew J Flick
    Cincinnati Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 117:3224-35. 2007
    ..Thus, fibrin(ogen) is an important, but context-dependent, determinant of arthritis, and one mechanism linking fibrin(ogen) to joint disease is coupled to alphaMbeta2-mediated inflammatory processes...
  4. ncbi request reprint Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury
    V L Ng
    Divisions of Gastroenterology, Hepatology, and Nutrition, Children's Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229-3039, USA
    J Hepatol 35:781-9. 2001
    ..CONCLUSIONS: Proteolytic clearance of non-fibrin matrix components by plasminogen must occur for HSCs to restore the quiescent phenotype during liver repair...
  5. pmc Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia
    Matthew J Flick
    Division of Experimental Hematology and Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 121:1783-94. 2013
    ..These findings indicate that host fibrin(ogen) and bacterial ClfA are dual determinants of virulence and that therapeutic interventions at the level of fibrinogen could be advantageous in S. aureus septicemia...
  6. ncbi request reprint Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency
    T H Bugge
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Cell 87:709-19. 1996
    ..Mice deficient in Plg and Fib are phenotypically indistinguishable from Fib-deficient mice. These data suggest that the fundamental and possibly only essential physiological role of Plg is fibrinolysis...
  7. pmc Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury
    J F Pohl
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, USA
    Am J Pathol 159:2179-86. 2001
    ..Taken together, these data suggest that the progressive accumulation of fibrin-unrelated matrix substrates in Plg(0) livers after a chronic injury results from the combined effects of impaired proteolysis and increased matrix production...
  8. pmc Fibrinogen deficiency is compatible with the development of atherosclerosis in mice
    Q Xiao
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Clin Invest 101:1184-94. 1998
    ....
  9. pmc The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A
    Matthew J Flick
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Blood 117:6326-37. 2011
    ..These studies provide a proof-of-principle that pro/thrombin variants engineered with altered substrate specificity may offer therapeutic opportunities for limiting inflammatory disease processes...
  10. ncbi request reprint Mechanisms linking hemostatic factors to tumor growth in mice
    Jay L Degen
    Division of Developmental Biology, Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Pathophysiol Haemost Thromb 33:31-5. 2003
  11. pmc Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice
    J A Bezerra
    Division of Gastroenterology and Nutrition, Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 101:1175-83. 1998
    ..HGFL-deficient mice will provide a valuable means to assess the role of HGFL in hepatic and systemic responses to inflammatory and infectious stimuli in vivo...
  12. ncbi request reprint Genetic manipulation of fibrinogen and fibrinolysis in mice
    J L Degen
    Children s Hospital Research Foundation, Children s Hospital Medical Center, IDR NRB Room 2042, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Ann N Y Acad Sci 936:276-90. 2001
    ..Studies illustrating the role and interplay of these factors in disease progression are highlighted...
  13. ncbi request reprint Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice
    T T Suh
    Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Genes Dev 9:2020-33. 1995
    ..Microscopic analysis of spontaneous lesions found in A alpha-/- mice suggests that fibrin(ogen) plays a fundamental role in the organization of cells at sites of injury...
  14. pmc Plasminogen activators direct reorganization of the liver lobule after acute injury
    J A Bezerra
    Division of Gastroenterology and Nutrition, Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229 3039, USA
    Am J Pathol 158:921-9. 2001
    ..These data demonstrate that tPA and uPA play a critical role in hepatic repair via proteolysis of matrix elements and clearance of cellular debris from the field of injury...
  15. ncbi request reprint Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice
    A F Drew
    Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    Invest Ophthalmol Vis Sci 41:67-72. 2000
    ..Fibrin deposition and resolution after excimer laser photokeratectomy were investigated in relation to corneal repair and restoration of clarity in mice with a genetic deficiency of plasminogen...
  16. pmc Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver
    J A Bezerra
    Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 96:15143-8. 1999
    ....
  17. ncbi request reprint Genetic interactions between the coagulation and fibrinolytic systems
    J L Degen
    Children s Hospital Research Foundation, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Thromb Haemost 86:130-7. 2001
    ..New insights regarding the role(s) and interplay of hemostatic factors that have emerged from detailed studies of mice carrying multiple deficits in coagulation and fibrinolytic system components are highlighted...
  18. pmc Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia
    Faisal Adhami
    Division of Developmental Biology and Division of Neurology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Am J Pathol 172:1704-16. 2008
    ....
  19. pmc Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain
    Netanel A Horowitz
    Cancer and Blood Diseases Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Blood 118:2889-95. 2011
    ....
