Yi Wen Chen

Summary

Affiliation: Children's National Medical Center
Country: USA

Publications

  1. ncbi request reprint Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32
    Matthew C Kostek
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Physiol Genomics 31:42-52. 2007
  2. ncbi request reprint Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease
    Zhiyong Chen
    Department of Vascular and Applied Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Hum Genet 122:367-72. 2007
  3. pmc IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse
    Matthew C Kostek
    Laboratory of Muscle and Translational Therapeutics, Department of Exercise Science, University of South Carolina, Columbia, SC, USA
    BMC Musculoskelet Disord 13:106. 2012
  4. ncbi request reprint Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy
    Y W Chen
    Research Center for Genetic Medicine, Children s National Medical Center, George Washington University, Washington, DC, USA
    Neurology 65:826-34. 2005
  5. pmc Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis
    Yi Wen Chen
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC, USA
    BMC Immunol 9:43. 2008
  6. ncbi request reprint Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb-MyoD pathways in muscle regeneration
    Marina Bakay
    Research Center for Genetic Medicine, Children s National Medical Center, Washington DC 20010, USA
    Brain 129:996-1013. 2006
  7. pmc Development and production of an oligonucleotide MuscleChip: use for validation of ambiguous ESTs
    Rehannah H A Borup
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue N W, Washington, DC 20010, USA
    BMC Bioinformatics 3:33. 2002
  8. pmc Response of rat muscle to acute resistance exercise defined by transcriptional and translational profiling
    Yi Wen Chen
    Research Center for Genetic Medicine, Children s National Medical Center and George Washington University, Washington DC, USA
    J Physiol 545:27-41. 2002
  9. ncbi request reprint Molecular responses of human muscle to eccentric exercise
    Yi Wen Chen
    Center for Genetic Medicine, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
    J Appl Physiol 95:2485-94. 2003
  10. ncbi request reprint Interactively optimizing signal-to-noise ratios in expression profiling: project-specific algorithm selection and detection p-value weighting in Affymetrix microarrays
    Jinwook Seo
    Research Center for Genetic Medicine, Children s National Medical Center, MD, USA
    Bioinformatics 20:2534-44. 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32
    Matthew C Kostek
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Physiol Genomics 31:42-52. 2007
    ..The molecular differences might contribute to mechanisms underlying the physiological adaptations seen with training using the two modes of exercise...
  2. ncbi request reprint Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease
    Zhiyong Chen
    Department of Vascular and Applied Surgery, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Hum Genet 122:367-72. 2007
    ..Odds ratios ranged from 4.72 to 12.57 in individuals carrying any two of these three markers. These findings suggested that the susceptibility to BD was in part controlled by genes involved in the innate and adaptive immunity...
  3. pmc IL-6 signaling blockade increases inflammation but does not affect muscle function in the mdx mouse
    Matthew C Kostek
    Laboratory of Muscle and Translational Therapeutics, Department of Exercise Science, University of South Carolina, Columbia, SC, USA
    BMC Musculoskelet Disord 13:106. 2012
    ..The purpose of the current study was to examine the effect of blocking IL-6 signaling on the muscle phenotype including muscle weakness and pathology in the mdx mouse...
  4. ncbi request reprint Early onset of inflammation and later involvement of TGFbeta in Duchenne muscular dystrophy
    Y W Chen
    Research Center for Genetic Medicine, Children s National Medical Center, George Washington University, Washington, DC, USA
    Neurology 65:826-34. 2005
    ..To identify stage-specific induction of molecular pathology pathways in Duchenne muscular dystrophy (DMD)...
  5. pmc Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis
    Yi Wen Chen
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC, USA
    BMC Immunol 9:43. 2008
    ....
  6. ncbi request reprint Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb-MyoD pathways in muscle regeneration
    Marina Bakay
    Research Center for Genetic Medicine, Children s National Medical Center, Washington DC 20010, USA
    Brain 129:996-1013. 2006
    ..Our data is consistent with mutations of nuclear lamina components leading to destabilization of the transcriptome in differentiated cells...
  7. pmc Development and production of an oligonucleotide MuscleChip: use for validation of ambiguous ESTs
    Rehannah H A Borup
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue N W, Washington, DC 20010, USA
    BMC Bioinformatics 3:33. 2002
    ..The 120,000 oligonucleotides were synthesized by photolithography and light-activated chemistry on each microarray...
  8. pmc Response of rat muscle to acute resistance exercise defined by transcriptional and translational profiling
    Yi Wen Chen
    Research Center for Genetic Medicine, Children s National Medical Center and George Washington University, Washington DC, USA
    J Physiol 545:27-41. 2002
    ..This novel finding of p53 induction following exercise also demonstrates the power of expression profiling for identification of novel pathways involved in the response to muscle contraction...
  9. ncbi request reprint Molecular responses of human muscle to eccentric exercise
    Yi Wen Chen
    Center for Genetic Medicine, Children s National Medical Center, George Washington University, Washington, DC 20010, USA
    J Appl Physiol 95:2485-94. 2003
    ....
  10. ncbi request reprint Interactively optimizing signal-to-noise ratios in expression profiling: project-specific algorithm selection and detection p-value weighting in Affymetrix microarrays
    Jinwook Seo
    Research Center for Genetic Medicine, Children s National Medical Center, MD, USA
    Bioinformatics 20:2534-44. 2004
    ..Also, we hypothesized that use of the Microarray Suite (MAS) 5.0 probe set detection p-value as a weighting function would improve the performance of all probe set algorithms...
