Chung Che Chang

Summary

Country: USA

Publications

  1. ncbi A novel multiparametric approach for analysis of cytoplasmic immunoglobulin light chains by flow cytometry
    C C Chang
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mod Pathol 14:1015-21. 2001
  2. ncbi Mantle cell lymphoma of the hard palate: a case report and review of the differential diagnosis based on the histomorphology and immunophenotyping pattern
    Chung Che Chang
    Medical College of Wisconsin and Marquette University, Milwaukee, Wis, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:316-20. 2003
  3. pmc Molecular genetics of pediatric soft tissue tumors: clinical application
    Chung Che Chang
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mol Diagn 5:143-54. 2003
  4. ncbi CD5+ T-cell/histiocyte-rich large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mod Pathol 15:1051-7. 2002
  5. ncbi Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia
    Chung Che Chang
    Department of Pathology, Division of Hematology Oncology, and Division of Biostatistics, Medical College of Wisconsin, Milwaukee 53226, USA
    Blood 100:4671-5. 2002
  6. ncbi Expression of p53, c-Myc, or Bcl-6 suggests a poor prognosis in primary central nervous system diffuse large B-cell lymphoma among immunocompetent individuals
    Chung Che Chang
    Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA
    Arch Pathol Lab Med 127:208-12. 2003
  7. ncbi Histogenetic phenotypes of B cells in posttransplant lymphoproliferative disorders by immunohistochemical analysis correlate with transplant type: solid organ vs hematopoietic stem cell transplantation
    Louis Novoa-Takara
    Department of Pathology, Medical College of Wisconsin, Milwaukee, USA
    Am J Clin Pathol 123:104-12. 2005
  8. doi Enhanced antimyeloma cytotoxicity by the combination of arsenic trioxide and bortezomib is further potentiated by p38 MAPK inhibition
    Jianguo Wen
    Department of Pathology, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
    Leuk Res 34:85-92. 2010
  9. doi Combination of an aptamer probe to CD4 and antibodies for multicolored cell phenotyping
    Peng Zhang
    Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
    Am J Clin Pathol 134:586-93. 2010
  10. pmc Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with 'MCW melanoma cocktail'--a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase
    Vinod B Shidham
    Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA
    BMC Cancer 3:15. 2003

Collaborators

Detail Information

Publications70

  1. ncbi A novel multiparametric approach for analysis of cytoplasmic immunoglobulin light chains by flow cytometry
    C C Chang
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mod Pathol 14:1015-21. 2001
    ..Our preliminary observations with a small cohort of patients imply that this minute clonal population may have important prognostic significance. The prognostic significance should be confirmed by further studies...
  2. ncbi Mantle cell lymphoma of the hard palate: a case report and review of the differential diagnosis based on the histomorphology and immunophenotyping pattern
    Chung Che Chang
    Medical College of Wisconsin and Marquette University, Milwaukee, Wis, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:316-20. 2003
    ..Awareness of MCL of the hard palate will prompt pathologists to perform adequate immunohistochemical analysis to aid in confirming the diagnosis...
  3. pmc Molecular genetics of pediatric soft tissue tumors: clinical application
    Chung Che Chang
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mol Diagn 5:143-54. 2003
    ..Furthermore, the potential development of targeted therapy based on the understanding of the molecular pathology of a specific soft tissue tumor may complement existing treatments and improve disease outcome...
  4. ncbi CD5+ T-cell/histiocyte-rich large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Mod Pathol 15:1051-7. 2002
    ..This will lead to identifying more cases to understand the clinical and biologic characteristics of this variant...
  5. ncbi Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia
    Chung Che Chang
    Department of Pathology, Division of Hematology Oncology, and Division of Biostatistics, Medical College of Wisconsin, Milwaukee 53226, USA
    Blood 100:4671-5. 2002
    ..Our results suggest that B-CLL with expression of MUM1/IRF4, indicative of postgerminal center origin, has a more favorable clinical course and that MUM1/IRF4 is an important prognostic marker in B-CLL...
