Mark E Alexander

Summary

Affiliation: Children's Hospital
Country: USA

Publications

  1. ncbi request reprint Microvolt t-wave alternans with exercise in pediatrics and congenital heart disease: limitations and predictive value
    Mark E Alexander
    Arrhythmia Service, Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pacing Clin Electrophysiol 29:733-41. 2006
  2. ncbi request reprint Implications of implantable cardioverter defibrillator therapy in congenital heart disease and pediatrics
    Mark E Alexander
    Arrhythmia Service, Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Cardiovasc Electrophysiol 15:72-6. 2004
  3. doi request reprint System survival of nontransvenous implantable cardioverter-defibrillators compared to transvenous implantable cardioverter-defibrillators in pediatric and congenital heart disease patients
    Andrew E Radbill
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Heart Rhythm 7:193-8. 2010
  4. ncbi request reprint Impact of transvenous ventricular pacing leads on tricuspid regurgitation in pediatric and congenital heart disease patients
    Gregory Webster
    Department of Cardiology, Children s Hospital, Boston, 300 Longwood Ave, Boston, MA 02115, USA
    J Interv Card Electrophysiol 21:65-8. 2008
  5. doi request reprint Results of a multicenter retrospective implantable cardioverter-defibrillator registry of pediatric and congenital heart disease patients
    Charles I Berul
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 51:1685-91. 2008
  6. ncbi request reprint Patient, procedural, and hardware factors associated with pacemaker lead failures in pediatrics and congenital heart disease
    Elizabeth B Fortescue
    Arrhythmia Service, Department of Cardiology, Children s Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Heart Rhythm 1:150-9. 2004
  7. ncbi request reprint Comparison of modern steroid-eluting epicardial and thin transvenous pacemaker leads in pediatric and congenital heart disease patients
    Elizabeth B Fortescue
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    J Interv Card Electrophysiol 14:27-36. 2005
  8. doi request reprint Exercise testing identifies patients at increased risk for morbidity and mortality following Fontan surgery
    Susan M Fernandes
    Department of Cardiology, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Congenit Heart Dis 6:294-303. 2011
  9. doi request reprint Permanent atrial pacing lead implant route after Fontan operation
    Kazuhiro Takahashi
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Pacing Clin Electrophysiol 32:779-85. 2009
  10. ncbi request reprint Cryoablation for accessory pathways located near normal conduction tissues or within the coronary venous system in children and young adults
    Yaniv Bar-Cohen
    Electrophysiology Division, Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Heart Rhythm 3:253-8. 2006

Detail Information

Publications48

  1. ncbi request reprint Microvolt t-wave alternans with exercise in pediatrics and congenital heart disease: limitations and predictive value
    Mark E Alexander
    Arrhythmia Service, Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pacing Clin Electrophysiol 29:733-41. 2006
    ..The incidence and potential significance of sustained TWA in pediatric and congenital heart disease (CHD) populations has not been well defined...
  2. ncbi request reprint Implications of implantable cardioverter defibrillator therapy in congenital heart disease and pediatrics
    Mark E Alexander
    Arrhythmia Service, Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Cardiovasc Electrophysiol 15:72-6. 2004
    ..The incidence of appropriate and inappropriate discharges, indicators of system failure, and clinical implications of implantable cardioverter defibrillator (ICD) therapy in children and young adults with heart disease is poorly defined...
  3. doi request reprint System survival of nontransvenous implantable cardioverter-defibrillators compared to transvenous implantable cardioverter-defibrillators in pediatric and congenital heart disease patients
    Andrew E Radbill
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Heart Rhythm 7:193-8. 2010
    ..Outcomes with these hybrid configurations are not well understood...
  4. ncbi request reprint Impact of transvenous ventricular pacing leads on tricuspid regurgitation in pediatric and congenital heart disease patients
    Gregory Webster
    Department of Cardiology, Children s Hospital, Boston, 300 Longwood Ave, Boston, MA 02115, USA
    J Interv Card Electrophysiol 21:65-8. 2008
    ..The literature in adults is inconclusive and no studies have investigated the association between pacing leads and TR in children or congenital heart disease patients...
