Research Topics
| U S AlonSummaryAffiliation: Children's Mercy Hospital Country: USA Publications
Research Grants
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Publications
Preservation of bone mass in pediatric dialysis and transplant patientsU S Alon
Section of Pediatric Nephrology and Bone and Mineral Disorders Clinic, The Children s Mercy Hospital, University of Missouri at Kansas City, Kansas City, MO 64108, USA
Adv Ren Replace Ther 8:191-205. 2001..Bone health and the child's somatic growth at ESRD or after kidney transplantation are closely related, and therapy should be aimed at achieving optimal results for both...
Calcimimetics as an adjuvant treatment for familial hypophosphatemic ricketsUri S Alon
Pediatric Nephrology, Bone and Mineral Disorders Clinic, Children s Mercy Hospital, University of Missouri, Kansas City, MO 64108, USA
Clin J Am Soc Nephrol 3:658-64. 2008....
Medical treatment of pediatric urolithiasisUri S Alon
Bone and Mineral Disorders Clinic, Children s Mercy Hospital and Clinics, University of Missouri at Kansas City, 64108, USA
Pediatr Nephrol 24:2129-35. 2009..This review discusses the current options of medical treatment of pediatric urolithiasis...
Hypertension in hypophosphatemic rickets--role of secondary hyperparathyroidismUri S Alon
Section of Pediatric Nephrology, Children s Mercy Hospital, University of Missouri at Kansas City, 2401 Gillham Road, Kansas City, MO 64108, USA
Pediatr Nephrol 18:155-8. 2003..Emphasis should therefore be placed on prevention of the development of HPTD as a complication of XLH treatment, and close monitoring for hypertension in those who do develop HPTD...
Evaluation and treatment of pediatric idiopathic urolithiasis-revisitedUri S Alon
Section of Pediatric Nephrology, Children s Mercy Hospital, University of Missouri at Kansas City, Kansas City, Missouri 64108, USA
Pediatr Nephrol 19:516-20. 2004..Children rarely comply with the recommendation of high fluid intake...
Clinical practice. Fibroblast growth factor (FGF)23: a new hormoneUri S Alon
Bone and Mineral Disorders Clinic, Section of Pediatric Nephrology, Children s Mercy Hospitals and Clinics, University of Missouri at Kansas City School of Medicine, 2401 Gillham Road, Kansas City, MO 64108, USA
Eur J Pediatr 170:545-54. 2011..This review addresses the physiology and pathophysiology of FGF23 and its clinical applications...
Idiopathic hypercalciuria of childhood: 4- to 11-year outcomeU S Alon
Section of Pediatric Nephrology, The Children s Mercy Hospital, University of Missouri at Kansas City, 64108, USA
Pediatr Nephrol 14:1011-5. 2000..If they are at risk then long-term compliance with a low-Na/high-K diet might be beneficial, as it can normalize calciuria in the majority of these children...
Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemiaUri S Alon
Section of Pediatric Nephrology, Bone and Mineral Disorders Clinic, Children s Mercy Hospitals and Clinics, University of Missouri at Kansas City, 2401 Gillham Road, Kansas City, MI 64108, USA
Pediatr Nephrol 25:1747-50. 2010..Over the 12-month treatment period no complications were noted. We conclude that cinacalcet may be considered a new, and currently the only, tool in treating children with symptomatic FHH...
Diseases and clinical applications of the calcium sensing receptorUri S Alon
Section of Pediatric Nephrology, Children s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA
Pediatr Endocrinol Rev 5:482-8. 2007..This review article will address our current understanding of the physiology, pathophysiology, diseases and clinical applications of the CaSR...
C1q nephropathy presenting as rapidly progressive crescentic glomerulonephritisT Srivastava
Section of Nephrology, The Children s Mercy Hospital, University of Missouri at Kansas City, 64108, USA
Pediatr Nephrol 14:976-9. 2000..C1q nephropathy should be added to the differential diagnosis of glomerulonephritis in young children and in the patient with crescentic glomerulonephritis...
