K M Cecil

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Bipolar Disord 4:357-65. 2002
  2. ncbi Magnetic resonance spectroscopy in a 9-day-old heterozygous female child with creatine transporter deficiency
    Kim M Cecil
    Division of Radiology, Children s Hospital Medical Center, University of Cincinnati Medical Center, OH 45229, USA
    J Comput Assist Tomogr 27:44-7. 2003
  3. ncbi CT, MRI and MRS of Epstein-Barr virus infection: case report
    K M Cecil
    Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Neuroradiology 42:619-22. 2000
  4. ncbi Irreversible brain creatine deficiency with elevated serum and urine creatine: a creatine transporter defect?
    K M Cecil
    Division of Radiology, Children s Hospital Medical Center and the University of Cincinnati, OH 45229, USA
    Ann Neurol 49:401-4. 2001
  5. ncbi The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy
    K M Cecil
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, USA
    Breast Cancer Res Treat 68:45-54. 2001
  6. ncbi Magnetic resonance spectroscopy of the pediatric brain
    K M Cecil
    Department of Radiology and Division of Pediatrics, Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio 45229, USA
    Top Magn Reson Imaging 12:435-52. 2001
  7. ncbi Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation
    Kim M Cecil
    Department of Radiology MC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Comput Assist Tomogr 26:818-20. 2002
  8. ncbi Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy
    Kim M Cecil
    Department of Radiology MLC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Comput Assist Tomogr 26:948-51. 2002
  9. ncbi Brain MRI and proton MRS findings in infants and children with respiratory chain defects
    A Dinopoulos
    Cincinnati Children s Hospital Medical Center, Division of Neurology, Cincinnati, Ohio 45229 3039, USA
    Neuropediatrics 36:290-301. 2005
  10. ncbi Exposure to lead appears to selectively alter metabolism of cortical gray matter
    I Trope
    Philadelphia, PA 19104, USA
    Pediatrics 107:1437-42. 2001

