David I Bernstein

Summary

Affiliation: Children's Hospital Medical Center
Country: USA

Publications

  1. ncbi request reprint Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in children
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH, USA
    Pediatr Infect Dis J 22:28-34. 2003
  2. doi request reprint Opposing effects of cat and dog ownership and allergic sensitization on eczema in an atopic birth cohort
    Tolly G Epstein
    Department of Medicine, Division of Immunology, University of Cincinnati, Cincinnati, OH, USA
    J Pediatr 158:265-71.e1-5. 2011
  3. ncbi request reprint Protection against congenital cytomegalovirus infection and disease in guinea pigs, conferred by a purified recombinant glycoprotein B vaccine
    Mark R Schleiss
    Division of Infectious Diseases, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Infect Dis 189:1374-81. 2004
  4. pmc Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy
    Nicholas Farley
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Antiviral Res 86:188-95. 2010
  5. ncbi request reprint Preconception vaccination with a glycoprotein B (gB) DNA vaccine protects against cytomegalovirus (CMV) transmission in the guinea pig model of congenital CMV infection
    Mark R Schleiss
    Division of Infectious Diseases, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Infect Dis 188:1868-74. 2003
  6. pmc The adjuvant CLDC increases protection of a herpes simplex type 2 glycoprotein D vaccine in guinea pigs
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Vaccine 28:3748-53. 2010
  7. ncbi request reprint Reductions in cross-neutralizing antibody responses in infants after attenuation of the human rotavirus vaccine candidate 89-12
    Richard L Ward
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Infect Dis 194:1729-36. 2006
  8. ncbi request reprint Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection
    Fernando J Bravo
    Cincinnati Children s Hospital Medical Center, OH 45229, USA
    J Infect Dis 193:591-7. 2006
  9. pmc Exposure to traffic-related particles and endotoxin during infancy is associated with wheezing at age 3 years
    Patrick H Ryan
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Am J Respir Crit Care Med 180:1068-75. 2009
  10. ncbi request reprint Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs
    Nigel Bourne
    Division of Infectious Diseases, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Infect Dis 187:542-9. 2003

Detail Information

Publications94

  1. ncbi request reprint Effect of yearly vaccinations with live, attenuated, cold-adapted, trivalent, intranasal influenza vaccines on antibody responses in children
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH, USA
    Pediatr Infect Dis J 22:28-34. 2003
    ..The cold-adapted, trivalent influenza vaccine (CAIV-T) may become an option for annual vaccination. However, there is little information regarding the immune response to repeated immunization with CAIV-T...
  2. doi request reprint Opposing effects of cat and dog ownership and allergic sensitization on eczema in an atopic birth cohort
    Tolly G Epstein
    Department of Medicine, Division of Immunology, University of Cincinnati, Cincinnati, OH, USA
    J Pediatr 158:265-71.e1-5. 2011
    ..To examine risk factors for eczema at age 4 years...
  3. ncbi request reprint Protection against congenital cytomegalovirus infection and disease in guinea pigs, conferred by a purified recombinant glycoprotein B vaccine
    Mark R Schleiss
    Division of Infectious Diseases, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Infect Dis 189:1374-81. 2004
    ..These are the first data indicating that a recombinant gB vaccine protects against congenital CMV infection and disease...
  4. pmc Recurrent vaginal shedding of herpes simplex type 2 virus in the mouse and effects of antiviral therapy
    Nicholas Farley
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Antiviral Res 86:188-95. 2010
    ..Thus, this model provides an inexpensive model for evaluating therapeutic strategies and immune control of persistent HSV...
  5. ncbi request reprint Preconception vaccination with a glycoprotein B (gB) DNA vaccine protects against cytomegalovirus (CMV) transmission in the guinea pig model of congenital CMV infection
    Mark R Schleiss
    Division of Infectious Diseases, Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    J Infect Dis 188:1868-74. 2003
    ..These data support the concept that subunit gB vaccination may be useful in protecting against CMV-induced disease...
  6. pmc The adjuvant CLDC increases protection of a herpes simplex type 2 glycoprotein D vaccine in guinea pigs
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Vaccine 28:3748-53. 2010
    ..CLDC enhanced protection compared to MPL/Alum and is the first vaccine to reduce recurrent virus shedding, a key to decreasing the spread of HSV-2...
