M B Cohen
Affiliation: Children's Hospital Medical Center
- Validation and characterization of a human volunteer challenge model for cholera by using frozen bacteria of the new Vibrio cholerae epidemic serotype, O139M B Cohen
Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Infect Immun 67:6346-9. 1999..This model provides a reproducible illness of sufficient severity for testing the efficacies of new O139 or combined O1-O139 vaccines...
- Randomized, controlled human challenge study of the safety, immunogenicity, and protective efficacy of a single dose of Peru-15, a live attenuated oral cholera vaccineMitchell B Cohen
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Infect Immun 70:1965-70. 2002..This vaccine may therefore be a safe and effective tool to prevent cholera in travelers and is a strong candidate for further evaluation to prevent cholera in an area where cholera is endemic...
- Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysisMichael D Bates
Division of Gastroenterology, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Gastroenterology 122:1467-82. 2002..We hypothesized that functional patterning along the A-P axis of the GI tract could be defined at the molecular level by analyzing expression profiles of large numbers of genes...
- Proguanylin secretion and the role of negative-feedback inhibition in a villous epithelial cell lineJeffrey A Rudolph
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
Am J Physiol Gastrointest Liver Physiol 283:G695-702. 2002..These data describe the use of C2/bbe1 cells as a model for proguanylin secretion in villous epithelial cells and demonstrate their potential use for the study of the regulatory mechanisms governing proguanylin synthesis and secretion...
- Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse modelElizabeth A Mann
Division of Digestive Diseases, VA Medical Center and University of Cincinnati, Cincinnati, OH 45267, USA
Int J Cancer 116:500-5. 2005..We propose that these alterations are a possible compensatory mechanism by which loss of GC-C signaling also affects tumorigenesis...
- Novel mechanism of cyclic AMP mediated extracellular signal regulated kinase activation in an intestinal cell lineJeffrey A Rudolph
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio, 45229, United States
Cell Signal 19:1221-8. 2007..These results directly implicate PKAII as a mediator of cell survival in T84 cells and provide evidence for an additional means by which cAMP can influence intestinal cell turnover...
- A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitisMichael R Konikoff
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Gastroenterology 131:1381-91. 2006..Although several therapies are advocated, no placebo-controlled trials have been conducted. We aimed to determine the efficacy of swallowed fluticasone propionate (FP) in the treatment of eosinophilic esophagitis...
- The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic responseNoeet Elitsur
Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, and The University of Cincinnati, OH 45229, USA
J Pediatr Gastroenterol Nutr 43:S74-81. 2006..To explore the in vivo role of guanylin and uroguanylin in the regulation of sodium excretion, we used gene-targeted mice in which the uroguanylin, guanylin or the peptide receptor guanylate cyclase C gene expression had been ablated...
- Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitisCarine Blanchard
Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Clin Invest 116:536-47. 2006..Finally, mice deficient in the eotaxin receptor (also known as CCR3) were protected from experimental EE. These results implicate eotaxin-3 as a critical effector molecule for EE and provide insight into disease pathogenesis...
- Effect of secretagogues and pH on intestinal transport in guanylin-deficient miceAlan N Charney
Nephrology Section, VA Medical Center and New York University School of Medicine, 423 E 23rd Street, New York, NY 10010, USA
Biochim Biophys Acta 1671:79-86. 2004..The effectiveness of guanylin in this segment suggests a difference in the intestinal secretory actions of STa and guanylin...
- Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferationKris A Steinbrecher
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children s Hospital Research Foundation, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Am J Pathol 161:2169-78. 2002..We speculate that the increase in colonocyte number is related to decreased levels of cGMP and that this increase in proliferation plays a role in susceptibility to intestinal adenoma formation and/or progression...
- Coordinate upregulation of guanylin and uroguanylin expression by hypertonicity in HT29-18-N2 cellsKris A Steinbrecher
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children s Hospital Research Foundation, Children s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio 45229, USA
Am J Physiol Cell Physiol 283:C1729-37. 2002..We conclude that guanylin and uroguanylin are released in response to hypertonic stress and that regulation of these genes may be mediated by PKC isoforms...
- Host-induced epidemic spread of the cholera bacteriumD Scott Merrell
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
Nature 417:642-5. 2002....
- Heat-stable enterotoxin of Escherichia coli (STa) can stimulate duodenal HCO3(-) secretion via a novel GC-C- and CFTR-independent pathwayZachary M Sellers
Department of Medicine, Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA
FASEB J 22:1306-16. 2008..Further understanding of this alternative receptor and its signaling pathway may provide important insights into rectification of intestinal bicarbonate secretion in cystic fibrosis...