DEBORAH A DEAN

Summary

Affiliation: Children's Hospital Oakland Research Institute
Country: USA

Publications

  1. pmc Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease
    Troy A Skwor
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS Negl Trop Dis 2:e264. 2008
  2. pmc Association of carotid plaque Lp-PLA(2) with macrophages and Chlamydia pneumoniae infection among patients at risk for stroke
    Berna Atik
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, USA
    PLoS ONE 5:e11026. 2010
  3. pmc Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis
    Berna Atik
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, USA
    PLoS ONE 3:e3600. 2008
  4. pmc Discovering and differentiating new and emerging clonal populations of Chlamydia trachomatis with a novel shotgun cell culture harvest assay
    Naraporn Somboonna
    Children s Hospital, Oakland Research Institute, Oakland, California, USA
    Emerg Infect Dis 14:445-53. 2008
  5. pmc Comparative expression profiling of the Chlamydia trachomatis pmp gene family for clinical and reference strains
    Alexandra Nunes
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS ONE 2:e878. 2007
  6. pmc Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages
    Naraporn Somboonna
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland, Research Institute, Oakland, California, USA
    MBio 2:e00045-11. 2011
  7. pmc Interplay of recombination and selection in the genomes of Chlamydia trachomatis
    Sandeep J Joseph
    Department of Medicine, Division of Infectious, Diseases Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Biol Direct 6:28. 2011
  8. ncbi request reprint Chlamydia pneumoniae and acute chest syndrome in patients with sickle cell disease
    Deborah Dean
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    J Pediatr Hematol Oncol 25:46-55. 2003
  9. pmc Chlamydia trachomatis today: treatment, detection, immunogenetics and the need for a greater global understanding of chlamydial disease pathogenesis
    D Dean
    Children s Global Health Initiative, University of California at San Francisco, San Francisco, USA
    Drugs Today (Barc) 45:25-31. 2009
  10. pmc Predicting phenotype and emerging strains among Chlamydia trachomatis infections
    Deborah Dean
    Children s Global Health Initiativ, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Emerg Infect Dis 15:1385-94. 2009

