Sharon C A Chen

Summary

Country: USA

Publications

  1. ncbi request reprint Cryptococcosis in Australasia and the treatment of cryptococcal and other fungal infections with liposomal amphotericin B
    Sharon C A Chen
    Centre of Infectious Diseases and Microbiology, Westmead Hospital, Sydney, Australia
    J Antimicrob Chemother 49:57-61. 2002
  2. pmc Fatal mycotic aneurysms due to Scedosporium and Pseudallescheria infection
    Adrian Ong
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia
    J Clin Microbiol 49:2067-71. 2011
  3. doi request reprint Not just little adults: candidemia epidemiology, molecular characterization, and antifungal susceptibility in neonatal and pediatric patients
    Christopher C Blyth
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmend, New South Wales 2145, Australia
    Pediatrics 123:1360-8. 2009
  4. doi request reprint Abundance of Pseudallescheria/Scedosporium species in the Australian urban environment suggests a possible source for scedosporiosis including the colonization of airways in cystic fibrosis
    Azian Harun
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead Millennium Institute, The University of Sydney, Australia
    Med Mycol 48:S70-6. 2010
  5. doi request reprint Pneumonia and lung infections due to emerging and unusual fungal pathogens
    Sharon C A Chen
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, Australia
    Semin Respir Crit Care Med 32:703-16. 2011
  6. pmc Matrix-assisted laser desorption ionization-time of flight mass spectrometry identification of yeasts is contingent on robust reference spectra
    Angie Pinto
    Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Sydney, New South Wales, Australia
    PLoS ONE 6:e25712. 2011
  7. doi request reprint Scedosporium aurantiacum is as virulent as S. prolificans, and shows strain-specific virulence differences, in a mouse model
    Azian Harun
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead Millennium Institute, The University of Sydney, Australia
    Med Mycol 48:S45-51. 2010
  8. doi request reprint Clinical associations and prevalence of Scedosporium spp. in Australian cystic fibrosis patients: identification of novel risk factors?
    Christopher C Blyth
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW, Australia
    Med Mycol 48:S37-44. 2010
  9. doi request reprint Genotyping of Scedosporium species: a review of molecular approaches
    Azian Harun
    Molecular Mycology Research Laboratory, University of Sydney, Western Clinical School at Westmead Hospital, Westmead Millennium Institute, Sydney, Australia
    Med Mycol 47:406-14. 2009
  10. doi request reprint Antifungal therapy in invasive fungal infections
    Sharon C A Chen
    Centre for Infectious Diseases and Microbiology, Westmead Hospital and The University of Sydney, Sydney, Australia
    Curr Opin Pharmacol 10:522-30. 2010

