Research Topics
| K M CecilSummaryAffiliation: Children's Hospital Medical Center Country: USA Publications
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Detail Information
Publications
Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopyKim M Cecil
Imaging Research Center, Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Bipolar Disord 4:357-65. 2002..Patients with bipolar disorder having a manic or mixed episode were hypothesized to demonstrate metabolic abnormalities within the frontal lobe...- Magnetic resonance spectroscopy in a 9-day-old heterozygous female child with creatine transporter deficiencyKim M Cecil
Division of Radiology, Children s Hospital Medical Center, University of Cincinnati Medical Center, OH 45229, USA
J Comput Assist Tomogr 27:44-7. 2003..A 9-day-old heterozygous female child with this syndrome demonstrated a significant reduction of creatine on proton MRS. She is a carrier of the R514X nonsense mutation... - CT, MRI and MRS of Epstein-Barr virus infection: case reportK M Cecil
Department of Radiology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Neuroradiology 42:619-22. 2000..MRS of the lesions showed decreased N-acetyl aspartate and elevation of some amino acids, indicating an infectious rather than ischemic etiology. This case illustrates the use of MRS to narrow differential diagnosis... - Irreversible brain creatine deficiency with elevated serum and urine creatine: a creatine transporter defect?K M Cecil
Division of Radiology, Children s Hospital Medical Center and the University of Cincinnati, OH 45229, USA
Ann Neurol 49:401-4. 2001..In this study, we report a novel brain creatine deficiency syndrome most likely representing a creatine transporter defect... - The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopyK M Cecil
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, USA
Breast Cancer Res Treat 68:45-54. 2001..Cancerous lesions demonstrate elevated composite choline levels arising from increased cellular proliferation. Our study investigated if MR spectroscopy of the breast would be useful for characterizing benign and malignant lesions... - Magnetic resonance spectroscopy of the pediatric brainK M Cecil
Department of Radiology and Division of Pediatrics, Children s Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio 45229, USA
Top Magn Reson Imaging 12:435-52. 2001..In this article, we review the major metabolites demonstrated by MR spectroscopy and present examples of MR spectra obtained in various pathological processes encountered in children... - Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementationKim M Cecil
Department of Radiology MC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Comput Assist Tomogr 26:818-20. 2002..Recognition of this chemical on brain proton MRS as an exogenous compound is necessary to avoid confusion as a pathologic metabolite of pediatric metabolic disease... - Reversible MR imaging and MR spectroscopy abnormalities in association with metronidazole therapyKim M Cecil
Department of Radiology MLC 5031, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
J Comput Assist Tomogr 26:948-51. 2002..Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment. Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole... - Brain MRI and proton MRS findings in infants and children with respiratory chain defectsA Dinopoulos
Cincinnati Children s Hospital Medical Center, Division of Neurology, Cincinnati, Ohio 45229 3039, USA
Neuropediatrics 36:290-301. 2005.... - Exposure to lead appears to selectively alter metabolism of cortical gray matterI Trope
Philadelphia, PA 19104, USA
Pediatrics 107:1437-42. 2001..MRS has the ability to monitor brain metabolism by detecting a number of neurochemicals among which is N-acetylaspartate, a metabolite shown to decrease in processes that involve neuronal loss... - Discrepancy between neuroimaging findings and clinical phenotype in Alexander diseaseA Dinopoulos
Department of Neurology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
AJNR Am J Neuroradiol 27:2088-92. 2006..The degree of demyelination and the timing of the axonal degeneration may determine phenotypic severity of the disease. Conventional neuroimaging techniques cannot always predict the outcome... - Proton MR spectroscopy in inflammatory and infectious brain disordersK M Cecil
Department of Radiology, MR Section, University of Pennsylvania, Philadelphia 19104, USA
Neuroimaging Clin N Am 8:863-80. 1998..The results reported in the literature support the view that MR spectroscopy can be employed in longitudinal studies to monitor the response to therapy and therefore may lead to individual optimized treatment effectiveness... - Diffuse axonal pathology detected with magnetization transfer imaging following brain injury in the pigJ C McGowan
Department of Radiology, University of Pennsylvania, Philadelphia 19104, USA
Magn Reson Med 41:727-33. 1999..Positive and negative predictive values for MTR detection of DAI were 67 and 56%, respectively, and in acute studies alone, 89 and 61%. Gains in sensitivity over conventional imaging for detection of DAI were demonstrated... - Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhoodW Yuan
Departments of Radiology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
AJNR Am J Neuroradiol 28:1919-25. 2007..The purposes of this study were to examine the alteration of fractional anisotropy (FA) in children with TBI experienced during early childhood and to quantify the association between FA and injury severity... 
Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithiumNick C Patel
College of Pharmacy, University of Georgia, Medical College of Georgia, Augusta, Georgia 30912 2450, USA
J Child Adolesc Psychopharmacol 18:132-9. 2008..This proton magnetic resonance spectroscopy (1H MRS) study identified the in vivo effects of lithium on N-acetyl-aspartate (NAA) concentrations in adolescent bipolar depression...- Late proton magnetic resonance spectroscopy following traumatic brain injury during early childhood: relationship with neurobehavioral outcomesNicolay Chertkoff Walz
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
J Neurotrauma 25:94-103. 2008..Some neurometabolite levels differed between the TBI and OI groups more than 1 year post-injury and were related to injury severity, as well as some neurobehavioral outcomes following TBI during early childhood... - Magnetic resonance spectroscopy and metabolic imaging in white matter diseases and pediatric disordersKim M Cecil
Department of Radiology and Pediatrics, Cincinnati Children s Hospital Medical Center and the College of Medicine of the University of Cincinnati, Cincinnati, OH 45229, USA
Top Magn Reson Imaging 17:275-93. 2006..With this composite summary, the reader should find it easier to implement and interpret spectroscopy in the clinical setting for the diagnosis and monitoring of patients with white matter disorders... 
Lithium treatment effects on Myo-inositol in adolescents with bipolar depressionNick C Patel
Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0004, USA
Biol Psychiatry 60:998-1004. 2006..This study used proton magnetic resonance spectroscopy (1H MRS) to identify the in vivo effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression...- Neurochemical effects of olanzapine in first-hospitalization manic adolescents: a proton magnetic resonance spectroscopy studyMelissa P DelBello
Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
Neuropsychopharmacology 31:1264-73. 2006..Additionally, olanzapine-induced increases in choline may lead to alteration of abnormalities in cell membrane metabolism or second messenger pathways that are thought to be involved in the pathophysiology of bipolar disorder... - Elevated lactate as an early marker of brain injury in inflicted traumatic brain injuryKathi L Makoroff
Department of Pediatrics, Mayerson Center for Safe and Healthy Children, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Pediatr Radiol 35:668-76. 2005..The metabolic and neurochemical abnormalities that underlie traumatic brain injury remain poorly understood, but hypoxia-ischemic injury might play an important role... - Presence of normal creatine in the muscle of a patient with a mutation in the creatine transporter: a case studyGail J Pyne-Geithman
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Mol Cell Biochem 262:35-9. 2004..Identifying this alternative creatine-transport mechanism may be useful in treating the neurologic and cognitive impairments of patients with creatine-transporter deficiency... - Proton magnetic resonance spectroscopy of the frontal lobe and cerebellar vermis in children with a mood disorder and a familial risk for bipolar disordersKim M Cecil
Imaging Research Center, Department of Radiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Child Adolesc Psychopharmacol 13:545-55. 2003.... - The clinical syndrome of creatine transporter deficiencyTon J DeGrauw
Division of Neurology, Childrens Hospital Medical Center, Cincinnati, OH 45229, USA
Mol Cell Biochem 244:45-8. 2003..MR Spectroscopy is a non-invasive method for obtaining a preliminary diagnosis of this disorder. Muscle creatine uptake may be normal in this disorder... - MR spectroscopy of metabolic disordersKim M Cecil
Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Neuroimaging Clin N Am 16:87-116, viii. 2006..Although many conditions have a similar presentation, MRS offers valuable information for the individual patient in diagnosis and therapy when integrated fully into the clinical setting... - The impact of early childhood lead exposure on brain organization: a functional magnetic resonance imaging study of language functionWeihong Yuan
Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
Pediatrics 118:971-7. 2006..CONCLUSION: This study indicates that childhood lead exposure has a significant and persistent impact on brain reorganization associated with language function... - Incidence of brain creatine transporter deficiency in males with developmental delay referred for brain magnetic resonance imagingAmy Newmeyer
Division of Developmental Disabilities, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Dev Behav Pediatr 26:276-82. 2005..This study suggests that brain creatine deficiency is an important consideration in the differential diagnosis of males with global developmental delay referred for brain MRI; brain MRS should be considered in such cases... - MR imaging and spectroscopy in juvenile Huntington diseaseMark Schapiro
Division of Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Pediatr Radiol 34:640-3. 2004..Imaging findings of caudate atrophy and abnormal T2 prolongation in the putamina with MR spectroscopy findings consistent with dense gliosis can be helpful indicators of juvenile Huntington disease... - Decreased brain volume in adults with childhood lead exposureKim M Cecil
Cincinnati Children s Environmental Health Center, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, United States of America
PLoS Med 5:e112. 2008..In this study, we examined the relationship between childhood lead exposure and adult brain volume using magnetic resonance imaging (MRI). We also explored how volume changes correlate with historic neuropsychological assessments...