  6. ncbi Expression of p53, c-Myc, or Bcl-6 suggests a poor prognosis in primary central nervous system diffuse large B-cell lymphoma among immunocompetent individuals
    Chung Che Chang
    Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA
    Arch Pathol Lab Med 127:208-12. 2003
    ..Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) in immunocompetent individuals, although rare, has been rising in incidence. Currently, no reliable prognostic markers are available for these individuals...
  7. ncbi Histogenetic phenotypes of B cells in posttransplant lymphoproliferative disorders by immunohistochemical analysis correlate with transplant type: solid organ vs hematopoietic stem cell transplantation
    Louis Novoa-Takara
    Department of Pathology, Medical College of Wisconsin, Milwaukee, USA
    Am J Clin Pathol 123:104-12. 2005
    ..Findings also suggest a correlation between histogenetic phenotype of B-cell PTLD and type of transplantation...
  8. doi Enhanced antimyeloma cytotoxicity by the combination of arsenic trioxide and bortezomib is further potentiated by p38 MAPK inhibition
    Jianguo Wen
    Department of Pathology, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
    Leuk Res 34:85-92. 2010
    ..The results suggest the opportunity for using p38 MAPK inhibition to enhance the efficacy of ATO+bortezomib in myeloma...
  9. doi Combination of an aptamer probe to CD4 and antibodies for multicolored cell phenotyping
    Peng Zhang
    Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
    Am J Clin Pathol 134:586-93. 2010
    ..Multicolored flow cytometry analysis revealed that the CD4 aptamer could be combined with antibodies to phenotype cells from bone marrow, lymph nodes, and pleural fluid, suggesting that the aptamer probe has value for clinical use...
  10. pmc Improved immunohistochemical evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma with 'MCW melanoma cocktail'--a mixture of monoclonal antibodies to MART-1, Melan-A, and tyrosinase
    Vinod B Shidham
    Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA
    BMC Cancer 3:15. 2003
    ..If a cocktail of these antibodies could be used, only one section would be required instead of three generating significant cost savings...
  11. doi A systematic modeling study on the pathogenic role of p38 MAPK activation in myelodysplastic syndromes
    Huiming Peng
    Department of Radiology, The Methodist Hospital, The Methodist Hospital Research Institute, and Weill Cornell Medical College, Houston, TX, USA
    Mol Biosyst 8:1366-74. 2012
    ..Our study suggests that the combination of molecular biological studies and systematic modeling is a powerful tool for comprehensive investigation of the complex cellular mechanisms involved in MDS pathogenesis...
  12. ncbi Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis
    Sergej Konoplev
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 38:1760-3. 2007
    ....
  13. pmc Transfecting the hard-to-transfect lymphoma/leukemia cells using a simple cationic polymer nanocomplex
    Nianxi Zhao
    Department of Pathology and Genomic Medicine, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
    J Control Release 159:104-10. 2012
    ..These findings demonstrated a simple, efficient method for in vitro gene delivery into hard-to-transfect cells. The nanocomplexes are biodegradable and have minimal cytotoxicity, suggesting the potential use for in vivo gene delivery...
  14. ncbi The role of beta-catenin in chronic myeloproliferative disorders
    Monica P Jauregui
    Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Hum Pathol 39:1454-8. 2008
    ..In addition, beta-catenin may be a useful marker for differentiating polycythemia vera and essential thrombocythemia from other types of chronic myeloproliferative disorders...
  15. pmc Using oligonucleotide aptamer probes for immunostaining of formalin-fixed and paraffin-embedded tissues
    Zihua Zeng
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mod Pathol 23:1553-8. 2010
    ..Therefore, our findings indicate that the synthetic oligonucleotide CD30 aptamer can be used as a probe for immunostaining of fixed tissue sections for disease diagnosis...
