Susan M Abdel-Rahman

Summary

Affiliation: Children's Mercy Hospital
Country: USA

Publications

  1. ncbi request reprint Mucosal eosinophilia and response to H1/H2 antagonist and cromolyn therapy in pediatric dyspepsia
    Craig A Friesen
    Section of Gastroenterology, The Children s Mercy Hospital and Clinics, 2401 Gilham Road, Kansas City, MO 64108, USA
    Clin Pediatr (Phila) 45:143-7. 2006
  2. pmc Update on terbinafine with a focus on dermatophytoses
    Jason G Newland
    Division of Infectious Diseases, Children s Mercy Hospitals and Clinics, Kansas City, MO, USA
    Clin Cosmet Investig Dermatol 2:49-63. 2009
  3. doi request reprint Evaluation of the Mercy TAPE: performance against the standard for pediatric weight estimation
    Susan M Abdel-Rahman
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, MO, and the Department of Pediatrics, University of Missouri Kansas City, School of Medicine, Kansas City, Mo Electronic address
    Ann Emerg Med 62:332-339.e6. 2013
  4. pmc Genetic predictors of susceptibility to cutaneous fungal infections: a pilot genome wide association study to refine a candidate gene search
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    J Dermatol Sci 67:147-52. 2012
  5. ncbi request reprint Polymorphic exocellular protease expression in clinical isolates of Trichophyton tonsurans
    S M Abdel-Rahman
    University of Missouri Kansas City School of Pharmacy, USA
    Mycopathologia 150:117-20. 2001
  6. doi request reprint Strain differentiation of dermatophytes
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology, The Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Suite 0411, Kansas City, MO 64108, USA
    Mycopathologia 166:319-33. 2008
  7. ncbi request reprint The integration of pharmacokinetics and pharmacodynamics: understanding dose-response
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospital and Clinics, Department of Pediatrics, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Annu Rev Pharmacol Toxicol 44:111-36. 2004
  8. ncbi request reprint Trichophyton rubrum tinea capitis in a young child
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital, Kansas City, MO 64108, USA
    Pediatr Dermatol 21:63-5. 2004
  9. doi request reprint Examining Trichophyton tonsurans genotype and biochemical phenotype as determinants of disease severity in tinea capitis
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology, The Children s Mercy Hospitals and Clinics, and Department of Pediatrics, University of Missouri Kansas City, School of Medicine, Kansas City, MO 64108, USA
    Med Mycol 46:217-23. 2008
  10. pmc Multilocus genotyping identifies infections by multiple strains of Trichophyton tonsurans
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    J Clin Microbiol 45:1949-53. 2007

Research Grants

  1. FUNGAL PROTEIN/GLYCOPROTEIN EXPRESSION IN TINEA CAPITIS
    Susan Abdel Rahman; Fiscal Year: 2003
  2. Evaluating Trichophyton tonsurans Carriage and Infection
    Susan Abdel Rahman; Fiscal Year: 2006