  7. ncbi request reprint Reductions in cross-neutralizing antibody responses in infants after attenuation of the human rotavirus vaccine candidate 89-12
    Richard L Ward
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Infect Dis 194:1729-36. 2006
    ..Even so, the Rotarix vaccine developed from attenuated 89-12 was found to elicit excellent protection against non-G1 rotaviruses...
  8. ncbi request reprint Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection
    Fernando J Bravo
    Cincinnati Children s Hospital Medical Center, OH 45229, USA
    J Infect Dis 193:591-7. 2006
    ..Using the guinea pig model of congenital CMV infection, we sought to determine whether antiviral treatment of a CMV-infected dam could improve the outcome of offspring...
  9. pmc Exposure to traffic-related particles and endotoxin during infancy is associated with wheezing at age 3 years
    Patrick H Ryan
    Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Am J Respir Crit Care Med 180:1068-75. 2009
    ..Murine models demonstrate a synergistic production of reactive oxygen species on coexposure to diesel exhaust particles and endotoxin...
  10. ncbi request reprint Herpes simplex virus (HSV) type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs
    Nigel Bourne
    Division of Infectious Diseases, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Infect Dis 187:542-9. 2003
    ....
  11. pmc Potent adjuvant activity of cationic liposome-DNA complexes for genital herpes vaccines
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Clin Vaccine Immunol 16:699-705. 2009
    ..CLDC appears to be a potent adjuvant for HSV vaccines and should be evaluated further...
  12. pmc N-Methanocarbathymidine is more effective than acyclovir for treating neonatal herpes simplex virus infection in guinea pigs
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, United States
    Antiviral Res 92:386-8. 2011
    ..In fact, (N)-MCT improved survival up to 3 dpi, the last time point evaluated. (N)-MCT was highly effective and superior to high dose ACV therapy for the treatment of neonatal herpes in the guinea pig model...
  13. doi request reprint Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Infect Dis 197:667-75. 2008
    ..Influenza A H5N1 viruses pose a significant threat to human health...
  14. ncbi request reprint Psychological, behavioral, and interpersonal impact of human papillomavirus and Pap test results
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Womens Health (Larchmt) 14:650-9. 2005
    ..The purpose of this study was to explore the short-term psychological, behavioral, and interpersonal impact of human papillomavirus (HPV) and Pap results in adolescent and young adult women...
  15. pmc Effects of herpes simplex virus type 2 glycoprotein vaccines and CLDC adjuvant on genital herpes infection in the guinea pig
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Vaccine 29:2071-8. 2011
    ..Improvements in HSV-2 vaccines may require inclusion of more T cell targets, more potent adjuvants or live virus vaccines...
  16. ncbi request reprint A phase 1 study of 4 live, recombinant human cytomegalovirus Towne/Toledo chimeric vaccines
    Thomas C Heineman
    Division of Infectious Diseases and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63110, and Division of Pediatric Infectious Diseases, Children s Hospital Medical Center, University of Cincinnati, OH, USA
    J Infect Dis 193:1350-60. 2006
    ..Although not evaluated for this indication, live attenuated HCMV vaccines based on the Towne strain are well-tolerated and have demonstrated moderate efficacy in other clinical settings...
  17. pmc Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Clin Infect Dis 56:344-51. 2013
    ..Herpes simplex virus infections type 1 (HSV-1) and type 2 (HSV-2) are common, but the epidemiology of HSV disease is changing...
  18. ncbi request reprint Personal meaning of human papillomavirus and Pap test results in adolescent and young adult women
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Health Psychol 26:192-200. 2007
    ..The objective of this study was to explore personal meaning of HPV and Pap test results in adolescent and young adult women...
  19. ncbi request reprint Estimating the rotavirus hospitalization disease burden and trends, using capture-recapture methods
    Mary Allen Staat
    Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Pediatr Infect Dis J 29:1083-6. 2010
    ..Our objective was to use capture-recapture methods to estimate rotavirus hospitalization rates and to examine trends over time...
  20. pmc Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection
    Rhonda D Cardin
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Virol J 6:214. 2009
    ..The activity of these agents against animal cytomegalovirus (CMV) infections in vitro and in vivo was therefore investigated...
  21. pmc The non-nucleoside antiviral, BAY 38-4766, protects against cytomegalovirus (CMV) disease and mortality in immunocompromised guinea pigs
    Mark R Schleiss
    Division of Infectious Diseases, Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Antiviral Res 65:35-43. 2005
    ..Mortality differences were accompanied by reduction in DNAemia in Hartley guinea pigs. Based upon its favorable safety, pharmacokinetic, and therapeutic profiles, BAY 38-4766 warrants further investigation in the GPCMV model...
