Bruce Ames

Summary

Affiliation: Children's Hospital Oakland Research Institute
Country: USA

Publications

  1. pmc A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial
    Michele L Mietus-Snyder
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, 94609, USA
    FASEB J 26:3515-27. 2012
  2. ncbi request reprint An enthusiasm for metabolism
    Bruce N Ames
    Children s Hospital Oakland Res Inst, Oakland, CA 94609 1673, USA
    J Biol Chem 278:4369-80. 2003
  3. ncbi request reprint Delaying the mitochondrial decay of aging-a metabolic tune-up
    Bruce N Ames
    Department of Molecular and Cellular Biology, University of California, Berkeley, California 94609, USA
    Alzheimer Dis Assoc Disord 17:S54-7. 2003
  4. ncbi request reprint Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging
    Bruce N Ames
    Nutrition, Metabolisms and Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, U States
    Mol Aspects Med 26:363-78. 2005
  5. ncbi request reprint Mitochondrial decay, a major cause of aging, can be delayed
    Bruce N Ames
    University of California, Berkeley, CA, USA
    J Alzheimers Dis 6:117-21. 2004
  6. ncbi request reprint Delaying the mitochondrial decay of aging
    Bruce N Ames
    University of California, Berkeley, and Children s Hospital Oakland Research Institute, USA
    Ann N Y Acad Sci 1019:406-11. 2004
  7. ncbi request reprint Are vitamin and mineral deficiencies a major cancer risk?
    Bruce N Ames
    Nutrition Genomics Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, California 94609 1673, USA
    Nat Rev Cancer 2:694-704. 2002
  8. pmc Increasing longevity by tuning up metabolism. To maximize human health and lifespan, scientists must abandon outdated models of micronutrients
    Bruce N Ames
    The Children s Hospital Oakland Research Institute, Oakland, CA, USA
    EMBO Rep 6:S20-4. 2005
  9. ncbi request reprint Delaying the mitochondrial decay of aging with acetylcarnitine
    Bruce N Ames
    Nutritional Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1033:108-16. 2004
  10. ncbi request reprint High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms
    Bruce N Ames
    Department of Molecular and Cellular Biology, University of California, Berkeley, USA
    Am J Clin Nutr 75:616-58. 2002