Research Grants

Collaborators

Detail Information

Publications24

  1. pmc Role of secreted conjunctival mucosal cytokine and chemokine proteins in different stages of trachomatous disease
    Troy A Skwor
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS Negl Trop Dis 2:e264. 2008
    ..Vaccine development requires, in part, knowledge of the mucosal host immune responses in both healthy and trachomatous conjuctivae-an area of research that remains insufficiently studied...
  2. pmc Association of carotid plaque Lp-PLA(2) with macrophages and Chlamydia pneumoniae infection among patients at risk for stroke
    Berna Atik
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, USA
    PLoS ONE 5:e11026. 2010
    ..Since lipoprotein-associated phospholipase A2 (Lp-PLA(2)) mediates inflammation in atherosclerosis, we hypothesized that serum Lp-PLA(2) mass and activity levels and plaque Lp-PLA(2) may be influenced by plaque C. pneumoniae infection...
  3. pmc Identification of novel single nucleotide polymorphisms in inflammatory genes as risk factors associated with trachomatous trichiasis
    Berna Atik
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, USA
    PLoS ONE 3:e3600. 2008
    ..While there are a number of environmental and behavioral risk factors for trachoma, genetic factors that influence inflammation and TT risk remain ill defined...
  4. pmc Discovering and differentiating new and emerging clonal populations of Chlamydia trachomatis with a novel shotgun cell culture harvest assay
    Naraporn Somboonna
    Children s Hospital, Oakland Research Institute, Oakland, California, USA
    Emerg Infect Dis 14:445-53. 2008
    ....
  5. pmc Comparative expression profiling of the Chlamydia trachomatis pmp gene family for clinical and reference strains
    Alexandra Nunes
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS ONE 2:e878. 2007
    ..trachomatis. However, there is only limited information on their biologic role, especially for biological variants (biovar) and clinical strains...
  6. pmc Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages
    Naraporn Somboonna
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland, Research Institute, Oakland, California, USA
    MBio 2:e00045-11. 2011
    ..Given the lack of a genetic system for producing stable C. trachomatis mutants, identifying naturally occurring recombinants can clarify gene function and provide opportunities for discovering avenues for genomic manipulation...
  7. pmc Interplay of recombination and selection in the genomes of Chlamydia trachomatis
    Sandeep J Joseph
    Department of Medicine, Division of Infectious, Diseases Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Biol Direct 6:28. 2011
    ..trachomatis genomes to assess the contribution of recombination and selection in this pathogen and to understand the major evolutionary forces acting on the genome of this bacterium...
  8. ncbi request reprint Chlamydia pneumoniae and acute chest syndrome in patients with sickle cell disease
    Deborah Dean
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    J Pediatr Hematol Oncol 25:46-55. 2003
    ..The purpose of this study was to analyze the clinical course and outcome of C. pneumoniae-associated ACS among SCD patients as part of the National Acute Chest Syndrome Study...
  9. pmc Chlamydia trachomatis today: treatment, detection, immunogenetics and the need for a greater global understanding of chlamydial disease pathogenesis
    D Dean
    Children s Global Health Initiative, University of California at San Francisco, San Francisco, USA
    Drugs Today (Barc) 45:25-31. 2009
    ..We provide preliminary data on rates of chlamydial STDs and host genetic factors that predispose to infection among adolescent pregnant and nonpregnant commercial sex worker populations residing in Quito, Ecuador...
  10. pmc Predicting phenotype and emerging strains among Chlamydia trachomatis infections
    Deborah Dean
    Children s Global Health Initiativ, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Emerg Infect Dis 15:1385-94. 2009
    ..Multilocus and SNP typing can now be used to detect diverse and emerging C. trachomatis strains for epidemiologic and evolutionary studies of trachoma and STI populations worldwide...
  11. ncbi request reprint Evidence for long-term cervical persistence of Chlamydia trachomatis by omp1 genotyping
    D Dean
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Infect Dis 182:909-16. 2000
    ..These data demonstrate that cervical infections with C class serovars can persist for years and may have specific biologic properties that allow for modulation of the major outer membrane protein in response to immune selection...
  12. pmc In vitro recombinants of antibiotic-resistant Chlamydia trachomatis strains have statistically more breakpoints than clinical recombinants for the same sequenced loci and exhibit selection at unexpected loci
    Tara Srinivasan
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, USA
    J Bacteriol 194:617-26. 2012
    ..Additional genomic studies are needed to determine the factors responsible for the observed selection biases at unexpected loci and whether these are important for LGT to inform approaches for genetically manipulating C. trachomatis...
  13. pmc Multiple Chlamydiaceae species in trachoma: implications for disease pathogenesis and control
    Deborah Dean
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
    PLoS Med 5:e14. 2008
    ....
  14. pmc Persistent Chlamydia trachomatis infections resist apoptotic stimuli
    D Dean
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Infect Immun 69:2442-7. 2001
    ....
  15. pmc Characterization of humoral immune responses to chlamydial HSP60, CPAF, and CT795 in inflammatory and severe trachoma
    Troy Skwor
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Invest Ophthalmol Vis Sci 51:5128-36. 2010
    ....
  16. pmc Polymorphisms in the nine polymorphic membrane proteins of Chlamydia trachomatis across all serovars: evidence for serovar Da recombination and correlation with tissue tropism
    João P Gomes
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    J Bacteriol 188:275-86. 2006
    ..Thus, our data suggest a possible structural or functional role that may vary among pmp genes in promoting antigenic polymorphisms and/or diverse adhesions-receptors that may be involved in immune evasion and differential tissue tropism...
  17. ncbi request reprint Risk factors for recurrence of postoperative trichiasis: implications for trachoma blindness prevention
    Hui Zhang
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Arch Ophthalmol 122:511-6. 2004
    ..Trachoma is the leading worldwide cause of preventable blindness. Surgery can alleviate trachomatous trichiasis (TT), the blinding sequelae of trachoma, but recurrence rates are high...
  18. pmc Evolution of Chlamydia trachomatis diversity occurs by widespread interstrain recombination involving hotspots
    João P Gomes
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Genome Res 17:50-60. 2007
    ....
  19. ncbi request reprint Population-based genetic epidemiologic analysis of Chlamydia trachomatis serotypes and lack of association between ompA polymorphisms and clinical phenotypes
    Kim Millman
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Microbes Infect 8:604-11. 2006
    ....
  20. ncbi request reprint Impact of annual targeted treatment on infectious trachoma and susceptibility to reinfection
    Berna Atik
    Children s Hospital Oakland Research Institute, Oakland, Calif 94609, USA
    JAMA 296:1488-97. 2006
    ....
  21. ncbi request reprint Chlamydia pneumoniae burden in carotid arteries is associated with upregulation of plaque interleukin-6 and elevated C-reactive protein in serum
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA, USA
    Arterioscler Thromb Vasc Biol 25:2648-53. 2005
    ....
  22. pmc A systemic network for Chlamydia pneumoniae entry into human cells
    Anyou Wang
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    J Bacteriol 192:2809-15. 2010
    ..pneumoniae entry, but the entire network is resistant to the six-gene depletion, indicating a resilient network. Our results reveal a complex network for C. pneumoniae entry involving at least six key proteins...

Research Grants20

  1. PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    Deborah Dean; Fiscal Year: 2000
    ..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
  2. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2005
    ....
  3. Pathogenesis of Persistent Chlamydial STDs
    Deborah Dean; Fiscal Year: 2006
    ..abstract_text> ..
  4. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  5. Pathogenesis of Persistent Chlamydial STDs
    Deborah Dean; Fiscal Year: 2007
    ..1 Description, ..
  6. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  8. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  9. PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    Deborah Dean; Fiscal Year: 2003
    ..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
  10. MOLECULAR TYPING OF RECURRENT CHLAMYDIAL STDS
    Deborah Dean; Fiscal Year: 1999
    ....
  11. MOLECULAR TYPING OF RECURRENT CHLAMYDIAL STDS
    Deborah Dean; Fiscal Year: 2000
    ....
  12. PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    Deborah Dean; Fiscal Year: 2001
    ..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
  13. PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    Deborah Dean; Fiscal Year: 2002
    ..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
  14. PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    Deborah Dean; Fiscal Year: 2004
    ..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
  15. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2004
    ....
  16. Pathogenesis of Persistent Chlamydial STDs
    Deborah Dean; Fiscal Year: 2003
    ..abstract_text> ..
  17. PATHOGENESIS OF CHLAMYDIAL OCULAR INFECTIONS
    Deborah Dean; Fiscal Year: 2003
    ..A greater understanding of the pathogenesis of trachoma will aid in developing public health interventions and a vaccine that can be implemented in trachoma endemic areas throughout the world. ..
  18. C. trachomatis genomics, strain typing, and evolution
    Deborah Dean; Fiscal Year: 2007
    ..abstract_text> ..