  22. ncbi request reprint HSV-1 and HSV-2 Seroprevalence in the United States among Asymptomatic Women Unaware of Any Herpes Simplex Virus Infection (Herpevac Trial for Women)
    Joann M Schulte
    From the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, EMMES Corporation, Rockville, Maryland, The Department of Medicine, University of Alabama at Birmingham, Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, Pediatric Infectious Diseases, University of Colorado Denver, Aurora, Department of Epidemiology, University of North Carolina Chapel Hill, Division of Infectious Diseases, Allergy, and Immunology, Saint Louis University, St Louis, Missouri, and GlaxoSmithKline, King of Prussia, Pennsylvania
    South Med J 107:79-84. 2014
    ..The objective of the study was to assess the seroprevalence of type-specific antibodies to HSV-1 and HSV-2 in the United States...
  23. pmc A model of human cytomegalovirus infection in severe combined immunodeficient mice
    Fernando J Bravo
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, ML 6014, Cincinnati, OH 45229 3039, USA
    Antiviral Res 76:104-10. 2007
    ..0001). These results indicate that the Gelfoam-HCMV SCID mouse model is suitable for the in vivo evaluation of new antivirals against HCMV and is simpler and more convenient than previous models...
  24. ncbi request reprint An animal model of neonatal cytomegalovirus infection
    Fernando J Bravo
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Antiviral Res 60:41-9. 2003
    ..001) and viral replication but did not improve weight gain. This model should be useful for further evaluations of the pathogenesis of CMV infections and for evaluation of antiviral drugs and vaccines...
  25. pmc Asking the right questions to ascertain early childhood secondhand smoke exposures
    Jocelyn M Biagini Myers
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    J Pediatr 160:1050-1. 2012
    ..We present 4 questions that incorporate several locations of exposure and provide a more comprehensive account of children's smoke exposures than maternal smoking alone...
  26. pmc Adolescent perceptions of risk and need for safer sexual behaviors after first human papillomavirus vaccination
    Tanya L Kowalczyk Mullins
    Division of Adolescent Medicine, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Arch Pediatr Adolesc Med 166:82-8. 2012
    ....
  27. pmc Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection
    Fernando J Bravo
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Antimicrob Agents Chemother 55:35-41. 2011
    ..Taken together, HDP-CDV shows potential as a well-tolerated antiviral candidate for treatment of congenital human CMV (HCMV) infection...
  28. pmc Correlate of immune protection against HSV-1 genital disease in vaccinated women
    Robert B Belshe
    Department of Internal Medicine, Division of Infectious Diseases, Allergy and Immunology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Infect Dis 209:828-36. 2014
    ..Subjects had been previously selected to be seronegative for HSV-1 and HSV-2. We found that vaccine was 82% protective against HSV-1 genital disease, but offered no significant protection against HSV-2 genital disease...
  29. doi request reprint Phase 1 study of the safety and immunogenicity of a live, attenuated respiratory syncytial virus and parainfluenza virus type 3 vaccine in seronegative children
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA
    Pediatr Infect Dis J 31:109-14. 2012
    ..Respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) are important causes of lower respiratory tract illness and hospitalization in young children. Currently, there is no licensed vaccine against RSV or PIV3...
  30. ncbi request reprint A live attenuated human rotavirus vaccine
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, Ohio 45229, USA
    Drugs Today (Barc) 43:281-91. 2007
    ..The vaccine is administered as two oral doses with at least four weeks between doses. The first dose may be administered from the age of 6 weeks, and both doses should be completed by 24 weeks of age...
  31. ncbi request reprint Quantitative-competitive PCR monitoring of viral load following experimental guinea pig cytomegalovirus infection
    Mark R Schleiss
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Virol Methods 108:103-10. 2003
    ..Viral load determination should be useful for monitoring outcomes following vaccine studies, as well as responses to experimental antiviral agents...
  32. ncbi request reprint Rotavirus immunoglobulin a responses stimulated by each of 3 doses of a quadrivalent human/bovine reassortant rotavirus vaccine
    Richard L Ward
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Infect Dis 189:2290-3. 2004
    ..In total, 16, 19, and 15 vaccine recipients had increases after 1, 2, and 3 doses, respectively, indicating that a 3-dose regimen increased the immune response elicited by this vaccine...