Detail Information

Publications63

  1. pmc A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial
    Michele L Mietus-Snyder
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, 94609, USA
    FASEB J 26:3515-27. 2012
    ..These results lay the groundwork for mechanistic/deconstruction experiments to identify critical bar components and putative synergistic combinations responsible for observed effects...
  2. ncbi request reprint An enthusiasm for metabolism
    Bruce N Ames
    Children s Hospital Oakland Res Inst, Oakland, CA 94609 1673, USA
    J Biol Chem 278:4369-80. 2003
  3. ncbi request reprint Delaying the mitochondrial decay of aging-a metabolic tune-up
    Bruce N Ames
    Department of Molecular and Cellular Biology, University of California, Berkeley, California 94609, USA
    Alzheimer Dis Assoc Disord 17:S54-7. 2003
  4. ncbi request reprint Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging
    Bruce N Ames
    Nutrition, Metabolisms and Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, U States
    Mol Aspects Med 26:363-78. 2005
    ..An optimum intake of micronutrients could tune up metabolism and give a marked increase in health, particularly for the poor, elderly, and obese, at little cost...
  5. ncbi request reprint Mitochondrial decay, a major cause of aging, can be delayed
    Bruce N Ames
    University of California, Berkeley, CA, USA
    J Alzheimers Dis 6:117-21. 2004
    ..Our progress over the last decade in delaying the mitochondrial decay of aging is briefly reviewed...
  6. ncbi request reprint Delaying the mitochondrial decay of aging
    Bruce N Ames
    University of California, Berkeley, and Children s Hospital Oakland Research Institute, USA
    Ann N Y Acad Sci 1019:406-11. 2004
    ..Mitochondria provide energy for basic metabolic processes, and their decay with age impairs cellular metabolism and leads to cellular decline. Progress over the last decade in delaying the mitochondrial decay of aging is reviewed...
  7. ncbi request reprint Are vitamin and mineral deficiencies a major cancer risk?
    Bruce N Ames
    Nutrition Genomics Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, California 94609 1673, USA
    Nat Rev Cancer 2:694-704. 2002
    ..Optimizing vitamin and mineral intake by encouraging dietary change, multivitamin and mineral supplements, and fortifying foods might therefore prevent cancer and other chronic diseases...
  8. pmc Increasing longevity by tuning up metabolism. To maximize human health and lifespan, scientists must abandon outdated models of micronutrients
    Bruce N Ames
    The Children s Hospital Oakland Research Institute, Oakland, CA, USA
    EMBO Rep 6:S20-4. 2005
  9. ncbi request reprint Delaying the mitochondrial decay of aging with acetylcarnitine
    Bruce N Ames
    Nutritional Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1033:108-16. 2004
    ..placebo. A meta-analysis of 4 clinical trials of LA for treatment of neuropathic deficits in diabetes showed significant efficacy vs. placebo...
  10. ncbi request reprint High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms
    Bruce N Ames
    Department of Molecular and Cellular Biology, University of California, Berkeley, USA
    Am J Clin Nutr 75:616-58. 2002
    ....
  11. pmc Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage
    Bruce N Ames
    Nutrition and Metabolism Center, Children s Hospital of Oakland Research Institute, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 103:17589-94. 2006
    ..A multivitamin-mineral supplement is one low-cost way to ensure intake of the Recommended Dietary Allowance of micronutrients throughout life...
  12. doi request reprint Optimal micronutrients delay mitochondrial decay and age-associated diseases
    Bruce N Ames
    Children s Hospital Oakland Research Institute, Nutrition and Metabolism Center, Oakland, CA 94609, USA
    Mech Ageing Dev 131:473-9. 2010
    ..The loss of enzyme function can be ameliorated by high doses of a B vitamin, which raises coenzyme levels, and indicates the importance of understanding the effects of age, or polymorphisms, on micronutrient requirements...
  13. ncbi request reprint The metabolic tune-up: metabolic harmony and disease prevention
    Bruce N Ames
    University of California, Berkeley and Children s Hospital, Oakland, CA 94609, USA
    J Nutr 133:1544S-8S. 2003
    ....
  14. ncbi request reprint Supplements and tuning up metabolism
    Bruce N Ames
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Nutr 134:3164S-3168S. 2004
  15. pmc Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid
    Jiankang Liu
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:2356-61. 2002
    ..These results suggest that feeding ALCAR and LA to old rats improves performance on memory tasks by lowering oxidative damage and improving mitochondrial function...
  16. pmc Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid
    Jiankang Liu
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:1876-81. 2002
    ..Thus, feeding old rats high levels of key mitochondrial metabolites can ameliorate oxidative damage, enzyme activity, substrate-binding affinity, and mitochondrial dysfunction...
  17. ncbi request reprint Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites
    Jiankang Liu
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720, USA
    Ann N Y Acad Sci 959:133-66. 2002
    ..This loss of activity due to coenzyme or substrate binding appears to be true for a number of other enzymes as well, including mitochondrial complex III and IV...
  18. ncbi request reprint Iron accumulation during cellular senescence
    David W Killilea
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Ann N Y Acad Sci 1019:365-7. 2004
    ..Thus, iron accumulation is not a cause, but a consequence of normal cellular senescence in vitro. Senescence-associated iron accumulation may contribute to the increased oxidative stress and cellular dysfunction seen in senescent cells...
  19. ncbi request reprint Iron accumulation during cellular senescence in human fibroblasts in vitro
    David W Killilea
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Antioxid Redox Signal 5:507-16. 2003
    ..These data indicate that iron accumulation occurs during normal cellular senescence in vitro. This accumulation of iron may contribute to the increased oxidative stress and cellular dysfunction seen in senescent cells...
  20. doi request reprint Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts
    Ashutosh Lal
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, California, USA
    Redox Rep 13:2-10. 2008
    ..We conclude that LA is highly effective in reversing oxidative stress arising from iron overload and that its antioxidant efficacy is further enhanced in combination with ALCAR...
  21. ncbi request reprint Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts
    Hani Atamna
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Nutr 137:25-30. 2007
    ..The findings are discussed in relation to aging and birth defects in humans...
  22. pmc Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine
    Jiangang Long
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Neurochem Res 34:755-63. 2009
    ....
  23. ncbi request reprint Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts
    Emily Ho
