M B Cohen

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. pmc Validation and characterization of a human volunteer challenge model for cholera by using frozen bacteria of the new Vibrio cholerae epidemic serotype, O139
    M B Cohen
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Infect Immun 67:6346-9. 1999
  2. pmc Randomized, controlled human challenge study of the safety, immunogenicity, and protective efficacy of a single dose of Peru-15, a live attenuated oral cholera vaccine
    Mitchell B Cohen
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Infect Immun 70:1965-70. 2002
  3. ncbi request reprint Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis
    Michael D Bates
    Division of Gastroenterology, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 122:1467-82. 2002
  4. ncbi request reprint Proguanylin secretion and the role of negative-feedback inhibition in a villous epithelial cell line
    Jeffrey A Rudolph
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Physiol Gastrointest Liver Physiol 283:G695-702. 2002
  5. ncbi request reprint Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model
    Elizabeth A Mann
    Division of Digestive Diseases, VA Medical Center and University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Cancer 116:500-5. 2005
  6. ncbi request reprint Novel mechanism of cyclic AMP mediated extracellular signal regulated kinase activation in an intestinal cell line
    Jeffrey A Rudolph
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio, 45229, United States
    Cell Signal 19:1221-8. 2007
  7. ncbi request reprint A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis
    Michael R Konikoff
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 131:1381-91. 2006
  8. ncbi request reprint The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response
    Noeet Elitsur
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, and The University of Cincinnati, OH 45229, USA
    J Pediatr Gastroenterol Nutr 43:S74-81. 2006
  9. pmc Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis
    Carine Blanchard
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:536-47. 2006
  10. ncbi request reprint Effect of secretagogues and pH on intestinal transport in guanylin-deficient mice
    Alan N Charney
    Nephrology Section, VA Medical Center and New York University School of Medicine, 423 E 23rd Street, New York, NY 10010, USA
    Biochim Biophys Acta 1671:79-86. 2004

Collaborators

  • David N Taylor
  • Sims K Kochi
  • M D Bates
  • J A Bezerra
  • R A Giannella
  • D Scott Merrell
  • Alan N Charney
  • F Qadri
  • Hui Dong
  • Elizabeth A Mann
  • Jeffrey A Rudolph
  • Kris A Steinbrecher
  • Carine Blanchard
  • Michael R Konikoff
  • Zachary M Sellers
  • Philip E Putnam
  • Noeet Elitsur
  • Amal H Assa'ad
  • Cassie Kirby
  • Sean C Jameson
  • Rachel Akers
  • Marc E Rothenberg
  • Margaret H Collins
  • Jennifer A Hawkins
  • Kwang Hyun Ko
  • Kim E Barrett
  • Anders Smith
  • Julia Pratt
  • Reena Mourya
  • Richard J Noel
  • Ning Wang
  • Simon P Hogan
  • John N Lorenz
  • Bridget K Buckmeier
  • Seema S Aceves
  • Alicia A McDonough
  • Keith F Stringer
  • J Pablo Abonia
  • Bruce J Aronow
  • Patricia C Fulkerson
  • Anil Mishra
  • Li E Yang
  • David Witte
  • Steve A Wowk
  • Guangju Luo
  • David P Witte

