Gregory M Cooper

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. pmc Tissue interactions between craniosynostotic dura mater and bone
    Gregory M Cooper
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15224, USA
    J Craniofac Surg 23:919-24. 2012
  2. ncbi request reprint Noggin inhibits postoperative resynostosis in craniosynostotic rabbits
    Gregory M Cooper
    Department of Surgery, Division of Pediatric Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 22:1046-54. 2007
  3. pmc Inkjet-based biopatterning of bone morphogenetic protein-2 to spatially control calvarial bone formation
    Gregory M Cooper
    Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15224, USA
    Tissue Eng Part A 16:1749-59. 2010
  4. doi request reprint BMP-4 response in wild-type and craniosynostotic rabbit bone cells
    Gregory M Cooper
    Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 125:1403-11. 2010
  5. pmc Testing the critical size in calvarial bone defects: revisiting the concept of a critical-size defect
    Gregory M Cooper
    Department of Surgery, Division of Plastic Surgery, University of Pittsburgh, PA, USA
    Plast Reconstr Surg 125:1685-92. 2010
  6. pmc Direct comparison of progenitor cells derived from adipose, muscle, and bone marrow from wild-type or craniosynostotic rabbits
    Gregory M Cooper
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 127:88-97. 2011
  7. doi request reprint The influence of sex on the chondrogenic potential of muscle-derived stem cells: implications for cartilage regeneration and repair
    Tomoyuki Matsumoto
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Arthritis Rheum 58:3809-19. 2008
  8. pmc Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cells
    Seiji Kubo
    Children s Hospital of Pittsburgh, and University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Arthritis Rheum 60:155-65. 2009
  9. doi request reprint Leporine-derived adipose precursor cells exhibit in vitro osteogenic potential
    Jason R Dudas
    Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Craniofac Surg 19:360-8. 2008
  10. doi request reprint Ex vivo Noggin gene therapy inhibits bone formation in a mouse model of postoperative resynostosis
    Gregory M Cooper
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 123:94S-103S. 2009

Collaborators

Detail Information

Publications53

  1. pmc Tissue interactions between craniosynostotic dura mater and bone
    Gregory M Cooper
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15224, USA
    J Craniofac Surg 23:919-24. 2012
    ....
  2. ncbi request reprint Noggin inhibits postoperative resynostosis in craniosynostotic rabbits
    Gregory M Cooper
    Department of Surgery, Division of Pediatric Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 22:1046-54. 2007
    ..This study used a single dose of Noggin protein to prevent resynostosis and improve postoperative outcomes in a rabbit model of craniosynostosis...
  3. pmc Inkjet-based biopatterning of bone morphogenetic protein-2 to spatially control calvarial bone formation
    Gregory M Cooper
    Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15224, USA
    Tissue Eng Part A 16:1749-59. 2010
    ..These results demonstrate that three-dimensional biopatterning of a growth factor and growth factor modifier within a construct can direct cell differentiation in vitro and tissue formation in vivo in register to printed patterns...
  4. doi request reprint BMP-4 response in wild-type and craniosynostotic rabbit bone cells
    Gregory M Cooper
    Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 125:1403-11. 2010
    ..The authors hypothesized that cells derived from suture-associated regions of bone from craniosynostotic rabbits were more osteogenic and proliferative than bone cells derived from wild-type rabbits...
  5. pmc Testing the critical size in calvarial bone defects: revisiting the concept of a critical-size defect
    Gregory M Cooper
    Department of Surgery, Division of Plastic Surgery, University of Pittsburgh, PA, USA
    Plast Reconstr Surg 125:1685-92. 2010
    ..This study was undertaken to test the concept of the critical size in several different models. A review of the theoretical and scientific bases for the critical-size defect was also undertaken...
  6. pmc Direct comparison of progenitor cells derived from adipose, muscle, and bone marrow from wild-type or craniosynostotic rabbits
    Gregory M Cooper
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 127:88-97. 2011
    ..In this article, the authors compare cells isolated from wild-type rabbits or rabbits with nonsyndromic craniosynostosis, defined as the premature fusion of one or more of the cranial sutures...
  7. doi request reprint The influence of sex on the chondrogenic potential of muscle-derived stem cells: implications for cartilage regeneration and repair
    Tomoyuki Matsumoto
    Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Arthritis Rheum 58:3809-19. 2008
    ..To explore possible differences in muscle-derived stem cell (MDSC) chondrogenic differentiation in vitro and articular cartilage regeneration in vivo between murine male MDSCs (M-MDSCs) and female MDSCs (F-MDSCs)...