  16. doi P38 MAPK inhibition enhancing ATO-induced cytotoxicity against multiple myeloma cells
    Jianguo Wen
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX, USA
    Br J Haematol 140:169-80. 2008
    ..These results suggest that ATO-induced p38 MAPK activation plays an important role in the resistance to ATO in myeloma cells and that p38 MAPK inhibition may overcome resistance to ATO treatment in myeloma patients...
  17. ncbi Mantle cell lymphoma in lymph nodes with metastatic small cell carcinoma of lung: a diagnostic and treatment dilemma
    Bal Kampalath
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Leuk Lymphoma 45:409-14. 2004
    ..In such cases an optimum treatment strategy should be adopted to cover both malignancies with minimal toxic effect...
  18. ncbi Relative importance of CD38 expression over myeloid-associated markers expression in predicting the clinical course of B-CLL patients
    Chung Che Chang
    Department of Pathology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Leuk Lymphoma 44:977-82. 2003
    ..10/16 or 63%). Thus, our results suggest that CD38 is superior to myeloid-associated markers in predicting the prognosis of patients with B-CLL. Further studies with a larger sample size are indicated to confirm our observation...
  19. ncbi Bone marrow stromal cells from myeloma patients support the growth of myeloma stem cells
    Yongdong Feng
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Stem Cells Dev 19:1289-96. 2010
    ..These findings indicate that the myeloma BMSCs create a microenvironment supportive of myeloma stem cells via, at least partially, the CXCR4 signaling pathway...
  20. doi Unique biomechanical interactions between myeloma cells and bone marrow stroma cells
    Yongdong Feng
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, 6565 Fannin, MS205, Houston, TX 77030, USA
    Prog Biophys Mol Biol 103:148-56. 2010
    ..The increase of stiffness may in turn support the growth of myeloma cells and myeloma stem cells...
  21. ncbi Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals
    Ann M Leen
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, Texas 77030, USA
    Nat Med 12:1160-6. 2006
    ..Monoculture-derived multispecific CTL infusion could provide a safe and efficient means to restore virus-specific immunity in the immunocompromised host...
  22. doi Phenotyping studies of clonotypic B lymphocytes from patients with multiple myeloma by flow cytometry
    E Joseph Conway
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, Texas 77030, USA
    Arch Pathol Lab Med 133:1594-9. 2009
    ..These cells have been postulated to act as a therapy-resistant tumor reservoir that drives recurrence...
  23. ncbi Detection of the JAK2(V617F) mutation in myeloproliferative disorders by melting curve analysis using the LightCycler system
    Randall J Olsen
    Department of Pathology, Baylor College of Medicine, Houston, Texas, USA
    Arch Pathol Lab Med 130:997-1003. 2006
    ..A specific mutation, JAK2(V617F), was recently recognized as having diagnostic value for myeloproliferative disorders. No practical assay is currently available for routine use in a clinical laboratory...
  24. ncbi Immunostaining of cytology smears: a comparative study to identify the most suitable method of smear preparation and fixation with reference to commonly used immunomarkers
    Vinod B Shidham
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Diagn Cytopathol 29:217-21. 2003
    ..Most importantly, method C, which is the desired choice for cytomorphological staining, was not suitable for immunostaining...
  25. ncbi Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Surg Pathol 28:464-70. 2004
    ..Immunohistochemical analysis on paraffin-embedded tissues is more readily available than gene expression profiling by cDNA microarray and may provide similar prognostic information...
  26. pmc Conditional random pattern model for copy number aberration detection
    Fuhai Li
    Center for Bioengineering and Informatics, Department of Radiology, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA
    BMC Bioinformatics 11:200. 2010
    ..Thus, more sophisticated statistical models are needed to make the CNAs detection, using the low SNR signals, more robust and reliable...