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Cryptococcosis in Australasia and the treatment of cryptococcal and other fungal infections with liposomal amphotericin B
    Sharon C A Chen
    Centre of Infectious Diseases and Microbiology, Westmead Hospital, Sydney, Australia
    J Antimicrob Chemother 49:57-61. 2002
    ..The main barrier to replacement of conventional amphotericin with lipid preparations was seen as an issue of cost...
  2. pmc Fatal mycotic aneurysms due to Scedosporium and Pseudallescheria infection
    Adrian Ong
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia
    J Clin Microbiol 49:2067-71. 2011
    ..The thoracoabdominal aorta was affected in one patient, and cerebral vessels were affected in the other. Despite voriconazole therapy and surgical resection, the patients died. Previously reported cases are reviewed...
  3. doi request reprint Not just little adults: candidemia epidemiology, molecular characterization, and antifungal susceptibility in neonatal and pediatric patients
    Christopher C Blyth
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Hawkesbury Road, Westmend, New South Wales 2145, Australia
    Pediatrics 123:1360-8. 2009
    ..The purpose of this work was to identify differences in incidence, risk factors, microbiology, treatment, and clinical outcome of candidemia in neonates, children, and adults that might impact on management...
  4. doi request reprint Abundance of Pseudallescheria/Scedosporium species in the Australian urban environment suggests a possible source for scedosporiosis including the colonization of airways in cystic fibrosis
    Azian Harun
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead Millennium Institute, The University of Sydney, Australia
    Med Mycol 48:S70-6. 2010
    ..They emphasize the importance of environmental studies to assess the clinical risk of infection...
  5. doi request reprint Pneumonia and lung infections due to emerging and unusual fungal pathogens
    Sharon C A Chen
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, Australia
    Semin Respir Crit Care Med 32:703-16. 2011
    ..Surgical resection of diseased tissue and support of the host immune system are often required to optimize outcomes...
  6. pmc Matrix-assisted laser desorption ionization-time of flight mass spectrometry identification of yeasts is contingent on robust reference spectra
    Angie Pinto
    Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Sydney, New South Wales, Australia
    PLoS ONE 6:e25712. 2011
    ..We evaluated its ability to identify a range of yeasts in comparison with phenotypic methods...
  7. doi request reprint Scedosporium aurantiacum is as virulent as S. prolificans, and shows strain-specific virulence differences, in a mouse model
    Azian Harun
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead Millennium Institute, The University of Sydney, Australia
    Med Mycol 48:S45-51. 2010
    ..prolificans, causing death in 60-100% of mice (P > 0.05). There were significant strain-specific virulence differences (P < 0.005), indicating a possible link between genotype and virulence in S. aurantiacum...
  8. doi request reprint Clinical associations and prevalence of Scedosporium spp. in Australian cystic fibrosis patients: identification of novel risk factors?
    Christopher C Blyth
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW, Australia
    Med Mycol 48:S37-44. 2010
    ..Studies are required to confirm independent risk factors for Scedosporium colonization and to determine its impact on lung disease...
  9. doi request reprint Genotyping of Scedosporium species: a review of molecular approaches
    Azian Harun
    Molecular Mycology Research Laboratory, University of Sydney, Western Clinical School at Westmead Hospital, Westmead Millennium Institute, Sydney, Australia
    Med Mycol 47:406-14. 2009
    ..This review discusses the methods that have been applied for genotyping of these increasingly important pathogens...
  10. doi request reprint Antifungal therapy in invasive fungal infections
    Sharon C A Chen
    Centre for Infectious Diseases and Microbiology, Westmead Hospital and The University of Sydney, Sydney, Australia
    Curr Opin Pharmacol 10:522-30. 2010
    ..New therapies such as addition of the iron chelator, deferasirox, in the treatment of zygomycosis in diabetic patients, appear promising but additional agents with new targets of action are urgently needed...
  11. doi request reprint Echinocandin antifungal drugs in fungal infections: a comparison
    Sharon C A Chen
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, New South Wales, Australia
    Drugs 71:11-41. 2011
    ..Combination regimens incorporating an echinocandin showing promise in the treatment of aspergillosis. However, echinocandins remain expensive to use...
  12. pmc Clinical utility of the cryptococcal antigen lateral flow assay in a diagnostic mycology laboratory
    Brendan J McMullan
    Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Westmead, New South Wales, Australia
    PLoS ONE 7:e49541. 2012
    ..A recently introduced lateral flow immunoassay (LFA) to detect cryptococcal antigen (CRAG) is reportedly more rapid and convenient than standard latex agglutination (LA), but has not yet been evaluated in a diagnostic laboratory setting...
  13. pmc Multicenter study of posaconazole therapeutic drug monitoring: exposure-response relationship and factors affecting concentration
    Michael J Dolton
    Faculty of Pharmacy, University of Sydney, Sydney, Australia
    Antimicrob Agents Chemother 56:5503-10. 2012
    ..01). Low posaconazole concentrations are common and are associated with breakthrough fungal infection, supporting the utility of monitoring posaconazole concentrations to ensure optimal systemic exposure...