  5. doi request reprint Results of a multicenter retrospective implantable cardioverter-defibrillator registry of pediatric and congenital heart disease patients
    Charles I Berul
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 51:1685-91. 2008
    ..We sought to determine the implications of implantable cardioverter-defibrillator (ICD) placement in children and patients with congenital heart disease (CHD)...
  6. ncbi request reprint Patient, procedural, and hardware factors associated with pacemaker lead failures in pediatrics and congenital heart disease
    Elizabeth B Fortescue
    Arrhythmia Service, Department of Cardiology, Children s Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Heart Rhythm 1:150-9. 2004
    ..To examine outcomes of children with pacemakers over a 22-year period and identify risk factors for lead failure...
  7. ncbi request reprint Comparison of modern steroid-eluting epicardial and thin transvenous pacemaker leads in pediatric and congenital heart disease patients
    Elizabeth B Fortescue
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    J Interv Card Electrophysiol 14:27-36. 2005
    ..We compared performances of modern thin transvenous (TTV) and steroid-eluting epicardial (SEE) leads in patients followed at one pediatric center...
  8. doi request reprint Exercise testing identifies patients at increased risk for morbidity and mortality following Fontan surgery
    Susan M Fernandes
    Department of Cardiology, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Congenit Heart Dis 6:294-303. 2011
    ..The objective of this study was to examine the relationship between exercise test data and mortality in patients who have had the Fontan procedure...
  9. doi request reprint Permanent atrial pacing lead implant route after Fontan operation
    Kazuhiro Takahashi
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Pacing Clin Electrophysiol 32:779-85. 2009
    ..Atrial pacing is indicated for sinus node dysfunction (SND) after Fontan surgery; preferred lead implantation technique is debated. We compare outcomes of transvenous (TV) and epicardial (Epi) atrial lead implants in this population...
  10. ncbi request reprint Cryoablation for accessory pathways located near normal conduction tissues or within the coronary venous system in children and young adults
    Yaniv Bar-Cohen
    Electrophysiology Division, Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Heart Rhythm 3:253-8. 2006
    ..Cryoablation may offer advantages over radiofrequency (RF) ablation for certain arrhythmia substrates, such as septal accessory pathways (APs). Data for young patients, especially regarding recurrence risk, require expansion...
  11. doi request reprint Digital music players cause interference with interrogation telemetry for pacemakers and implantable cardioverter-defibrillators without affecting device function
    Gregory Webster
    Department of Cardiology, Children s Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Heart Rhythm 5:545-50. 2008
    ..A preliminary study reported interference in 50% of patients whose devices were interrogated near Apple iPods...
  12. ncbi request reprint Age, size, and lead factors alone do not predict venous obstruction in children and young adults with transvenous lead systems
    Yaniv Bar-Cohen
    From the Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA
    J Cardiovasc Electrophysiol 17:754-9. 2006
    ..Venous occlusion is a recognized complication of transvenous pacing, and lead cross-sectional area indexed to body surface area (BSA) has been used to predict venous obstruction in children...
  13. doi request reprint Lead extraction in pediatric and congenital heart disease patients
    Frank Cecchin
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Circ Arrhythm Electrophysiol 3:437-44. 2010
    ..Data on the safety and efficacy of different lead extraction techniques in this specific patient population are limited...
  14. doi request reprint Cardiac resynchronization therapy (and multisite pacing) in pediatrics and congenital heart disease: five years experience in a single institution
    Frank Cecchin
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cardiovasc Electrophysiol 20:58-65. 2009
    ..We sought to determine the functional assessment and clinical outcomes in pediatric and CHD CRT patients followed uniformly at one institution...
  15. pmc Multiple accessory pathways in the young: the impact of structural heart disease
    Justin P Zachariah
    Department of Cardiology, Boston Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Am Heart J 165:87-92. 2013
    ..In a large cohort of pediatric patients with and without SHD undergoing invasive electrophysiology study, we examined the prevalence of MultAP and the effect of both MultAP and SHD on ablation outcomes...