Detail Information

Publications51

  1. ncbi request reprint Mucosal eosinophilia and response to H1/H2 antagonist and cromolyn therapy in pediatric dyspepsia
    Craig A Friesen
    Section of Gastroenterology, The Children s Mercy Hospital and Clinics, 2401 Gilham Road, Kansas City, MO 64108, USA
    Clin Pediatr (Phila) 45:143-7. 2006
    ..Overall, the response rate to this treatment pathway was 90%. Duodenal eosinophilia is common in pediatric patients with dyspepsia. These patients appear to be clinically amenable to combination H1/H2 therapy and/or oral cromolyn...
  2. pmc Update on terbinafine with a focus on dermatophytoses
    Jason G Newland
    Division of Infectious Diseases, Children s Mercy Hospitals and Clinics, Kansas City, MO, USA
    Clin Cosmet Investig Dermatol 2:49-63. 2009
    ..Finally, the available data on the newest topical and systemic formulations are introduced...
  3. doi request reprint Evaluation of the Mercy TAPE: performance against the standard for pediatric weight estimation
    Susan M Abdel-Rahman
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, MO, and the Department of Pediatrics, University of Missouri Kansas City, School of Medicine, Kansas City, Mo Electronic address
    Ann Emerg Med 62:332-339.e6. 2013
    ..We assessed the performance of 2 new devices (2D- and 3D-Mercy TAPE) to implement the Mercy Method for pediatric weight estimation and contrasted their accuracy with the Broselow method...
  4. pmc Genetic predictors of susceptibility to cutaneous fungal infections: a pilot genome wide association study to refine a candidate gene search
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    J Dermatol Sci 67:147-52. 2012
    ..Trichophyton tonsurans is the foremost fungal pathogen of minority children in the U.S. Despite overwhelming infection rates, it does not appear that this fungus infects children in a non-specific manner...
  5. ncbi request reprint Polymorphic exocellular protease expression in clinical isolates of Trichophyton tonsurans
    S M Abdel-Rahman
    University of Missouri Kansas City School of Pharmacy, USA
    Mycopathologia 150:117-20. 2001
    ....
  6. doi request reprint Strain differentiation of dermatophytes
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology, The Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Suite 0411, Kansas City, MO 64108, USA
    Mycopathologia 166:319-33. 2008
    ....
  7. ncbi request reprint The integration of pharmacokinetics and pharmacodynamics: understanding dose-response
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospital and Clinics, Department of Pediatrics, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Annu Rev Pharmacol Toxicol 44:111-36. 2004
    ..As we continue to apply these tools across the continuum of age and disease, they provide a powerful means to enhance our understanding of drug action, drug interactions, and intrinsic host factors that influence pharmacologic response...
  8. ncbi request reprint Trichophyton rubrum tinea capitis in a young child
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital, Kansas City, MO 64108, USA
    Pediatr Dermatol 21:63-5. 2004
    ..Related anthropophilic organisms commonly isolated in other dermatophytoses are infrequently observed in tinea capitis. We report the unusual occurrence of tinea capitis in a young boy infected with Trichophyton rubrum...
  9. doi request reprint Examining Trichophyton tonsurans genotype and biochemical phenotype as determinants of disease severity in tinea capitis
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology, The Children s Mercy Hospitals and Clinics, and Department of Pediatrics, University of Missouri Kansas City, School of Medicine, Kansas City, MO 64108, USA
    Med Mycol 46:217-23. 2008
    ..tonsurans cause more severe disease. These observations are consistent with reports that recently diverge anthropophilies are associated with diminished inflammatory involvement...
  10. pmc Multilocus genotyping identifies infections by multiple strains of Trichophyton tonsurans
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    J Clin Microbiol 45:1949-53. 2007
    ..This communication details mixed Trichophyton tonsurans infections and highlights the need to confirm the presence of multiple strains in a clinical single isolate by use of a multilocus approach...
  11. ncbi request reprint Considerations in the rational design and conduct of phase I/II pediatric clinical trials: avoiding the problems and pitfalls