Detail Information

Publications14

  1. pmc Validation and characterization of a human volunteer challenge model for cholera by using frozen bacteria of the new Vibrio cholerae epidemic serotype, O139
    M B Cohen
    Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Infect Immun 67:6346-9. 1999
    ..This model provides a reproducible illness of sufficient severity for testing the efficacies of new O139 or combined O1-O139 vaccines...
  2. pmc Randomized, controlled human challenge study of the safety, immunogenicity, and protective efficacy of a single dose of Peru-15, a live attenuated oral cholera vaccine
    Mitchell B Cohen
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Infect Immun 70:1965-70. 2002
    ..This vaccine may therefore be a safe and effective tool to prevent cholera in travelers and is a strong candidate for further evaluation to prevent cholera in an area where cholera is endemic...
  3. ncbi request reprint Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis
    Michael D Bates
    Division of Gastroenterology, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Gastroenterology 122:1467-82. 2002
    ..We hypothesized that functional patterning along the A-P axis of the GI tract could be defined at the molecular level by analyzing expression profiles of large numbers of genes...
  4. ncbi request reprint Proguanylin secretion and the role of negative-feedback inhibition in a villous epithelial cell line
    Jeffrey A Rudolph
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Am J Physiol Gastrointest Liver Physiol 283:G695-702. 2002
    ..These data describe the use of C2/bbe1 cells as a model for proguanylin secretion in villous epithelial cells and demonstrate their potential use for the study of the regulatory mechanisms governing proguanylin synthesis and secretion...
  5. ncbi request reprint Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model
    Elizabeth A Mann
    Division of Digestive Diseases, VA Medical Center and University of Cincinnati, Cincinnati, OH 45267, USA
    Int J Cancer 116:500-5. 2005
    ..We propose that these alterations are a possible compensatory mechanism by which loss of GC-C signaling also affects tumorigenesis...
  6. ncbi request reprint Novel mechanism of cyclic AMP mediated extracellular signal regulated kinase activation in an intestinal cell line
    Jeffrey A Rudolph
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio, 45229, United States
    Cell Signal 19:1221-8. 2007
    ..These results directly implicate PKAII as a mediator of cell survival in T84 cells and provide evidence for an additional means by which cAMP can influence intestinal cell turnover...
  7. ncbi request reprint A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis
    Michael R Konikoff
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Gastroenterology 131:1381-91. 2006
    ..Although several therapies are advocated, no placebo-controlled trials have been conducted. We aimed to determine the efficacy of swallowed fluticasone propionate (FP) in the treatment of eosinophilic esophagitis...
  8. ncbi request reprint The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response
    Noeet Elitsur
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, and The University of Cincinnati, OH 45229, USA
    J Pediatr Gastroenterol Nutr 43:S74-81. 2006
    ..To explore the in vivo role of guanylin and uroguanylin in the regulation of sodium excretion, we used gene-targeted mice in which the uroguanylin, guanylin or the peptide receptor guanylate cyclase C gene expression had been ablated...
  9. pmc Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis
    Carine Blanchard
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Clin Invest 116:536-47. 2006
    ..Finally, mice deficient in the eotaxin receptor (also known as CCR3) were protected from experimental EE. These results implicate eotaxin-3 as a critical effector molecule for EE and provide insight into disease pathogenesis...
  10. ncbi request reprint Effect of secretagogues and pH on intestinal transport in guanylin-deficient mice
    Alan N Charney
    Nephrology Section, VA Medical Center and New York University School of Medicine, 423 E 23rd Street, New York, NY 10010, USA
    Biochim Biophys Acta 1671:79-86. 2004
    ..The effectiveness of guanylin in this segment suggests a difference in the intestinal secretory actions of STa and guanylin...
  11. pmc Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation
    Kris A Steinbrecher
    Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital Research Foundation, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Am J Pathol 161:2169-78. 2002
    ..We speculate that the increase in colonocyte number is related to decreased levels of cGMP and that this increase in proliferation plays a role in susceptibility to intestinal adenoma formation and/or progression...
  12. ncbi request reprint Coordinate upregulation of guanylin and uroguanylin expression by hypertonicity in HT29-18-N2 cells
    Kris A Steinbrecher
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Hospital Research Foundation, Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio 45229, USA
    Am J Physiol Cell Physiol 283:C1729-37. 2002
    ..We conclude that guanylin and uroguanylin are released in response to hypertonic stress and that regulation of these genes may be mediated by PKC isoforms...
  13. pmc Host-induced epidemic spread of the cholera bacterium
    D Scott Merrell
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nature 417:642-5. 2002
    ....
  14. ncbi request reprint Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3(-) secretion via a novel GC-C- and CFTR-independent pathway
    Zachary M Sellers
    Department of Medicine, Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
    FASEB J 22:1306-16. 2008
    ..Further understanding of this alternative receptor and its signaling pathway may provide important insights into rectification of intestinal bicarbonate secretion in cystic fibrosis...