    University of California, Berkeley, CA 94720, USA
    J Nutr 133:2543-8. 2003
    ..Zinc adequacy appears to be necessary for maintaining DNA integrity and may be important in the prevention of DNA damage and cancer...
  24. ncbi request reprint Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease
    Jiankang Liu
    Nutritional Genomic Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Nutr Neurosci 8:67-89. 2005
    ..Thus, optimal doses of combinations of mt-nutrients to delay and repair mitochondrial decay could be a strategy for preventing and treating cognitive dysfunction, including AD and PD...
  25. ncbi request reprint Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals
    Joyce C McCann
    Nutrition, Metabolism and Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Am J Clin Nutr 82:281-95. 2005
    ....
  26. ncbi request reprint Chronic ethanol perturbs testicular folate metabolism and dietary folate deficiency reduces sex hormone levels in the Yucatan micropig
    Lynn M Wallock-Montelius
    Children s Hospital Oakland Research Institute, Oakland, California 94609, and Department of Internal Medicine, University of California, Davis 95616, USA
    Biol Reprod 76:455-65. 2007
    ..Furthermore, methionine synthase may influence the hormonal regulation of spermatogenesis...
  27. pmc Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging
    Hani Atamna
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 99:14807-12. 2002
    ..Thus, heme deficiency or dysregulation may be an important and preventable component of the neurodegenerative process...
  28. ncbi request reprint A role for supplements in optimizing health: the metabolic tune-up
    Bruce N Ames
    Children s Hospital Oakland Research Institute, CA 94609, USA
    Arch Biochem Biophys 423:227-34. 2004
    ..Many common micronutrient deficiencies, such as iron or biotin, cause mitochondrial decay with oxidant leakage leading to accelerated aging and neural decay...
  29. ncbi request reprint Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
    Hani Atamna
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    FASEB J 22:703-12. 2008
    ..MB may be useful to delay mitochondrial dysfunction with aging and the decrease in complex IV in Alzheimer disease...
  30. ncbi request reprint Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?
    Joyce C McCann
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    FASEB J 22:982-1001. 2008
    ..Despite residual uncertainty, recommendations for vitamin D supplementation of at-risk groups, including nursing infants, the elderly, and African-Americans appear warranted to ensure adequacy...
  31. ncbi request reprint The role of Fe2+-induced lipid peroxidation in the initiation of the mitochondrial permeability transition
    Vladimir Gogvadze
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Arch Biochem Biophys 414:255-60. 2003
    ..Lipid peroxidation products do not appear to participate in the initial phase of the permeability transition, but sensitize mitochondria toward MPT...
  32. doi request reprint Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
    Joyce C McCann
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Am J Clin Nutr 90:889-907. 2009
    ....
  33. pmc Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia
    Jung H Suh
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3418-27. 2009
    ..The method was used to assess thiol redox states in plasma and erythrocytes isolated from healthy subjects and thalassemia patients...
  34. ncbi request reprint An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function
    Joyce C McCann
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Am J Clin Nutr 85:931-45. 2007
    ..In children >2 y of age and in adolescents with ID-A, evidence suggests cognitive or behavioral deficits; however, the surprisingly small number of studies conducted in either humans or animals prevents a thorough assessment...
  35. pmc Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line
    Emily Ho
    University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:16770-5. 2002
    ..Thus, low intracellular zinc status causes oxidative DNA damage and induces DNA-repair protein expression, but binding of p53 and important downstream signals leading to proper DNA repair are lost without zinc...
  36. pmc Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts
    David W Killilea
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Proc Natl Acad Sci U S A 105:5768-73. 2008
    ....
  37. ncbi request reprint An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring
    Joyce C McCann
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    Neurosci Biobehav Rev 30:696-712. 2006
    ..Discussion topics include methodological issues, such as the importance of independent replication, causal criteria, and uncertainties in interpreting test results...
  38. pmc Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid
    Lihong Jia
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Invest Ophthalmol Vis Sci 48:339-48. 2007
    ....
  39. ncbi request reprint 5-Methyltetrahydrofolate inhibits photosensitization reactions and strand breaks in DNA
    Tal Offer
    Nutrition and Metabolism Center, CHORI, Oakland, California, USA
    FASEB J 21:2101-7. 2007
    ..These observations suggest a new role for reduced folate in protection from ultraviolet damage and have bearing on the hypothesis that folate photodegradation influenced the evolution of human skin color...
  40. pmc N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration
    Ludmila A Voloboueva
    Children s Hospital Oakland Research Institute, Nutrition and Metabolism Center, 5700 Martin Luther King Jr Way, Oakland, CA 94609 1673, USA
    FASEB J 21:4077-86. 2007
    ..NtBHA might be useful in AMD due to its potential to reduce oxidative stress, mitochondrial damage, and age-related iron accumulation, which may damage normal RPE function and lead to loss of vision...
  41. doi request reprint Daily supplementation with iron increases lipid peroxidation in young women with low iron stores
    Sarah M King
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Exp Biol Med (Maywood) 233:701-7. 2008
    ..The increased indicators of lipid peroxidation with duration of supplementation and as iron status improved suggest that providing daily nearly 100 mg iron may not be a totally innocuous regimen for correcting iron depletion in women...
  42. ncbi request reprint Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats
    Jiankang Liu
    Department of Molecular and Cell Biology, Uniersity of California, Berkeley, CA 94720, USA
    Ann N Y Acad Sci 1033:117-31. 2004
    ..However, ALC was effective, unlike L-carnitine, in decreasing oxidative damage, including MDA, oxo8dG/oxo8G, and nitrotyrosine, in old rat brain. These data suggest that ALC may be a better dietary supplement than L-carnitine...
  43. ncbi request reprint Measuring chromosome breaks in patients with thalassemia
    Tal Offer
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1054:439-44. 2005
    ..Our findings indicate that higher levels of micronuclei frequencies are present in thalassemic RBCs...
  44. ncbi request reprint 5-Chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation. A gas chromatography-mass spectrometry assay
    Qing Jiang
