Research Topics
| Kim M CecilSummaryAffiliation: Children's Hospital Medical Center Country: USA Publications
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Publications
Magnetic resonance spectroscopy and metabolic imaging in white matter diseases and pediatric disordersKim M Cecil
Department of Radiology and Pediatrics, Cincinnati Children s Hospital Medical Center and the College of Medicine of the University of Cincinnati, Cincinnati, OH 45229, USA
Top Magn Reson Imaging 17:275-93. 2006..With this composite summary, the reader should find it easier to implement and interpret spectroscopy in the clinical setting for the diagnosis and monitoring of patients with white matter disorders...
Proton magnetic resonance spectroscopy in adults with childhood lead exposureKim M Cecil
Cincinnati Children s Environmental Health Center at Cincinnati Children s Hospital Medical Center, Ohio 45229, USA
Environ Health Perspect 119:403-8. 2011..Childhood lead exposure adversely affects neurodevelopment. However, few studies have examined changes in human brain metabolism that may underlie known adverse cognitive and behavioral outcomes...- Altered myelination and axonal integrity in adults with childhood lead exposure: a diffusion tensor imaging studyChristopher J Brubaker
Cincinnati Children s Environmental Health Center at the Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Neurotoxicology 30:867-75. 2009..This study indicates that childhood lead exposure is associated with a significant and persistent impact on white matter microstructure as quantified with diffusivity changes suggestive of altered myelination and axonal integrity... - Lithium treatment effects on Myo-inositol in adolescents with bipolar depressionNick C Patel
Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0004, USA
Biol Psychiatry 60:998-1004. 2006..This study used proton magnetic resonance spectroscopy (1H MRS) to identify the in vivo effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression... - Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy studyMelissa P DelBello
Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
Neuropsychopharmacology 31:1264-73. 2006..Additionally, olanzapine-induced increases in choline may lead to alteration of abnormalities in cell membrane metabolism or second messenger pathways that are thought to be involved in the pathophysiology of bipolar disorder... - The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language functionWeihong Yuan
Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
Pediatrics 118:971-7. 2006..CONCLUSION: This study indicates that childhood lead exposure has a significant and persistent impact on brain reorganization associated with language function... - Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disordersKim M Cecil
Imaging Research Center, Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Child Adolesc Psychopharmacol 13:545-55. 2003.... - Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy studyDiana M Lindquist
Imaging Research Center, Dept of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Schizophr Res 128:83-90. 2011..Only the Cho/Cr ratio showed a significant time-by-treatment effect (p=0.0285). These results are in agreement with previous studies of the striatum. However, regional and disease-specific effects remain unresolved... - Elevated lactate as an early marker of brain injury in inflicted traumatic brain injuryKathi L Makoroff
Department of Pediatrics, Mayerson Center for Safe and Healthy Children, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Pediatr Radiol 35:668-76. 2005..The metabolic and neurochemical abnormalities that underlie traumatic brain injury remain poorly understood, but hypoxia-ischemic injury might play an important role... - The clinical syndrome of creatine transporter deficiencyTon J DeGrauw
Division of Neurology, Childrens Hospital Medical Center, Cincinnati, OH 45229, USA
Mol Cell Biochem 244:45-8. 2003..MR Spectroscopy is a non-invasive method for obtaining a preliminary diagnosis of this disorder. Muscle creatine uptake may be normal in this disorder... - The influence of age of lead exposure on adult gray matter volumeChristopher J Brubaker
Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Neurotoxicology 31:259-66. 2010..This study demonstrates that maximum blood lead levels do not fully account for gray matter changes associated with childhood lead exposure, particularly in the frontal lobes of young men... - Presence of normal creatine in the muscle of a patient with a mutation in the creatine transporter: a case studyGail J Pyne-Geithman
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Mol Cell Biochem 262:35-9. 2004..Identifying this alternative creatine-transport mechanism may be useful in treating the neurologic and cognitive impairments of patients with creatine-transporter deficiency... - Incidence of brain creatine transporter deficiency in males with developmental delay referred for brain magnetic resonance imagingAmy Newmeyer
Division of Developmental Disabilities, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Dev Behav Pediatr 26:276-82. 2005..This study suggests that brain creatine deficiency is an important consideration in the differential diagnosis of males with global developmental delay referred for brain MRI; brain MRS should be considered in such cases... 