  27. ncbi Follicular hyperplasia, follicular lysis, and progressive transformation of germinal centers. A sequential spectrum of morphologic evolution in lymphoid hyperplasia
    Chung Che Chang
    Department of Pathology, Medical College of Wisconsin, Milwaukee, USA
    Am J Clin Pathol 120:322-6. 2003
    ..The maintenance of bcl-2 expression in mantle B cells in PTGC may cause differential diagnostic pitfalls in florid PTGC vs follicular lymphoma, particularly the so-called floral variant...
  28. ncbi Expression of human 8-oxoguanine DNA glycosylase (hOGG1) in follicular lymphoma
    Andrea M Sheehan
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Mod Pathol 18:1512-8. 2005
    ..Additionally, finding absent/minimal hOGG1 expression in a subset of Bcl-2-negative follicular lymphomas suggests that hOGG1 may have utility in diagnosing Bcl-2-negative follicular lymphomas...
  29. pmc Using an RNA aptamer probe for flow cytometry detection of CD30-expressing lymphoma cells
    Peng Zhang
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Lab Invest 89:1423-32. 2009
    ..In conclusion, the developed CD30 aptamer probe could act as a replacement and/or a supplement for antibodies in the diagnosis of the CD30-expressing lymphomas...
  30. pmc Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma
    Chung Che Chang
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston TX, USA
    J Hematol Oncol 2:47. 2009
    ..The goal of the current study was to evaluate the genetic similarities and differences among PL, DLBCL (AIDS-related and non AIDS-related) and PCM using array-based comparative genomic hybridization...
  31. ncbi Luteinizing Hormone-Releasing Hormone (LHRH)-I antagonist cetrorelix inhibits myeloma cell growth in vitro and in vivo
    Jianguo Wen
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, 6565 Fannin MS205, Houston, TX 77030, USA
    Mol Cancer Ther 10:148-58. 2011
    ..Our findings indicate that Cetrorelix induces cytotoxicity in myeloma cells through various mechanisms and provide a rationale for investigating Cetrorelix for the treatment of MM...
  32. ncbi Atypical NK-cell proliferation of the gastrointestinal tract in a patient with antigliadin antibodies but not celiac disease
    Francisco Vega
    Department of Pathology, Baylor College of Medicine, The Methodist Hospital, Houston, TX 77030, USA
    Am J Surg Pathol 30:539-44. 2006
    ..It is as yet unknown whether this process occurs more commonly in patients with gluten sensitivity, or in other settings, and the pathogenesis is as yet undetermined...
  33. ncbi Pathologic quiz case: a young woman with an indurated skin plaque
    Nashwa Abed
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Arch Pathol Lab Med 127:e267-8. 2003
  34. ncbi Primary central nervous system histiocytic sarcoma with relapse to mediastinum: a case report and review of the literature
    Ming Cao
    Department of Pathology, The Methodist Hospital, Weill Medical College of Cornell University, Houston, TX 77030, USA
    Arch Pathol Lab Med 131:301-5. 2007
    ..A thorough discussion of the differential diagnosis of histiocytic sarcoma and a review of primary central nervous system histiocytic sarcoma are also presented...
  35. pmc Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients
    Vinod B Shidham
    Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA
    BMC Gastroenterol 3:5. 2003
    ..However, studies methodically evaluating different histomorphological features of A-GVHD are rare...
  36. ncbi Fulminant multisystem non-langerhans cell histiocytic proliferation with hemophagocytosis: a variant form of Erdheim-Chester disease
    R Nagarjun Rao
    Department of Pathology, Medical College of Wisconsin, Milwaukee, USA
    Arch Pathol Lab Med 129:e39-43. 2005
    ....
  37. ncbi Humanized anti-CD20 monoclonal antibody (Rituximab) treatment for post-transplant lymphoproliferative disorder
    Vasundhara Ganne
    Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Clin Transplant 17:417-22. 2003
    ..The treatment of PTLD includes reduction/withdrawal of immunosuppression and chemotherapy. This study reports our center experience with humanized monoclonal antibody against CD-20 (Rituximab) for the treatment of PTLD...
