Silva A Arslanian

Summary

Affiliation: Children's Hospital of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Clamp techniques in paediatrics: what have we learned?
    Silva A Arslanian
    Children s Hospital of Pittsburgh, Weight Management and Wellness Center, and Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Pittsburgh, PA 15213, USA
    Horm Res 64:16-24. 2005
  2. pmc 25-Hydroxyvitamin D in obese youth across the spectrum of glucose tolerance from normal to prediabetes to type 2 diabetes
    Javier de las Heras
    Division of Pediatric Metabolism, Hospital Universitario de Cruces, Barakaldo, Vizcaya, Spain
    Diabetes Care 36:2048-53. 2013
  3. pmc Measuring β-cell function relative to insulin sensitivity in youth: does the hyperglycemic clamp suffice?
    Lindsey Sjaarda
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes Care 36:1607-12. 2013
  4. pmc Declining beta-cell function relative to insulin sensitivity with increasing fasting glucose levels in the nondiabetic range in children
    Hala Tfayli
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes Care 33:2024-30. 2010
  5. ncbi request reprint Family history of type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth
    Silva A Arslanian
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 28:115-9. 2005
  6. ncbi request reprint Hyperinsulinemia in african-american children: decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity
    Silva A Arslanian
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital, University of Pittsburgh, Pennsylvania 15213, USA
    Diabetes 51:3014-9. 2002
  7. pmc In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes?
    Fida Bacha
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:100-5. 2009
  8. ncbi request reprint Ghrelin and peptide YY in youth: are there race-related differences?
    Fida Bacha
    Weight Management and Wellness Center, Children s Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, PA 15213, USA
    J Clin Endocrinol Metab 91:3117-22. 2006
  9. ncbi request reprint Racial differences in adiponectin in youth: relationship to visceral fat and insulin sensitivity
    SoJung Lee
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Weight Management and Wellness Center, Children s Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto St, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 29:51-6. 2006
  10. ncbi request reprint Waist circumference is an independent predictor of insulin resistance in black and white youths
    SoJung Lee
    Children s Hospital of Pittsburgh, Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Weight Management and Wellness Center, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, PA 15213, USA
    J Pediatr 148:188-94. 2006

Research Grants

  1. CHILDHOOD METABOLIC MARKERS OF ADULT MORBIDITY IN BLACKS
    Silva Arslanian; Fiscal Year: 2007
  2. Research and Academic Training in Pediatric Diabetes
    Silva Arslanian; Fiscal Year: 2007
  3. Type 2 Diabetes in Youth: Beta Cell Preservation
    Silva Arslanian; Fiscal Year: 2007
  4. INSULIN RESISTANCE IN CHILDHOOD
    Silva Arslanian; Fiscal Year: 2007
  5. Academic Career Development in Pediatric Diabetes(K12)
    Silva Arslanian; Fiscal Year: 2005
  6. CHILDHOOD METABOLIC MARKERS OF ADULT MORBIDITY IN BLACKS
    Silva Arslanian; Fiscal Year: 2000
  7. CHILDHOOD METABOLIC MARKERS OF ADULT MORBIDITY IN BLACKS
    Silva Arslanian; Fiscal Year: 2009

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Clamp techniques in paediatrics: what have we learned?
    Silva A Arslanian
    Children s Hospital of Pittsburgh, Weight Management and Wellness Center, and Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Pittsburgh, PA 15213, USA
    Horm Res 64:16-24. 2005
    ..This article will delineate our paediatric experience with the clamp technique, the hyperinsulinaemic-euglycaemic clamp in assessing in vivo insulin sensitivity, and the hyperglycaemic clamp in assessing insulin secretion...
  2. pmc 25-Hydroxyvitamin D in obese youth across the spectrum of glucose tolerance from normal to prediabetes to type 2 diabetes
    Javier de las Heras
    Division of Pediatric Metabolism, Hospital Universitario de Cruces, Barakaldo, Vizcaya, Spain
    Diabetes Care 36:2048-53. 2013
    ....
  3. pmc Measuring β-cell function relative to insulin sensitivity in youth: does the hyperglycemic clamp suffice?
    Lindsey Sjaarda
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes Care 36:1607-12. 2013
    ....
