Yanyuan Wu

Summary

Affiliation: Charles R. Drew University of Medicine and Science
Country: USA

Publications

  1. ncbi Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Mol Cancer Res 10:1597-606. 2012
  2. ncbi FOXO1A is a target for HER2-overexpressing breast tumors
    Yanyuan Wu
    Divisions of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, University of California at Los Angeles David Geffen School of Medicine, Los Angeles, California 90059, USA
    Cancer Res 70:5475-85. 2010
  3. ncbi IGF gene polymorphisms and breast cancer in African-American and Hispanic women
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Oncol 38:1663-73. 2011
  4. ncbi Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Internal Medicine, Charles R, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    BMC Cancer 10:32. 2010
  5. ncbi Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Cancer 117:3814-23. 2011
  6. ncbi Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells
    Dhruva Kumar Mishra
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Mol Cancer Ther 9:33-45. 2010
  7. ncbi Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer
    Yanyuan Wu
    Divisions of Cancer Research and Training, Hematology Oncology, Department of Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Breast Cancer Res 10:R3. 2008
  8. ncbi Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells
    Aye Aye Thant
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Anticancer Res 28:3579-92. 2008

Collaborators

Detail Information

Publications8

  1. ncbi Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Mol Cancer Res 10:1597-606. 2012
    ..This could be an important mechanism leading to trastuzumab resistance in HER2-overexpressing breast cancer cells...
  2. ncbi FOXO1A is a target for HER2-overexpressing breast tumors
    Yanyuan Wu
    Divisions of Cancer Research and Training, Department of Medicine, Charles R Drew University of Medicine and Science, University of California at Los Angeles David Geffen School of Medicine, Los Angeles, California 90059, USA
    Cancer Res 70:5475-85. 2010
    ..In summary, trastuzumab can inhibit proliferation of HER2-overexpressing breast cancer cells by reactivating FOXO1A through inhibition of the PI3K/Akt pathway. FOXO1A may therefore serve as a target for HER2-overexpressing breast tumors...
  3. ncbi IGF gene polymorphisms and breast cancer in African-American and Hispanic women
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Int J Oncol 38:1663-73. 2011
    ..In summary, our study demonstrated a significant association of IGF-1 polymorphisms and breast cancer. Future studies are necessary to understand the mechanistic value of these polymorphisms in breast cancer risk...
  4. ncbi Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation
    Yanyuan Wu
    Division of Cancer Research and Training, Department of Internal Medicine, Charles R, Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    BMC Cancer 10:32. 2010
    ..Epigenetic changes associated with promoter DNA methylation results in silencing of several tumor suppressor genes that lead to increased risk for tumor formation and for progression of the cancer...
  5. ncbi Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles
    Marianna Sarkissyan
    Division of Cancer Research and Training, Center to Eliminate Cancer Health Disparities, Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Cancer 117:3814-23. 2011
    ..The objective of the current study was to investigate the association of obesity with breast cancer in a minority cohort...
  6. ncbi Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells
    Dhruva Kumar Mishra
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Mol Cancer Ther 9:33-45. 2010
    ..In summary, our study identified candidate genes that are methylated in prostate cancer...
  7. ncbi Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer
    Yanyuan Wu
    Divisions of Cancer Research and Training, Hematology Oncology, Department of Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Breast Cancer Res 10:R3. 2008
    ..Cellular and molecular studies have shown that activation of the cell signaling phosphatidylinositol-3-kinase/Akt cascade via the HER2/neu and other receptor tyrosine kinases induces cell proliferation...
  8. ncbi Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells
    Aye Aye Thant
    Division of Cancer Research and Training, Department of Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Anticancer Res 28:3579-92. 2008
    ..The mechanisms that could explain the poor sensitivity to 5-FU in certain colorectal cancer (CRC) cells were investigated and whether or not cotreatment with low doses of selenium would offer a therapeutic benefit was explored...