    S M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospitals and Clinics, Kansas City, Missouri, USA
    Clin Pharmacol Ther 81:483-94. 2007
    ..Illustrations are provided from our experience, which highlight problems that may arise when trials are not designed with the pediatric patient in mind...
  12. ncbi request reprint Tracking Trichophyton tonsurans through a large urban child care center: defining infection prevalence and transmission patterns by molecular strain typing
    Susan M Abdel-Rahman
    Department of Pediatric Clinical Pharmacology, Children s Mercy Hospitals and Clinics, 2401 Gillham Rd, Suite 0411, Kansas City, MO 64108, USA
    Pediatrics 118:2365-73. 2006
    ..This investigation was designed to gain insight into the natural course of T. tonsurans infection...
  13. doi request reprint Divergence among an international population of Trichophyton tonsurans isolates
    Susan M Abdel-Rahman
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital, 2401 Gillham Road, Suite 0411, Kansas City, MO 64108, USA
    Mycopathologia 169:1-13. 2010
    ..The degree of genetic variation observed in this study coupled with the geographic localization would support the argument for allopatric divergence within this species...
  14. doi request reprint The prevalence of infections with Trichophyton tonsurans in schoolchildren: the CAPITIS study
    Susan M Abdel-Rahman
    Children s Mercy Hospitals and Clinics, Department of Pediatrics, Division of Clinical Pharmacology and Medical Toxicology, Kansas City, MO 64108, USA
    Pediatrics 125:966-73. 2010
    ..Although Trichophyton tonsurans has become the leading cause of tinea capitis in the United States, reported infection rates vary widely, and prevalence estimates for the pediatric population at large remain poorly characterized...
  15. ncbi request reprint Investigation of terbinafine as a CYP2D6 inhibitor in vivo
    S M Abdel-Rahman
    Children s Mercy Hospital, and the Department of Pediatrics, Pharmacy Practice, Pharmacology, and the Pharmaceutical Sciences, University of Missouri Kansas City, 64108, USA
    Clin Pharmacol Ther 65:465-72. 1999
    ..This prospective open-label study was designed to confirm our previous finding that terbinafine may inhibit CYP2D6...
  16. doi request reprint Pharmacologic considerations for oseltamivir disposition: focus on the neonate and young infant
    Susan M Abdel-Rahman
    Division of Clinical Pharmacology and Medical Toxicology, The Childrens Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA
    Paediatr Drugs 13:19-31. 2011
    ..In addition, the available pediatric pharmacokinetic data for oseltamivir and its active metabolite are summarized and current 'information gaps' deserving of future study are presented...
  17. doi request reprint Single-dose pharmacokinetics and tolerability of daptomycin 8 to 10 mg/kg in children aged 2 to 6 years with suspected or proved Gram-positive infections
    Susan M Abdel-Rahman
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    Pediatr Infect Dis J 30:712-4. 2011
    ..2 μg/mL) and area under the curve (429.1 μg · h/mL, 549.7 μg · h/mL) were observed for each dose cohort, respectively. Half-life, clearance, and distribution volume were similar between groups. Both doses were well tolerated...
  18. ncbi request reprint Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine
    S M Abdel-Rahman
    Section of Pediatric Clinical Pharmacology and Experimental Therapeutics, The Children s Mercy Hospital, Kansas City, Missouri 64108, USA
    Drug Metab Dispos 27:770-5. 1999
    ..This agent needs to be evaluated in vivo to determine the impact of CYP2D6 inhibition by terbinafine on the metabolism of concomitantly administered CYP2D6 substrates...
  19. ncbi request reprint Trichophyton tonsurans exocellular protease expression: correlation with clinical presentation in tinea capitis
    S M Abdel-Rahman
    Divisions of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital, 2401 Gillham Road, Suite 0411, Kansas City, MO 64108, USA
    Clin Exp Dermatol 27:268-71. 2002
    ....
  20. ncbi request reprint Developmental pharmacokinetics and pharmacodynamics of nizatidine
    Susan M Abdel-Rahman
    Children s Mercy Hospital, Kansas City, Missouri, 64108, USA
    J Pediatr Gastroenterol Nutr 38:442-51. 2004
    ..To characterize the impact of development on the pharmacokinetics and pharmacodynamics of nizatidine...
  21. ncbi request reprint Omeprazole disposition in children following single-dose administration
    Gregory L Kearns
