P Robertson

Summary

Affiliation: Cephalon Inc
Country: USA

Publications

  1. ncbi request reprint Steady-state pharmacokinetics and tolerability of modafinil given alone or in combination with methylphenidate in healthy volunteers
    E T Hellriegel
    Department of Drug Disposition, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
    J Clin Pharmacol 41:895-904. 2001
  2. ncbi request reprint In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil
    P Robertson
    Department of Drug Safety and Disposition, Cephalon, Inc, West Chester, Pennsylvania, USA
    Drug Metab Dispos 28:664-71. 2000
  3. ncbi request reprint Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers
    Philmore Robertson
    Department of Drug Disposition, Cephalon, Inc, West Chester, PA 19380, USA
    Clin Pharmacol Ther 71:46-56. 2002
  4. ncbi request reprint Clinical pharmacokinetic profile of modafinil
    Philmore Robertson
    Department of Drug Safety and Disposition, Cephalon, Inc, West Chester, Pennsylvania, USA
    Clin Pharmacokinet 42:123-37. 2003
  5. ncbi request reprint Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects
    Mona Darwish
    Clinical Pharmacology, Cephalon Inc, Frazer, PA 19355, USA
    Clin Pharmacokinet 47:61-74. 2008
  6. ncbi request reprint Absorption of fentanyl from fentanyl buccal tablet in cancer patients with or without oral mucositis: a pilot study
    Mona Darwish
    Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania 19355, USA
    Clin Drug Investig 27:605-11. 2007
  7. ncbi request reprint Absolute and relative bioavailability of fentanyl buccal tablet and oral transmucosal fentanyl citrate
    Mona Darwish
    Cephalon Inc, 41 Moores Road, Frazer, PA 19355, USA
    J Clin Pharmacol 47:343-50. 2007
  8. ncbi request reprint Single-dose and steady-state pharmacokinetics of fentanyl buccal tablet in healthy volunteers
    Mona Darwish
    Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania, USA
    J Clin Pharmacol 47:56-63. 2007
  9. ncbi request reprint Comparison of equivalent doses of fentanyl buccal tablets and arteriovenous differences in fentanyl pharmacokinetics
    Mona Darwish
    Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania 19355, USA
    Clin Pharmacokinet 45:843-50. 2006
  10. ncbi request reprint Pharmacokinetic properties of fentanyl effervescent buccal tablets: a phase I, open-label, crossover study of single-dose 100, 200, 400, and 800 microg in healthy adult volunteers
    Mona Darwish
    Department of Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania 19355, USA
    Clin Ther 28:707-14. 2006