  33. pmc Seroprevalence of cytomegalovirus (CMV) and risk factors for infection in adolescent males
    Laura Patricia Stadler
    Department of Pediatrics, Division of Infectious Diseases, University of Kentucky, Lexington, KY 40536 0284, USA
    Clin Infect Dis 51:e76-81. 2010
    ..Although the seroprevalence of CMV and associated exposure and behavioral risk factors have been reported in adolescent females, few data exist about males...
  34. ncbi request reprint Rhesus rotavirus vaccine effectiveness and factors associated with receipt of vaccine
    Mary Allen Staat
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Pediatr Infect Dis J 25:1013-8. 2006
    ..The objective of this study was to determine the effectiveness of the RotaShield vaccine against rotavirus gastroenteritis requiring hospitalization and to evaluate factors associated with vaccine receipt...
  35. pmc Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Antimicrob Agents Chemother 52:2727-33. 2008
    ..001) and 60 min (50%, P = 0.07) against disease. These observations suggest that APs may have microbicidal activity and potential as broad-spectrum antiherpetic agents and represent a novel class of agents that should be studied further...
  36. ncbi request reprint Safety and immunogenicity of glycoprotein D-adjuvant genital herpes vaccine
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
    Clin Infect Dis 40:1271-81. 2005
    ....
  37. ncbi request reprint Lack of induction of autoantibody responses following immunization with cytomegalovirus (CMV) glycoprotein B (gB) in healthy CMV-seronegative subjects
    Mark R Schleiss
    Division of Infectious Diseases, 3333 Burnet Avenue, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Vaccine 23:687-92. 2004
    ..These data reinforce the favorable safety profile of CMV gB vaccines...
  38. doi request reprint Chronic traffic pollution exposure is associated with eosinophilic, but not neutrophilic inflammation in older adult asthmatics
    Tolly G Epstein
    Department of Medicine, Division of Immunology, Allergy and Rheumatology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA
    J Asthma 50:983-9. 2013
    ..In this study, we sought to define the relationship between exposure to traffic pollutants, biomarkers in induced sputum, and asthma control in older adults...
  39. ncbi request reprint Treatment of herpes simplex virus infections
    Rebecca C Brady
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Avenue, Mail Location 6014, Cincinnati, OH 45229 3039, USA
    Antiviral Res 61:73-81. 2004
    ..This article will review the common presentations for HSV disease and the current recommendations for the treatment of these infections. A detailed summary of the antiviral drugs used to treat HSV infections is also presented...
  40. doi request reprint Predicting susceptibility to norovirus GII.4 by use of a challenge model involving humans
    Robert Frenck
    Division Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH, USA
    J Infect Dis 206:1386-93. 2012
    ..We performed the first GII.4 challenge study involving humans and prospectively evaluated the relationship between HBGAs and norovirus infection and associated illness...
  41. ncbi request reprint Attitudes about human papillomavirus vaccine in young women
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Int J STD AIDS 14:300-6. 2003
    ..005), and higher number of sexual partners (P=0.028). Information on attitudes about HPV vaccination and predictors of intention to receive a vaccine may guide immunization initiatives for young adults...
  42. doi request reprint Rotavirus meningoencephalitis in a previously healthy child and a review of the literature
    Michelle Dickey
    Division of Infectious Disease, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Pediatr Infect Dis J 28:318-21. 2009
    ..A review of the literature describes 23 cases of central nervous system disease attributed to rotavirus...
  43. pmc Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort
    Jocelyn M Biagini Myers
    Division of Asthma Research, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Invest Dermatol 130:430-7. 2010
    ..The results also demonstrate a susceptibility effect of the combination of CD14 and IL4Ralpha SNPs with eczema...
  44. ncbi request reprint Rotavirus overview
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA
    Pediatr Infect Dis J 28:S50-3. 2009
    ..Rotavirus vaccination is now included as part of the routine vaccination schedule for all infants in the United States...
  45. doi request reprint Rotarix: a rotavirus vaccine for the world
    Richard L Ward
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Clin Infect Dis 48:222-8. 2009
    ..This article describes the history of the development of the RIX4414 vaccine...
