Constantinos Chrysostomou

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. doi request reprint A phase II/III, multicenter, safety, efficacy, and pharmacokinetic study of dexmedetomidine in preterm and term neonates
    Constantinos Chrysostomou
    Department of Pediatric Critical Care Medicine, Cardiac Intensive Care Unit, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA Electronic address
    J Pediatr 164:276-82.e1-3. 2014
  2. doi request reprint Short- and intermediate-term survival after extracorporeal membrane oxygenation in children with cardiac disease
    Constantinos Chrysostomou
    Department of Critical Care Medicine, Cardiac Intensive Care Unit, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    J Thorac Cardiovasc Surg 146:317-25. 2013
  3. doi request reprint Dexmedetomidine: therapeutic use for the termination of reentrant supraventricular tachycardia
    Constantinos Chrysostomou
    Department of Critical Care Medicine, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    Congenit Heart Dis 8:48-56. 2013
  4. pmc Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations
    Constantinos Chrysostomou
    Department of Critical Care Medicine, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Ann Thorac Surg 92:964-72; discussion 972. 2011
  5. doi request reprint Dexmedetomidine use in a pediatric cardiac intensive care unit: can we use it in infants after cardiac surgery?
    Constantinos Chrysostomou
    Department of Pediatrics and Critical Care Medicine, Division of Cardiac Intensive Care, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pediatr Crit Care Med 10:654-60. 2009
  6. doi request reprint Dexmedetomidine: a novel drug for the treatment of atrial and junctional tachyarrhythmias during the perioperative period for congenital cardiac surgery: a preliminary study
    Constantinos Chrysostomou
    Department of Cardiology, Cardiac ICU, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
    Anesth Analg 107:1514-22. 2008
  7. ncbi request reprint Dexmedetomidine: sedation, analgesia and beyond
    Constantinos Chrysostomou
    University of Pittsburgh Medical Center, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Expert Opin Drug Metab Toxicol 4:619-27. 2008
  8. ncbi request reprint Use of dexmedetomidine in children after cardiac and thoracic surgery
    Constantinos Chrysostomou
    Department of Critical Care Medicine, Division of Pediatric Cardiac Critical Care, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pediatr Crit Care Med 7:126-31. 2006
  9. doi request reprint Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease
    Constantinos Chrysostomou
    Department of Pediatric Cardiology, Division of Cardiac Intensive Care, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201, USA
    Intensive Care Med 36:836-42. 2010
  10. pmc Giant aneurysm of the atrial septum associated with premature closure of foramen ovale
    Constantinos Chrysostomou
    Division of Cardiac Intensive Care, Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, USA
    Cardiovasc Ultrasound 3:20. 2005