  38. ncbi Pathologic quiz case: An elderly woman with lymphocytosis
    Nashwa Abed
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wis 53226, USA
    Arch Pathol Lab Med 127:e51-2. 2003
  39. doi p38 mitogen-activated protein kinase has different degrees of activation in myeloproliferative disorders and myelodysplastic syndromes
    Munir Shahjahan
    Department of Pathology, Methodist Hospital and Methodist Research Institute, Houston, TX, USA
    Am J Clin Pathol 130:635-41. 2008
    ..007) cases. Increased p38 MAPK activation may have a role in inhibiting hematopoiesis leading to cytopenias in MDS, and relatively decreased p38 activation in MPD might promote hematopoiesis, resulting in cytosis...
  40. pmc Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in Myelodysplastic Syndromes
    Dominik Beck
    Bioengineering and Bioinformatics Program, Department of Pathology, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX, 77030, USA
    BMC Med Genomics 4:19. 2011
    ..Little is known about small regulatory RNAs and how they contribute to pathogenesis, progression and transcriptome changes in MDS...
  41. pmc The implication of identifying JAK2 ( V617F ) in myeloproliferative neoplasms and myelodysplastic syndromes with bone marrow fibrosis
    Randall J Olsen
    Department of Pathology and Laboratory Medicine, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX, USA
    J Hematop 1:111-7. 2008
    ..Our results suggest that JAK2 ( V617F ) allele evaluation can be a useful ancillary test for discriminating MDS from MPN in specimens with bone marrow fibrosis...
  42. pmc Selective gene transfection of individual cells in vitro with plasmonic nanobubbles
    Ekaterina Y Lukianova-Hleb
    Joint American, Belarussian Laboratory for Fundamental and Biomedical Nanophotonics, Rice University, Houston, TX, USA
    J Control Release 152:286-93. 2011
    ..Thus, PNBs provided targeted gene delivery at the single cell level in a single pulse procedure that can be used for safe and effective gene therapy...
  43. ncbi Subcutaneous plasmacytomas with tropism to sites of previous trauma in a multiple myeloma patient treated with an autologous bone marrow transplant
    Michael D Rosenblum
    Department of Medical Scientist Training Program MSTP, Medical College of Wisconsin, Milwaukee, USA
    Am J Hematol 72:274-7. 2003
    ..Selection of tumor cell subclones with unique chemokine receptor expression profiles that may explain this clinical observation is discussed...
  44. doi Lymphocyte sub-populations and non-Langerhans' cell monocytoid cells in pulmonary Langerhans' cell histiocytosis
    R Nagarjun Rao
    Department of Pathology, Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA
    Pathol Res Pract 204:315-22. 2008
    ..A small sub-population of NLMC was also present. Further studies are required to better define and to evaluate the role of cytotoxic T cells and NLMC in the pathogenesis of PLCH...
  45. ncbi Simian virus 40 in posttransplant lymphoproliferative disorders
    Regis A Vilchez
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Pathol 37:1130-6. 2006
    ..These results suggest that SV40 may be associated with a small subset of PTLD cases. Additional studies are needed to determine the role of SV40 in EBV-negative PTLD...
  46. pmc Interleukin-2 Functions in Anaplastic Large Cell Lymphoma Cells through Augmentation of Extracellular Signal-Regulated Kinases 1/2 Activation
    Masanori Ito
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX, USA
    Int J Biomed Sci 7:181-90. 2011
    ..Our findings demonstrate that IL-2 signaling plays a functional role in ALCL cells, and enhances lymphoma cell survival by increasing activation of the ERK1/2 pathway...
  47. pmc NSMAP: a method for spliced isoforms identification and quantification from RNA-Seq
    Zheng Xia
    Department of Radiology, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    BMC Bioinformatics 12:162. 2011
    ..Novel study on isoform inference and estimation purely from RNA-Seq without annotation information is desirable...