  8. pmc Blocking vascular endothelial growth factor with soluble Flt-1 improves the chondrogenic potential of mouse skeletal muscle-derived stem cells
    Seiji Kubo
    Children s Hospital of Pittsburgh, and University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Arthritis Rheum 60:155-65. 2009
    ....
  9. doi request reprint Leporine-derived adipose precursor cells exhibit in vitro osteogenic potential
    Jason R Dudas
    Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Craniofac Surg 19:360-8. 2008
    ..The mechanism underlying the sex-based variation in osteoblastic differentiation is unknown but may involve signaling via factors such as estrogen...
  10. doi request reprint Ex vivo Noggin gene therapy inhibits bone formation in a mouse model of postoperative resynostosis
    Gregory M Cooper
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 123:94S-103S. 2009
    ..This study tested the hypothesis that treatment of suturectomy sites with Noggin, an extracellular antagonist of bone morphogenetic proteins, would inhibit postoperative resynostosis in a mouse suturectomy model...
  11. doi request reprint Custom porous polyethylene implants for large-scale pediatric skull reconstruction: early outcomes
    Alexander Y Lin
    Division of Plastic Surgery and Department of Oral Biology, University of Pittsburgh, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania 15201, USA
    J Craniofac Surg 23:67-70. 2012
    ..We present a clinical series that demonstrates successful use of porous polyethylene cranioplasties in large pediatric cranial defects...
  12. doi request reprint Recombinant human bone morphogenetic protein-2-induced craniosynostosis and growth restriction in the immature skeleton
    Christopher R Kinsella
    Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 127:1173-81. 2011
    ..In the skeletally immature patient, the safety of rhBMP-2 therapy remains uncertain. Experiments are needed that investigate the effect of rhBMP-2 on growth and development in clinically relevant models...
  13. doi request reprint Regenerative surgery in cranioplasty revisited: the role of adipose-derived stem cells and BMP-2
    Darren M Smith
    Division of Plastic Surgery, University of Pittsburgh, and Children s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
    Plast Reconstr Surg 128:1053-60. 2011
    ..In this article, the authors evaluate and compare the relative efficacy of adipose-derived stem cells, bone morphogenetic protein (BMP)-2, and adipose-derived stem cells osteoinduced with BMP-2 in addressing these defects...
  14. doi request reprint Novel model of calvarial defect in an infected unfavorable wound: reconstruction with rhBMP-2. Part II
    Christopher R Kinsella
    Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA 15201, USA
    J Craniofac Surg 23:410-4. 2012
    ..The purpose of this study was to compare the effectiveness of rhBMP-2 in a rabbit model of an unfavorable scarred calvarial wound with the criterion standard of autograft...
  15. doi request reprint Blocking bone morphogenetic protein function using in vivo noggin therapy does not rescue premature suture fusion in rabbits with delayed-onset craniosynostosis
    James Cray
    Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pittsburgh, PA 15201, USA
    Plast Reconstr Surg 127:1163-72. 2011
    ..The present study was designed to test the hypothesis that BMP inhibition using noggin therapy may rescue sutures destined to fuse by inhibiting initial ossification...
  16. ncbi request reprint Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits
    Mark P Mooney
    Department of Oral Biology, Cleft Palate Craniofacial Center, University of Pittsburgh, and Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Craniofac Surg 18:336-46; discussion 347-9. 2007
    ..Thus, this biologically based therapy may be a potential surgical adjunct in the treatment of infants with craniosynostosis...
  17. doi request reprint Novel animal model of calvarial defect in an infected unfavorable wound: reconstruction with rhBMP-2
    Gary E DeCesare
    Division of Plastic Surgery and the Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 127:588-94. 2011
    ..This study was designed to evaluate the efficacy of rhBMP-2/absorbable collagen sponge to improve healing in the previously infected, unfavorable calvarial defect model...
  18. ncbi request reprint VEGF improves, whereas sFlt1 inhibits, BMP2-induced bone formation and bone healing through modulation of angiogenesis
    Hairong Peng
    Growth and Development Laboratory, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Bone Miner Res 20:2017-27. 2005
    ..Results indicate that VEGF antagonist inhibited BMP2-elicited bone formation, whereas the delivery of exogenous VEGF enhanced BMP2-induced bone formation and bone healing through modulation of angiogenesis...