Collaborators

Detail Information

Publications28

  1. ncbi Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Bipolar Disord 4:357-65. 2002
    ..Patients with bipolar disorder having a manic or mixed episode were hypothesized to demonstrate metabolic abnormalities within the frontal lobe...
  2. ncbi Magnetic resonance spectroscopy in a 9-day-old heterozygous female child with creatine transporter deficiency
    Kim M Cecil
    Division of Radiology, Children s Hospital Medical Center, University of Cincinnati Medical Center, OH 45229, USA
    J Comput Assist Tomogr 27:44-7. 2003
    ..A 9-day-old heterozygous female child with this syndrome demonstrated a significant reduction of creatine on proton MRS. She is a carrier of the R514X nonsense mutation...
  3. ncbi CT, MRI and MRS of Epstein-Barr virus infection: case report
    K M Cecil
    Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Neuroradiology 42:619-22. 2000
    ..MRS of the lesions showed decreased N-acetyl aspartate and elevation of some amino acids, indicating an infectious rather than ischemic etiology. This case illustrates the use of MRS to narrow differential diagnosis...
  4. ncbi Irreversible brain creatine deficiency with elevated serum and urine creatine: a creatine transporter defect?
    K M Cecil
    Division of Radiology, Children s Hospital Medical Center and the University of Cincinnati, OH 45229, USA
    Ann Neurol 49:401-4. 2001
    ..In this study, we report a novel brain creatine deficiency syndrome most likely representing a creatine transporter defect...
  5. ncbi The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy
    K M Cecil
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, USA
    Breast Cancer Res Treat 68:45-54. 2001
    ..Cancerous lesions demonstrate elevated composite choline levels arising from increased cellular proliferation. Our study investigated if MR spectroscopy of the breast would be useful for characterizing benign and malignant lesions...
  6. ncbi Magnetic resonance spectroscopy of the pediatric brain
    K M Cecil
    Department of Radiology and Division of Pediatrics, Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio 45229, USA
    Top Magn Reson Imaging 12:435-52. 2001
    ..In this article, we review the major metabolites demonstrated by MR spectroscopy and present examples of MR spectra obtained in various pathological processes encountered in children...
  7. ncbi Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation
    Kim M Cecil
    Department of Radiology MC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Comput Assist Tomogr 26:818-20. 2002
    ..Recognition of this chemical on brain proton MRS as an exogenous compound is necessary to avoid confusion as a pathologic metabolite of pediatric metabolic disease...
  8. ncbi Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapy
    Kim M Cecil
    Department of Radiology MLC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    J Comput Assist Tomogr 26:948-51. 2002
    ..Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment. Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole...
  9. ncbi Brain MRI and proton MRS findings in infants and children with respiratory chain defects
    A Dinopoulos
    Cincinnati Children s Hospital Medical Center, Division of Neurology, Cincinnati, Ohio 45229 3039, USA
    Neuropediatrics 36:290-301. 2005
    ....
  10. ncbi Exposure to lead appears to selectively alter metabolism of cortical gray matter
    I Trope
    Philadelphia, PA 19104, USA
    Pediatrics 107:1437-42. 2001
    ..MRS has the ability to monitor brain metabolism by detecting a number of neurochemicals among which is N-acetylaspartate, a metabolite shown to decrease in processes that involve neuronal loss...
  11. ncbi Discrepancy between neuroimaging findings and clinical phenotype in Alexander disease
    A Dinopoulos
    Department of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    AJNR Am J Neuroradiol 27:2088-92. 2006
    ..The degree of demyelination and the timing of the axonal degeneration may determine phenotypic severity of the disease. Conventional neuroimaging techniques cannot always predict the outcome...
  12. ncbi Proton MR spectroscopy in inflammatory and infectious brain disorders
    K M Cecil
    Department of Radiology, MR Section, University of Pennsylvania, Philadelphia 19104, USA
    Neuroimaging Clin N Am 8:863-80. 1998
    ..The results reported in the literature support the view that MR spectroscopy can be employed in longitudinal studies to monitor the response to therapy and therefore may lead to individual optimized treatment effectiveness...
  13. ncbi Diffuse axonal pathology detected with magnetization transfer imaging following brain injury in the pig
    J C McGowan
    Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
    Magn Reson Med 41:727-33. 1999
    ..Positive and negative predictive values for MTR detection of DAI were 67 and 56%, respectively, and in acute studies alone, 89 and 61%. Gains in sensitivity over conventional imaging for detection of DAI were demonstrated...
  14. ncbi Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood
    W Yuan
    Departments of Radiology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    AJNR Am J Neuroradiol 28:1919-25. 2007
    ..The purposes of this study were to examine the alteration of fractional anisotropy (FA) in children with TBI experienced during early childhood and to quantify the association between FA and injury severity...
  15. doi Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium
    Nick C Patel