  46. doi request reprint Age-related changes in magnitude and diversity of cross-reactive CD4+ T-cell responses to the novel pandemic H1N1 influenza hemagglutinin
    Ramu A Subbramanian
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, Ohio, USA
    Hum Immunol 71:957-63. 2010
    ..These results have important ramifications for our understanding of influenza immunity in humans and development of vaccine strategies against this important pathogen...
  47. ncbi request reprint Live attenuated human rotavirus vaccine, Rotarix
    David I Bernstein
    Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    Semin Pediatr Infect Dis 17:188-94. 2006
    ..Efficacy against severe rotavirus gastroenteritis and hospitalization have ranged from 85 to 100 percent...
  48. pmc Associations between multiple environmental exposures and Glutathione S-Transferase P1 on persistent wheezing in a birth cohort
    Kathy T Schroer
    Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    J Pediatr 154:401-8, 408.e1. 2009
    ....
  49. ncbi request reprint Pediatricians' intention to administer human papillomavirus vaccine: the role of practice characteristics, knowledge, and attitudes
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Adolesc Health 37:502-10. 2005
    ..The objective of this study was to examine pediatrician characteristics and attitudes associated with intention to recommend two hypothetical human papillomavirus (HPV) vaccines...
  50. ncbi request reprint Topical SMIP-7.7, a toll-like receptor 7 agonist, protects against genital herpes simplex virus type-2 disease in the guinea pig model of genital herpes
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Antivir Chem Chemother 23:189-96. 2014
    ..The guinea pig model of genital HSV-2 disease was therefore used to evaluate the efficacy of a new TLR-7 agonist, SMIP-7.7...
  51. pmc Safety and immune responses in children after concurrent or sequential 2009 H1N1 and 2009-2010 seasonal trivalent influenza vaccinations
    Sharon E Frey
    Division of Infectious Diseases, Allergy and Immunology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    J Infect Dis 206:828-37. 2012
    ....
  52. pmc Vaccine-type human papillomavirus and evidence of herd protection after vaccine introduction
    Jessica A Kahn
    Division of Adolescent Medicine, MLC 4000, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA
    Pediatrics 130:e249-56. 2012
    ....
  53. pmc Efficacy results of a trial of a herpes simplex vaccine
    Robert B Belshe
    Division of Infectious Diseases, Allergy, and Immunology, Saint Louis University, St Louis, MO 63104, USA
    N Engl J Med 366:34-43. 2012
    ..Efficacy was not observed in men or HSV-1 seropositive women...
  54. ncbi request reprint Human papillomavirus vaccines and adolescents
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Curr Opin Obstet Gynecol 17:476-82. 2005
    ..This review will describe human papillomavirus (HPV) vaccines in development, summarize data regarding safety and efficacy of these vaccines, and discuss key issues related to HPV vaccine implementation...
  55. pmc Epidemiology and risk factors for human papillomavirus infection in a diverse sample of low-income young women
    Tasneem Shikary
    University of Cincinnati College of Medicine, Cincinnati, OH, USA
    J Clin Virol 46:107-11. 2009
    ..Defining type-specific HPV epidemiology in sexually experienced women will help estimate the potential clinical benefits of vaccinating this population...
  56. ncbi request reprint Rotarix: development of a live attenuated monovalent human rotavirus vaccine
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Pediatr Ann 35:38-43. 2006
  57. doi request reprint Randomized, double-blind, Phase 1 trial of an alphavirus replicon vaccine for cytomegalovirus in CMV seronegative adult volunteers
    David I Bernstein
    Division of Infectious Diseases, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 44259, USA
    Vaccine 28:484-93. 2009
    ..This alphavirus replicon particle vaccine was safe and induced neutralizing antibody and multifunctional T cell responses against three CMV antigens that are important targets for protective immunity...
  58. pmc Relative moldiness index as predictor of childhood respiratory illness
    Stephen J Vesper
    US Environmental Protection Agency, Cincinnati, OH, USA
    J Expo Sci Environ Epidemiol 17:88-94. 2007
    ..27). Conversely, a method developed and validated in this paper, using the RMI index fit to a logistic function, can be used to predict the occurrence of illness in homes and allows stake-holders the choice among various levels of risk...
  59. ncbi request reprint Clinical presentations of rotavirus infection among hospitalized children
    Mary Allen Staat
    Division of Infectious Disease, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Infect Dis J 21:221-7. 2002
    ..Although rotaviruses (RVs) are the most common cause of severe gastroenteritis in children, there is a lack of information detailing the spectrum of clinical manifestations of RV disease resulting in hospitalization...