  19. ncbi request reprint Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits
    Mark P Mooney
    Department of Oral Medicine and Pathology, the Cleft Palate Craniofacial Center, and the School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Plast Reconstr Surg 119:1200-12; discussion 1213-5. 2007
    ..Interference with TGF-beta2 function with the use of neutralizing antibodies may inhibit resynostosis. The present study was designed to test this hypothesis...
  20. doi request reprint Novel animal model of calvarial defect: part IV. Reconstruction of a calvarial wound complicated by durectomy
    Zoe M Macisaac
    Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 131:512e-9e. 2013
    ..The authors assessed the effectiveness of rhBMP-2-mediated bone regeneration in calvarial defects complicated by durectomy...
  21. doi request reprint BMP-2-based repair of large-scale calvarial defects in an experimental model: regenerative surgery in cranioplasty
    Darren M Smith
    Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Craniofac Surg 19:1315-22. 2008
    ..rhBMP-2/ACS may offer a viable treatment option for craniofacial surgeons facing a shortage of bone, with the potential to replace autologous bone grafts and render their attendant morbidities obsolete...
  22. doi request reprint Novel animal model of calvarial defect: part III. Reconstruction of an irradiated wound with rhBMP-2
    Christopher R Kinsella
    Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 130:643e-650e. 2012
    ..The authors compared the effectiveness of rhBMP-2 with the accepted standard of autologous graft for repair of irradiated calvarial defects...
  23. doi request reprint BMP-2-mediated regeneration of large-scale cranial defects in the canine: an examination of different carriers
    Christopher R Kinsella
    Division of Plastic Surgery and Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 127:1865-73. 2011
    ..The aim of the authors' study was to investigate the use of rhBMP-2 in addressing calvarial defects in a large-animal model through a variety of modifications to this U.S. Food and Drug Administration-approved therapy...
  24. pmc Masticatory hypermuscularity is not related to reduced cranial volume in myostatin-knockout mice
    James Cray
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Pittsburgh, Pennsylvania 15201, USA
    Anat Rec (Hoboken) 294:1170-7. 2011
    ..The results presented here do not support the hypothesis that a reduction in masticatory musculature relaxed compressive forces on the cranial vault allowing for greater encephalization...
  25. doi request reprint Bone morphogenetic protein 2 therapy for craniofacial surgery
    Darren M Smith
    University of Pittsburgh, Division of Plastic Surgery, Pittsburgh, Pennsylvania, USA
    J Craniofac Surg 19:1244-59. 2008
    ....
  26. pmc Bone regeneration mediated by BMP4-expressing muscle-derived stem cells is affected by delivery system
    Arvydas Usas
    Stem Cell Research Center, Children s Hospital of Pittsburgh of UPMC and Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Tissue Eng Part A 15:285-93. 2009
    ..In summary, hydrogels are suitable carriers for osteocompetent MDSCs in promoting bone regeneration, especially at craniofacial injury sites...
  27. ncbi request reprint The osteogenic potential of adipose-derived stem cells for the repair of rabbit calvarial defects
    Jason R Dudas
    Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Plast Surg 56:543-8. 2006
    ..The present study was designed to assess the osteogenic potential and utility of using ASCs to regenerate bone in a rabbit calvarial defect model...
  28. doi request reprint Effects of flutamide therapy on craniofacial growth and development in a model of craniosynostosis
    James Cray
    Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15201, USA
    J Craniofac Surg 21:711-8. 2010
    ..Results suggest that androgen receptor-blocking using flutamide may only provide a transient rescue to suture fusion in this model. Further research is needed to investigate the effects of hormones on suture development and maintenance...
  29. ncbi request reprint Intracranial volume changes in craniosynostotic rabbits: effects of age and surgical correction
    Gregory M Cooper
    Department of Orthopedic Surgery, the Cleft Palate Craniofacial Center, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Plast Reconstr Surg 117:1886-90. 2006
    ..The authors previously reported that bilateral coronal suture fusion resulted in a reduction in intracranial volume in a rabbit model of nonsyndromic, familial coronal suture synostosis...
  30. pmc Effect of host sex and sex hormones on muscle-derived stem cell-mediated bone formation and defect healing
    Laura B Meszaros
    Stem Cell Research Center, Department of Orthopaedic Surgery and Children s Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, USA
    Tissue Eng Part A 18:1751-9. 2012
    ..However, in this healing model, some volume differences were found between hosts of the same sex. In both models, these differences were attributed to varying rates of endochondral bone formation in male and female hosts...