    Departments of Pediatrics and Pharmacology, University of Missouri, Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, Missouri, USA
    J Clin Pharmacol 43:840-8. 2003
    ..No association between age and CL/F, t1/2, or lambda z was observed. The range of t1/2 values for omeprazole was similar to those reported in adults (1-1.5 h)...
  22. doi request reprint Single-dose pharmacokinetics of daptomycin in children with suspected or proved gram-positive infections
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospital, University of Missouri, Kansas City, MO 64108, USA
    Pediatr Infect Dis J 27:330-4. 2008
    ..Although the pharmacokinetics of daptomycin have been well characterized in adults, no studies have evaluated the pharmacokinetics and tolerability in a pediatric population...
  23. ncbi request reprint Developmental pharmacology--drug disposition, action, and therapy in infants and children
    Gregory L Kearns
    Department of Pediatrics, University of Missouri at Kansas City, Kansas City, MO, USA
    N Engl J Med 349:1157-67. 2003
  24. ncbi request reprint Clinical efficacy and pharmacokinetics of montelukast in dyspeptic children with duodenal eosinophilia
    Craig A Friesen
    Section of Gastroenterology, The Children s Mercy Hospital and Clinics, Kansas City, Missouri 64108, USA
    J Pediatr Gastroenterol Nutr 38:343-51. 2004
    ..We evaluated the effect of this drug in children with eosinophilic duodenitis, defined histologically as duodenal mucosa with peak eosinophil count of more than 10 eosinophils/hpf...
  25. ncbi request reprint Effect of diet on the development of drug metabolism by cytochrome P-450 enzymes in healthy infants
    Michael J Blake
    Department of Pediatrics, University of Missouri Kansas City, School of Medicine and the Division of Pediatric Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA
    Pediatr Res 60:717-23. 2006
    ..Dietary modification of CYP activity may modulate drug biotransformation and thus alter systemic exposure to xenobiotics from a very early age...
  26. pmc Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-beta-cyclodextrin in infants, children, and adolescents
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospital, University of Missouri Kansas City, Kansas City, MO, USA
    Antimicrob Agents Chemother 51:2668-73. 2007
    ..Based on the findings of this investigation, it appears that intravenous itraconazole can be administered to infants beyond 6 months, children, and adolescents using a weight-normalized approach to dosing...
  27. pmc Genetic Heterogeneity in the rRNA Gene Locus of Trichophyton tonsurans
    Andrea Gaedigk
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital, Kansas City, Missouri 64108, USA
    J Clin Microbiol 41:5478-87. 2003
    ..tonsurans from other dermatophytes. Of the 92 isolates evaluated, this genotyping scheme distinguished 12 distinct strains, providing evidence of genetic heterogeneity in T. tonsurans...
  28. pmc A large outbreak of Trichophyton tonsurans among health care workers in a pediatric hospital
    Jodi Shroba
    Department of Nursing, Children s Mercy Hospitals and Clinics, Kansas City, Missouri 64108, USA
    Am J Infect Control 37:43-8. 2009
    ..We describe a staff outbreak of T tonsurans infection among health care workers in a freestanding pediatric hospital...
  29. pmc Summary of the National Institute of Child Health and Human Development-best pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop-Pediatric Biopharmaceutics Classification System Working Group
    Susan M Abdel-Rahman
    Division of Pediatric Pharmacology and Medical Toxicology, The Children s Mercy Hospital, Kansas City, Missouri, USA
    Clin Ther 34:S11-24. 2012
    ....
  30. ncbi request reprint The bioequivalence of nizatidine (Axid) in two extemporaneously and one commercially prepared oral liquid formulations compared with capsule
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital and Clinics, 2401 Gillham Road, Suite 0411, Kansas City, MO 64108, USA
    J Clin Pharmacol 43:148-53. 2003
    ..g., 0.80-1.25). Thus, nizatidine in infant formula and the commercially prepared oral syrup can be considered bioequivalent to the reference capsule...
  31. ncbi request reprint Comparison of various urine collection intervals for caffeine and dextromethorphan phenotyping in children
    Mary Jayne Kennedy
    Division of Pediatric Clinical Pharmacology, The Children s Mercy Hospitals and Clinics, Kansas City, MO, USA
    J Clin Pharmacol 44:708-14. 2004
    ..Longer collection periods may be required, however, in younger children or CYP2D6 poor metabolizers...