  14. ncbi request reprint Clinical manifestations of Cryptococcus gattii infection: determinants of neurological sequelae and death
    Sharon C A Chen
    Centre for Infectious Diseases and Microbiology, Westmead Millennium Institute, Sydney, Australia
    Clin Infect Dis 55:789-98. 2012
    ..Longer-term morbidity and outcomes of Cryptococcus gattii infection are not described. We analyzed clinical, microbiological, and outcome data in Australian patients followed for 12 months, to identify prognostic determinants...
  15. pmc Defining reference sequences for Nocardia species by similarity and clustering analyses of 16S rRNA gene sequence data
    Manal Helal
    Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
    PLoS ONE 6:e19517. 2011
    ....
  16. pmc secA1 gene sequence polymorphisms for species identification of Nocardia species and recognition of intraspecies genetic diversity
    Fanrong Kong
    Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    J Clin Microbiol 48:3928-34. 2010
    ..The secA1 locus has potential for species identification as an adjunct to 16S rRNA gene sequencing but requires additional deduced amino acid sequence analysis. It may be a suitable marker for phylogenetic/subtyping studies...
  17. ncbi request reprint Sporotrichosis (Sporothrix schenckii infection) in the New South Wales mid-north coast, 2000-2010
    Shobini Sivagnanam
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, NSW
    Med J Aust 196:588-90. 2012
    ..schenckii infections that occurred during the period 2000-2010. Microbiology laboratory staff and medical practitioners in the NSW mid-north coast were contacted to identify cases through database searches and clinical data collection...
  18. doi request reprint Current status of matrix-assisted laser desorption ionisation-time of flight mass spectrometry in the clinical microbiology laboratory
    Jen Kok
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, New South Wales, Australia
    Pathology 45:4-17. 2013
    ..Novel applications include strain typing and the detection of antimicrobial resistance, but these are not widely used. This review discusses the technical aspects, current applications, and limitations of MALDI-TOF MS...
  19. pmc Molecular typing of Australian Scedosporium isolates showing genetic variability and numerous S. aurantiacum
    Laurence Delhaes
    Westmead Hospital, Westmead, New South Wales, Australia
    Emerg Infect Dis 14:282-90. 2008
    ..Twelve S. prolificans isolates from 2 suspected case clusters were examined by amplified fragment length polymorphism analysis. No specific clusters were confirmed...
  20. ncbi request reprint Fungal-derived immune modulating molecules
    Tania C Sorrell
    Westmead Hospital, Westmead NSW, Australia
    Adv Exp Med Biol 666:108-20. 2009
    ..Recent advances in this area in relation to the pathogenesis of fungal infections are summarized in this chapter...
  21. pmc Assignment of reference 5'-end 16S rDNA sequences and species-specific sequence polymorphisms improves species identification of Nocardia
    Fanrong Kong
    Centre for Infectious Diseases and Microbiology, The University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia
    Open Microbiol J 3:97-105. 2009
    ....
  22. pmc Identification of bacteria in blood culture broths using matrix-assisted laser desorption-ionization Sepsityperâ„¢ and time of flight mass spectrometry
    Jen Kok
    Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia
    PLoS ONE 6:e23285. 2011
    ..A diagnostic algorithm for positive blood culture broths that incorporates gram staining and MALDI-TOF MS should identify the majority of pathogens, particularly to genus level...
  23. doi request reprint Nosocomial Pneumocystis jirovecii pneumonia: lessons from a cluster in kidney transplant recipients
    Lisa M Phipps
    Department of Renal Medicine, Westmead Hospital, Westmead, NSW, Sydney, Australia
    Transplantation 92:1327-34. 2011
    ..Pneumocystis jirovecii pneumonia (PJP) is an important infection-related complication, whose mode of transmission remains uncertain...
  24. ncbi request reprint Antifungal agents
    Sharon C A Chen
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, NSW, Australia
    Med J Aust 187:404-9. 2007
    ..Caspofungin has minimal adverse effects. Combination antifungal therapy may be appropriate in selected patients with invasive fungal infections, but is empiric and driven by individual physician practice...
  25. ncbi request reprint Cryptococcal phospholipase B antigen is not detected in serum of patients infected with Cryptococcus neoformans using a sandwich enzyme-linked immunosorbent assay
    Qi Xuan Wu
    Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, New South Wales, Australia
    FEMS Yeast Res 7:465-70. 2007
    ..Despite its sensitivity, this ELISA is of limited diagnostic value. Exploration of further extracellular molecules suitable for serodiagnosis of active cryptococcal infection is warranted...
  26. ncbi request reprint A review of nucleic acid-based diagnostic tests for systemic mycoses with an emphasis on polymerase chain reaction-based assays
    Sharon C A Chen
    Centre for Infectious Diseases and Microbiology, University of Sydney, Westmead Hospital, New South Wales, Australia
    Med Mycol 40:333-57. 2002
    ..The wide application of PCR-based assays relies on the introduction of standardized protocols following their evaluation in multicentre, prospective studies...
  27. pmc In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes
    Zhongsheng Tong
    Centre for Infectious Diseases and Microbiology Laboratory, Westmead Hospital, Westmead, New South Wales 2145, Australia
    Antimicrob Agents Chemother 51:2219-22. 2007
    ..Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 microg/ml, respectively. MI was more active than ITC (P < 0.001)...