Jorge N Artaza

Summary

Affiliation: Charles R. Drew University of Medicine and Science
Country: USA

Publications

  1. pmc Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells
    Jorge N Artaza
    Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Endocrinol 200:207-21. 2009
  2. pmc Vitamin D and cardiovascular disease: potential role in health disparities
    Jorge N Artaza
    Department of Internal Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    J Health Care Poor Underserved 22:23-38. 2011
  3. pmc 1,25(OH)2vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells
    Jorge N Artaza
    Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Steroid Biochem Mol Biol 119:73-83. 2010
  4. ncbi request reprint Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts
    Jorge N Artaza
    Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, The Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California, 90059 USA
    J Endocrinol 196:235-49. 2008
  5. pmc Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways
    Rajan Singh
    Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 150:1259-68. 2009
  6. ncbi request reprint Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse
    Jorge N Artaza
    Division of Endocrinology Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Endocrinol 194:63-76. 2007
  7. ncbi request reprint Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew School of Medicine, Los Angeles, California 90059, USA
    Endocrinology 147:141-54. 2006
  8. ncbi request reprint Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocrinology 146:3547-57. 2005
  9. pmc Sildenafil promotes neuroprotection of the pelvic ganglia neurones after bilateral cavernosal nerve resection in the rat
    Su M Hlaing
    Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    BJU Int 111:159-70. 2013
  10. ncbi request reprint Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass
    Thomas R Magee
    Department of Urology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024, USA
    J Gene Med 8:1171-81. 2006

Collaborators

Detail Information

Publications19

  1. pmc Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells
    Jorge N Artaza
    Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Endocrinol 200:207-21. 2009
    ....
  2. pmc Vitamin D and cardiovascular disease: potential role in health disparities
    Jorge N Artaza
    Department of Internal Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    J Health Care Poor Underserved 22:23-38. 2011
    ....
  3. pmc 1,25(OH)2vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells
    Jorge N Artaza
    Department of Internal Medicine, Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Steroid Biochem Mol Biol 119:73-83. 2010
    ..The data provide a mechanistic explanation for the anti-proliferative and anti-apoptotic properties of 1,25D in mesenchymal multipotent cells...
  4. ncbi request reprint Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts
    Jorge N Artaza
    Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, The Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California, 90059 USA
    J Endocrinol 196:235-49. 2008
    ....
  5. pmc Regulation of myogenic differentiation by androgens: cross talk between androgen receptor/ beta-catenin and follistatin/transforming growth factor-beta signaling pathways
    Rajan Singh
    Division of Endocrinology and Research Centers in Minority Institutions Core Laboratory, Charles Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 150:1259-68. 2009
    ..In conclusion, our data suggest the involvement of AR, beta-catenin, and TCF-4 pathway during androgen action to activate a number of Wnt target genes, including Fst, and cross communication with the Smad signaling pathway...
  6. ncbi request reprint Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse
    Jorge N Artaza
    Division of Endocrinology Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Endocrinol 194:63-76. 2007
    ..In conclusion, Mst does not affect cardiac systolic function in mice overexpressing or lacking the active protein, but it reduces cardiac mass and cardiomyocyte proliferation...
  7. ncbi request reprint Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew School of Medicine, Los Angeles, California 90059, USA
    Endocrinology 147:141-54. 2006
    ..These data provide evidence for a regulatory role for androgens in inhibiting adipogenic differentiation and a mechanistic explanation consistent with the observed reduction in fat mass in men treated with androgens...
  8. ncbi request reprint Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocrinology 146:3547-57. 2005
    ..In conclusion, myostatin promotes the differentiation of multipotent mesenchymal cells into the adipogenic lineage and inhibits myogenesis...
  9. pmc Sildenafil promotes neuroprotection of the pelvic ganglia neurones after bilateral cavernosal nerve resection in the rat
    Su M Hlaing
    Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    BJU Int 111:159-70. 2013
    ..To determine the gene expression profile of pelvic ganglia neurones after bilateral cavernosal nerve resection (BCNR) and subsequent treatment with sildenafil in relation to neurotrophic-related pathways...
  10. ncbi request reprint Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass
    Thomas R Magee
    Department of Urology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024, USA
    J Gene Med 8:1171-81. 2006
    ..We investigated whether a plasmid expressing a short hairpin interfering RNA (shRNA) against myostatin and transduced using electroporation would increase local skeletal muscle mass...
  11. pmc 1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells
    Leah A Garcia
    Department of Internal Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocrinology 152:2976-86. 2011
    ..This study identifies key vitamin D-related molecular pathways for muscle regulation and supports the rationale for vitamin D intervention studies in select muscle disorder conditions...
  12. pmc 1,25(OH)(2)vitamin D(3) enhances myogenic differentiation by modulating the expression of key angiogenic growth factors and angiogenic inhibitors in C(2)C(12) skeletal muscle cells
    Leah A Garcia
    Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Steroid Biochem Mol Biol 133:1-11. 2013
    ....
  13. ncbi request reprint Vitamin D and the cardiovascular system
    Jorge N Artaza
    Charles Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    Clin J Am Soc Nephrol 4:1515-22. 2009
    ....
  14. pmc Sildenafil promotes smooth muscle preservation and ameliorates fibrosis through modulation of extracellular matrix and tissue growth factor gene expression after bilateral cavernosal nerve resection in the rat
    Fara Sirad
    Department of Internal Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA, USA
    J Sex Med 8:1048-60. 2011
    ..However, the downstream mechanisms by which these drugs protect the corpora cavernosa remain poorly understood...
  15. ncbi request reprint Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin
    Suzanne Reisz-Porszasz
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 285:E876-88. 2003
    ..The mechanism of gender specificity remains to be clarified...
  16. ncbi request reprint Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
    ..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men...
  17. ncbi request reprint 1,25-Vitamin D3 promotes cardiac differentiation through modulation of the WNT signaling pathway
    Su M Hlaing
    Departments of Internal MedicineHealth and Life SciencesDivision of EndocrinologyMetabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USADepartment of MedicineDavid Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Mol Endocrinol 53:303-17. 2014
    ..These results indicate that vitamin D repletion to prevent and/or improve cardiovascular disorders that are linked with abnormal cardiac differentiation, such as post infarction cardiac remodeling, deserve further study. ..
  18. ncbi request reprint Sildenafil attenuates inflammation and oxidative stress in pelvic ganglia neurons after bilateral cavernosal nerve damage
    Leah A Garcia
    Division of Endocrinology, Metabolism and Molecular Medicine, Department of Internal Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Int J Mol Sci 15:17204-20. 2014
    ..In summary, PDE5i can attenuate the production of damaging factors and can up-regulate the expression of beneficial factors in the MPG that may ameliorate neuropathic pain, promote neuroprotection, and favor nerve regeneration. ..
  19. ncbi request reprint Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Cell Physiol 190:170-9. 2002
    ..In conclusion, myostatin was expressed mostly in C2C12 myotubes nuclei expressing MHC-II. Its predominant nuclear localization suggests that it may play a role in transcriptional regulation...