  20. ncbi request reprint Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction
    T H Bugge
    Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Genes Dev 9:794-807. 1995
    ..Therefore, Plg plays a pivotal role in fibrinolysis and hemostasis but is not essential for urokinase proenzyme activation, development, or growth to sexual maturity...
  21. pmc Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator
    T H Bugge
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 93:5899-904. 1996
    ....
  22. doi request reprint Hemostatic factors, innate immunity and malignancy
    Jay L Degen
    Cancer and Blood Diseases Institute, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Thromb Res 129:S1-5. 2012
    ....
  23. ncbi request reprint Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice
    Nancy J Roszell
    Comprehensive Sickle Cell Center, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Hematol 82:1044-8. 2007
    ..Rather, our findings suggest that the contribution of fibrinogen to tissue repair may in some contexts limit sickle cell disease pathophysiology...
  24. ncbi request reprint Plasminogen is a critical determinant of vascular remodeling in mice
    A F Drew
    Children s Hospital Research Foundation, Cincinnati, OH 45229 3039, USA
    Circ Res 87:133-9. 2000
    ..In addition, these studies reveal a fibrin-independent role of plasminogen in preventing medial atrophy in challenged vessels...
  25. pmc Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3
    K Holmb├Ąck
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    EMBO J 15:5760-71. 1996
    ..Despite the preservation of clotting function, gamma delta 5/gamma delta 5 mice were unable to control blood loss following a surgical challenge and occasionally developed fatal neonatal bleeding events...
  26. pmc Prothrombin deficiency results in embryonic and neonatal lethality in mice
    W Y Sun
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 95:7597-602. 1998
    ..This study directly demonstrates that FII is important in maintaining vascular integrity during development as well as postnatal life...
  27. ncbi request reprint Role of fibrinogen- and platelet-mediated hemostasis in mouse embryogenesis and reproduction
    J S Palumbo
    Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio, USA
    J Thromb Haemost 2:1368-79. 2004
    ..These findings support the notion that the function of coagulation factors for in utero development and pregnancy is mechanistically distinct from their ability to mediate the formation of hemostatic platelet-fibrin(ogen) aggregates...
  28. ncbi request reprint Wound-healing defects in mice lacking fibrinogen
    A F Drew
    Division of Developmental Biology, Children s Hospital Research Foundation, 3333 Burnet Ave, Cincinnati, PH 45229 3039, USA
    Blood 97:3691-8. 2001
    ..However, fibrin (ogen) is important for appropriate cellular migration and organization within wound fields and in initially establishing wound strength and stability. (Blood. 2001;97:3691-3698)..
  29. pmc Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms
    Joseph S Palumbo
    Divisions of Hematology, Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Blood 110:133-41. 2007
    ..However, TF also supported the early success of micrometastases through an additional mechanism independent of natural killer cells, but coupled to circulating prothrombin...
  30. pmc Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
    Kumar Shanmukhappa
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the Department of Pediatrics of the University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    BMC Gastroenterol 6:40. 2006
    ..Based on the efficient activation of plasminogen when uPA is bound to its receptor (uPAR) and on the role of uPA in plasmin-mediated liver repair, we hypothesized that uPA requires uPAR for efficient liver repair...
  31. ncbi request reprint Plasminogen directs the pleiotropic effects of uPA in liver injury and repair
    Angela R Currier
    Division of Gastroenterology, Hepatology, and Nutrition, Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Physiol Gastrointest Liver Physiol 284:G508-15. 2003
    ..These data demonstrate that plasminogen directs the hepatocyte injury induced by uPAT and mediates the reparative properties of uPA in the liver...
  32. ncbi request reprint Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells
    Joseph S Palumbo
    Division of Hematology Oncology, Children s Hospital Research Foundation, and University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Blood 105:178-85. 2005
    ....
  33. doi request reprint Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function
    J S Palumbo
    Division of Hematology Oncology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Thromb Haemost 6:812-9. 2008
    ..As the transglutaminase that ultimately stabilizes platelet/fibrin thrombi through the covalent crosslinking of fibrin, factor (F) XIII is another thrombin substrate that is likely to support hematogenous metastasis...
  34. ncbi request reprint Crescentic glomerulonephritis is diminished in fibrinogen-deficient mice
    A F Drew
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Renal Physiol 281:F1157-63. 2001
    ....
  35. ncbi request reprint Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice
    T H Bugge
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Oncogene 16:3097-104. 1998
    ..The data provide direct evidence that plasmin(ogen) is a tumor progression factor in PymT-induced mammary cancer, and support the hypothesis that hemostatic factors play an important role in tumor biology...
  36. ncbi request reprint The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility
    T H Bugge
    Division of Basic Science, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Biol Chem 270:16886-94. 1995
    ..These mice provide a means to test the proposed function of uPA/uPAR in wound repair, atherogenesis, and tumor cell invasion in vivo...