    College of Pharmacy, University of Georgia, Medical College of Georgia, Augusta, Georgia 30912 2450, USA
    J Child Adolesc Psychopharmacol 18:132-9. 2008
    ..This proton magnetic resonance spectroscopy (1H MRS) study identified the in vivo effects of lithium on N-acetyl-aspartate (NAA) concentrations in adolescent bipolar depression...
  16. doi Late proton magnetic resonance spectroscopy following traumatic brain injury during early childhood: relationship with neurobehavioral outcomes
    Nicolay Chertkoff Walz
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Neurotrauma 25:94-103. 2008
    ..Some neurometabolite levels differed between the TBI and OI groups more than 1 year post-injury and were related to injury severity, as well as some neurobehavioral outcomes following TBI during early childhood...
  17. ncbi Magnetic resonance spectroscopy and metabolic imaging in white matter diseases and pediatric disorders
    Kim M Cecil
    Department of Radiology and Pediatrics, Cincinnati Children s Hospital Medical Center and the College of Medicine of the University of Cincinnati, Cincinnati, OH 45229, USA
    Top Magn Reson Imaging 17:275-93. 2006
    ..With this composite summary, the reader should find it easier to implement and interpret spectroscopy in the clinical setting for the diagnosis and monitoring of patients with white matter disorders...
  18. pmc Lithium treatment effects on Myo-inositol in adolescents with bipolar depression
    Nick C Patel
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0004, USA
    Biol Psychiatry 60:998-1004. 2006
    ..This study used proton magnetic resonance spectroscopy (1H MRS) to identify the in vivo effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression...
  19. ncbi Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy study
    Melissa P DelBello
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Neuropsychopharmacology 31:1264-73. 2006
    ..Additionally, olanzapine-induced increases in choline may lead to alteration of abnormalities in cell membrane metabolism or second messenger pathways that are thought to be involved in the pathophysiology of bipolar disorder...
  20. ncbi Elevated lactate as an early marker of brain injury in inflicted traumatic brain injury
    Kathi L Makoroff
    Department of Pediatrics, Mayerson Center for Safe and Healthy Children, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Pediatr Radiol 35:668-76. 2005
    ..The metabolic and neurochemical abnormalities that underlie traumatic brain injury remain poorly understood, but hypoxia-ischemic injury might play an important role...
  21. ncbi Presence of normal creatine in the muscle of a patient with a mutation in the creatine transporter: a case study
    Gail J Pyne-Geithman
    Department of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Mol Cell Biochem 262:35-9. 2004
    ..Identifying this alternative creatine-transport mechanism may be useful in treating the neurologic and cognitive impairments of patients with creatine-transporter deficiency...
  22. ncbi Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disorders
    Kim M Cecil
    Imaging Research Center, Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Child Adolesc Psychopharmacol 13:545-55. 2003
    ....
  23. ncbi The clinical syndrome of creatine transporter deficiency
    Ton J DeGrauw
    Division of Neurology, Childrens Hospital Medical Center, Cincinnati, OH 45229, USA
    Mol Cell Biochem 244:45-8. 2003
    ..MR Spectroscopy is a non-invasive method for obtaining a preliminary diagnosis of this disorder. Muscle creatine uptake may be normal in this disorder...
  24. ncbi MR spectroscopy of metabolic disorders
    Kim M Cecil
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Neuroimaging Clin N Am 16:87-116, viii. 2006
    ..Although many conditions have a similar presentation, MRS offers valuable information for the individual patient in diagnosis and therapy when integrated fully into the clinical setting...
  25. ncbi The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language function
    Weihong Yuan
    Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Pediatrics 118:971-7. 2006
    ..The purpose of this work was to assess the long-term impact of childhood lead exposure on the neurosubstrate of language function and brain organization...
  26. ncbi Incidence of brain creatine transporter deficiency in males with developmental delay referred for brain magnetic resonance imaging
    Amy Newmeyer
    Division of Developmental Disabilities, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Dev Behav Pediatr 26:276-82. 2005
    ..This study suggests that brain creatine deficiency is an important consideration in the differential diagnosis of males with global developmental delay referred for brain MRI; brain MRS should be considered in such cases...
  27. ncbi MR imaging and spectroscopy in juvenile Huntington disease
    Mark Schapiro
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Pediatr Radiol 34:640-3. 2004
    ..Imaging findings of caudate atrophy and abnormal T2 prolongation in the putamina with MR spectroscopy findings consistent with dense gliosis can be helpful indicators of juvenile Huntington disease...
  28. pmc Decreased brain volume in adults with childhood lead exposure
    Kim M Cecil
    Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
    PLoS Med 5:e112. 2008
    ..In this study, we examined the relationship between childhood lead exposure and adult brain volume using magnetic resonance imaging (MRI). We also explored how volume changes correlate with historic neuropsychological assessments...