  16. pmc Costs and benefits of targeted screening for causes of sudden cardiac death in children and adolescents
    Laurel K Leslie
    Institute for Clinical Research and Health Policy Studies at Tufts Medical Center, Boston, MA 02111, USA
    Circulation 125:2621-9. 2012
    ....
  17. doi request reprint Atrioventricular nodal reentrant tachycardia with 2:1 block in pediatric patients
    Tarun Mahajan
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston Massachusetts 02115, USA
    Heart Rhythm 5:1391-5. 2008
    ..Episodic 2:1 block occurs in 9% of adults with atrioventricular nodal reentry tachycardia (AVNRT), but developmental differences in conduction physiology among children could influence this phenomenon...
  18. ncbi request reprint Radiofrequency catheter ablation of ventricular tachycardia in children and young adults with congenital heart disease
    James G Morwood
    Department of Cardiology, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Heart Rhythm 1:301-8. 2004
    ..The aim of this study was to expand data on outcomes for radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in young patients and to identify obstacles to success...
  19. pmc Circulating matrix metalloproteinases in adolescents with hypertrophic cardiomyopathy and ventricular arrhythmia
    Justin P Zachariah
    Department of Cardiology, Children s Hospital Boston and Department of Pediatrics, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    Circ Heart Fail 5:462-6. 2012
    ..We explored differences in circulating markers of extracellular matrix turnover between young HCM patients with versus without history of serious arrhythmia...
  20. doi request reprint Reproducibility of echocardiographic diagnosis of left ventricular noncompaction
    Susan F Saleeb
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Echocardiogr 25:194-202. 2012
    ..Limited studies exist on the reproducibility of diagnosing LVNC...
  21. ncbi request reprint Relation of right ventricular pacing in tetralogy of Fallot to electrical resynchronization
    Elizabeth A Stephenson
    Department of Cardiology, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Am J Cardiol 93:1449-52, A12. 2004
    ..Effective pacing therapy may require site-specific placement of pacing leads and precise pacemaker programming...
  22. doi request reprint Nonfluoroscopic imaging systems reduce radiation exposure in children undergoing ablation of supraventricular tachycardia
    Christina Y Miyake
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Heart Rhythm 8:519-25. 2011
    ..The current standard of care for imaging during supraventricular tachycardia (SVT) ablation uses fluoroscopy, which exposes otherwise healthy children to the potential harmful effects of radiation...
  23. doi request reprint Ascending aortic dilation in patients with congenital complete heart block
    Andrew E Radbill
    Department of Cardiology, Children s Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Heart Rhythm 5:1704-8. 2008
    ..Aortic dilation has been anecdotally observed in some children with CCHB, but detailed reports are lacking...
  24. doi request reprint The electroanatomic mechanisms of atrial tachycardia in patients with tetralogy of Fallot and double outlet right ventricle
    Douglas Y Mah
    Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    J Cardiovasc Electrophysiol 22:1013-7. 2011
    ..The electroanatomic mechanism of AT in postoperative tetralogy of Fallot (TOF) and double outlet right ventricle (DORV) patients has not been fully explored...
  25. ncbi request reprint Circadian and seasonal variation of malignant arrhythmias in a pediatric and congenital heart disease population
    Elizabeth A Stephenson
    Departmentof Cardilogy, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cardiovasc Electrophysiol 13:1009-14. 2002
    ..We sought to establish whether pediatric and young adult congenital heart disease implantable cardioverter defibrillator (ICD) recipients have circadian or seasonal variability in shock frequency, similar to adult populations...
  26. doi request reprint Prospective evaluation of defibrillation threshold and postshock rhythm in young ICD recipients
    Andrew E Radbill
    Department of Pediatrics, Vanderbilt University School of Medicine, and the Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee 37232 9119, USA
    Pacing Clin Electrophysiol 35:1487-93. 2012
    ..We describe the first prospective evaluation of defibrillation threshold (DFT) and postshock rhythm in this population...
  27. doi request reprint Lyme carditis in children: presentation, predictive factors, and clinical course
    John M Costello
    Harvard Medical School, Division of Cardiac Intensive Care, Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Bader 600, Boston, MA 02115, USA
    Pediatrics 123:e835-41. 2009
    ..We sought to identify predictive factors for Lyme carditis in children and to characterize the clinical course of these patients...