  4. pmc Declining beta-cell function relative to insulin sensitivity with increasing fasting glucose levels in the nondiabetic range in children
    Hala Tfayli
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes Care 33:2024-30. 2010
    ..This investigation tested the hypothesis that beta-cell function relative to insulin sensitivity decreases with increasing FPG in youth...
  5. ncbi request reprint Family history of type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth
    Silva A Arslanian
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 28:115-9. 2005
    ..beta-Cell compensation for insulin sensitivity was calculated as the product of insulin sensitivity x first-phase insulin secretion, termed glucose disposition index (GDI)...
  6. ncbi request reprint Hyperinsulinemia in african-american children: decreased insulin clearance and increased insulin secretion and its relationship to insulin sensitivity
    Silva A Arslanian
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital, University of Pittsburgh, Pennsylvania 15213, USA
    Diabetes 51:3014-9. 2002
    ..Dietary factors may have a role. Additional studies are needed to determine whether metabolic/nutritional factors, possibly mediated through free fatty acids, may play a role in the hyperinsulinism observed in AA children...
  7. pmc In vivo insulin sensitivity and secretion in obese youth: what are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes?
    Fida Bacha
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:100-5. 2009
    ..The aim of this study was to investigate the differences in insulin sensitivity (IS) and secretion in obese adolescents with IGT compared with those with normal glucose tolerance (NGT) and type 2 diabetes...
  8. ncbi request reprint Ghrelin and peptide YY in youth: are there race-related differences?
    Fida Bacha
    Weight Management and Wellness Center, Children s Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, PA 15213, USA
    J Clin Endocrinol Metab 91:3117-22. 2006
    ..Impaired regulation of ghrelin/PYY may be conducive to obesity. We hypothesized that racial differences in childhood obesity could partly be explained by differences in ghrelin/PYY dynamics...
  9. ncbi request reprint Racial differences in adiponectin in youth: relationship to visceral fat and insulin sensitivity
    SoJung Lee
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Weight Management and Wellness Center, Children s Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto St, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 29:51-6. 2006
    ....
  10. ncbi request reprint Waist circumference is an independent predictor of insulin resistance in black and white youths
    SoJung Lee
    Children s Hospital of Pittsburgh, Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Weight Management and Wellness Center, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, PA 15213, USA
    J Pediatr 148:188-94. 2006
    ..We examined how well waist circumference (WC) reflects total and abdominal fat and whether WC predicts insulin resistance independent of body mass index (BMI) percentile in youths...
  11. ncbi request reprint Growth hormone treatment in adolescent males with idiopathic short stature: changes in body composition, protein, fat, and glucose metabolism
    Tamara S Hannon
    Division of Pediatric Endocrinology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 92:3033-9. 2007
    ..Cross-sectional observations show an inverse relationship between pubertal increase in GH and insulin sensitivity, suggesting that pubertal insulin resistance may be mediated by GH...
  12. ncbi request reprint Evidence for heterogeneous pathogenesis of insulin-treated diabetes in black and white children
    Ingrid M Libman
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 26:2876-82. 2003
    ..To further explore this issue, we compared clinical, biochemical, and autoimmune characteristics at disease diagnosis and follow-up treatment in an expanded number of black and white children with and without the presence of AAs...
  13. pmc Metabolomic profiling of amino acids and β-cell function relative to insulin sensitivity in youth
    Sara F Michaliszyn
    Children s Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 97:E2119-24. 2012
    ..In longitudinal studies of adults, elevated amino acid (AA) concentrations predicted future type 2 diabetes mellitus (T2DM)...
  14. ncbi request reprint Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors
    Fida Bacha
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 88:2534-40. 2003
    ..Although differences in fat patterning may help explain the more atherogenic risk profile in whites, the cause of the more diabetogenic insulin sensitivity/secretion profile in blacks remains unknown and needs to be investigated further...
  15. pmc In vivo insulin sensitivity and lipoprotein particle size and concentration in black and white children
    Stephen F Burns
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:2087-93. 2009
    ..To examine sex-specific black/white differences in lipoprotein profile and the role of visceral adiposity and to assess the relationship between insulin sensitivity and lipoprotein profiles in each group...
  16. ncbi request reprint Use of markers of dyslipidemia to identify overweight youth with insulin resistance
    Tamara S Hannon
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Pediatr Diabetes 7:260-6. 2006
    ..Markers to identify overweight youth with insulin resistance are of clinical importance...