Effect of thiazide on established furosemide-induced nephrocalcinosis in the young ratS Knoll
Section of Pediatric Nephrology, Children s Mercy Hospital, University of Missouri at Kansas City 64108, USA
Pediatr Nephrol 14:32-5. 2000..Urine Ca excretion was significantly lower in groups F and G than groups D and E. We conclude that once established, NC caused by furosemide is not affected by CTZ therapy in spite of the anticalciuric property of the latter...
Cell-cycle regulatory proteins in podocyte cell in idiopathic nephrotic syndrome of childhoodTarak Srivastava
Section of Nephrology and Department of Pathology, The Children s Mercy Hospital, University of Missouri at Kansas City, 64108, USA
Kidney Int 63:1374-81. 2003..We investigated for alterations in the expression of cyclin kinase inhibitors, p27, p57, p21, and cyclins D and A in the podocyte cell of children with INS...
Effect of the calcimimetic NPS R-467 on furosemide-induced nephrocalcinosis in the young ratAnirut Pattaragarn
Section of Pediatric Nephrology, Children's Mercy Hospital, University of Missouri-Kansas City, Kansas City, Missouri 64108, USA
Kidney Int 65:1684-9. 2004..2, 0.7 +/- 0.8, and 1.0 +/- 1.2) in groups C, D, and E, respectively. CONCLUSION: The calcimimetic agent NPS R-467 prevents the development of hyperparathyroidism and attenuates nephrocalcinosis in the furosemide-treated young rat...
Essentials of laboratory medicine for the nephrology clinicianTarak Srivastava
Section of Nephrology, Children s Mercy Hospital and University of Missouri, 2401Gillham Road, Kansas City, MO 64108, USA
Pediatr Nephrol 22:170-82. 2007..An understanding of the considerations and limitations in laboratory medicine will be helpful to the pediatric nephrologist when ordering and interpreting biochemical tests...
Parathyroid-hormone-related protein-mediated hypercalcemia in benign congenital mesoblastic nephromaTarak Srivastava
University of Missouri, Kansas City, MO 64108, USA
Pediatr Nephrol 26:799-803. 2011....
Impact of standardization of creatinine methodology on the assessment of glomerular filtration rate in childrenTarak Srivastava
Section of Nephrology, University of Missouri at Kansas City, MO 64108, USA
Pediatr Res 65:113-6. 2009....
Atorvastatin may have no effect on acute phase reaction in children after intravenous bisphosphonate infusionTarak Srivastava
Bone and Mineral Disorder Clinic, Section of Nephrology, Children s Mercy Hospital and University of Missouri, Kansas City, Missouri 64108, USA
J Bone Miner Res 24:334-7. 2009..We conclude that in vivo Atorvastatin may not be as effective in modulating the acute phase reaction associated with intravenous bisphosphonate as would have been anticipated from in vitro studies...
Urine calcium/citrate ratio in children with hypercalciuric stonesTarak Srivastava
Bone and Mineral Disorder Clinic, University of Missouri at Kansas City, 2401 Gillham Road, Kansas City, MO 64108, USA
Pediatr Res 66:85-90. 2009..Whether intervention in hypercalciuric children to lower urine calcium/citrate <0.326 will provide protection against stone formation needs to be studied...
Utility of follow-up renal sonography in children with vesicoureteral reflux and normal initial sonogramLisa H Lowe
Department of Radiology, Children s Mercy Hospital and University of Missouri, Kansas City, Missouri 64108, USA
Pediatrics 113:548-50. 2004....
Synaptopodin expression in idiopathic nephrotic syndrome of childhoodT Srivastava
Section of Nephrology and Department of Pathology, The Children's Mercy Hospital, University of Missouri at Kansas City, Kansas City, Missouri, USA
Kidney Int 59:118-25. 2001..CONCLUSION: We conclude that measurement of synaptopodin has the potential to be used as a marker to study the alteration in podocyte cell and response to therapy in INS...
Bilateral nephrectomy reverses hypothyroidism in congenital nephrotic syndromeV Chadha
Section of Pediatric Nephrology, The Children s Mercy Hospital, Kansas City, MO 64108, USA
Pediatr Nephrol 13:209-11. 1999..Abatement of massive proteinuria enables discontinuation of thyroid supplementation, and a transient rise in TSH in the early post-nephrectomy stage should be potentially expected...