  48. ncbi Acute leukemia immunohistochemistry: a systematic diagnostic approach
    Randall J Olsen
    Department of Pathology, The Methodist Hospital, 6565 Fannin St, M227, Houston, TX 77030, USA
    Arch Pathol Lab Med 132:462-75. 2008
    ..Although no one marker is pathognomonic for one malignancy, a well-chosen panel of antibodies can efficiently aid the diagnosis and classification of acute leukemias...
  49. ncbi Myelodysplastic syndromes: clinicopathologic features, pathobiology, and molecular pathogenesis
    Ha Thanh Nishino
    Department of Pathology, The Methodist Hospital, Houston, TX 77030, USA
    Arch Pathol Lab Med 129:1299-310. 2005
    ..This heterogeneity in disease characterization has led to evolving classification systems, developing prognostic models, and continuing research efforts to elucidate its pathobiology and pathogenesis...
  50. ncbi Restricted kappa/lambda light chain ratio by flow cytometry in germinal center B cells in Hashimoto thyroiditis
    Henry I Chen
    Department of Pathology, Baylor College of Medicine, Houston, TX, USA
    Am J Clin Pathol 125:42-8. 2006
    ..This finding frequently is present in HT. Pathologists should be familiar with this phenomenon to prevent misdiagnosis of follicular lymphoma in patients with HT...
  51. ncbi Monocytes with altered phenotypes in posttrauma patients
    Bal Kampalath
    Department of Pathology, Medical College of Wisconsin, Milwauke, USA
    Arch Pathol Lab Med 127:1580-5. 2003
    ..CD4 plays an integral role in most of the functions of HLA-DR. In newborn infants, who have impaired immune responsiveness, we found a concomitant reduction of CD4 on monocytes with decreased HLA-DR expression...
  52. ncbi High throughput quantitative reverse transcription PCR assays revealing over-expression of cancer testis antigen genes in multiple myeloma stem cell-like side population cells
    Jianguo Wen
    Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA
    Br J Haematol 166:711-9. 2014
    ..Our findings indicate that multiple CTA have unique expression profiles in MM SP, suggesting that CTA may serve as targets for immunotherapy that it specific for MM stem cells and which may lead to the long-term cure of MM. ..
  53. ncbi Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis study
    Arsalan Ahmed
    The Department of Pathology and Laboratory Medicine, The Methodist Hospital and Research Institute, Houston, TX 77030, USA
    Pathol Res Pract 205:634-8. 2009
    ..Further studies are warranted to confirm our observation and to study the mechanisms by which mast cells contribute to fibrosis in the MPN setting...
  54. ncbi BCL10 expression in ocular adnexal lymphomas
    Choladda Vejabhuti
    Department of Pathology, Baylor College of Medicine, Houston, Texas, USA
    Am J Ophthalmol 140:836-843. 2005
    ..To study BCL10 expression in ocular adnexal lymphoma in the US population and its association with clinical outcomes...
  55. ncbi MCW melanoma cocktail for the evaluation of micrometastases in sentinel lymph nodes of cutaneous melanoma
    Vinod B Shidham
    Medical College of Wisconsin, Department of Pathology, Milwaukee, WI 53226 USA
    Expert Rev Mol Diagn 5:281-90. 2005
    ....
  56. doi Changes of red blood cell surface markers in a blood doping model of neocytolysis
    Chung Che Chang
    Department of Pathology, The Methodist Hospital and The Methodist Hospital Research Institute, Weill Medical College of Cornell University, NY, USA
    J Investig Med 57:650-4. 2009
    ..Progress in understanding the process is hampered by the lack of established markers to distinguish young from older RBC...
  57. ncbi The role of Janus Kinase 2 V617F mutation in extramedullary hematopoiesis of the spleen in neoplastic myeloid disorders
    Pin Pen Hsieh
    Department of Pathology and Laboratory Medicine, The Methodist Hospital and The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Mod Pathol 20:929-35. 2007
    ..Also, dysregulation of downstream pathways such as Bcl-xL may be important to CMPD disease pathogenesis in the spleen...