  17. pmc Surrogate lipid markers for small dense low-density lipoprotein particles in overweight youth
    Stephen F Burns
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA
    J Pediatr 161:991-6. 2012
    ..To determine if the ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL) and non-HDL cholesterol concentration could identify youth with small dense low-density lipoprotein (LDL)...
  18. pmc 25-hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth
    Kumaravel Rajakumar
    Department of Pediatrics, Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes Care 35:627-33. 2012
    ..To examine the relationships between plasma 25-hydroxyvitamin D [25(OH)D] and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity, disposition index (DI), in black and white youth...
  19. ncbi request reprint Cardiorespiratory fitness in youth: relationship to insulin sensitivity and beta-cell function
    SoJung Lee
    Children s Hospital of Pittsburgh, Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Weight Management and Wellness Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Obesity (Silver Spring) 14:1579-85. 2006
    ..We examined whether the relationship between cardiorespiratory fitness (CRF) and insulin sensitivity (IS)/secretion is independent of adiposity in healthy African-American (n = 65) and white (n = 57) youth...
  20. pmc Hyperinsulinemia in African-American adolescents compared with their American white peers despite similar insulin sensitivity: a reflection of upregulated beta-cell function?
    Tamara S Hannon
    Division of Pediatric Endocrinology, Metabolism, and Diabetes, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 31:1445-7. 2008
    ..The aim of the present investigation was to assess whether glucose-stimulated insulin response is higher in AA versus AW adolescents who have comparable in vivo insulin sensitivity...
  21. pmc Fat oxidation in black and white youth: a metabolic phenotype potentially predisposing black girls to obesity
    SoJung Lee
    University of Pittsburgh, School of Medicine, Weight Management and Wellness Center, Pediatric Clinical and Translational Research Center, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 93:4547-51. 2008
    ..Thus, we examined the relationships between race, pubertal development, and postabsorptive fat oxidation in youth...
  22. pmc HbA(1c) diagnostic categories and β-cell function relative to insulin sensitivity in overweight/obese adolescents
    Lindsey A Sjaarda
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes Care 35:2559-63. 2012
    ..We hypothesized that alterations in the pathophysiologic mechanisms of type 2 diabetes may be evident in the American Diabetes Association recommended at-risk/prediabetes category (HbA(1c) 5.7 to <6.5%)...
  23. pmc Declining β-cell function relative to insulin sensitivity with escalating OGTT 2-h glucose concentrations in the nondiabetic through the diabetic range in overweight youth
    Stephen F Burns
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Diabetes Care 34:2033-40. 2011
    ..Cell function relative to insulin sensitivity, assessed by clamp disposition index (DI) and oral disposition index (DI(O)), were compared among groups...
  24. pmc Type 2 diabetes in youth: are there racial differences in β-cell responsiveness relative to insulin sensitivity?
    Fida Bacha
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Diabetes 13:259-65. 2012
    ..Non-diabetic African American (AA) youth have an upregulated insulin secretion relative to insulin sensitivity (IS) compared with their American White (AW) peers. We investigated if similar racial differences exist in youth with T2DM...
  25. ncbi request reprint Are obesity-related metabolic risk factors modulated by the degree of insulin resistance in adolescents?
    Fida Bacha
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus and the Weight Management and Wellness Center, Children s Hospital of Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 29:1599-604. 2006
    ..However, wide variations in insulin sensitivity are noted in obese youth. It is not clear if greater insulin resistance confers a higher risk of cardiovascular comorbidities and risk for type 2 diabetes...
  26. ncbi request reprint Longitudinal study of physiologic insulin resistance and metabolic changes of puberty
    Tamara S Hannon
    Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus and Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatr Res 60:759-63. 2006
    ..These metabolic changes are proposed to be partially mediated by increased GH secretion and are consistent with the Randle cycle of competition between glucose and fat oxidation...
  27. pmc From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation
    Fida Bacha
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 33:2225-31. 2010
    ..We investigated differences in insulin sensitivity and secretion among youth with IFG, IGT, and coexistent IFG/IGT compared with those with normal glucose tolerance (NGT) and type 2 diabetes...
  28. ncbi request reprint Adiponectin in youth: relationship to visceral adiposity, insulin sensitivity, and beta-cell function
    Fida Bacha
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 27:547-52. 2004
    ..The present study investigated the relationship of adiponectin levels in adolescents to 1) obesity and body fat distribution and 2) insulin sensitivity and the components of syndrome X...