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Steady-state pharmacokinetics and tolerability of modafinil given alone or in combination with methylphenidate in healthy volunteers
    E T Hellriegel
    Department of Drug Disposition, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
    J Clin Pharmacol 41:895-904. 2001
    ..The results indicate that administration of low-dose methylphenidate 8 hours after treatment with modafinil does not appear to alter the steady-state pharmacokinetics of modafinil in healthy volunteers...
  2. ncbi request reprint In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil
    P Robertson
    Department of Drug Safety and Disposition, Cephalon, Inc, West Chester, Pennsylvania, USA
    Drug Metab Dispos 28:664-71. 2000
    ..Although effects obtained in vitro are not always predictive of effects in vivo, such results provide a rational basis for understanding drug-drug interactions that are observed clinically and for planning subsequent investigations...
  3. ncbi request reprint Effect of modafinil on the pharmacokinetics of ethinyl estradiol and triazolam in healthy volunteers
    Philmore Robertson
    Department of Drug Disposition, Cephalon, Inc, West Chester, PA 19380, USA
    Clin Pharmacol Ther 71:46-56. 2002
    ..Modafinil has been reported to produce a concentration-related induction of CYP3A4/5 activity in vitro in primary cultures of human hepatocytes...
  4. ncbi request reprint Clinical pharmacokinetic profile of modafinil
    Philmore Robertson
    Department of Drug Safety and Disposition, Cephalon, Inc, West Chester, Pennsylvania, USA
    Clin Pharmacokinet 42:123-37. 2003
    ..In summary, the results show that modafinil is a moderately long-lived drug that is well absorbed and extensively metabolised...
  5. ncbi request reprint Interaction profile of armodafinil with medications metabolized by cytochrome P450 enzymes 1A2, 3A4 and 2C19 in healthy subjects
    Mona Darwish
    Clinical Pharmacology, Cephalon Inc, Frazer, PA 19355, USA
    Clin Pharmacokinet 47:61-74. 2008
    ..Study 3 evaluated the potential for armodafinil to inhibit the activity of CYP2C19 using oral omeprazole as the probe substrate...
  6. ncbi request reprint Absorption of fentanyl from fentanyl buccal tablet in cancer patients with or without oral mucositis: a pilot study
    Mona Darwish
    Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania 19355, USA
    Clin Drug Investig 27:605-11. 2007
    ....
  7. ncbi request reprint Absolute and relative bioavailability of fentanyl buccal tablet and oral transmucosal fentanyl citrate
    Mona Darwish
    Cephalon Inc, 41 Moores Road, Frazer, PA 19355, USA
    J Clin Pharmacol 47:343-50. 2007
    ..The rate and extent of fentanyl absorption were greater following administration of FBT compared to OTFC. An approximately 30% smaller dose of FBT achieved systemic exposures comparable to OTFC...
  8. ncbi request reprint Single-dose and steady-state pharmacokinetics of fentanyl buccal tablet in healthy volunteers
    Mona Darwish
    Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania, USA
    J Clin Pharmacol 47:56-63. 2007
    ..This was attributed to the redistribution of fentanyl from a deep tissue compartment into the plasma. This study indicates that fentanyl buccal tablet has predictable pharmacokinetics following multiple-dose administration...
  9. ncbi request reprint Comparison of equivalent doses of fentanyl buccal tablets and arteriovenous differences in fentanyl pharmacokinetics
    Mona Darwish
    Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania 19355, USA
    Clin Pharmacokinet 45:843-50. 2006
    ..The fentanyl buccal tablet (FBT) is designed to enhance the rate and extent of fentanyl absorption through the buccal mucosa...
  10. ncbi request reprint Pharmacokinetic properties of fentanyl effervescent buccal tablets: a phase I, open-label, crossover study of single-dose 100, 200, 400, and 800 microg in healthy adult volunteers
    Mona Darwish
    Department of Clinical Pharmacology, Cephalon, Inc, Frazer, Pennsylvania 19355, USA
    Clin Ther 28:707-14. 2006
    ..The fentanyl effervescent buccal tablet (FEBT) is designed to enhance the rate and extent of the absorption of fentanyl, an opioid, through the buccal mucosa...
  11. ncbi request reprint Bioequivalence following buccal and sublingual placement of fentanyl buccal tablet 400 microg in healthy subjects
    Mona Darwish
    Clinical Pharmacology, Cephalon Inc, Frazer, PA 19355, USA
    Clin Drug Investig 28:1-7. 2008
    ..e. above a molar tooth between the upper gum and cheek) and sublingual (i.e. placed under the tongue) placement in order to provide an alternative option to patients...
  12. ncbi request reprint Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes
    Ajay Madan
    XenoTech, LLC, 16825 West 116th Street, Lenexa, KS 66219, USA
    Drug Metab Dispos 31:421-31. 2003
    ....
  13. ncbi request reprint Steady-state pharmacokinetics and tolerability of modafinil administered alone or in combination with dextroamphetamine in healthy volunteers
    Edward T Hellriegel
    Department of Drug Disposition, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
    J Clin Pharmacol 42:450-60. 2002
    ..The results indicate that administration of low-dose dextroamphetamine in this dosing regimen does not alter the steady-state pharmacokinetics of modafinil. The combination has a similar tolerability profile as modafinil alone...
  14. ncbi request reprint Effect of modafinil at steady state on the single-dose pharmacokinetic profile of warfarin in healthy volunteers
    Philmore Robertson
    Department of Drug Disposition, Cephalon, Inc, West Chester, Pennsylvania 19380, USA
    J Clin Pharmacol 42:205-14. 2002
    ..However, limitations arising from investigation of single doses of warfarin preclude global conclusions about the potential for more subtle interactions after chronic warfarin administration...
  15. ncbi request reprint Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor
    John L Marshall
    Georgetown University Medical Center Lombardi Cancer Center, Washington, DC 20007, USA
    Invest New Drugs 23:31-7. 2005
    ..The objectives were to determine the maximum tolerated dose (MTD), dose-limiting toxicities, and pharmacokinetic profile of this orally administered agent...