Research Topics
| David W BrownSummaryAffiliation: Children's Hospital Country: USA Publications
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Detail Information
Publications
Reliability and accuracy of echocardiographic right heart evaluation in the U.S. Melody Valve Investigational TrialDavid W Brown
Department of Cardiology, Children s Hospital and Department of Pediatrics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
J Am Soc Echocardiogr 25:383-392.e4. 2012..The aim of this study was to evaluate the reliability and accuracy of echocardiography for evaluating RV parameters in patients in the five-center Melody TPV trial...- Variation in preoperative and intraoperative care for first-stage palliation of single-ventricle heart disease: a report from the Joint Council on Congenital Heart Disease National Quality Improvement CollaborativeDavid W Brown
Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Congenit Heart Dis 6:108-15. 2011..We sought to describe the preoperative and intraoperative characteristics of the first 100 patients enrolled in the National Pediatric Cardiology Quality Improvement Collaborative registry... 
Clinical outcomes and utility of cardiac catheterization prior to superior cavopulmonary anastomosisDavid W Brown
Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
J Thorac Cardiovasc Surg 126:272-81. 2003....- Sudden unexpected death after balloon valvuloplasty for congenital aortic stenosisDavid W Brown
Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 56:1939-46. 2010..The aims of this study were to determine the incidence and risk factors of sudden unexpected death (SUD) after balloon aortic valvuloplasty (BAVP) for congenital aortic stenosis (AS) and to assess the effect of exercise restriction... - Aortic valve reinterventions after balloon aortic valvuloplasty for congenital aortic stenosis intermediate and late follow-upDavid W Brown
Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 56:1740-9. 2010..the aim of this study was to evaluate the long-term results of transcatheter balloon aortic valvuloplasty, the preferred treatment for congenital aortic stenosis (AS)... - Aortic wall injury as a complication of neonatal aortic valvuloplasty: incidence and risk factorsDavid W Brown
Department of Cardiology, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
Circ Cardiovasc Interv 1:53-9. 2008..We reviewed single-center data to determine the incidence of aortic injury during balloon aortic valvuloplasty and to identify risk factors... - Cardiac magnetic resonance versus routine cardiac catheterization before bidirectional glenn anastomosis in infants with functional single ventricle: a prospective randomized trialDavid W Brown
Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Circulation 116:2718-25. 2007..Because catheterization is invasive and exposes patients to ionizing radiation, cardiac magnetic resonance (CMR) may be a safe and effective alternative... 
Left ventricular diastolic function in children and young adults with congenital aortic valve diseaseKevin G Friedman
Department of Cardiology, Children s Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 111:243-9. 2013..In conclusion, DD is common in young patients with AS and AS+AR but not in those with pure AR. A greater LV mass and previous aortic valve dilation were associated with DD...- The evolving role of intraoperative balloon pulmonary valvuloplasty in valve-sparing repair of tetralogy of FallotJoshua D Robinson
Department of Cardiology, Children s Hospital, Boston, MA, USA
J Thorac Cardiovasc Surg 142:1367-73. 2011..This study reviewed a single institution's experience with valve-sparing repair and investigated the role of intraoperative balloon valvuloplasty... - Dilation of the ascending aorta after balloon valvuloplasty for aortic stenosis during infancy and childhoodDoff B McElhinney
Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA
Am J Cardiol 110:702-8. 2012..More significant residual AS after valvuloplasty was associated with lower AA Z scores over time. In conclusion, AA dilation is common in children with congenital AS and continues to progress over many years after balloon valvuloplasty... - Short-term performance of the transcatheter Melody valve in high-pressure hemodynamic environments in the pulmonary and systemic circulationsBabar S Hasan
Department of Cardiology, Children s Hospital, 300 Longwood Ave, Boston, MA 02115, USA
Circ Cardiovasc Interv 4:615-20. 2011..The function of this valve when subjected to high-pressure loads in humans is unknown. The aim of this study was to describe the immediate and short-term results of Melody valves implanted in a high-pressure environment... - Cerebral blood flow characteristics and biometry in fetuses undergoing prenatal intervention for aortic stenosis with evolving hypoplastic left heart syndromeDoff B McElhinney