  29. pmc Progressive deterioration of β-cell function in obese youth with type 2 diabetes
    Fida Bacha
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
    Pediatr Diabetes 14:106-11. 2013
    ..In adults, type 2 diabetes (T2DM) is characterized with progressive deterioration in insulin secretion. Data are scanty in youth. We investigated prospectively the change in β-cell function and in insulin sensitivity in youth with T2DM...
  30. pmc β-Cell lipotoxicity after an overnight intravenous lipid challenge and free fatty acid elevation in African American versus American white overweight/obese adolescents
    Kara S Hughan
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 98:2062-9. 2013
    ..The present study investigated β-cell lipotoxicity to test whether increased free fatty acid (FFA) levels result in greater β-cell dysfunction in AA vs AW OW/OB adolescents...
  31. doi request reprint Race and gender differences in the relationships between anthropometrics and abdominal fat in youth
    SoJung Lee
    Children s Hospital of Pittsburgh, Division of Weight Management and Wellness, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 16:1066-71. 2008
    ..We examined the influence of race and gender on abdominal adipose tissue (AT) distribution for a given anthropometric measure including waist circumference (WC), waist-to-hip ratio (WHR) and waist-to-height (W/Ht) in youth...
  32. pmc Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth
    SoJung Lee
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
    Pediatr Diabetes 12:250-7. 2011
    ..We examined the influence of the measurement site of VAT on the relationships between VAT and metabolic syndrome (MetS) in African-American (AA) and American-White (AW) youth...
  33. pmc Effects of an intravenous lipid challenge and free fatty acid elevation on in vivo insulin sensitivity in African American versus Caucasian adolescents
    Stephen F Burns
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:355-60. 2009
    ..The present investigation determined whether elevating FFA is more deleterious to insulin sensitivity in African American than in Caucasian adolescents...
  34. pmc Vitamin D status, adiposity, and lipids in black American and Caucasian children
    Kumaravel Rajakumar
    Department of Pediatrics, Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 96:1560-7. 2011
    ..The aim of the study was to examine the relationship between vitamin D status, total and abdominal adiposity, and lipids in black and white children...
  35. ncbi request reprint Type 2 diabetes in children and adolescents: a review for the primary care provider
    Tamara S Hannon
    Department of Pediatrics, Children s Hospital, University of Pittsburgh Medical Center, PA 15213, USA
    Pediatr Ann 35:880-7. 2006
  36. ncbi request reprint Waist circumference, blood pressure, and lipid components of the metabolic syndrome
    SoJung Lee
    Weight Management and Wellness Center and Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Pediatr 149:809-16. 2006
    ..To examine whether waist circumference (WC) predicts blood pressure (BP) and lipid components of the metabolic syndrome independent of body mass index (BMI) percentile in youths...
  37. pmc Waist circumference, atherogenic lipoproteins, and vascular smooth muscle biomarkers in children
    Stephen F Burns
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 94:4914-22. 2009
    ..The present study determined differences in lipoprotein particle size and subclass concentration and markers of vascular smooth muscle function in children using WC percentile cutoffs...
  38. pmc Family-based treatment of severe pediatric obesity: randomized, controlled trial
    Melissa A Kalarchian
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatrics 124:1060-8. 2009
    ..We evaluated the efficacy of family-based, behavioral weight control in the management of severe pediatric obesity...
  39. ncbi request reprint Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: amelioration of exaggerated adrenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance
    Silva A Arslanian
    Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 87:1555-9. 2002
    ..In conclusion, double blind, placebo-controlled studies will determine whether insulin-sensitizing therapy corrects not only ovarian hyperandrogenism but also functional adrenal hyperandrogenism in adolescents with PCOS...
  40. ncbi request reprint Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African-American children?
    Fida Bacha
    Division of Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, PA 15213, USA
    Pediatr Diabetes 6:100-2. 2005
    ..Lower adiponectin does not seem to explain the racial differences in insulin sensitivity. The relationship of hyperinsulinemia and hypoadiponectinemia needs to be further explored...