  31. doi request reprint Precise control of osteogenesis for craniofacial defect repair: the role of direct osteoprogenitor contact in BMP-2-based bioprinting
    Darren M Smith
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Ann Plast Surg 69:485-8. 2012
    ..Here, we investigate the importance of direct contact between bioprinted BMP-2 and the dura mater (a source of osteoprogenitors) in mediating calvarial healing...
  32. pmc Age-related changes in craniofacial morphology in GDF-8 (myostatin)-deficient mice
    Lisa Vecchione
    Pittsburgh Cleft Craniofacial Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Anat Rec (Hoboken) 293:32-41. 2010
    ..These findings reiterate the role that masticatory muscle function plays on the ontogeny of the cranial vault, base, and most notably the mandible...
  33. doi request reprint Parasagittal suture after strip craniectomy
    Christopher R Kinsella
    Divisions of Pediatric Plastic Surgery, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Craniofac Surg 22:66-7. 2011
    ....
  34. doi request reprint A successful algorithm for limiting postoperative fistulae following palatal procedures in the patient with orofacial clefting
    Joseph E Losee
    Division of Plastic Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Plast Reconstr Surg 122:544-54. 2008
    ..Presented here is a successful algorithm for performing palatal procedures and decreasing the rate of postoperative fistulas in a large, single-surgeon, consecutive series...
  35. ncbi request reprint Noggin improves bone healing elicited by muscle stem cells expressing inducible BMP4
    Hairong Peng
    Growth and Development Laboratory, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Ther 12:239-46. 2005
    ..We believe that this regulatable tissue engineering strategy, enhanced by utilizing a specific antagonist, constitutes a new paradigm for tissue engineering and regenerative medicine...
  36. doi request reprint Scalp reconstruction: regeneration with acellular dermal matrix
    Christopher R Kinsella
    Division of Pediatric Plastic Surgery, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pennsylvania 15224, USA
    J Craniofac Surg 21:605-7. 2010
    ..Our group proposes a novel use of acellular dermal matrix (ADM) to preserve these deficient areas without the need for excision or staged management of osteomyelitic calvaria...
  37. ncbi request reprint Malignant transformation of multipotent muscle-derived cells by concurrent differentiation signals
    Jonathan B Pollett
    Stem Cell Research Center, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Stem Cells 25:2302-11. 2007
    ..This theory represents a potential link between somatic stem cells and cancer and suggests an involvement of the niche/environment in transformation...
  38. pmc Molecular analysis of coronal perisutural tissues in a craniosynostotic rabbit model using polymerase chain reaction suppression subtractive hybridization
    James J Cray
    Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh and Pediatric Craniofacial Biology Laboratory, Children s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA
    Plast Reconstr Surg 128:95-103. 2011
    ..To understand the pathogenesis of craniosynostosis, the authors compared gene expression in perisutural tissues between wild-type and craniosynostotic rabbits using polymerase chain reaction suppression subtractive hybridization...
  39. doi request reprint Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1
    Tomoyuki Matsumoto
    Stem Cell Research Center, Children s Hospital of Pittsburgh, and University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Arthritis Rheum 60:1390-405. 2009
    ....
  40. doi request reprint Calcium aluminate, RGD-modified calcium aluminate, and beta-tricalcium phosphate implants in a calvarial defect
    Natasa D Miljkovic
    Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15261, USA
    J Craniofac Surg 20:1538-43. 2009
    ..There was no soft tissue reaction around the beta-TCP implant. These observations suggest that more specific adhesion peptides may be needed to activate the bioinert CaAl implant and promote bone formation in the craniofacial skeleton...
  41. doi request reprint Demineralized bone matrix and resorbable mesh bilaminate cranioplasty: a novel method for reconstruction of large-scale defects in the pediatric calvaria
    Mimi T Chao
    Division of Pediatric Plastic Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh, PA, USA
    Plast Reconstr Surg 123:976-82. 2009
    ..The authors present their experience using demineralized bone matrix and resorbable mesh bilaminate for the repair of large-scale cranial defects in pediatric patients...
  42. pmc Molecular Analysis of Twist1 and FGF Receptors in a Rabbit Model of Craniosynostosis: Likely Exclusion as the Loci of Origin
    Phillip H Gallo
    Department of Plastic Surgery, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Genomics 2013:305971. 2013
    ..Although a locus in intronic or flanking sequences of FGFR3 remains possible, no direct structural mutation was identified for FGFR3...
