Affiliation: Charles R. Drew University of Medicine and Science
- Human immunodeficiency virus type 1 infection and replication in normal human oral keratinocytesXuan Liu
Department of Oral and Maxillofacial Surgery, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Virol 77:3470-6. 2003..Coculture studies showed that infectious HIV-1 virions can also be conveyed from NHOKs to activated peripheral blood lymphocytes, suggesting a potential role of oral epithelial cells in the transmission of HIV infection...
- HIV-1 infection in peripheral blood lymphocytes (PBLs) exposed to alcoholXuan Liu
Department of Oral and Maxillofacial Surgery, Charles R Drew University of Medicine and Science, Hawkins Building, Room 3067, 1731 East 120th Street, Los Angeles, CA 90059, USA
Virology 307:37-44. 2003..Thus, alcohol may facilitate enhanced viral infection by increasing the availability of HIV-1 co-receptor. This effect is associated with increases in intracellular cAMP...
- Alcohol enhances HIV type 1 infection in normal human oral keratinocytes by up-regulating cell-surface CXCR4 coreceptorHongying Chen
Department of Oral and Maxillofacial Surgery, Charles R. Drew University of Medicine and Science, Los Angeles, California 90059, USA
AIDS Res Hum Retroviruses 20:513-9. 2004..These data suggest that alcohol may influence oral HIV transmission by altering the cellular compartmentalization of CXCR4 in cells of the oral cavity...
- Potential biomarkers for head and neck squamous cell carcinomaJimmy J Brown
Department of Otolaryngology Head and Neck Surgery, Charles R Drew University of Medicine and Science, 1731 East 20th Street, Los Angeles, CA 90059, USA
Laryngoscope 113:393-400. 2003....
- Identification of genes required for immortalization in human papillomavirus-infected human oral keratinocytesJunko Nishitani
Department of Otolaryngology, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Cell Mol Biol (Noisy-le-grand) 48:OL331-41. 2002..The altered expression of these genes maybe associated with cellular proliferation or differentiation and the early stages of oral carcinogenesis...
- Human papillomavirus type 16 E6 and E7 oncoproteins upregulate c-IAP2 gene expression and confer resistance to apoptosisHuidong Yuan
Department of Oral and Maxillofacial Surgery, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
Oncogene 24:5069-78. 2005..Thus, upregulation of c-IAP2 by E6 and E7 may confer resistance to apoptosis that is necessary for sustained growth of some HPV16- and HPV18-positive cancer cells...
- PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanismsDaniel J Freeman
Howard Hughes Medical Institute, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Cancer Cell 3:117-30. 2003..This study provides a novel mechanism by which the loss of PTEN can functionally control "two" hits in the course of tumor development by concurrently modulating p53 activity...
- Differential protein expression in mouse splenic mononuclear cells treated with polysaccharides from spores of Ganoderma lucidumChao Ma
Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China
Phytomedicine 15:268-76. 2008..The results of the present study help to provide insight into the immuno-modulating activities of GL-SP...
- Improved heterologous gene expression in Trichoderma reesei by cellobiohydrolase I gene (cbh1) promoter optimizationTi Liu
State Key Laboratory of Microbial Technology, Shandong University, Jinan 250100, China
Acta Biochim Biophys Sin (Shanghai) 40:158-65. 2008....
- The nucleocapsid protein of severe acute respiratory syndrome coronavirus inhibits cell cytokinesis and proliferation by interacting with translation elongation factor 1alphaBing Zhou
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Biotechnology, Beijing, China
J Virol 82:6962-71. 2008..Proliferation of human peripheral blood lymphocytes and other human cell lines was significantly inhibited by the infection of recombinant retrovirus expressing SARS-CoV N protein...
- CXCR4 down-regulation by small interfering RNA inhibits invasion and tubule formation of human retinal microvascular endothelial cellsKeming Yu
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, PR China
Biochem Biophys Res Commun 358:990-6. 2007..As such, CXCR4 antagonists may become a therapeutic target for the treatment of retinal angiopathies...
- Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitisXuan Liu
Division of Neuroimmunology, Neurotec Department, Karolinska Institute, 14183 Huddinge, Stockholm, Sweden
Mult Scler 11:381-9. 2005..In line with the suppression of EAE induced by MBP-pulsed DC, the dynamic change of cytokines and growth factors in spinal cords should constitute a beneficial microenvironment against EAE...
- Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathwayXuan Liu
Beijing Digestive Diseases Center and Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
J Cell Biochem 105:53-60. 2008..These novel findings may shed new light on the understanding of beta-adrenergic signaling in the control of esophageal cancer cell growth...
- Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and SwedenXuan Liu
Neurotec Department, Division of Neuroimmunology, Karolinska Institute, 141 86 Stockholm, Sweden
Neurobiol Dis 20:961-8. 2005..Higher levels of AR mRNA are present in HC from Sassari. The findings indicate that the expression levels of anti-inflammatory nuclear receptor superfamily genes in MS appear to reflect both ethnic and environmental influences...
- Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activityYutaka Maeda
Environmental Toxicology Graduate Program, University of California, Riverside, California 92521, USA
Mol Endocrinol 16:402-10. 2002..These results suggest that p53, like other transcriptional repressors, inhibits transcription by multiple mechanisms, one of which involves interaction with the ligand-binding domain and recruitment of histone deacetylase activity...
- Antigen-specific T cell functions are suppressed over the estrogen-dendritic cell-indoleamine 2,3-dioxygenase axisBao guo Xiao
Division of Neuroimmunology, Neurotec Department, Karolinska Institute, Alfred Nobels Alle 10, 141 83 Stockholm, Sweden
Steroids 69:653-9. 2004..This observation could open up a novel therapeutic target for influencing the course of MS and other diseases with an autoimmune diseases background...
- Neural expression and regulation of NSSR1 proteinsLei Liu
Laboratory of Genomic Physiology and Center for Brain Research, School of Life Sciences, Fudan University, Shanghai, PR China
Neuroreport 14:1847-50. 2003..The results suggest that NSSR1 is important in regulation of brain function and neural differentiation, possibly via regulating the neural-specific alternative splicing of genes...
- [Relationship between hMSH2 and FHIT gene expression in non-small cell lung cancer]Li-qin Zhu
Department of Pathology, Wuhan University, Wuhan, Hubei, PR China
Ai Zheng 22:571-4. 2003..01, RR=-0.54). CONCLUSION: FHIT gene may be a negative regulatory gene of hMSH(2) gene, and play an important role in the inactivation mechanism of hMSH(2) gene...
- [A study on cyclooxygenase-2 protein expression and vasculature during experimental rat lung carcinogenesis]Hong Gang Li
Department of Pathology, Medical College of Wuhan University, Wuhan 430071, P R China
Ai Zheng 21:605-9. 2002..The aim of this study was to investigate the expression of COX-2 protein and its association with microvessel density (MVD) during the experimental rat lung carcinogenesis...
- [Expression of HIF-1 alpha and its relationship to apoptosis and proliferation in lung cancer]Li Fang Fan
Department of Pathology, Medical College, Wuhan University, Wuhan 430071, P R China lifang
Ai Zheng 21:254-8. 2002..This study was designed to investigate the expression of hypoxia inducible facter-1 alpha(HIF-1 alpha) and its relationship to bcl-2, Bax, PCNA in lung cancer...
- [Microdissection and PCR-SSCP detected mutation and expression of p53 and K-ras gene in carcinogenesis and development of induced rat lung carcinoma]Honggang Li
Department of Pathology, Medical College, Wuhan University, Wuhan 430071, China
Zhonghua Bing Li Xue Za Zhi 31:331-6. 2002..500). CONCLUSIONS: p53 gene mutation and K-ras overexpression were early events in the carcinogenesis and development of rat lung carcinoma induced by MCA and DEN, while K-ras mutation does not play any important role...
- Expression of inflammation related enzymes during experimental rat lung carcinogenesisHonggang Li
Department of Pathology, Medical College, Wuhan University, Wuhan 430071, China
Zhonghua Zhong Liu Za Zhi 24:316-9. 2002..To investigate the expression of two inflammation related enzymes - cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) during the experimental rat lung carcinogenesis...
- TSP-1 secreted by bone marrow stromal cells contributes to retinal ganglion cell neurite outgrowth and survivalKeming Yu
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, People s Republic of China
PLoS ONE 3:e2470. 2008....
- ALCOHOL MODULATES HIV-1 REPLICATION IN LATENT CD4+ CELLSXuan Liu; Fiscal Year: 2005..Excessive alcohol consumption may hasten the progression of latent, asymptomatic infection to AIDS. In addition, the proposed study is expected to reveal novel target sites for antiretroviral treatment. ..