  58. pmc Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer
    Catherine M Bollard
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, TX 77030, USA
    Blood 110:2838-45. 2007
    ..This study is registered at http://www.cancer.gov/clinicaltrials (protocol IDs: BCM-H-9936, NCT00062868, NCT00070226)...
  59. pmc Array comparative genomic hybridization detects chromosomal abnormalities in hematological cancers that are not detected by conventional cytogenetics
    Lina Shao
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77021 2039, USA
    J Mol Diagn 12:670-9. 2010
    ..This pilot study clearly demonstrates high sensitivity of oligonucleotide aCGH for potential use in diagnosis and follow-up in patients with hematological neoplasms...
  60. ncbi A unique collision tumor in breast: invasive ductal carcinoma and mucosa-associated lymphoid tissue lymphoma
    Barbara Susnik
    Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA
    Arch Pathol Lab Med 128:99-101. 2004
    ..The morphology and results of immunohistochemistry, flow cytometry, and cytogenetic analysis were consistent with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue...
  61. ncbi Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity?
    Steven H Wong
    Milwaukee County Medical Examiners Office, Milwaukee, WI, USA
    J Forensic Sci 48:1406-15. 2003
    ..However, pharmacogenomics, complementing other case findings, served as an adjunct in interpreting methadone toxicity of poor and intermediate metabolizers...
  62. pmc Prognostic impact of C-REL expression in diffuse large B-cell lymphoma
    Choladda V Curry
    Pathology, The Methodist Hospital Research Institute, The Methodist Hospital, 6565 Fannin St MS 205, Houston, TX, 77030, USA
    J Hematop 2:20-6. 2009
    ..These results suggest that c-REL nuclear expression may be a prognostic factor in DLBCL and it may improve patient risk stratification in combination with GCB/non-GCB phenotyping...
  63. ncbi Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90
    Yang Shi
    Division of Pediatric Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Mol Cell Cardiol 38:625-35. 2005
    ..NO production and decreases uncoupled NOS3 activity. We conclude increased association of hsp90 with NOS3 is a major mechanism by which BN/Mcw hearts are more resistant to ischemia than SS/Mcw hearts...
  64. pmc Conditional random pattern algorithm for LOH inference and segmentation
    Ling Yun Wu
    Center for Biotechnology and Informatics, Department of Radiology, The Methodist Hospital Research Institute, Weill Medical College, Cornell University, Houston, TX 77030, USA
    Bioinformatics 25:61-7. 2009
    ..But genotyping errors are always unavoidable, and there are about 70% non-informative SNPs whose LOH status can only be inferred from the neighboring informative SNPs...
  65. ncbi Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles
    Francisco Vega
    Department of Pathology, Baylor College of Medicine corrected Houston, TX corrected USA
    Mod Pathol 18:806-15. 2005
    ..These results do not support the suggestion in the WHO classification that plasmablastic lymphoma is a variant of diffuse large B-cell lymphoma...
  66. ncbi Correspondence re: Aguilera NS, Tomaszewski MM, Moad JC, Bauer FA, Taubenberger JK, Abbondanzo SL. Cutaneous follicle center lymphoma: a clinicopathologic study of 19 cases. Mod pathol. 2001;14:828-35. and Franco R, Fernandez-Vazquez A, Mollejo M, Cruz MA
    Chung Che Chang
    Mod Pathol 15:584-5; author reply 585-6. 2002
  67. ncbi CD10 expression and survival
    Chung Che Chang
    Am J Clin Pathol 117:660-1; author reply 661-2. 2002
  68. ncbi Efficacy of alemtuzumab treatment for refractory T-cell large granular lymphocytic leukemia
    Michael D Rosenblum
    Blood 103:1969-71. 2004
  69. ncbi Analysis of immunohistochemical markers in bone marrow sections to evaluate for myelodysplastic syndromes and acute myeloid leukemias
    Cherie H Dunphy
    Divisions of Hematopathology, Departments of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
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    ....
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