  60. ncbi request reprint Comparison of adolescent and young adult self-collected and clinician-collected samples for human papillomavirus
    Jessica A Kahn
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Obstet Gynecol 103:952-9. 2004
    ..To examine the concordance between self-collected and clinician-collected samples for human papillomavirus (HPV) DNA...
  61. ncbi request reprint Prevalence of diarrheagenic Escherichia coli in acute childhood enteritis: a prospective controlled study
    Mitchell B Cohen
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Pediatr 146:54-61. 2005
    ..Since diarrheagenic E. coli are not identified by common clinical laboratory techniques, we hypothesized that these organisms might be an unrecognized cause of enteritis in children in the U.S...
  62. ncbi request reprint Rotavirus deaths: rare or unrecognized?
    Mary Allen Staat
    University of Cincinnati, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, Division of Infectious Diseases, Ohio 45229, USA
    Clin Pediatr (Phila) 44:535-7. 2005
  63. doi request reprint A randomized, double-blind, placebo-controlled, phase 1/2a study of the safety and immunogenicity of a live, attenuated human parainfluenza virus type 3 vaccine in healthy infants
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Vaccine 29:7042-8. 2011
    ....
  64. doi request reprint Pandemic and seasonal H1N1 influenza hemagglutinin-specific T cell responses elicited by seasonal influenza vaccination
    Ramu A Subbramanian
    Cincinnati Children s Hospital Medical Center, Division of Infectious Diseases, Department of Pediatrics, Cincinnati, OH, USA
    Vaccine 28:8258-67. 2010
    ..Cross reactive T cell responses to the pandemic H1N1 HA existed among the cohort before the circulation of the virus to varying degrees and these responses were boosted by seasonal vaccination...
  65. ncbi request reprint Human papillomavirus vaccines
    Jessica A Kahn
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH, USA
    Pediatr Infect Dis J 22:443-5. 2003
  66. pmc Adherence to the HPV vaccine dosing intervals and factors associated with completion of 3 doses
    Lea E Widdice
    Division of Adolescent Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Ave, MLC 4000, Cincinnati, OH 45229 3039, USA
    Pediatrics 127:77-84. 2011
    ..The objectives of this study were to determine (1) adherence to the immunization schedule for the human papillomavirus quadrivalent vaccine and (2) factors associated with completion of the 3-dose series...
  67. ncbi request reprint Modification of primary and recurrent genital herpes in guinea pigs by passive immunization
    Nigel Bourne
    Children s Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    J Gen Virol 83:2797-801. 2002
    ..The amount of DNA in the ganglia of As+72-treated animals was not significantly lower than that of controls. These observations have implications for both the dynamics of latency establishment and desirable vaccine characteristics...
  68. ncbi request reprint Second-year follow-up evaluation of live, attenuated human rotavirus vaccine 89-12 in healthy infants
    David I Bernstein
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Infect Dis 186:1487-9. 2002
    ..001 for each). These encouraging results have led to continued evaluation, in several countries, of a vaccine candidate derived from strain 89-12...
  69. pmc Specific fungal exposures, allergic sensitization, and rhinitis in infants
    Melissa Osborne
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH, USA
    Pediatr Allergy Immunol 17:450-7. 2006
    ..05), and Cladosporium and SPT(+) to aeroallergens (p < 0.05). This study indicates that health outcome may vary by fungal genera; some fungal types may have sensitizing effects while others may have a beneficial role...
  70. ncbi request reprint Effect of previous or simultaneous immunization with canarypox expressing cytomegalovirus (CMV) glycoprotein B (gB) on response to subunit gB vaccine plus MF59 in healthy CMV-seronegative adults
    David I Bernstein
    Division of Infectious Diseases, Children s Hospital Medical Center, CH 1, 3333 Burnet Ave Rm 1345, Cincinnati, Ohio 45229 3039, USA
    J Infect Dis 185:686-90. 2002
    ..All 3 vaccine regimens induced high-titer antibody and lymphoproliferative responses, but no benefit for priming or simultaneous vaccination was detected...
  71. pmc Optimum diagnostic assay and clinical specimen for routine rotavirus surveillance
    Lauren J Stockman
    National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 46:1842-3. 2008
    ..Testing of bulk stools by EIA appears to be optimum for rotavirus surveillance...