Success and safety of same-day kidney biopsy in children and adolescentsA M Simckes
Section of Pediatric Nephrology, The Children s Mercy Hospital, Kansas City, MO 64108, USA
Pediatr Nephrol 14:946-52. 2000..We conclude that in selected patients, same-day discharge after renal biopsy may be performed safely without an increased risk of complications...
Antacid-induced rickets in infancyA Pattaragarn
Section of Pediatric Nephrology, Children's Mercy Hospital, University of Missouri at Kansas City, USA
Clin Pediatr (Phila) 40:389-93. 2001..Pediatricians should avoid or minimize the use of aluminum-containing antacids, and when used, carefully monitor mineral metabolism...
Bisphosphonates in children with hypercalciuria and reduced bone mineral densityMichael Freundlich
Pediatric Nephrology, University of Miami, Miami, FL, USA
Pediatr Nephrol 23:2215-20. 2008..These short-term beneficial effects indicate the need for larger prospective studies on the potential of bisphosphonates to serve as a new tool in treating children with IH and reduced BMD...
Reversal of hypercalcemic acute kidney injury by treatment with intravenous bisphosphonatesAri Auron
Section of Pediatric Nephrology, Blank Children s Hospital, Iowa Health System, Des Moines, IA, USA
Pediatr Nephrol 24:613-7. 2009..On the basis of cumulative data and our experience, we suggest that i.v. application of bisphosphonates be moved from the second to the first line of treatment of hypercalcemic AKI...
Measurement of urinary concentration: a critical appraisal of methodologiesV Chadha
Section of Pediatric Nephrology, Children's Mercy Hospital, University of Missouri at Kansas City, 2401 Gillham Road, Kansas City, MO 64108, USA
Pediatr Nephrol 16:374-82. 2001..For the clinician who is interpreting urine SG results, it is important to be aware of these limitations and understand the reasons for possible potential errors of each particular method...
Normal urinary calcium/creatinine ratios in African-American and Caucasian childrenN P So
Section of Pediatric Nephrology, The Children's Mercy Hospital, University of Missouri at Kansas City, 64108, USA
Pediatr Nephrol 16:133-9. 2001..Contrary to what has previously been reported in hypercalciuric children, no significant relationship was found between UCa/Cr and UNa/K in healthy children...
Random urine calcium/osmolality in the assessment of calciuria in children with decreased muscle massW Richmond
Section of Nephrology, Children's Mercy Hospital, University of Missouri, Kansas City, MO 64108, USA
Clin Nephrol 64:264-70. 2005..m. and 2:00 p.m. best represented 24-hour urine data. CONCLUSION: In children with DMM, UCa/Osm can successfully replace UCa/Cr as a screening tool for hypercalciuria...
Pathophysiology of hypercalciuria in childrenTarak Srivastava
Section of Nephrology, Bone and Mineral Disorder Clinic, The Children s Mercy Hospital and Clinics, University of Missouri, 2401 Gillham Road, Kansas City, MO 64108, USA
Pediatr Nephrol 22:1659-73. 2007....
Citrate clearance in children receiving continuous venovenous renal replacement therapyVimal Chadha
Section of Pediatric Nephrology, The Children's Mercy Hospital, University of Missouri at Kansas City, Kansas City, Missouri, USA
Pediatr Nephrol 17:819-24. 2002..Sufficient citrate clearance to prevent its toxic accumulation is achieved by convective clearance (CVVH) alone and diffusive clearance (CVVHDF) does not appear to be mandatory when utilizing citrate anticoagulation during CRRT...
Resolution of medullary nephrocalcinosis in children with metabolic bone disordersAri Auron
Section of Pediatric Nephrology, The Children's Mercy Hospital, University of Missouri at Kansas City School of Medicine, 64108, USA
Pediatr Nephrol 20:1143-5. 2005..Further studies are suggested to explore the possible role of anticalciuric diuretics in promoting the resolution of NC...
The role of bisphosphonates in diseases of childhoodTarak Srivastava
Section of Nephrology, The Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA
Eur J Pediatr 162:735-51. 2003....