  41. ncbi request reprint Childhood obesity and type 2 diabetes mellitus
    Tamara S Hannon
    Division of Weight Management and Wellness, University of Pittsburgh School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Pediatrics 116:473-80. 2005
    ..Health care professionals are advised to perform the appropriate screening in children at risk for T2DM, diagnose the condition as early as possible, and provide rigorous management of the disease...
  42. pmc Measures of beta-cell function during the oral glucose tolerance test, liquid mixed-meal test, and hyperglycemic clamp test
    Fida Bacha
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    J Pediatr 152:618-21. 2008
    ....
  43. pmc β-Cell Lipotoxicity in Response to Free Fatty Acid Elevation in Prepubertal Youth: African American Versus Caucasian Contrast
    Sara F Michaliszyn
    Division of Weight Management, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
    Diabetes 62:2917-22. 2013
    ....
  44. pmc Metabolomic profiling of fatty acid and amino acid metabolism in youth with obesity and type 2 diabetes: evidence for enhanced mitochondrial oxidation
    Stephanie J Mihalik
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Diabetes Care 35:605-11. 2012
    ..We compared acylcarnitine (AcylCN) species, common amino acid and fat oxidation (FOX) byproducts, and plasma amino acids in normal weight (NW; n = 39), obese (OB; n = 64), and type 2 diabetic (n = 17) adolescents...
  45. ncbi request reprint Metabolic differences between Caucasian and African-American children and the relationship to type 2 diabetes mellitus
    Silva A Arslanian
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital, University of Pittsburgh, PA 15213, USA
    J Pediatr Endocrinol Metab 15:509-17. 2002
    ..Treatment of type 2 DM should focus on identifying individuals at risk and instituting lifestyle changes to reduce the risk and stem the development of DM...
  46. pmc Sleep-disordered breathing in obese adolescents is associated with visceral adiposity and markers of insulin resistance
    Tamara S Hannon
    Division of Weight Management and Wellness, Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Int J Pediatr Obes 6:157-60. 2011
    ..Further study to allow for critical assessment of the relationships between sleep-disordered breathing and cardiometabolic risk factors in obese youth remains necessary...
  47. ncbi request reprint Ghrelin suppression in overweight children: a manifestation of insulin resistance?
    Fida Bacha
    Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus, Children s Hospital of Pittsburgh, 3705 Fifth Avenue at DeSoto Street, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 90:2725-30. 2005
    ..Alterations in ghrelin suppression in OW children may be yet another manifestation of the insulin resistance of obesity. Whether this is responsible for differences in satiety in OW individuals merits additional investigation...
  48. ncbi request reprint Prevention and treatment of type 2 diabetes in youth
    Ingrid M Libman
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Horm Res 67:22-34. 2007
    ..Evidence-based research and clinical experience in pediatrics, possibly modeled after adult trials, need to be developed if this public health threat is to be contained...
  49. ncbi request reprint Changing prevalence of overweight children and adolescents at onset of insulin-treated diabetes
    Ingrid M Libman
    Department of Pediatrics, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Diabetes Care 26:2871-5. 2003
    ..The aim of this study was to compare the prevalence of being overweight in black and white children and adolescents at onset of insulin-treated diabetes during two time periods: 1979-1989 (period I) and 1990-1998 (period II)...
  50. ncbi request reprint Short-term pharmacologically induced growth study of ontogenetic allometry of oxygen uptake in children
    Govindasamy Balasekaran
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Ann Hum Biol 32:746-59. 2005
    ..However, a wide deviation in the allometric coefficients for VO2max may be apparent when selected pediatric cohorts are studied in conjunction with clinical intervention for growth abnormalities...
  51. ncbi request reprint Comparison of maximal oxygen consumption between black and white prepubertal and pubertal children
    Joseph L Andreacci
    Center for Exercise and Health Fitness Research, School of Health, Physical and Recreation Education, University of Pittsburgh, Pittsburgh, PA 16261, USA
    Pediatr Res 56:706-13. 2004
    ..Further investigations should study Hb flow rate (a function of [Hb] x maximal cardiac output) in black and white children as it relates to VO2max...
  52. pmc Parents' Readiness to Change Affects BMI Reduction Outcomes in Adolescents with Polycystic Ovary Syndrome
    Karen P Jakubowski
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
    J Obes 2012:298067. 2012
    ..15, p = 0.043). Findings support future research which carefully assesses adolescent and parent SOC and potentially develops interventions targeting adolescent and parental readiness to adopt healthy lifestyle goals...
