M S Saporito
Affiliation: Cephalon Inc
- MPTP activates c-Jun NH(2)-terminal kinase (JNK) and its upstream regulatory kinase MKK4 in nigrostriatal neurons in vivoM S Saporito
Cephalon Inc, West Chester, PA 19380, USA
J Neurochem 75:1200-8. 2000..These data implicate this signaling pathway in MPTP-mediated nigrostriatal dopaminergic death and suggest that it may be activated in the degenerative process in Parkinson's disease...
- CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivoM S Saporito
Cephalon Inc, West Chester, Pennsylvania, USA
J Pharmacol Exp Ther 288:421-7. 1999..These data implicate a c-jun N-terminal kinase signaling system in MPTP-mediated dopaminergic degeneration and suggest that CEP-1347/KT-7515 may have potential as a treatment for Parkinson's disease...