  28. ncbi request reprint Radiofrequency catheter ablation of septal accessory pathways in the pediatric age group
    Ravi Mandapati
    Department of Cardiology, Boston Children s Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 92:947-50. 2003
    ..The risks of AV block and accessory pathway recurrence are most relevant to anteroseptal and midseptal pathways. These data may be factored into patient selection and the decision whether to ablate...
  29. doi request reprint Cardiac tumors and associated arrhythmias in pediatric patients, with observations on surgical therapy for ventricular tachycardia
    Christina Y Miyake
    Department of Cardiology, Children s Hospital Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 58:1903-9. 2011
    ..The aim of this study was to describe a large experience with primary cardiac tumors in pediatric patients, characterize associated arrhythmias, and expand knowledge of natural history and treatment options...
  30. doi request reprint How revealing are insertable loop recorders in pediatrics?
    Patricia A Frangini
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Pacing Clin Electrophysiol 31:338-43. 2008
    ..We sought to determine the diagnostic utility of the Reveal ILR (Medtronic, Inc., Minneapolis, MN, USA) in pediatric patients...
  31. ncbi request reprint Prospective trial of electroanatomically guided, irrigated catheter ablation of atrial tachycardia in patients with congenital heart disease
    John K Triedman
    Children s Hospital Boston, Massachusetts 02115, USA
    Heart Rhythm 2:700-5. 2005
    ..Retrospective studies suggest these rates might be increased by the use of irrigated radiofrequency (RF) ablation...
  32. ncbi request reprint Inaccuracy of Wolff-Parkinson-white accessory pathway localization algorithms in children and patients with congenital heart defects
    Yaniv Bar-Cohen
    Electrophysiology Division, Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Cardiovasc Electrophysiol 17:712-6. 2006
    ..We hypothesize that these algorithms have low diagnostic accuracy in children and even lower in those with CHD...
  33. ncbi request reprint Efficacy of atrial antitachycardia pacing using the Medtronic AT500 pacemaker in patients with congenital heart disease
    Elizabeth A Stephenson
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Cardiol 92:871-6. 2003
    ..Atrial tachycardias in congenital heart disease are amenable to ATP algorithms in the AT500 pacemaker...
  34. doi request reprint The role of cardiac resynchronization therapy for arterial switch operations complicated by complete heart block
    Douglas Y Mah
    The Department of Cardiology, Boston Children s Hospital, Boston, Massachusetts Department of Cardiovascular Surgery, Boston Children s Hospital, Boston, Massachusetts Electronic address
    Ann Thorac Surg 96:904-9. 2013
    ..We sought to examine the perioperative factors associated with LV dysfunction in patients with D-TGA and ventricular septal defects (VSD) after ASO...
  35. pmc Electrocardiogram screening for disorders that cause sudden cardiac death in asymptomatic children: a meta-analysis
    Angie Mae Rodday
    Tufts Medical Center, Boston, Massachusetts, USA
    Pediatrics 129:e999-1010. 2012
    ..We estimated (1) phenotypic (ECG- or echocardiogram [ECHO]-based) prevalence of selected pediatric disorders associated with SCD, and (2) sensitivity, specificity, and predictive value of ECG, alone or with ECHO...
  36. doi request reprint Marked QT prolongation and ventricular tachycardia of a transient nature in young children with cardiomyopathy
    Douglas Mah
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts, USA
    Pacing Clin Electrophysiol 35:e247-50. 2012
    ..Both had associated ventricular arrhythmias, with one having torsade de pointes, and the other nonsustained ventricular tachycardia. Normalization of their QTc occurred as their ventricular function improved...
  37. doi request reprint Cardiac risk after craniopharyngioma therapy
    Sandy Mong
    Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Neurol 38:256-60. 2008
    ..QTc-prolonging medication and stimulants should be used with caution in this population, and routine electrocardiogram screening may identify those at highest risk...