  53. pmc Cognitive-behavioral therapy for physical and emotional disturbances in adolescents with polycystic ovary syndrome: a pilot study
    Dana L Rofey
    Children s Hospital of Pittsburgh, USA
    J Pediatr Psychol 34:156-63. 2009
    ....
  54. pmc Surrogate estimates of insulin sensitivity in obese youth along the spectrum of glucose tolerance from normal to prediabetes to diabetes
    Lindsey George
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 96:2136-45. 2011
    ..In epidemiological studies of childhood obesity, simple and reliable surrogate estimates of insulin sensitivity are needed because the gold standard, the hyperinsulinemic-euglycemic clamp, is not feasible on a large scale...
  55. pmc Drospirenone/ethinyl estradiol versus rosiglitazone treatment in overweight adolescents with polycystic ovary syndrome: comparison of metabolic, hormonal, and cardiovascular risk factors
    Hala Tfayli
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15224, USA
    J Clin Endocrinol Metab 96:1311-9. 2011
    ..Adolescents with polycystic ovary syndrome (PCOS) have insulin resistance and higher rates of the metabolic syndrome...
  56. pmc Islet cell antibody-positive versus -negative phenotypic type 2 diabetes in youth: does the oral glucose tolerance test distinguish between the two?
    Hala Tfayli
    Division of Weight Management and Wellness, Children s Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Diabetes Care 33:632-8. 2010
    ..This underscores the importance of using more sensitive methods and the importance of determining antibody status in obese youths with CDx-type 2 diabetes...
  57. ncbi request reprint Eating disorders. A meter tells the real story
    Denise Charron-Prochownik
    Diabetes Forecast 55:63-5. 2002
  58. pmc Prediction equations for resting energy expenditure in overweight and normal-weight black and white children
    Jennifer R McDuffie
    Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Clin Nutr 80:365-73. 2004
    ..Accurate estimation of children's resting energy expenditure (REE) is important for planning dietary therapy...
  59. ncbi request reprint Comparison of maximal oxygen consumption between obese black and white adolescents
    Joseph L Andreacci
    Department of Exercise, Bloomsburg University, Bloomsburg, PA 17815, USA
    Pediatr Res 58:478-82. 2005
    ..Further investigations should study Hb flow rate (a function of [Hb] . maximal cardiac output) and physical activity/inactivity patterns in obese black and white children as it relates to VO2max...

Research Grants16

  1. CHILDHOOD METABOLIC MARKERS OF ADULT MORBIDITY IN BLACKS
    Silva Arslanian; Fiscal Year: 2007
    ..The ultimate goal is to reduce the morbidity and mortality related to obesity, T2DM and CVD in black Americans by intervention/prevention strategies early in childhood. ..
  2. Research and Academic Training in Pediatric Diabetes
    Silva Arslanian; Fiscal Year: 2007
    ..This program will foster the development of a diverse and highly trained workforce of pediatric diabetologists to assume leadership roles related to the nation's biomedical and behavioral research efforts in childhood diabetes. ..
  3. Type 2 Diabetes in Youth: Beta Cell Preservation
    Silva Arslanian; Fiscal Year: 2007
    ..A comprehensive approach to therapeutic interventions in children with type 2 diabetes mellitus will form the basis for prevention of adult morbidity and mortality starting early in childhood. ..
  4. INSULIN RESISTANCE IN CHILDHOOD
    Silva Arslanian; Fiscal Year: 2007
    ....
  5. Academic Career Development in Pediatric Diabetes(K12)
    Silva Arslanian; Fiscal Year: 2005
    ..abstract_text> ..
  6. CHILDHOOD METABOLIC MARKERS OF ADULT MORBIDITY IN BLACKS
    Silva Arslanian; Fiscal Year: 2000
    ..An understanding of the normal physiologic changes in hormonal regulation of energy metabolism that occur during puberty is essential for a thorough evaluation of the pathophysiologic alterations that lead to disease states. ..
  7. CHILDHOOD METABOLIC MARKERS OF ADULT MORBIDITY IN BLACKS
    Silva Arslanian; Fiscal Year: 2009
    ..The ultimate goal is to reduce the morbidity and mortality related to obesity, T2DM and CVD in black Americans by intervention/prevention strategies early in childhood. ..