  43. ncbi request reprint Transforming growth factor-beta isoform expression in the perisutural tissues of craniosynostotic rabbits
    Elyane Poisson
    Department of Orthodontics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Cleft Palate Craniofac J 41:392-402. 2004
    ....
  44. ncbi request reprint Coronal suturectomy does not cause acute postoperative displacement in the cranial bases of craniosynostotic rabbits
    David A Putz
    Departments of Anthropology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Craniofac Surg 13:196-201. 2002
    ..These findings suggest that postoperative cranial base changes may be related more to chronically altered growth patterns than to acutely altered changes in intracranial pressure or dural tension...
  45. doi request reprint Microanatomical variation of the nasal capsular cartilage in newborn primates
    Timothy D Smith
    School of Physical Therapy, Slippery Rock University, Pennsylvania, USA
    Anat Rec (Hoboken) 295:950-60. 2012
    ....
  46. doi request reprint Brief communication: Ectocranial suture closure in Pongo: pattern and phylogeny
    James Cray
    Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh, PA 15224, USA
    Am J Phys Anthropol 143:473-7. 2010
    ..However, the lateral-anterior pattern of fusion, in which there is a strong superior to inferior pattern, for Pongo is unique among these species, reflecting its phylogenetic distinctness among great ape taxa...
  47. pmc Timing of ectocranial suture activity in Gorilla gorilla as related to cranial volume and dental eruption
    James Cray
    Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Pittsburgh, PA, USA
    J Anat 218:471-9. 2011
    ..These data are suggestive of suture fusion extending further into ontogeny than brain expansion, similar to Homo and Pan. This finding allows for the possibility that masticatory forces influence ectocranial suture morphology...
  48. doi request reprint Comparative microcomputed tomography and histological study of maxillary pneumatization in four species of new world monkeys: the perinatal period
    Timothy D Smith
    School of Physical Therapy, Slippery Rock University, Slippery Rock, PA, USA
    Am J Phys Anthropol 144:392-410. 2011
    ..Taken together, these findings suggest that pneumatization in Saimiri is suppressed by an inward growth trajectory of the orbits, relatively large posterior dentition, and a correspondingly compressed nasal region...
  49. doi request reprint Divided parietal bone in plagiocephaly
    Regina A Fenton
    Division of Pediatric Plastic Surgery, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA
    J Craniofac Surg 22:355-8. 2011
    ..Disagreement exists as to how the presence of this suture affects the shape of the skull. We present a case of a supernumerary suture in the parietal bone leading to plagiocephaly and discuss the role this suture plays in cranial growth...
  50. ncbi request reprint VEGF and BMP expression in mouse osteosarcoma cells
    Kurt R Weiss
    Stem Cell Research Center, Children s Hospital of Pittsburgh and Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Clin Orthop Relat Res 450:111-7. 2006
    ..Inhibition of BMPs and VEGF should be investigated further as a possible strategy for decreasing the incidence of pulmonary metastases in osteosarcoma...
  51. ncbi request reprint Conversion Furlow palatoplasty: salvage of speech after straight-line palatoplasty and "incomplete intravelar veloplasty"
    Negin Noorchashm
    Division of Pediatric Plastic Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Ann Plast Surg 56:505-10. 2006
    ..We propose that a conversion Furlow palatoplasty performed with a "complete IVVP" will correct postoperative velopharyngeal insufficiency (VPI) and alleviate the need for pharyngoplasty...
  52. pmc Regression modeling to inform cell incorporation into therapies for craniosynostosis
    James Cray
    Department of Oral Biology, Surgery Plastic Surgery, and Orthodontics, Georgia, USA
    J Craniofac Surg 24:226-31. 2013
    ....
  53. pmc Accelerated calvarial healing in mice lacking Toll-like receptor 4
    Dan Wang
    Department of Plastic Surgery, University of Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e46945. 2012
    ..Further work is required to determine if this is due to inflammation driven by TLR4 activation...

Research Grants3

  1. Tissue Engineering a Suture Replacement for Children with Craniosynostosis
    Gregory Cooper; Fiscal Year: 2009
    ..The technology that will be developed in performing the proposed work will have broad impact on the field of stem cell biology, the application of tissue engineering, and on the treatment of children with craniosynostosis. ..
  2. Tissue Engineering a Suture Replacement for Children with Craniosynostosis
    Gregory M Cooper; Fiscal Year: 2010
    ..The technology that will be developed in performing the proposed work will have broad impact on the field of stem cell biology, the application of tissue engineering, and on the treatment of children with craniosynostosis. ..