  38. ncbi request reprint Influence of patient factors and ablative technologies on outcomes of radiofrequency ablation of intra-atrial re-entrant tachycardia in patients with congenital heart disease
    John K Triedman
    Department of Cardiology, Boston Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Am Coll Cardiol 39:1827-35. 2002
    ..The goal of this study was to identify factors associated with radiofrequency catheter ablation (RFCA) outcomes of intra-atrial re-entrant tachycardia (IART)...
  39. ncbi request reprint Transient prolonged corrected QT interval in Lyme disease
    Stephen P Seslar
    Arrhythmia Service, Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Pediatr 148:692-7. 2006
    ..Three patients presented with QT interval prolongation associated with Lyme disease, a previously unreported manifestation of Lyme carditis. Implications and a proposed clinical management approach are discussed...
  40. doi request reprint Cardiac troponin T as a screening test for myocarditis in children
    Matthew A Eisenberg
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Pediatr Emerg Care 28:1173-8. 2012
    ..The objective of this study was to define the test characteristics of cardiac troponin T (cTnT) in pediatric patients who presented with suspected myocarditis...
  41. doi request reprint Radiofrequency-assisted transseptal perforation for electrophysiology procedures in children and adults with repaired congenital heart disease
    Jesse J Esch
    Department of Cardiology, Boston Children s Hospital, Boston, MA 02115, USA
    Pacing Clin Electrophysiol 36:607-11. 2013
    ..We sought to describe our early experience with radiofrequency (RF) needle transseptal perforation to facilitate ablation procedures in this population...
  42. ncbi request reprint Value of programmed ventricular stimulation after tetralogy of fallot repair: a multicenter study
    Paul Khairy
    Boston Adult Congenital Heart and Electrophysiology Services, Department of Cardiology, Children s Hospital Boston, 300 Longwood Ave, Boston, Mass 02115, USA
    Circulation 109:1994-2000. 2004
    ....
  43. doi request reprint Recovery of oxygen consumption after maximal exercise in children
    Tajinder P Singh
    Department of Cardiology, Children s Hospital Boston, Boston, MA 02115, USA
    Med Sci Sports Exerc 43:555-9. 2011
    ..The purpose of this study was to test the hypothesis that the oxygen consumption (VO(2)) decline during the first minute of recovery after exercise will be faster in children with a higher peak VO(2)...
  44. ncbi request reprint Fainting freshmen and sinking sophomores: cardiovascular issues of the adolescent
    Amy Desrochers DiVasta
    Division of Adolescent and Young Adult Medicine, Department of Cardiology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 16:350-6. 2004
    ....
  45. pmc Malnutrition and hemodynamic status in adolescents hospitalized for anorexia nervosa
    Amy D DiVasta
    Department of Cardiology, Children s Hospital Boston, 333 Longwood Ave, Boston, MA 02115, USA
    Arch Pediatr Adolesc Med 164:706-13. 2010
    ..To determine the effects of malnutrition on hemodynamic status of adolescents hospitalized for anorexia nervosa...
  46. ncbi request reprint Ablation of nonautomatic focal atrial tachycardia in children and adults with congenital heart disease
    Stephen P Seslar
    Electrophysiology and Pacing, Children s Specialists of San Diego, Division of Cardiology, Children s Hospital San Diego, MC 5004, San Diego, CA 92123, USA
    J Cardiovasc Electrophysiol 17:359-65. 2006
    ..Nonautomatic focal atrial tachycardia (NAFAT) has been characterized in adults with structurally normal hearts. This article characterizes NAFAT in a population of patients with complex congenital heart disease...
  47. ncbi request reprint Transvenous pacing in infants: a faith based initiative?
    Mark E Alexander
    Pacing Clin Electrophysiol 27:1463-5. 2004
  48. ncbi request reprint Modification to the Fontan procedure for the prophylaxis of intra-atrial reentrant tachycardia: short-term results of a prospective randomized blinded trial
    Kathryn K Collins
    University of California San Francisco, San Francisco, CA, USA
    J Thorac Cardiovasc Surg 127:721-9. 2004
    ..We evaluated the feasibility, safety, and short-term efficacy of an interventional atrial incision placed at the time of the Fontan operation to reduce the development of intra-atrial reentrant tachycardia...