- What to look for beyond "pathogenic" factors in senile dementia? A functional deficiency of Ca²⁺ signalingMing Chen
Aging Research Laboratory, Bay Pines VA Healthcare System, Bay Pines, Florida, USA
J Alzheimers Dis 27:679-89. 2011..We also seek answers for why unproven hypotheses can become dogmas and inhibit self-correcting mechanisms of science...
- Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor proteinMing Chen
Neurobiology of Aging Research Laboratory, Bay Pines VA Medical Center, Bay Pines, FL 33744, USA
Biochem Biophys Res Commun 330:714-21. 2005....
- Stimulation of beta-amyloid precursor protein alpha-processing by phorbol ester involves calcium and calpain activationMing Chen
Neurobiology of Aging Research Laboratory, Medical Research Service, Bay Pines VA Medical Center, FL 33744, USA
Biochem Biophys Res Commun 316:332-40. 2004..The implications of the findings are discussed in relation to the regulatory mechanism of APP alpha-processing...
- Evidence supporting the role of calpain in the α-processing of amyloid-β precursor proteinHuey T Nguyen
Aging Research Laboratory, Bay Pines VA Medical Center, Bay Pines, FL 33744, USA
Biochem Biophys Res Commun 420:530-5. 2012..This model is discussed with an interesting fact that three other deposited proteins (tau, spectrin and crystalline) are also the known substrates of calpain. Finally we discuss some current misconceptions in senile dementia research...
- Elevated [Ca2+]i levels occur with decreased calpain activity in aged fibroblasts and their reversal by energy-rich compounds: new paradigm for Alzheimer's disease preventionHuey T Nguyen
Aging Research Laboratory, Bay Pines VA Healthcare System, Bay Pines, FL, USA
J Alzheimers Dis 37:835-48. 2013..Thus, the study reinforces the concept that tonic promotion of bioenergetics and Ca2+ signaling function is a reasonable and new paradigm to protect the aging brain cells to prevent AD. ..
- High-energy compounds promote physiological processing of Alzheimer's amyloid-β precursor protein and boost cell survival in cultureDarrell R Sawmiller
Aging Research Laboratory, Bay Pines VA Healthcare System, Bay Pines, FL, USA
J Neurochem 123:525-31. 2012..At the same time, the study raises the possibility that the HECs may be useful to energize and strengthen the aging brain cells to slow down the progression of Alzheimer's disease...
- High-energy compounds mobilize intracellular Ca2+ and activate calpain in cultured cells: is calpain an energy-dependent protease?Huey T Nguyen
Aging Research Laboratory, Bay Pines VA Healthcare System, Bay Pines, FL 33744, USA
Brain Res Bull 102:9-14. 2014..More importantly, the HECs, as key intermediates in glucose catabolism, the primary source of energy supply in the brain, may be used as potential drugs for rational prevention of sAD. ..
- Immunotherapy reduces vascular amyloid-beta in PDAPP miceSally Schroeter
Elan Pharmaceuticals, South San Francisco, California 94080, and Wyeth Pharmaceuticals, Cambridge, Massachusetts 02140, USA
J Neurosci 28:6787-93. 2008..These observations raise the possibility that Abeta immunotherapy can potentially slow or halt the course of CAA development in AD that is implicated in vascular dysfunction...
- Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolaseBin Ye
Department of Medicinal Chemistry, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA
Bioorg Med Chem Lett 18:3891-4. 2008..The lead compound in the series, 4q, has excellent potency and oral bioavailability...
- Agonistic AT(1) receptor autoantibody increases in serum of patients with refractory hypertension and improves Ca(2+) mobilization in cultured rat vascular smooth muscle cellsFeng Zhu
Laboratory of Cardiovascular Immunology, Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, China
Cell Mol Immunol 5:209-17. 2008..And AT(1)-AAs were suggested to involve in resistance to antihypertensive therapy...
- Tumor cytotoxicity and endothelial Rac inhibition induced by TNP-470 in anaplastic thyroid cancerDorit Nahari
Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9156, USA
Mol Cancer Ther 6:1329-37. 2007..In endothelial cells, TNP-470 prevented vascular endothelial growth factor-induced endothelial permeability, intercellular gap formation, and ruffle formation by preventing Rac1 activation...
- The therapeutic and preventive effect of RRR-alpha-vitamin E succinate on prostate cancer via induction of insulin-like growth factor binding protein-3Yi Yin
Department of Urology, George Whipple Laboratory for Cancer Research, University of Rochester, Rochester, New York 14642, USA
Clin Cancer Res 13:2271-80. 2007..We hypothesize that the protective effects of VES in prostate cancer are mediated by IGFBP-3 up-regulation. Using prostate cancer models, the involvement of IGFBP-3 in the anticancer effect of VES was investigated...
- The essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferaseMing Chen
Donald Danforth Plant Science Center, St Louis, Missouri 63132, USA
Plant Cell 18:3576-93. 2006..These results demonstrate that plant SPT is a heteromeric enzyme and that sphingolipids are essential components of plant cells and contribute to growth and development...
- Elevated endogenous nitric oxide increases Ca2+ flux via L-type Ca2+ channels by S-nitrosylation in rat hippocampal neurons during severe hypoxia and in vitro ischemiaYung Wui Tjong
Department of Physiology, University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong
Free Radic Biol Med 42:52-63. 2007..Taken together, the results suggest that an elevated endogenous NO production enhances the influx of Ca(2+) via the hippocampal L-type Ca(2+) channel by S-nitrosylation during an initial phase of energy deprivation...
- Hepatocytes express abundant surface class I MHC and efficiently use transporter associated with antigen processing, tapasin, and low molecular weight polypeptide proteasome subunit components of antigen processing and presentation pathwayMing Chen
Center for Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Immunol 175:1047-55. 2005..This type of response should promote rapid influx of newly generated peptides into the endoplasmic reticulum and preferential presentation of foreign/induced Ag by hepatic class I...
- Natural occurrence and synthesis of two new postspinel polymorphs of chromiteMing Chen
Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Wushan, Guangzhou 510640, China
Proc Natl Acad Sci U S A 100:14651-4. 2003....
- Genetic organization of genes encoding phenol hydroxylase, benzoate 1,2-dioxygenase alpha subunit and its regulatory proteins in Acinetobacter calcoaceticus PHEA-2Yuquan Xu
Department of Biotechnology, Institute for Application of Atomic Energy, Chinese Academy of Agricultural Sciences, P O Box 5109, Beijing, 100094, China
Curr Microbiol 46:235-40. 2003..The organization of the mph and ben operons is different from that described previously...
- Impacts of phosphate amendments on lead biogeochemistry at a contaminated siteXinde Cao
Soil and Water Science Department, University of Florida, Gainesville, Florida 32611 0290, USA
Environ Sci Technol 36:5296-304. 2002..Application of combined H3PO4 with phosphate rock may provide an effective alternative to the current phosphate remediation technologies for contaminated soils...
- Implications of amyloid precursor protein and subsequent beta-amyloid production to the pharmacotherapy of Alzheimer's diseaseCarlos H Rojas-Fernandez
Department of Pharmacy Practice, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 Coulter, Amarillo, TX 79106 1712, USA
Pharmacotherapy 22:1547-63. 2002....