Yanyuan Wu

Summary

Affiliation: Charles R. Drew University of Medicine and Science
Country: USA

Publications

  1. pmc Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Internal Medicine, Charles R, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    BMC Cancer 10:32. 2010
  2. pmc Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer
    Yanyuan Wu
    Divisions of Cancer Research and Training, Hematology Oncology, Department of Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Breast Cancer Res 10:R3. 2008
  3. pmc Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Mol Cancer Res 10:1597-606. 2012
  4. pmc Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California
    Cancer 120:1387-93. 2014
  5. pmc Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women
    Dhruva K Mishra
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California, USA
    PLoS ONE 8:e57967. 2013
  6. pmc FOXO1A is a target for HER2-overexpressing breast tumors
    Yanyuan Wu
    Divisions of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, University of California at Los Angeles David Geffen School of Medicine, Los Angeles, California 90059, USA
    Cancer Res 70:5475-85. 2010
  7. pmc Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells
    Dhruva Kumar Mishra
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Mol Cancer Ther 9:33-45. 2010
  8. pmc IGF gene polymorphisms and breast cancer in African-American and Hispanic women
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Oncol 38:1663-73. 2011
  9. pmc Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN
    Yanyuan Wu
    Division of Cancer Research and Training, David Geffen UCLA School of Medicine, Los Angeles, California, United States of America Department of Internal Medicine, David Geffen UCLA School of Medicine, Los Angeles, California, United States of America Charles R Drew University of Medicine and Science, David Geffen UCLA School of Medicine, Los Angeles, California, United States of America Jonsson Comprehensive Cancer Center and David Geffen UCLA School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 8:e78259. 2013
  10. ncbi Taxol induced apoptosis regulates amino acid transport in breast cancer cells
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Apoptosis 12:593-612. 2007

Collaborators

Detail Information

Publications17

  1. pmc Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Internal Medicine, Charles R, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    BMC Cancer 10:32. 2010
    ..Epigenetic changes associated with promoter DNA methylation results in silencing of several tumor suppressor genes that lead to increased risk for tumor formation and for progression of the cancer...
  2. pmc Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer
    Yanyuan Wu
    Divisions of Cancer Research and Training, Hematology Oncology, Department of Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Breast Cancer Res 10:R3. 2008
    ..Cellular and molecular studies have shown that activation of the cell signaling phosphatidylinositol-3-kinase/Akt cascade via the HER2/neu and other receptor tyrosine kinases induces cell proliferation...
  3. pmc Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Mol Cancer Res 10:1597-606. 2012
    ..This could be an important mechanism leading to trastuzumab resistance in HER2-overexpressing breast cancer cells...
  4. pmc Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California
    Cancer 120:1387-93. 2014
    ..In this study, the authors examined whether VDR gene single nucleotide polymorphisms (SNPs) were associated with CRC in predominately African American and Hispanic study participants...
  5. pmc Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women
    Dhruva K Mishra
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California, USA
    PLoS ONE 8:e57967. 2013
    ..This study examines whether VDR gene polymorphisms are associated with breast cancer in these cohorts...
  6. pmc FOXO1A is a target for HER2-overexpressing breast tumors
    Yanyuan Wu
    Divisions of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, University of California at Los Angeles David Geffen School of Medicine, Los Angeles, California 90059, USA
    Cancer Res 70:5475-85. 2010
    ..In summary, trastuzumab can inhibit proliferation of HER2-overexpressing breast cancer cells by reactivating FOXO1A through inhibition of the PI3K/Akt pathway. FOXO1A may therefore serve as a target for HER2-overexpressing breast tumors...
  7. pmc Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells
    Dhruva Kumar Mishra
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Mol Cancer Ther 9:33-45. 2010
    ..In summary, our study identified candidate genes that are methylated in prostate cancer...
  8. pmc IGF gene polymorphisms and breast cancer in African-American and Hispanic women
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Oncol 38:1663-73. 2011
    ..In summary, our study demonstrated a significant association of IGF-1 polymorphisms and breast cancer. Future studies are necessary to understand the mechanistic value of these polymorphisms in breast cancer risk...
  9. pmc Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN
    Yanyuan Wu
    Division of Cancer Research and Training, David Geffen UCLA School of Medicine, Los Angeles, California, United States of America Department of Internal Medicine, David Geffen UCLA School of Medicine, Los Angeles, California, United States of America Charles R Drew University of Medicine and Science, David Geffen UCLA School of Medicine, Los Angeles, California, United States of America Jonsson Comprehensive Cancer Center and David Geffen UCLA School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 8:e78259. 2013
    ....
  10. ncbi Taxol induced apoptosis regulates amino acid transport in breast cancer cells
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Apoptosis 12:593-612. 2007
    ..Similar response was observed with another chemotherapeutic agent Doxorubicin, suggesting that this increase is in response to apoptosis, and not only due to changes in cell cycle related events...
  11. pmc Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Cancer 117:3814-23. 2011
    ..The objective of the current study was to investigate the association of obesity with breast cancer in a minority cohort...
  12. ncbi Insulin-like growth factor I differentially regulates the expression of HIRF1/hCAF1 and BTG1 genes in human MCF-7 breast cancer cells
    Jaydutt V Vadgama
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Mol Med 18:129-39. 2006
    ..In summary, cloned HIRF1/hCAF1 is coregulated with BTG1 in response to IGF-I. The regulation of these genes as early response genes may have an important role in differentiation, growth and proliferation of breast cancer cells...
  13. pmc The clinical utilization of circulating cell free DNA (CCFDNA) in blood of cancer patients
    Yahya I Elshimali
    Division of Cancer Research and Training, Department of Internal Medicine, Charles Drew University of Medicine and Science, 1720 East 120th Street, Los Angeles, CA 90059, USA
    Int J Mol Sci 14:18925-58. 2013
    ..Detecting circulating DNA in cancer patients may help develop a DNA profile for early stage diagnosis in malignancies. The technical issues of obtaining, using, and analyzing CCFDNA from blood will be discussed. ..
  14. pmc Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice
    Yanyuan Wu
    Division of Cancer Research and Training, Charles R, Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    BMC Cancer 14:266. 2014
    ..Hence, transgenic mice were created to explore the oncogenic role of Akt1 in the development of mammary tumors...
  15. ncbi Plasma vascular endothelial growth factor is useful in assessing progression of breast cancer post surgery and during adjuvant treatment
    Yanyuan Wu
    Department of Medicine, Division of Laboratory Research and Development and Hematology Oncology, Molecular Oncology Program, Charles R Drew University of Medicine and Science, UCLA School of Medicine, Los Angeles, CA 90059, USA
    Int J Oncol 20:509-16. 2002
    ....
  16. pmc Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells
    Aye Aye Thant
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Anticancer Res 28:3579-92. 2008
    ..The mechanisms that could explain the poor sensitivity to 5-FU in certain colorectal cancer (CRC) cells were investigated and whether or not cotreatment with low doses of selenium would offer a therapeutic benefit was explored...
  17. pmc STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits
    Seyung S Chung
    Division of Cancer Research and Training, Charles R Drew University of Medicine and Science, Los Angeles, CA, USA
    Int J Oncol 44:403-11. 2014
    ..Based on our findings, targeting pSTAT3 could overcome Herceptin-induced resistance in HER2-overexpressing breast tumors...