Research Topics
| Hani AtamnaSummaryAffiliation: Children's Hospital Oakland Research Institute Country: USA Publications
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Detail Information
Publications
Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's diseaseHani Atamna
Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, CA 94609, USA
Proc Natl Acad Sci U S A 103:3381-6. 2006..The relevance of the binding of regulatory heme with excessive Abeta for mitochondrial dysfunction and neurotoxicity and other cytopathologies of AD is discussed...
Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's diseaseHani Atamna
Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
Mitochondrion 7:297-310. 2007..We further discuss how protecting mitochondria could confer resistance to oxidative and environmental insults. Therapies targeted at protecting mitochondria may improve the clinical outcome of AD patients...- Heme binding to Amyloid-beta peptide: mechanistic role in Alzheimer's diseaseHani Atamna
Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute CHORI, Oakland, CA 94609, USA
J Alzheimers Dis 10:255-66. 2006..Genetic, nutritional, and toxicological factors that influence heme metabolism will be discussed in relevance to AD... - Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathwaysHani Atamna
Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
FASEB J 22:703-12. 2008..MB may be useful to delay mitochondrial dysfunction with aging and the decrease in complex IV in Alzheimer disease... - A role for heme in Alzheimer's disease: heme binds amyloid beta and has altered metabolismHani Atamna
Nutritional Genomics Center, Children s Hospital Oakland Research Institute, CA 94609, USA
Proc Natl Acad Sci U S A 101:11153-8. 2004..g., heme-a) and resulting in functional heme deficiency. The model integrates disparate observations, including A beta, mitochondrial dysfunction, cholesterol, and the proposed efficacy of clioquinol... - Heme, iron, and the mitochondrial decay of ageingHani Atamna
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
Ageing Res Rev 3:303-18. 2004..This review discusses heme metabolism as related to metabolic changes seen in ageing and age-related disorders and highlights the possible role in iron deficiency... - Heme deficiency may be a factor in the mitochondrial and neuronal decay of agingHani Atamna
Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Proc Natl Acad Sci U S A 99:14807-12. 2002..Thus, heme deficiency or dysregulation may be an important and preventable component of the neurodegenerative process... - Iron accumulation during cellular senescenceDavid W Killilea
Children's Hospital Oakland Research Institute, Oakland, California 94609, USA
Ann N Y Acad Sci 1019:365-7. 2004..Thus, iron accumulation is not a cause, but a consequence of normal cellular senescence in vitro. Senescence-associated iron accumulation may contribute to the increased oxidative stress and cellular dysfunction seen in senescent cells... - Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblastsHani Atamna
Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
J Nutr 137:25-30. 2007..The findings are discussed in relation to aging and birth defects in humans... - Mineral and vitamin deficiencies can accelerate the mitochondrial decay of agingBruce N Ames
Nutrition, Metabolisms and Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, U States
Mol Aspects Med 26:363-78. 2005..An optimum intake of micronutrients could tune up metabolism and give a marked increase in health, particularly for the poor, elderly, and obese, at little cost... - Iron accumulation during cellular senescence in human fibroblasts in vitroDavid W Killilea
Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA
Antioxid Redox Signal 5:507-16. 2003..These data indicate that iron accumulation occurs during normal cellular senescence in vitro. This accumulation of iron may contribute to the increased oxidative stress and cellular dysfunction seen in senescent cells... 
Human and rodent amyloid-beta peptides differentially bind heme: relevance to the human susceptibility to Alzheimer's diseaseHani Atamna
Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Arch Biochem Biophys 487:59-65. 2009..Phylogenic variations in the amino acid sequence of Abeta explain tight heme-binding to huAbeta and likely contribute to the increased human susceptibility to AD...- N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degenerationLudmila A Voloboueva
Children s Hospital Oakland Research Institute, Nutrition and Metabolism Center, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
FASEB J 21:4077-86. 2007..NtBHA might be useful in AMD due to its potential to reduce oxidative stress, mitochondrial damage, and age-related iron accumulation, which may damage normal RPE function and lead to loss of vision... - The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with ageHani Atamna
Department of Molecular and Cell Biology, University of California, Berkeley/CHORI, 5700 Martin Luther King Jr. Way, Oakland, California 94609, USA
Arch Biochem Biophys 397:345-53. 2002..We review the physiological role of iron-sulfur clusters and heme in the integrity of the mitochondria and the generation of oxidants... - Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescenceJoseph M Dhahbi
Center for Genetics, Children s Hospital Oakland Research Institute, Oakland, California, United States of America
PLoS ONE 6:e20509. 2011..This result greatly extends existing information on the role of miRNAs in cell senescence and is consistent with miRNAs having a causal role in the process... - Gender and age-dependent differences in the mitochondrial apoptogenic pathway in Alzheimer's diseaseAna Lloret
Departamento de Fisiologia, Facultad de Medicina, Avda Blasco Ibanez 15, 46010 Valencia, Spain
Free Radic Biol Med 44:2019-25. 2008..Gender and age-related differences seen in the development of AD can also be partially explained... - Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolitesJiankang Liu
Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720, USA
Ann N Y Acad Sci 959:133-66. 2002..This loss of activity due to coenzyme or substrate binding appears to be true for a number of other enzymes as well, including mitochondrial complex III and IV...