  72. ncbi request reprint Development of candidate rotavirus vaccines derived from neonatal strains in India
    Roger I Glass
    Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 192:S30-5. 2005
    ..This unique project, which is developing a new rotavirus vaccine in India with the use of Indian strains, an Indian manufacturer, and an Indian clinical development program, aims to expedite introduction of rotavirus vaccines in India...
  73. ncbi request reprint Use of active surveillance to validate international classification of diseases code estimates of rotavirus hospitalizations in children
    Vincent P Hsu
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Pediatrics 115:78-82. 2005
    ..Our study evaluated the sensitivity of the rotavirus ICD code among children hospitalized for AGE by using active surveillance for rotavirus at a tertiary children's hospital...
  74. ncbi request reprint Transmissibility, infectivity and immunogenicity of a live human parainfluenza type 3 virus vaccine (HPIV3cp45) among susceptible infants and toddlers
    Shabir A Madhi
    University of the Witwatersrand Medical Research Council Respiratory and Meningeal Pathogens Research Unit, South Africa
    Vaccine 24:2432-9. 2006
    ..This study examined the transmissibility between young children of an intranasally administered live attenuated human parainfluenza virus type 3 (HPIV3)-cp45 vaccine candidate...
  75. ncbi request reprint Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infants
    H Fred Clark
    University of Pennsylvania School of Medicine, Philadelphia, and Merck and Co, Inc, West Point, Pennsylvania 19486, USA
    J Pediatr 144:184-90. 2004
    ..To investigate safety, efficacy, and immunogenicity of live quadrivalent rotavirus vaccine (QRV) containing human-bovine (WC3) reassortant rotavirus serotypes G1, G2, G3, and P1a...
  76. ncbi request reprint Nonmedical costs associated with rotavirus disease requiring hospitalization
    Brian P Lee
    Children s Hospital and Research Center at Oakland, Oakland, CA, USA
    Pediatr Infect Dis J 24:984-8. 2005
    ..Herein, we report the results from the largest prospective study in the United States determining the nonmedical costs of severe rotavirus infections...
  77. ncbi request reprint A case-control study to determine risk factors for hospitalization for rotavirus gastroenteritis in U.S. children
    Penelope H Dennehy
    Hasbro Children s Hospital and Brown Medical School, Department of Pediatrics, Division of Infectious Diseases, Providence, RI 02903
    Pediatr Infect Dis J 25:1123-31. 2006
    ....
  78. doi request reprint Safety and immunogenicity of concurrent administration of live attenuated influenza vaccine with measles-mumps-rubella and varicella vaccines to infants 12 to 15 months of age
    Terry Nolan
    School of Population Health, University of Melbourne and Murdoch Children s Research Institute, Carlton, Melbourne, Victoria 3010, Australia
    Pediatrics 121:508-16. 2008
    ..This study evaluated the safety, tolerability, and immunogenicity of live attenuated influenza vaccine administered concurrently with measles-mumps-rubella vaccine and varicella vaccine to healthy children 12 to 15 months of age...
  79. ncbi request reprint RIX4414 (Rotarix): a live attenuated human rotavirus vaccine
    David I Bernstein
    J Pediatr (Rio J) 83:193-5. 2007
  80. ncbi request reprint The underrecognized burden of influenza in young children
    Katherine A Poehling
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, USA
    N Engl J Med 355:31-40. 2006
    ..The disease burden of influenza infection among children is not well established. We conducted a population-based surveillance of medical visits associated with laboratory-confirmed influenza...
  81. ncbi request reprint Predictors of sexual satisfaction in an adolescent and college population
    Beth A Auslander
    Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555 0319, USA
    J Pediatr Adolesc Gynecol 20:25-8. 2007
    ..To assess the degree to which adolescents/young adults are satisfied in their current sexual relationships and to evaluate intrapersonal and interpersonal predictors of sexual satisfaction among that population...
  82. pmc Antibody-mediated neutralization of pertussis toxin-induced mitogenicity of human peripheral blood mononuclear cells
    Scott H Millen
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Infect Immun 72:615-20. 2004
    ..the convalescent group had higher titers in the PBMC assay. Results for pertussis toxin neutralization with the CHO assay appear to be distinct from those with the PBMC assay...