  11. ncbi request reprint Nuclear factor 90 mediates activation of the cellular antiviral expression cascade
    Irina Krasnoselskaya-Riz
    Department of Biochemistry and Molecular Biology, George Washington University School of Medicine, Washington, D C 20037, USA
    AIDS Res Hum Retroviruses 18:591-604. 2002
    ..This leads to a hypothesis as to the mechanism of action of NF90 in mediating endogenous antiviral responses...
  12. pmc Sources of variability and effect of experimental approach on expression profiling data interpretation
    Marina Bakay
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue, NW Washington, DC 20010 USA
    BMC Bioinformatics 3:4. 2002
    ....
  13. ncbi request reprint Transcriptional pathways associated with skeletal muscle disuse atrophy in humans
    Yi Wen Chen
    Center for Genetic Medicine Research, Children s National Medical Center, George Washington University, Washington, District of Columbia, USA
    Physiol Genomics 31:510-20. 2007
    ..Information obtained in this study complements findings in animal models of disuse and provides important feedback for future clinical studies targeting the restoration of muscle function following limb disuse in humans...
  14. ncbi request reprint Genetic medicine and the muscular dystrophies: triumphs and tribulations
    Eric P Hoffman
    Research Center for Genetic Medicine, Children s National Medical Center Pediatrics, George Washington University, Washington, DC 20010, USA
    Dev Med Child Neurol 44:136-40. 2002
  15. pmc miR-411 is up-regulated in FSHD myoblasts and suppresses myogenic factors
    Naoe Harafuji
    Center for Genetic Medicine Research, Children s Research Institute, Washington, DC, USA
    Orphanet J Rare Dis 8:55. 2013
    ..In addition, misregulation of microRNAs (miRNAs) has been reported in muscular dystrophies including FSHD. In this study, we identified a miRNA that is differentially expressed in FSHD myoblasts and investigated its function...
  16. pmc The role of TRAIL in mediating autophagy in myositis skeletal muscle: a potential nonimmune mechanism of muscle damage
    Heather M Alger
    Children s National Medical Center and George Washington University Medical Center, Washington, DC, USA
    Arthritis Rheum 63:3448-57. 2011
    ..We undertook this study to investigate the role of TRAIL in cell death and pathogenesis in vitro and in vivo, using myositis muscle tissues from humans and mice...
  17. pmc DUX4, a candidate gene of facioscapulohumeral muscular dystrophy, encodes a transcriptional activator of PITX1
    Manjusha Dixit
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC 20010, USA
    Proc Natl Acad Sci U S A 104:18157-62. 2007
    ..Our results suggest that up-regulation of both DUX4 and PITX1 in FSHD muscles may play critical roles in the molecular mechanisms of the disease...
  18. pmc Alterations in mRNA expression and protein products following spinal cord injury in humans
    Maria L Urso
    Department of Exercise Science, University of Massachusetts, Amherst, MA 01003, USA
    J Physiol 579:877-92. 2007
    ..Increased protein levels for PSMD11 and the metallothioneins 5 days post-SCI, specifically along the cell periphery, indicate that proteins in this region may be early targets for degradation post-SCI...
  19. ncbi request reprint Expression profiling of FSHD muscle supports a defect in specific stages of myogenic differentiation
    Sara T Winokur
    Department of Biological Chemistry, 202 Sprague Hall, University of California, Irvine, CA 92697, USA
    Hum Mol Genet 12:2895-907. 2003
    ..Improper nuclear localization of 4qter is discussed as an alternative model for FSHD gene regulation and pathogenesis...
  20. ncbi request reprint Analysis of human skeletal muscle after 48 h immobilization reveals alterations in mRNA and protein for extracellular matrix components
    Maria L Urso
    Department of Exercise Science, 110 Totman Bldg, University of Massachusetts, Amherst, 01003, USA
    J Appl Physiol 101:1136-48. 2006
    ..Our results suggest that 48 h of immobilization increases mRNA content for components of the UPP and metallothionein function while decreasing mRNA and protein for ECM components as well as decreased phosphorylation of Akt...
  21. ncbi request reprint Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction
    Kanneboyina Nagaraju
    Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Arthritis Rheum 52:1824-35. 2005
    ..This study was undertaken to investigate these pathways in myositis patients and in a class I major histocompatibility complex (MHC)-transgenic mouse model of myositis...
  22. ncbi request reprint Downregulation of myelination, energy, and translational genes in Menkes disease brain
    Po Ching Liu
    Unit on Pediatric Genetics, Laboratory of Clinical Genomics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1834, USA
    Mol Genet Metab 85:291-300. 2005
    ..Thirty known genes were altered in both cortex and cerebellum. Downregulation of genes involved in myelination, energy metabolism, and translation was the major finding. The cerebellum was more sensitive to copper deficiency...

Research Grants7

  1. Molecular pathophysiology of facioscapulohumeral muscul*
    Yi Wen Chen; Fiscal Year: 2003
    ..Further studies will likely include the delineation of a complete picture of the pathophysiology of FSHD, as well as identification of functional SNPs in the refined gene list that correlate with disease severity. ..
  2. Molecular Pathphysiology of FSHD muscular dystrophy via genome-wide approaches
    Yi Wen Chen; Fiscal Year: 2010
    ..The proposed research will identify key players in the pathological cascades of FSHD and define the interactions among them, which could potentially be used for developing treatments of the disease. ..
  3. Molecular Pathphysiology of FSHD muscular dystrophy via genome-wide approaches
    Yi Wen Chen; Fiscal Year: 2009
    ..A research associate will be hired to assist the experiments proposed in the aims with focus on aim 4C. ..
  4. Molecular Pathphysiology of FSHD muscular dystrophy via genome-wide approaches
    Yi Wen Chen; Fiscal Year: 2010
    ..The proposed research will identify key players in the pathological cascades of FSHD and define the interactions among them, which could potentially be used for developing treatments of the disease. ..