    Department of Molecular and Cell Biology, University of California, Berkeley, and Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Biol Chem 278:32834-40. 2003
    ..These findings may be relevant to the carcinogenesis associated with chronic inflammation...
  45. ncbi request reprint The role of heme and iron-sulfur clusters in mitochondrial biogenesis, maintenance, and decay with age
    Hani Atamna
    Department of Molecular and Cell Biology, University of California, Berkeley CHORI, 5700 Martin Luther King Jr Way, Oakland, California 94609, USA
    Arch Biochem Biophys 397:345-53. 2002
    ..We review the physiological role of iron-sulfur clusters and heme in the integrity of the mitochondria and the generation of oxidants...
  46. ncbi request reprint Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes
    Susan T Mashiyama
    Department of Cell and Molecular Biology, University of California, Berkley, CA 94720, USA
    Anal Biochem 330:58-69. 2004
    ..The assay requires 3 microg of DNA per folate-deficient sample, but more may be required for baseline DNA-uracil detection in healthy humans...
  47. ncbi request reprint Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats
    Qing Jiang
    Division of Biochemistry and Molecular Biology, University of California, Berkeley and Children s Hospital Oakland Research Institute, Oakland, California 94609 1673, USA
    FASEB J 17:816-22. 2003
    ..These findings provide strong evidence that gammaT shows anti-inflammatory activities in vivo that may be important for human disease prevention and therapy...
  48. ncbi request reprint Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation
    Qing Jiang
    Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA
    Free Radic Biol Med 33:1534-42. 2002
    ....
  49. pmc Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats
    Patrick B Walter
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:2264-9. 2002
    ..Untreated iron deficiency, as well as excessive-iron supplementation, are deleterious and emphasize the importance of maintaining optimal iron intake...
  50. pmc (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage
    Ludmila A Voloboueva
    Biophysics Graduate Group, University of California, Berkeley, USA
    Invest Ophthalmol Vis Sci 46:4302-10. 2005
    ..To determine whether (R)-alpha-lipoic acid (LA) protects cultured human fetal retinal pigment epithelial (hfRPE) cells against oxidative injury and identify the pathways that may mediate protection...
  51. ncbi request reprint Fe(2+) induces a transient Ca(2+) release from rat liver mitochondria
    Vladimir Gogvadze
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Arch Biochem Biophys 398:198-202. 2002
    ..When Fe(2+) accumulation is completed, reuptake of released Ca(2+) into mitochondria resumes. Finally, we propose that Fe(2+) either inhibits Ca(2+) entry at the uniporter or is transported by it into the matrix...
  52. ncbi request reprint Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison
    Chantal Courtemanche
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California, USA
    FASEB J 18:209-11. 2004
    ..Our results also suggest that research on biological effects of low-dose radiation should take into account the nutritional status of the subjects, because folate deficiency could confound the effects of low-dose radiation...
  53. doi request reprint Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging
    Joyce C McCann
    Nutrition and Metabolism Center, Children s Hospital Oakland Research Institute, 5700 Martin Luthur King Jr Way, Oakland, CA 94609, USA
    FASEB J 25:1793-814. 2011
    ..Modest Se deficiency is common in many parts of the world; optimal intake could prevent future disease...
  54. ncbi request reprint The case for strategic international alliances to harness nutritional genomics for public and personal health
    Jim Kaput
    Center of Excellence in Nutritional Genomics, University of California, Davis, CA 95616, USA
    Br J Nutr 94:623-32. 2005
    ....
  55. doi request reprint Unusual clustering of coefficients of variation in published articles from a medical biochemistry department in India
    Mark L Hudes
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way Oakland, CA 94609, USA
    FASEB J 23:689-703. 2009
    ..Two of these articles were coauthored by 1 of the 3 investigators, and 1 was from the same university but a different department. We are unable to offer a statistical or biological explanation for the unusual clustering observed...
  56. ncbi request reprint A simple assay for frequency of chromosome breaks and loss (micronuclei) by flow cytometry of human reticulocytes
    Tal Offer
    Nutritional Genomics Center, Children s Hospital of Oakland Research Institute, Oakland, California 94609, USA
    FASEB J 19:485-7. 2005
    ..This method, unlike available micronuclei assays, allows rapid evaluation of a large number of cells and therefore should prove to be useful in monitoring of human populations for genetic damage...
  57. ncbi request reprint Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro
    Chantal Courtemanche
    University of California, Berkeley, and Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Immunol 173:3186-92. 2004
    ..These data suggest that folate status may affect the immune system by reducing the capacity of CD8(+) cells to proliferate in response to activation...
  58. ncbi request reprint Analysis of plasma tocopherols alpha, gamma, and 5-nitro-gamma in rats with inflammation by HPLC coulometric detection
    Stephan Christen
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Lipid Res 43:1978-85. 2002
    ..The present HPLC method should be helpful in clarifying the precise physiological role of gammaT...
  59. ncbi request reprint Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes
    Robert A Jacob
    U S Department of Agriculture ARS Western Human Nutrition Research Center, University of California at Davis, 95616 8683, USA
    J Nutr 133:740-3. 2003
    ..In healthy young men, the endogenous antioxidant defense system and a modest intake of dietary antioxidants are adequate to minimize levels of in vivo oxidant damage such that they cannot be differentiated by current methods...
  60. pmc Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress
    Tory M Hagen
    Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 99:1870-5. 2002
    ..Feeding ALCAR in combination with LA increased metabolism and lowered oxidative stress more than either compound alone...
  61. ncbi request reprint Gamma-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms
    Qing Jiang
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
    Ann N Y Acad Sci 1031:399-400. 2004
    ..Our study suggests that gamma-tocopherol may be valuable in the prevention and therapy for certain types of cancer...
  62. ncbi request reprint Time to talk SENS: critiquing the immutability of human aging
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, UK
    Ann N Y Acad Sci 959:452-62; discussion 463-5. 2002
    ..Given the major demographic consequences if it came about, this possibility merits urgent debate...
  63. ncbi request reprint Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough
    Bruce N Ames
    Am J Clin Nutr 86:522-3; author reply 523-4. 2007