  83. ncbi request reprint Viral sexually transmitted disease vaccine acceptability among college students
    Constance W Boehner
    Department of Psychology, University of Cincinnati, Cincinnati, Ohio, USA
    Sex Transm Dis 30:774-8. 2003
    ..The object of this study was to examine factors that could affect vaccine acceptance among college students for 2 sexually transmitted diseases (STDs)...
  84. ncbi request reprint Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT)
    Joel I Ward
    University of California Los Angeles UCLA Center for Vaccine Research, Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, David Geffen School of Medicine UCLA, Torrance, California 90502 2502, USA
    Clin Infect Dis 43:151-7. 2006
    ..Acellular pertussis (aP) booster immunizations have been recommended for adolescents and older persons to enhance long-term protection and to possibly reduce community transmission of infections...
  85. ncbi request reprint Glycoprotein-D-adjuvant vaccine to prevent genital herpes
    Lawrence R Stanberry
    Department of Pediatrics and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston 77555 0351, USA
    N Engl J Med 347:1652-61. 2002
    ..An effective prophylactic vaccine would help control the spread of genital herpes...
  86. ncbi request reprint Vaccination success rate and reaction profile with diluted and undiluted smallpox vaccine: a randomized controlled trial
    Thomas R Talbot
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA s
    JAMA 292:1205-12. 2004
    ....
  87. ncbi request reprint Factors predicting the acceptance of herpes simplex virus type 2 antibody testing among adolescents and young adults
    Gregory D Zimet
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, USA
    Sex Transm Dis 31:665-9. 2004
    ..The rates and determinants of acceptance of herpes simplex virus type 2 (HSV-2) testing have not been adequately studied...
  88. ncbi request reprint Predictors of herpes simplex virus type 2 antibody positivity among persons with no history of genital herpes
    Kenneth H Fife
    Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
    Sex Transm Dis 31:676-81. 2004
    ..The demographic, historical, and behavioral factors that predict a positive herpes simplex virus type 2 (HSV-2) antibody test in persons without a history of genital herpes have not been well-defined...
  89. ncbi request reprint Longitudinal risk of herpes simplex virus (HSV) type 1, HSV type 2, and cytomegalovirus infections among young adolescent girls
    Lawrence R Stanberry
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Clin Infect Dis 39:1433-8. 2004
    ..Cross-sectional seroprevalence studies indicate that infections with herpes simplex virus (HSV) types 1 (HSV-1) and 2 (HSV-2) and cytomegalovirus (CMV) are common. However, data on the rates of acquisition of these infections are limited...
  90. pmc Influence of dog ownership and high endotoxin on wheezing and atopy during infancy
    Paloma Campo
    Department of Internal Medicine, Immunology Division, University of Cincinnati, Cincinnati, OH 45267 0563, USA
    J Allergy Clin Immunol 118:1271-8. 2006
    ..Increased exposure to microbial products early in life may protect from development of atopic disorders in childhood. Few studies have examined the relationship of endotoxin exposure and pet ownership on atopy and wheezing during infancy...
  91. pmc The effect of home characteristics on dust antigen concentrations and loads in homes
    Seung Hyun Cho
    Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267 0056, USA
    Sci Total Environ 371:31-43. 2006
    ..This study encompassed a wide range of home characteristics and various antigen types. Our findings provide information on home characteristics that can be used for allergen avoidance and in planning future exposure assessment studies...
  92. ncbi request reprint Safety and efficacy of olopatadine hydrochloride nasal spray for the treatment of seasonal allergic rhinitis
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center, San Diego, California 92123, USA
    Ann Allergy Asthma Immunol 95:600-6. 2005
    ..A nasal spray containing the antiallergy agent olopatadine hydrochloride is being developed for the treatment of seasonal allergic rhinitis (SAR)...
  93. pmc Environmental risk factors of rhinitis in early infancy
    Jocelyn M Biagini
    Department of Environmental Health, University of Cincinnati, and Division of Allergy and Immunology, Department of Pediatrics, Cincinati Children s Hospital Medical Center, OH 45267 0056, USA
    Pediatr Allergy Immunol 17:278-84. 2006
    ..This study suggests that ETS exposure, rather than visible mold, is associated with rhinitis and allergic rhinitis in infants. The analysis also suggests that mold may be a stronger risk factor for URI that ETS...
  94. ncbi request reprint Safety of the trivalent, cold-adapted influenza vaccine in preschool-aged children
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatrics 110:662-72. 2002
    ..To provide additional information on the safety of trivalent, cold-adapted influenza vaccine (CAIV-T) in children...