  32. doi request reprint Pediatric pharmacokinetics
    Jonathan Wagner
    Section of Cardiology and Division of Clinical Pharmacology and Medical Toxicology, Department of Pediatrics, Children s Mercy Hospital, University of Missouri Kansas City School of Medicine, Kansas City, MO, USA
    Pediatr Rev 34:258-69. 2013
    ..4. Understand that the anatomical and physiologic changes during development must be considered in predicting age-dependent changes in drug disposition...
  33. doi request reprint Comparative analysis of secreted enzymes between the anthropophilic-zoophilic sister species Trichophyton tonsurans and Trichophyton equinum
    Barry L Preuett
    Division of Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    Fungal Biol 114:429-37. 2010
    ..Such differences may contribute to how these genetically similar organisms have adapted to infect divergent host organisms...
  34. ncbi request reprint Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo
    Jennifer A Lowry
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA
    Clin Pharmacol Ther 73:209-22. 2003
    ..Cisapride was compared with midazolam in vivo to determine its potential applicability as a cytochrome P450 (CYP) 3A4 "probe." As well, we evaluated whether cisapride was transported by P-glycoprotein...
  35. ncbi request reprint Pharmacokinetics of rifapentine in children
    Michael J Blake
    Department of Pediatrics, University of Missouri Kansas City, School of Medicine, USA
    Pediatr Infect Dis J 25:405-9. 2006
    ..Although the pharmacokinetics of rifapentine has been investigated in adolescents and adults, no studies have assessed the pharmacokinetics of this drug in children or infants...
  36. doi request reprint Single-dose pharmacokinetics of roflumilast in children and adolescents
    Kathleen A Neville
    Department of Pediatrics, University of Missouri Kansas City and the Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64079, USA
    J Clin Pharmacol 48:978-85. 2008
    ..1 and 0.8 microg/L per 1 microg/kg dose for adolescents and children, respectively), pharmacokinetic parameters for roflumilast and roflumilast N-oxide were not different between age groups and were similar to adults...
  37. ncbi request reprint Characterization of the ALP1 gene locus of Trichophyton tonsurans
    Anahita Bhathena
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospital and Clinics, Kansas City, MO, USA
    Mycopathologia 160:265-72. 2005
    ..tonsurans strains, but they also reveal the presence of a genetic variation with functional consequences at the transcript level that may play a role in regulating disease severity...
  38. ncbi request reprint Impact of ontogeny on linezolid disposition in neonates and infants
    Gregory L Kearns
    Division of Pediatric Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, MO 64108, USA
    Clin Pharmacol Ther 74:413-22. 2003
    ..Evaluation of the pharmacokinetic data would appear to support the use of linezolid dosing regimens currently approved for infants and young children in neonates with postnatal age greater than 7 days...
  39. ncbi request reprint Pharmacokinetics of terbinafine in young children treated for tinea capitis
    Susan M Abdel-Rahman
    Children s Mercy Hospital, Kansas City, MO, USA
    Pediatr Infect Dis J 24:886-91. 2005
    ..This investigation was designed to evaluate the single dose and steady state pharmacokinetics of terbinafine in young children with tinea capitis...
  40. doi request reprint Pediatric pharmacokinetics: human development and drug disposition
    Ryan S Funk
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO 64108, USA
    Pediatr Clin North Am 59:1001-16. 2012
    ....
  41. pmc Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution in children and adolescents. Pediatric Pharmacology Research Unit Network
    G L Kearns
    Section of Pediatric Clinical Pharmacology and Experimental Therapeutics, Children s Mercy Hospital, Kansas City, Missouri, USA
    Antimicrob Agents Chemother 43:634-8. 1999
    ..e., 70 ng/ml). Thus, our data support the evaluation of a 5-mg/kg twice-daily oral dose of pleconaril for therapeutic trials in pediatric patients with enteroviral infections...
  42. ncbi request reprint Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network
    G L Kearns
    Department of Pediatrics, University of Missouri Kansas City, MO, USA
    Pediatr Infect Dis J 19:833-9. 2000
