Mara L Becker

Summary

Affiliation: Children's Mercy Hospital
Country: USA

Publications

  1. ncbi request reprint Interstitial pneumonitis in Blau syndrome with documented mutation in CARD15
    Mara L Becker
    Section of Rheumatology, Children s Mercy Hospitals and Clinics, Kansas City, Missouri 64108, and Oregon Health and Science University, Portland, USA
    Arthritis Rheum 56:1292-4. 2007
  2. doi request reprint Optimization of pediatric rheumatology therapeutics
    M L Becker
    Department of Pediatrics, Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, Missouri, USA
    Clin Pharmacol Ther 91:597-606. 2012
  3. pmc Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes
    Hongying Dai
    Department of Medical Research, Children s Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA
    BioData Min 5:3. 2012
  4. doi request reprint Pharmacogenomics in pediatric rheumatology
    Mara L Becker
    Division of Clinical Pharmacology and Toxicology, Section of Rheumatology, Children s Mercy Hospital, Kansas City, Missouri, USA
    Curr Opin Rheumatol 24:541-7. 2012
  5. doi request reprint Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability
    Mara L Becker
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, Missouri, USA
    Pharmacogenet Genomics 22:236-46. 2012
  6. doi request reprint Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations
    Mara L Becker
    Children s Mercy Hospital, Kansas City, Missouri, USA
    Arthritis Rheum 62:1803-12. 2010
  7. pmc Effectiveness and toxicity of methotrexate in juvenile idiopathic arthritis: comparison of 2 initial dosing regimens
    Mara L Becker
    Section of Rheumatology, Department of Pediatrics, Children s Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA
    J Rheumatol 37:870-5. 2010
  8. doi request reprint The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response
    Mara L Becker
    Children s Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA
    Arthritis Rheum 63:276-85. 2011
  9. pmc Identifying genomic and developmental causes of adverse drug reactions in children
    Mara L Becker
    Children s Mercy Hospitals and Clinics, Division of Clinical Pharmacology, 2401 Gillham Road, Kansas City, MO 64110, USA
    Pharmacogenomics 11:1591-602. 2010
  10. pmc Development of biomarkers to optimize pediatric patient management: what makes children different?
    Jennifer Goldman
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics and University of Missouri Kansas City, Kansas City, MO, USA
    Biomark Med 5:781-94. 2011

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Interstitial pneumonitis in Blau syndrome with documented mutation in CARD15
    Mara L Becker
    Section of Rheumatology, Children s Mercy Hospitals and Clinics, Kansas City, Missouri 64108, and Oregon Health and Science University, Portland, USA
    Arthritis Rheum 56:1292-4. 2007
    ..This case illustrates the continued evolution of the phenotype of a disease initially conceived as a familial inflammatory granulomatous disease limited to the triad of synovitis, dermatitis, and uveitis...
  2. doi request reprint Optimization of pediatric rheumatology therapeutics
    M L Becker
    Department of Pediatrics, Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, Missouri, USA
    Clin Pharmacol Ther 91:597-606. 2012
    ....
  3. pmc Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes
    Hongying Dai
    Department of Medical Research, Children s Mercy Hospital, 2401 Gillham Road, Kansas City, MO, 64108, USA
    BioData Min 5:3. 2012
    ..abstract:..
  4. doi request reprint Pharmacogenomics in pediatric rheumatology
    Mara L Becker
    Division of Clinical Pharmacology and Toxicology, Section of Rheumatology, Children s Mercy Hospital, Kansas City, Missouri, USA
    Curr Opin Rheumatol 24:541-7. 2012
    ..The genetic contribution to interindividual variability has emerged as a promising avenue of exploration; however, challenges remain in making this knowledge relevant in the clinical realm...
  5. doi request reprint Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability
    Mara L Becker
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, Missouri, USA
    Pharmacogenet Genomics 22:236-46. 2012
    ....
  6. doi request reprint Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations
    Mara L Becker
    Children s Mercy Hospital, Kansas City, Missouri, USA
    Arthritis Rheum 62:1803-12. 2010
    ..The present study was undertaken to measure intracellular MTXGlu concentrations in a cohort of patients with juvenile idiopathic arthritis (JIA) to determine the predictors of MTXGlu variability in these patients...
  7. pmc Effectiveness and toxicity of methotrexate in juvenile idiopathic arthritis: comparison of 2 initial dosing regimens
    Mara L Becker
    Section of Rheumatology, Department of Pediatrics, Children s Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA
    J Rheumatol 37:870-5. 2010
    ..To compare the incidence of liver toxicity and clinical response between 2 initial dosing regimens of methotrexate (MTX) for treatment of juvenile idiopathic arthritis (JIA)...
  8. doi request reprint The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response
    Mara L Becker
    Children s Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA
    Arthritis Rheum 63:276-85. 2011
    ..Therefore, this study was aimed at investigating the genetic predictors of MTXGlu variability and associations between MTXGlu and drug response in JIA...
  9. pmc Identifying genomic and developmental causes of adverse drug reactions in children
    Mara L Becker
    Children s Mercy Hospitals and Clinics, Division of Clinical Pharmacology, 2401 Gillham Road, Kansas City, MO 64110, USA
    Pharmacogenomics 11:1591-602. 2010
    ....
  10. pmc Development of biomarkers to optimize pediatric patient management: what makes children different?
    Jennifer Goldman
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics and University of Missouri Kansas City, Kansas City, MO, USA
    Biomark Med 5:781-94. 2011
    ..New and innovative approaches are necessary to provide reliable, validated biomarkers that can be used to improve and advance pediatric medical care...
  11. doi request reprint Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry
    Leon van Haandel
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    Rapid Commun Mass Spectrom 26:1617-30. 2012
    ..The present work presents high-throughput analytical methodology for the indirect comprehensive quantitation of the erythrocyte folate pool with commercially available standards...
  12. doi request reprint Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC-MS/MS
    Leon van Haandel
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA
    Bioanalysis 3:2783-96. 2011
    ..Therapeutic drug monitoring of intracellular methotrexate metabolites, the γ-polyglutamates (MTXGlu(n)), in human erythrocytes has shown promise in providing a basis for individualization of therapy...
  13. pmc Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction
    Hongying Dai
    Research Development and Clinical Investigation, Children s Mercy Hospital, Kansas City, MO, 64108, USA
    BioData Min 6:1. 2013
    ..abstract:..
  14. doi request reprint Developmental pharmacogenomics
    Kathleen A Neville
    Department of Pediatrics, University of Missouri Kansas City, Kansas City, MO, USA
    Paediatr Anaesth 21:255-65. 2011
    ....
  15. ncbi request reprint Blau syndrome and related genetic disorders causing childhood arthritis
    Mara L Becker
    Division of Pediatric Rheumatology, duPont Children s Hospital, Wilmington, DE 19899, USA
    Curr Rheumatol Rep 7:427-33. 2005
    ..This paper will review the clinical characteristics of these three disorders and their association with mutations in the CARD 15 gene...