  37. ncbi request reprint Ligneous conjunctivitis in plasminogen-deficient mice
    A F Drew
    Divisions of Developmental Biology and Pathology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Blood 91:1616-24. 1998
    ....
  38. pmc The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse
    R S Muraoka
    Graduate Program in Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 103:1277-85. 1999
    ..These results demonstrate a novel role for Ron in early mouse development and suggest that Ron plays a limiting role in the inflammatory response...
  39. ncbi request reprint Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice
    Joseph S Palumbo
    Division of Hematology Oncology, Children s Hospital Research Foundation and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    Cancer Res 62:6966-72. 2002
    ..These studies suggest that therapeutic strategies focusing on hemostatic factors may be effective in controlling solid tumor metastasis, particularly if used for the treatment of micrometastatic disease...
  40. pmc Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice
    Kumar Shanmukhappa
    Division of Pediatric Gastroenterology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 102:10182-7. 2005
    ..Collectively, these data reveal a regulatory role for the hemostatic factors plasmin(ogen) and fibrin(ogen) in cellular plasticity within adult tissues of the digestive system...
  41. ncbi request reprint Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice
    T H Bugge
    Divisions of Developmental Biology and Pathology, Children s Hospital Research Foundation, Cincinnati, OH, USA
    Blood 90:4522-31. 1997
    ....
  42. pmc Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis
    Q Xiao
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 94:10335-40. 1997
    ..These studies provide direct evidence that circulating hemostatic factors strongly influence vessel wall disease in the context of a disorder in lipid metabolism...
  43. pmc Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation
    T H Bugge
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 93:6258-63. 1996
    ..These studies indicate that TF plays an indispensable role in establishing and/or maintaining vascular integrity in the developing embryo at a time when embryonic and extraembryonic vasculatures are fusing and blood circulation begins...
  44. ncbi request reprint Plasminogen supports tumor growth through a fibrinogen-dependent mechanism linked to vascular patency
    Joseph S Palumbo
    Division of Hematology Oncology, Children s Hospital Research Foundation, and University of Cincinnati College of Medicine, OH 45229, USA
    Blood 102:2819-27. 2003
    ..Furthermore, these studies suggest that one target of plasmin(ogen) relevant to tumor progression in vivo is intravascular fibrin...
  45. ncbi request reprint Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression
    Felizabel Garcia Bannach
    Department of Cell Biology, Division of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:38579-88. 2002
    ..These results indicate the presence of regulatory elements in the 5'-flanking region of the murine plasminogen promoter that may regulate murine plasminogen gene expression and, hence, plasmin activity...
  46. pmc The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
    Ryan A Adams
    Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 204:571-82. 2007
    ....
  47. pmc Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy
    Faisal Adhami
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Room 3464, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Am J Pathol 169:566-83. 2006
    ..Together, these results suggest that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain...
  48. ncbi request reprint Fibrin but not adsorbed fibrinogen supports fibronectin assembly by spread platelets. Effects of the interaction of alphaIIb beta3 with the C terminus of the fibrinogen gamma-chain
    Jaehyung Cho
    Molecular and Cellular Pharmacology Program and Department of Medicine, University of Wisconsin Madison School of Medicine, Madison, Wisconsin 53706, USA
    J Biol Chem 280:35490-8. 2005
    ..This interaction is less dominant when platelets adhere to fibrin, resulting in enhanced fibronectin assembly...
  49. ncbi request reprint Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice
    H Michael Tucker
    Department of Physiology, Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone St, Lexington, KY 40536 0230, USA
    Neurosci Lett 368:285-9. 2004
    ..Hence, although plasmin is potentially important in the degradation of A beta aggregates, we interpret these data as suggesting that plasmin does not regulate steady-state A beta levels in non-pathologic conditions...
  50. pmc Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo
    Matthew J Flick
    Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Clin Invest 113:1596-606. 2004
    ....
  51. ncbi request reprint The thrombomodulin-protein C system is essential for the maintenance of pregnancy
    Berend Isermann
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA
    Nat Med 9:331-7. 2003
    ..These findings show a new function for the thrombomodulin-protein C system in controlling the growth and survival of trophoblast cells in the placenta. This function is essential for the maintenance of pregnancy...
  52. ncbi request reprint Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets
    Dubravka Kufrin
    Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, ARC Rm 317, Philadelphia, PA 19104, USA
    Blood 102:926-33. 2003
    ..These studies show the feasibility of delivering fibrinolytic agents to sites of incipient thrombus formation through selective storage in platelets and offer a new strategy to prevent thrombosis and hemorrhage...