Research Grants11

  1. Mitochondrial Metabiolites to Treat Parkinson's Disease
    Bruce Ames; Fiscal Year: 2005
    ..This project on PD is a new direction for our work on preventing mitochondrial decay and could lead to an effective and cost efficient prevention /therapy for PD. ..
  2. Mitochondrial Nutrients Protect RPE from Oxidant Damage
    Bruce Ames; Fiscal Year: 2006
    ..This in vitro analysis of mitochondrial nutrients may provide the basis for the development of therapeutic agents that can prevent and/or reduce the retinal and RPE pathophysiology observed in AMD. ..
  3. QUANTITATIVE METALLOPROTEOMICS: THE HUMAN ERYTHROCYTE
    Bruce Ames; Fiscal Year: 2006
    ..abstract_text> ..
  4. DO HIGH DOSE B VITAMINS DELAY AGE-RELATED DECAY
    Bruce Ames; Fiscal Year: 2005
    ....
  5. Tuning-Up Human Metabolism
    Bruce Ames; Fiscal Year: 2005
    ..Previous results showed that high doses of key mitochondrial metabolites delay mitochondrial decay and involve Km. 4) Minimizing DNA damage and cancer by optimizing micronutrient levels, particularly in the elderly. ..
  6. NATURAL VITAMIN E FORMS AS ANTI-INFLAMMATORY DRUGS
    Bruce Ames; Fiscal Year: 2003
    ..abstract_text> ..
  7. MALDI-TOF MASS SPECTROMETER
    Bruce Ames; Fiscal Year: 2002
    ..abstract_text> ..
  8. DELAYING MITOCHONDRIAL DECAY WITH CARNITINE AND LIPOATE
    Bruce Ames; Fiscal Year: 2001
    ..abstract_text> ..
  9. Metalloproteome of the Aging Rat Brain Mitochondria
    Bruce Ames; Fiscal Year: 2007
    ..Thus, this work has significant potential to integrate numerous aspects of mitochondrial metabolism and physiology and reveal novel opportunities for combating aging-related decline. ..