Lack of seasonal variations in urinary calcium/creatinine ratio in school-age childrenMichelle Stuart Hilgenfeld
Section of Nephrology, Children's Mercy Hospital, Kansas City, Missouri 64108, USA
Pediatr Nephrol 19:1153-5. 2004..Thus the current UCa/Cr value used to diagnose hypercalciuria does not require a seasonal adjustment...
Timing of follow-up voiding cystourethrogram in children with primary vesicoureteral reflux: development and application of a clinical algorithmMatthew Thompson
Section of Nephrology, Children's Mercy Hospital, University of Missouri, Kansas City, Missour 64108, USA
Pediatrics 115:426-34. 2005....
Urolithiasis in adolescent childrenTarak Srivastava
Section of Nephrology, The Children's Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USA
Adolesc Med Clin 16:87-109. 2005..In many children and adolescents with urolithiasis, a nonpharmacologic approach involving the adoption of healthy nutrition habits may suffice...
Podocyte proteins in Galloway-Mowat syndromeT Srivastava
Section of Nephrology, The Children's Mercy Hospital, University of Missouri at Kansas City, 2401 Gillham Road, Kansas City, MO 64108, USA
Pediatr Nephrol 16:1022-9. 2001....
Sustained beneficial effect of intravenous bisphosphonates after their discontinuation in childrenKim M Waterhouse
Bone and Mineral Disorders Clinic, Section of Pediatric Nephrology, The Children s Mercy Hospital and Clinics, University of Missouri Kansas City School of Medicine, Kansas City, MO, USA
Pediatr Nephrol 22:282-7. 2007..V. bisphosphonates continue to exert their beneficial effect for a mean of 26+/-2 months after their discontinuation; therefore, once therapeutic goals are achieved, the medication can be withheld, followed by periodic re-evaluation...
Use of the multipurpose drainage catheter for the provision of acute peritoneal dialysis in infants and childrenAri Auron
Section of Pediatric Nephrology, The Children s Mercy Hospitals and Clinics, University of Missouri at Kansas City, MO 64108, USA
Am J Kidney Dis 49:650-5. 2007....
Treatment of congenital nephrogenic diabetes insipidus by hydrochlorothiazide and cyclooxygenase-2 inhibitorAnirut Pattaragarn
Section of Pediatric Nephrology, The Children's Mercy Hospital, University of Missouri at Kansas City, Missouri 64108, USA
Pediatr Nephrol 18:1073-6. 2003..At age 8.5 months, the infant demonstrated catch-up growth and normal neurodevelopmental milestones. We conclude that the combination HCTZ/cyclooxygenase-2 inhibitor could be successfully used to treat infantile cNDI...
Ambulatory blood pressure monitoring in children and adolescentsAri M Simckes
Section of Nephrology, The Children's Mercy Hospital, Kansas City, MO 64108, USA
Clin Pediatr (Phila) 41:549-64. 2002..The role of ABPM in various clinical conditions and hypertension research in children is presented...
Antibiotic treatment and renal stone formation in cystic fibrosisUri S Alon
J Pediatr 141:598; author reply 598. 2002
VCUG timingUri S Alon
J Pediatr 141:146; author reply 146. 2002
Hearing impairment in familial X-linked hypophosphatemic ricketsGadi Fishman
Department of Pediatric Otolaryngology, Dana Children's Hospital, Tel-Aviv Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Eur J Pediatr 163:622-3. 2004
Stage I vitamin D-deficiency rickets mimicking pseudohypoparathyroidism type IITarak Srivastava
Section of Nephrology and Bone and Mineral Disorders Clinic, The Children's Mercy Hospital, University of Missouri at Kansas City 64108, USA
Clin Pediatr (Phila) 41:263-8. 2002..It has become essential for pediatricians to recognize VDR owing to its resurgence in developed countries...
Vitamin E therapy in IgA nephropathy: a double-blind, placebo-controlled studyJames C M Chan
Virginia Commonwealth University, Richmond, Virginia, USA
Pediatr Nephrol 18:1015-9. 2003....
Research Grants
- Tools for mapping transcriptional networksUri Alon; Fiscal Year: 2006..We expect that the analysis tools and concepts developed in E. coli will be very useful in mapping complex regulatory circuits in other cell types. ..