Late proton magnetic resonance spectroscopy following traumatic brain injury during early childhood: relationship with neurobehavioral outcomesNicolay Chertkoff Walz
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Neurotrauma 25:94-103. 2008..Some neurometabolite levels differed between the TBI and OI groups more than 1 year post-injury and were related to injury severity, as well as some neurobehavioral outcomes following TBI during early childhood...- MR imaging and spectroscopy in juvenile Huntington diseaseMark Schapiro
Division of Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Pediatr Radiol 34:640-3. 2004..Imaging findings of caudate atrophy and abnormal T2 prolongation in the putamina with MR spectroscopy findings consistent with dense gliosis can be helpful indicators of juvenile Huntington disease... - Pediatric sports-related concussion produces cerebral blood flow alterationsTodd A Maugans
Division of Neurosurgery, Department of Surgery, Cincinnati Children s Hospital Medical Center, MLC 2016, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
Pediatrics 129:28-37. 2012..The authors of this investigation explore these possibilities after pediatric SRC... - Correlation of diffusion tensor imaging with executive function measures after early childhood traumatic brain injuryBrad Kurowski
Department of Pediatric Rehabilitation Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
J Pediatr Rehabil Med 2:273-83. 2009..Examine relationships of diffusion tensor imaging (DTI) fractional anisotropy (FA) to executive function (EF) and attention measures following early childhood (3-7 years) traumatic brain injury (TBI)... - Magnetic resonance spectroscopy in a 9-day-old heterozygous female child with creatine transporter deficiencyKim M Cecil
Division of Radiology, Children s Hospital Medical Center, University of Cincinnati Medical Center, OH 45229, USA
J Comput Assist Tomogr 27:44-7. 2003..A 9-day-old heterozygous female child with this syndrome demonstrated a significant reduction of creatine on proton MRS. She is a carrier of the R514X nonsense mutation... - Megalencephalic leukoencephalopathy with subcortical cysts: a third confirmed case with literature reviewLili Miles
Division of Pathology and Laboratory Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
Pediatr Dev Pathol 12:180-6. 2009..597+1G>A), the 1st leading to deletion of amino acids 60 to 89 and the 2nd to deletion of amino acids 194 to 199. Fine uniform vacuolation of white matter with wide separation of myelinated axons is the hallmark of MLC in early childhood... - MR spectroscopy of metabolic disordersKim M Cecil
Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Neuroimaging Clin N Am 16:87-116, viii. 2006..Although many conditions have a similar presentation, MRS offers valuable information for the individual patient in diagnosis and therapy when integrated fully into the clinical setting... - Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopyKim M Cecil
Imaging Research Center, Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Bipolar Disord 4:357-65. 2002..Patients with bipolar disorder having a manic or mixed episode were hypothesized to demonstrate metabolic abnormalities within the frontal lobe... - Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapyKim M Cecil
Department of Radiology MLC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Comput Assist Tomogr 26:948-51. 2002..Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment. Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole... - Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementationKim M Cecil
Department of Radiology MC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Comput Assist Tomogr 26:818-20. 2002..Recognition of this chemical on brain proton MRS as an exogenous compound is necessary to avoid confusion as a pathologic metabolite of pediatric metabolic disease... - Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithiumNick C Patel
College of Pharmacy, University of Georgia, Medical College of Georgia, Augusta, Georgia 30912 2450, USA
J Child Adolesc Psychopharmacol 18:132-9. 2008..This proton magnetic resonance spectroscopy (1H MRS) study identified the in vivo effects of lithium on N-acetyl-aspartate (NAA) concentrations in adolescent bipolar depression... - Decreased brain volume in adults with childhood lead exposureKim M Cecil
Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
PLoS Med 5:e112. 2008..In this study, we examined the relationship between childhood lead exposure and adult brain volume using magnetic resonance imaging (MRI). We also explored how volume changes correlate with historic neuropsychological assessments...