Collaborators

Detail Information

Publications21

  1. doi request reprint A phase II/III, multicenter, safety, efficacy, and pharmacokinetic study of dexmedetomidine in preterm and term neonates
    Constantinos Chrysostomou
    Department of Pediatric Critical Care Medicine, Cardiac Intensive Care Unit, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA Electronic address
    J Pediatr 164:276-82.e1-3. 2014
    ..To investigate the safety, efficacy, and pharmacokinetic profile of dexmedetomidine in preterm and full-term neonates ≥ 28 to ≤ 44 weeks gestational age...
  2. doi request reprint Short- and intermediate-term survival after extracorporeal membrane oxygenation in children with cardiac disease
    Constantinos Chrysostomou
    Department of Critical Care Medicine, Cardiac Intensive Care Unit, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    J Thorac Cardiovasc Surg 146:317-25. 2013
    ..Despite established acceptance, ECMO outcomes are suboptimal with a survival between 38% and 55%. We evaluated factors associated with significantly increased survival in cardiac patients requiring ECMO...
  3. doi request reprint Dexmedetomidine: therapeutic use for the termination of reentrant supraventricular tachycardia
    Constantinos Chrysostomou
    Department of Critical Care Medicine, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA
    Congenit Heart Dis 8:48-56. 2013
    ..Dexmedetomidine has recently been shown to have potential antiarrhythmic effects, and here we describe our experience in the acute termination of reentrant SVT...
  4. pmc Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations
    Constantinos Chrysostomou
    Department of Critical Care Medicine, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    Ann Thorac Surg 92:964-72; discussion 972. 2011
    ..Whether routine perioperative use of DEX decreases the incidence of supraventricular and ventricular tachyarrhythmias was studied...
  5. doi request reprint Dexmedetomidine use in a pediatric cardiac intensive care unit: can we use it in infants after cardiac surgery?
    Constantinos Chrysostomou
    Department of Pediatrics and Critical Care Medicine, Division of Cardiac Intensive Care, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pediatr Crit Care Med 10:654-60. 2009
    ..To assess clinical response of dexmedetomidine alone or in combination with conventional sedatives/analgesics after cardiac surgery...
  6. doi request reprint Dexmedetomidine: a novel drug for the treatment of atrial and junctional tachyarrhythmias during the perioperative period for congenital cardiac surgery: a preliminary study
    Constantinos Chrysostomou
    Department of Cardiology, Cardiac ICU, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
    Anesth Analg 107:1514-22. 2008
    ..Though some animal data have shown that it can prevent certain types of ventricular tachycardia, its therapeutic role during these types of arrhythmias has not been studied...
  7. ncbi request reprint Dexmedetomidine: sedation, analgesia and beyond
    Constantinos Chrysostomou
    University of Pittsburgh Medical Center, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA
    Expert Opin Drug Metab Toxicol 4:619-27. 2008
    ..However, beyond its well-known properties, dexmedetomidine has recently been investigated for its potential in many other clinical scenarios, including neuroprotection, cardioprotection and renoprotection, with promising results...
  8. ncbi request reprint Use of dexmedetomidine in children after cardiac and thoracic surgery
    Constantinos Chrysostomou
    Department of Critical Care Medicine, Division of Pediatric Cardiac Critical Care, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pediatr Crit Care Med 7:126-31. 2006
    ..In this report, we describe our experience with the use of dexmedetomidine in spontaneously breathing as well as in mechanically ventilated patients, after congenital cardiac and thoracic surgery...
  9. doi request reprint Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease
    Constantinos Chrysostomou
    Department of Pediatric Cardiology, Division of Cardiac Intensive Care, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201, USA
    Intensive Care Med 36:836-42. 2010
    ..Assessment of electrocardiographic (ECG) effects of dexmedetomidine...
  10. pmc Giant aneurysm of the atrial septum associated with premature closure of foramen ovale
    Constantinos Chrysostomou
    Division of Cardiac Intensive Care, Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, USA
    Cardiovasc Ultrasound 3:20. 2005
    ..We describe the case of a 1 day old infant in whom PCFO resulted in severe right heart failure in addition to the formation of a giant atrial septal aneurysm...
  11. pmc Critical congenital heart disease--utility of routine screening for chromosomal and other extracardiac malformations
    Kimberly Baker
    Critical Care Medicine, Akron Children s Hospital, Akron, PA, USA
    Congenit Heart Dis 7:145-50. 2012
    ..Universal screening for these abnormalities with ultrasonographic and genetic testing maybe warranted because early detection could impact short and long-term outcomes...
  12. doi request reprint Diagnosis of abnormal diaphragm motion after cardiothoracic surgery: ultrasound performed by a cardiac intensivist vs. fluoroscopy
    Joan Sanchez De Toledo
    Division of Cardiac Intensive Care, Department of Pediatrics and Critical Care Medicine, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Penn 15224, USA
    Congenit Heart Dis 5:565-72. 2010
    ....
  13. doi request reprint Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study
    Judith P Lazol
    Department of Pediatric Cardiology, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pediatr Crit Care Med 11:589-92. 2010
    ..To characterize the effects of dexmedetomidine on the pulmonary artery pressure in patients after congenital cardiac surgery...
  14. doi request reprint Do neonates, infants and young children need a higher dose of enoxaparin in the cardiac intensive care unit?
    Joan Sanchez De Toledo
    Division of Cardiac Intensive Care, Department of Pediatrics and Critical Care Medicine, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Penn Avenue 45th Street, Pittsburgh, PA 15201, USA
    Cardiol Young 20:138-43. 2010
    ..The purpose of this study was to evaluate whether children less than 2 years old admitted to the cardiac intensive care unit require a higher enoxaparin dose than that currently recommended to achieve target anti-factor Xa levels...
  15. doi request reprint Total cavopulmonary connection in patients with apicocaval juxtaposition: optimal conduit route using preoperative angiogram and flow simulation
    Masahiro Yoshida
    Department of Cardiothoracic Surgery, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15201, USA
    Eur J Cardiothorac Surg 44:e46-52. 2013
    ..The purpose of this study was to identify a preoperative method for optimal conduit position using the IVC anatomy and computational fluid dynamics (CFD)...
  16. ncbi request reprint Cerebral regional oxygen saturation and serum neuromarkers for the prediction of adverse neurologic outcome in pediatric cardiac surgery
    Joan Sanchez-de-Toledo
    Pediatric Cardiac Intensive Care Unit, University of Pittsburgh, Pittsburgh, PA, USA
    Neurocrit Care 21:133-9. 2014
    ....
  17. doi request reprint Dexmedetomidine as the primary sedative during invasive procedures in infants and toddlers with congenital heart disease
    Kristin P Barton
    Division of Cardiology, Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Pediatr Crit Care Med 9:612-5. 2008
    ..In this report, we describe the use of dexmedetomidine as the primary sedative agent while performing invasive procedures in infants and toddlers with congenital heart disease who are breathing spontaneously...
  18. doi request reprint Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric cardiac surgery: a randomized controlled study
    Ana M Manrique
    Department of Pediatrics, Heart Center, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA
    J Thorac Cardiovasc Surg 139:162-169.e2. 2010
    ....
  19. doi request reprint Kounis syndrome or allergic coronary vasospasm in a two-year-old
    Brodie Parent
    University of Pittsburgh, School of Medicine, Children s Hospital of Pittsburgh of UPMC, 45th and Penn Avenue, Pittsburgh, PA 15201, USA
    Congenit Heart Dis 6:499-503. 2011
    ..We report the clinical course of this patient and postulate that Kounis syndrome was the explanation for his transient coronary vasospasm. To date, this is the youngest known patient with reported Kounis syndrome...
  20. doi request reprint Preoperative management in patients with single-ventricle physiology
    Evonne Krushansky
    Department of Pediatrics, Division of Cardiology, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15201, USA
    Congenit Heart Dis 7:96-102. 2012
    ..The objective of this study was to review our institutional experience managing preoperative patients with single-ventricle physiology using a combination of afterload reduction and inhaled hypoxemic therapy...