Affiliation: Cephalon Inc
- Correlation between ex vivo receptor occupancy and wake-promoting activity of selective H3 receptor antagonistsSiyuan Le
World Wide Discovery Research, CNS Biology, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
J Pharmacol Exp Ther 325:902-9. 2008..Robust waking activity at higher levels of H3R occupancy may be mechanistically different from activities at low levels of H3R occupancy...
- Detection of low level histamine H3 receptor occupancy by autoradiographySiyuan Le
World Wide Discovery Research, Cephalon, Inc, West Chester, PA 19380, USA
J Neurosci Methods 185:70-5. 2009..Furthermore, the increased sensitivity should be useful in providing dosing guidelines for H(3) antagonists in both preclinical and clinical settings...
- CEP-26401 (irdabisant), a potent and selective histamine H₃ receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activitiesRita Raddatz
Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
J Pharmacol Exp Ther 340:124-33. 2012..CEP-26401 may also have therapeutic utility in treating schizophrenia or as adjunctive therapy to approved antipsychotics...