Yanyuan Wu

Summary

Affiliation: Charles R. Drew University of Medicine and Science
Country: USA

Publications

  1. pmc Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Mol Cancer Res 10:1597-606. 2012
  2. pmc FOXO1A is a target for HER2-overexpressing breast tumors
    Yanyuan Wu
    Divisions of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, University of California at Los Angeles David Geffen School of Medicine, Los Angeles, California 90059, USA
    Cancer Res 70:5475-85. 2010
  3. pmc Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells
    Dhruva Kumar Mishra
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Mol Cancer Ther 9:33-45. 2010
  4. pmc IGF gene polymorphisms and breast cancer in African-American and Hispanic women
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Oncol 38:1663-73. 2011
  5. pmc Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Cancer 117:3814-23. 2011
  6. pmc Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women
    Dhruva K Mishra
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California, USA
    PLoS ONE 8:e57967. 2013
  7. ncbi request reprint Taxol induced apoptosis regulates amino acid transport in breast cancer cells
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Apoptosis 12:593-612. 2007
  8. pmc Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer
    Yanyuan Wu
    Divisions of Cancer Research and Training, Hematology Oncology, Department of Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Breast Cancer Res 10:R3. 2008
  9. pmc Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Internal Medicine, Charles R, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    BMC Cancer 10:32. 2010
  10. ncbi request reprint Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells
    Jaydutt V Vadgama
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Mol Med 18:129-39. 2006

Collaborators

Detail Information

Publications12

  1. pmc Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Mol Cancer Res 10:1597-606. 2012
    ..This could be an important mechanism leading to trastuzumab resistance in HER2-overexpressing breast cancer cells...
  2. pmc FOXO1A is a target for HER2-overexpressing breast tumors
    Yanyuan Wu
    Divisions of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, University of California at Los Angeles David Geffen School of Medicine, Los Angeles, California 90059, USA
    Cancer Res 70:5475-85. 2010
    ..In summary, trastuzumab can inhibit proliferation of HER2-overexpressing breast cancer cells by reactivating FOXO1A through inhibition of the PI3K/Akt pathway. FOXO1A may therefore serve as a target for HER2-overexpressing breast tumors...
  3. pmc Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells
    Dhruva Kumar Mishra
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Mol Cancer Ther 9:33-45. 2010
    ..In summary, our study identified candidate genes that are methylated in prostate cancer...
  4. pmc IGF gene polymorphisms and breast cancer in African-American and Hispanic women
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Oncol 38:1663-73. 2011
    ..In summary, our study demonstrated a significant association of IGF-1 polymorphisms and breast cancer. Future studies are necessary to understand the mechanistic value of these polymorphisms in breast cancer risk...
  5. pmc Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Cancer 117:3814-23. 2011
    ..The objective of the current study was to investigate the association of obesity with breast cancer in a minority cohort...
  6. pmc Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women
    Dhruva K Mishra
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California, USA
    PLoS ONE 8:e57967. 2013
    ..This study examines whether VDR gene polymorphisms are associated with breast cancer in these cohorts...
  7. ncbi request reprint Taxol induced apoptosis regulates amino acid transport in breast cancer cells
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Apoptosis 12:593-612. 2007
    ..Similar response was observed with another chemotherapeutic agent Doxorubicin, suggesting that this increase is in response to apoptosis, and not only due to changes in cell cycle related events...
  8. pmc Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer
    Yanyuan Wu
    Divisions of Cancer Research and Training, Hematology Oncology, Department of Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Breast Cancer Res 10:R3. 2008
    ..Cellular and molecular studies have shown that activation of the cell signaling phosphatidylinositol-3-kinase/Akt cascade via the HER2/neu and other receptor tyrosine kinases induces cell proliferation...
  9. pmc Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Internal Medicine, Charles R, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    BMC Cancer 10:32. 2010
    ..Epigenetic changes associated with promoter DNA methylation results in silencing of several tumor suppressor genes that lead to increased risk for tumor formation and for progression of the cancer...
  10. ncbi request reprint Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells
    Jaydutt V Vadgama
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Mol Med 18:129-39. 2006
    ..In summary, cloned HIRF1/hCAF1 is coregulated with BTG1 in response to IGF-I. The regulation of these genes as early response genes may have an important role in differentiation, growth and proliferation of breast cancer cells...
  11. pmc Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells
    Aye Aye Thant
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Anticancer Res 28:3579-92. 2008
    ..The mechanisms that could explain the poor sensitivity to 5-FU in certain colorectal cancer (CRC) cells were investigated and whether or not cotreatment with low doses of selenium would offer a therapeutic benefit was explored...
  12. ncbi request reprint Plasma vascular endothelial growth factor is useful in assessing progression of breast cancer post surgery and during adjuvant treatment
    Yanyuan Wu
    Department of Medicine, Division of Laboratory Research and Development and Hematology Oncology, Molecular Oncology Program, Charles R Drew University of Medicine and Science, UCLA School of Medicine, Los Angeles, CA 90059, USA
    Int J Oncol 20:509-16. 2002
    ....