Department of Cardiology, Children s Hospital Boston, and Pediatrics, Harvard Medical School, Boston, MA, USA
Ultrasound Med Biol 36:29-37. 2010..The mechanisms and significance of these abnormalities are unknown. Prenatal aortic valvuloplasty did not have a major impact on these indices. (E-mail: doff.mcelhinney@cardio.chboston.org)... - Association of socioeconomic position and medical insurance with fetal diagnosis of critical congenital heart diseaseVasum Peiris
Department of Cardiology, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Circ Cardiovasc Qual Outcomes 2:354-60. 2009..We sought to evaluate whether PD of critical congenital heart disease is related to socioeconomic (SE) position, medical insurance, and race... - Left ventricular remodeling and improvement in diastolic function after balloon aortic valvuloplasty for congenital aortic stenosisKevin G Friedman
Department of Cardiology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Circ Cardiovasc Interv 5:549-54. 2012..In congenital aortic stenosis, chronic pressure load has detrimental effects on left ventricular (LV) systolic and diastolic function. Reduction in LV pressure load with balloon aortic valvuloplasty (BAVP) may improve diastolic function... - Outcomes and risk factors for mortality in premature neonates with critical congenital heart diseaseHenry H Cheng
Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Pediatr Cardiol 32:1139-46. 2011..Patients with lower Apgar scores who receive preintervention mechanical ventilation and undergo more complex procedures are at greatest risk... - Risk factors for failed staged palliation after bidirectional Glenn in infants who have undergone stage one palliationKevin G Friedman
Department of Cardiology, Children s Hospital Boston, Boston, MA, USA
Eur J Cardiothorac Surg 40:1000-6. 2011..In this study, we examined risk factors for death or transplant and failure to reach Fontan completion after BDG in patients, who had previously undergone stage one palliation (S1P)... - Predictors of technical success and postnatal biventricular outcome after in utero aortic valvuloplasty for aortic stenosis with evolving hypoplastic left heart syndromeDoff B McElhinney
Department of Cardiology, Children s Hospital, Boston, MA 02115, USA
Circulation 120:1482-90. 2009..Prenatal balloon aortic valvuloplasty may improve left heart growth and function, possibly preventing evolution to hypoplastic left heart syndrome... - Echocardiographic evaluation before bidirectional Glenn operation in functional single-ventricle heart disease: comparison to catheter angiographyKenan W D Stern
Department of Cardiology, Children s Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Circ Cardiovasc Imaging 4:498-505. 2011..There is interest in noninvasive evaluation alone before BDG, but concern for echocardiography successfully imaging the relevant anatomy persists. We evaluated the accuracy of echocardiographic imaging of vascular anatomy... - Factors associated with subsequent arch reintervention after initial balloon aortoplasty in patients with Norwood procedure and arch obstructionDiego Porras
Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 58:868-76. 2011.... - Cardiac resynchronization therapy (and multisite pacing) in pediatrics and congenital heart disease: five years experience in a single institutionFrank Cecchin
Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 20:58-65. 2009..We sought to determine the functional assessment and clinical outcomes in pediatric and CHD CRT patients followed uniformly at one institution... - Unplanned reinterventions are associated with postoperative mortality in neonates with critical congenital heart diseaseMjaye L Mazwi
Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Mass, USA
J Thorac Cardiovasc Surg 145:671-7. 2013.... - What is the clinical utility of routine cardiac catheterization before a Fontan operation?Puja Banka
Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
Pediatr Cardiol 31:977-85. 2010..A more comprehensive imaging strategy not based solely on echocardiography should be considered... - Fetal diagnosis of interrupted aortic archMelanie Vogel
Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA
Am J Cardiol 105:727-34. 2010..Despite the diagnostic challenges, the frequency of prenatal diagnosis of the IAA is increasing... - Exercise Stress Echocardiographic Assessment of Outflow Tract and Ventricular Function in Patients With an Obstructed Right Ventricular-to-Pulmonary Artery Conduit After Repair of Conotruncal Heart DefectsBabar Sultan Hasan
Department of Cardiology, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts Electronic address
Am J Cardiol 110:1527-33. 2012..87; global RV strain -13.9 [-32, -9] vs -15.1 [-23, -6], p = 0.11). In conclusion, using ESE it was possible to evaluate abnormal ventricular function and conduit dysfunction at peak exercise in patients with an obstructed RV-PA conduit... - Birth before 39 weeks' gestation is associated with worse outcomes in neonates with heart diseaseJohn M Costello
Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Pediatrics 126:277-84. 2010..We sought to determine if a similar association exists between gestational age at delivery and adverse outcomes in neonates with critical congenital heart disease, with particular interest in those born at 37 to 38 weeks' gestation... - An echocardiographic model predicting severity of aortic regurgitation in congenital heart diseaseRebecca S Beroukhim
Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
Circ Cardiovasc Imaging 3:542-9. 2010.... - Dynamic evolution of practice guidelines: analysis of deviations from assessment and management plansMichael Farias
Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Pediatrics 130:93-8. 2012..For 3 different pediatric cardiac diagnoses managed by SCAMPs, we determined the frequency of, types of, and reasons for DEVs, which are considered to be a valuable source of information and innovation... - Ventricular function deteriorates with recurrent coarctation in hypoplastic left heart syndromeLuis Alesandro Larrazabal
Department of Cardiac Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Thorac Surg 86:869-74; discussion 869-74. 2008..Recurrent coarctation (re-CoA) after stage I palliation in hypoplastic left heart syndrome (HLHS) is deleterious. We studied whether re-CoA had an effect on ventricular systolic function... - In vivo monitoring of function of autologous engineered pulmonary valveDanielle Gottlieb
Children s Hospital Boston and Harvard Medical School, Boston, Mass Massachusetts General Hospital and Harvard Medical School, Boston, Mass
J Thorac Cardiovasc Surg 139:723-31. 2010..Building on prior experiments, we sought to define the in vivo changes in structure and function of autologous engineered pulmonary valved conduits... - Ascending aortic dilation in patients with congenital complete heart blockAndrew E Radbill
Department of Cardiology, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
Heart Rhythm 5:1704-8. 2008..Aortic dilation has been anecdotally observed in some children with CCHB, but detailed reports are lacking... - Robotic division of an unusual variant of a right aortic archBarbara L Robinson
Department of Cardiac Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Thorac Surg 84:670-3. 2007..This case report describes the rare form of retroesophageal left innominate artery with ligamentum between the base of the subclavian artery to the pulmonary artery, and the first time management by the novel robotic approach... - Associations between recommended levels of physical activity and health-related quality of life. Findings from the 2001 Behavioral Risk Factor Surveillance System (BRFSS) surveyDavid W Brown
National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Prev Med 37:520-8. 2003..The results persist even among adults with a chronic condition such as arthritis. CONCLUSIONS: These results highlight the need for health programs to increase participation in regular physical activity... - Diabetes mellitus and health-related quality of life among older adults. Findings from the behavioral risk factor surveillance system (BRFSS)David W Brown
Behavioral Surveillance Branch, Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
Diabetes Res Clin Pract 65:105-15. 2004..These results reinforce the importance of preventing diabetes and its complications through health education messages stressing a balanced diet and increased physical activity... - Racial differences in the use of aspirin: an important tool for preventing heart disease and strokeDavid W Brown
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Ethn Dis 15:620-6. 2005..Differences in sociodemographic characteristics and CVD risk factors do not account for lower aspirin use among racial/ethnic minorities. Additional studies should examine methods to increase aspirin use in these populations... - Electrocardiographic recording and timeliness of clinician evaluation in the emergency department in patients presenting with chest painDavid W Brown
Center for Disease Control and Prevention, Atlanta, Georgia, USA
Am J Cardiol 99:1115-8. 2007..7 per 1,000; 1.5 million vs 2004: 7.3 per 1,000; 1.3 million). In conclusion, most ED patient visits for undifferentiated and cardiac CP included an electrocardiogram and timely clinician evaluation... - Randomized, placebo-controlled, phase III surgical adjuvant clinical trial of megestrol acetate (Megace) in selected patients with malignant melanomaSvetomir Markovic
Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA
Am J Clin Oncol 25:552-6. 2002..Adjuvant therapy with megestrol acetate oral suspension administered at a dose of 160 mg twice a day for 2 years was not found to be effective in prolonging PFS or OS in patients with surgically resected, locally advanced melanoma...