Marcia A Chan

Summary

Affiliation: Children's Mercy Hospital
Country: USA

Publications

  1. pmc Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells
    Marcia A Chan
    Department of Pediatrics, Division of Immunology Research, Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    Clin Transl Allergy 3:29. 2013
  2. doi request reprint Asthma-related SNP in FCER2 is associated with increased expression of IL-4R on human B cells
    M A Chan
    Department of Pediatric Immunology, Children s Mercy Hospital, Kansas City, MO, USA
    Int J Immunogenet 38:533-8. 2011
  3. doi request reprint CD23-mediated cell signaling in human B cells differs from signaling in cells of the monocytic lineage
    Marcia A Chan
    Department of Pediatric Immunology Research, Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Clin Immunol 137:330-6. 2010
  4. doi request reprint FCER2 (CD23) asthma-related single nucleotide polymorphisms yields increased IgE binding and Egr-1 expression in human B cells
    Marcia A Chan
    Department of Pediatrics, Division of Immunology Research, Children s Mercy Hospitals and Clinics, Kansas City, Missouri
    Am J Respir Cell Mol Biol 50:263-9. 2014
  5. pmc The role of CD23 in IgE dependent signaling: implications from pharmacogenetics
    Lanny J Rosenwasser
    Allergy Immunology Division, Children s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA
    Trans Am Clin Climatol Assoc 122:27-33. 2011

Detail Information

Publications5

  1. pmc Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells
    Marcia A Chan
    Department of Pediatrics, Division of Immunology Research, Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    Clin Transl Allergy 3:29. 2013
    ..In vitro studies and animal models support the hypothesis that omalizumab inhibits IgE synthesis by B cells and causes elimination of IgE-expressing cells either by induction of apoptosis or induction of anergy or tolerance...
  2. doi request reprint Asthma-related SNP in FCER2 is associated with increased expression of IL-4R on human B cells
    M A Chan
    Department of Pediatric Immunology, Children s Mercy Hospital, Kansas City, MO, USA
    Int J Immunogenet 38:533-8. 2011
    ..Our data suggest that the SNP may favour increased IgE production through increased responsiveness to IL-4 in patients possessing this genotype...
  3. doi request reprint CD23-mediated cell signaling in human B cells differs from signaling in cells of the monocytic lineage
    Marcia A Chan
    Department of Pediatric Immunology Research, Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Clin Immunol 137:330-6. 2010
    ..Activation of the tyrosine kinase Fyn and the serine/threonine kinase Akt were only observed in B cells. These results suggest that the CD23-mediated signal transduction pathways in human B cells and human monocytes are different...
  4. doi request reprint FCER2 (CD23) asthma-related single nucleotide polymorphisms yields increased IgE binding and Egr-1 expression in human B cells
    Marcia A Chan
    Department of Pediatrics, Division of Immunology Research, Children s Mercy Hospitals and Clinics, Kansas City, Missouri
    Am J Respir Cell Mol Biol 50:263-9. 2014
    ..These observations may have implications in mechanisms responsible for the atopic phenotypes observed in patients with asthma who possess this genotype. ..
  5. pmc The role of CD23 in IgE dependent signaling: implications from pharmacogenetics
    Lanny J Rosenwasser
    Allergy Immunology Division, Children s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA
    Trans Am Clin Climatol Assoc 122:27-33. 2011
    ..A discussion of these three findings is presented...