    ..Pleconaril phamacokinetics was evaluated in 16 neonates (16.4 +/- 8.7 days postnatal age) with suspected enteroviral infection...
  43. ncbi request reprint Single dose pharmacokinetics of linezolid in infants and children
    G L Kearns
    Department of Pediatrics, University of Missouri Kansas City, USA
    Pediatr Infect Dis J 19:1178-84. 2000
    ..The safety and pharmacokinetics of intravenously administered linezolid were evaluated in children and adolescents to examine the potential for developmental dependence on its disposition characteristics...
  44. ncbi request reprint Cefpodoxime pharmacokinetics in children: effect of food
    G L Kearns
    Section of Pediatric Clinical Pharmacology and Experimental Therapeutics, The Children s Mercy Hospital, Kansas City, MO 64108, USA
    Pediatr Infect Dis J 17:799-804. 1998
    ..We report the results of a randomized two-way crossover study designed to characterize the disposition of a single dose (10 mg/kg) of cefpodoxime proxetil oral suspension in children, under fed and fasted conditions...
  45. pmc Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans
    A Gaedigk
    Division of Clinical Pharmacology and Experimental Therapeutics, Children s Mercy Hospital and Clinics, Kansas City, MO 64108, USA
    Pharmacogenomics J 5:173-82. 2005
    ..CYP2D6(*)45 and (*)46 have a combined frequency of 4% and can be identified by a common SNP. Carriers are predicted to exhibit an extensive or intermediate CYP2D6 phenotype...
  46. pmc Pharmacokinetics and tolerability of single-dose intravenous ertapenem in infants, children, and adolescents
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospital, Kansas City, MO, USA
    Pediatr Infect Dis J 29:1072-6. 2010
    ..Ertapenem is a carbapenem antibiotic with broad spectrum activity and a pharmacokinetic profile that favors once-daily administration in adults...
  47. ncbi request reprint Single-dose pharmacokinetics of nizatidine (Axid) in children
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospital and Clinics, Kansas City, Missouri 64108, USA
    J Clin Pharmacol 42:1089-96. 2002
    ..Finally, nizatidine plasma concentrations in pediatric patients following a single 5.0 mg/kg oral dose exceeded the EC50 value of the drug for gastric acid suppression determined from adult studies for approximately 6 hours...
  48. pmc Validation of an improved pediatric weight estimation strategy
    Susan M Abdel-Rahman
    Division of Clinical Pharmacology and Medical Toxicology, Children s Mercy Hospitals and Clinics, Kansas City, Missouri Department of Pediatrics, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri
    J Pediatr Pharmacol Ther 18:112-21. 2013
    ..To validate the recently described Mercy method for weight estimation in an independent cohort of children living in the United States...
  49. pmc Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations
    Laura P James
    Department of Pediatrics, University of Arkansas for Medical Sciences UAMS and Arkansas Children s Hospital Research Institute, Little Rock, AR, USA
    Eur J Clin Pharmacol 69:851-7. 2013
    ..APAP protein adducts were measured in blood samples collected from fasted individuals who participated in a crossover study of APAP (80 mg/kg) comparing extended release (ER) and immediate release (IR) formulations...
  50. pmc Griseofulvin Only Modestly Diminishes Persistence of Trichophyton tonsurans on the Scalp of Carriers
    Susan M Abdel-Rahman
    Division of Pediatric Clinical Pharmacology and Medical Toxicology, The Children s Mercy Hospital Department of Pediatrics, University of Missouri Kansas City School of Medicine, Kansas City, Missouri
    J Pediatr Pharmacol Ther 14:94-9. 2009
    ..This retrospective investigation examines antifungal drug therapy received during the previous investigation and characterizes the impact of treatment on persistence of the fungus on the scalp...
  51. pmc Montelukast in the treatment of duodenal eosinophilia in children with dyspepsia: effect on eosinophil density and activation in relation to pharmacokinetics
    Craig A Friesen
    The Children s Mercy Hospital and Clinics, Kansas City, Missouri, USA
    BMC Gastroenterol 9:32. 2009
    ..The mechanism of this clinical response is unknown but could involve a decrease in eosinophil density or activation...

Research Grants2

  1. FUNGAL PROTEIN/GLYCOPROTEIN EXPRESSION IN TINEA CAPITIS
    Susan Abdel Rahman; Fiscal Year: 2003
    ..abstract_text> ..
  2. Evaluating Trichophyton tonsurans Carriage and Infection
    Susan Abdel Rahman; Fiscal Year: 2006
    ..abstract_text> ..