M S Saporito

Summary

Affiliation: Cephalon Inc
Country: USA

Publications

  1. ncbi MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo
    M S Saporito
    Cephalon Inc, West Chester, PA 19380, USA
    J Neurochem 75:1200-8. 2000
  2. ncbi CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo
    M S Saporito
    Cephalon Inc, West Chester, Pennsylvania, USA
    J Pharmacol Exp Ther 288:421-7. 1999

Detail Information

Publications2

  1. ncbi MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivo
    M S Saporito
    Cephalon Inc, West Chester, PA 19380, USA
    J Neurochem 75:1200-8. 2000
    ..These data implicate this signaling pathway in MPTP-mediated nigrostriatal dopaminergic death and suggest that it may be activated in the degenerative process in Parkinson's disease...
  2. ncbi CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo
    M S Saporito
    Cephalon Inc, West Chester, Pennsylvania, USA
    J Pharmacol Exp Ther 288:421-7. 1999
    ..These data implicate a c-jun N-terminal kinase signaling system in MPTP-mediated dopaminergic degeneration and suggest that CEP-1347/KT-7515 may have potential as a treatment for Parkinson's disease...