Dorothy G Flood

Summary

Affiliation: Cephalon Inc
Country: USA

Publications

  1. ncbi FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction
    Dorothy G Flood
    Department of Neurobiology, Cephalon, Inc, West Chester, PA 19380, USA
    Neurobiol Aging 23:335-48. 2002
  2. doi Mood stabilizers increase prepulse inhibition in DBA/2NCrl mice
    Dorothy G Flood
    CNS Biology, Worldwide Discovery Research, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Psychopharmacology (Berl) 205:369-77. 2009
  3. ncbi Variables affecting prepulse inhibition of the startle reflex and the response to antipsychotics in DBA/2NCrl mice
    Dorothy G Flood
    CNS Biology, Worldwide Discovery Research, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Psychopharmacology (Berl) 195:203-11. 2007
  4. ncbi A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition
    Dorothy G Flood
    Department of CNS Biology, Discovery Research, Cephalon, Inc, West Chester, PA 19380, USA
    Neurobiol Aging 30:1078-90. 2009
  5. ncbi Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition
    Mary J Savage
    Department of Neurobiology, Cephalon Inc, West Chester, Pennsylvania 19380, USA
    J Neurosci 22:3376-85. 2002
  6. ncbi Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease
    Zhi liang Wu
    Cephalon, Inc, Neurobiology, 145 Brandywine Parkway, West Chester, PA 19380 4245, USA
    Neurobiol Aging 27:377-86. 2006
  7. doi Characterization of pharmacological and wake-promoting properties of the dopaminergic stimulant sydnocarb in rats
    John A Gruner
    CNS Biology, Worldwide Discovery Research, Cephalon, Inc, West Chester, Pennsylvania, USA
    J Pharmacol Exp Ther 337:380-90. 2011
  8. doi CEP-26401 (irdabisant), a potent and selective histamine H₃ receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities
    Rita Raddatz
    Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    J Pharmacol Exp Ther 340:124-33. 2012
  9. ncbi CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice
    John R Ciallella
    Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Eur J Pharmacol 515:179-87. 2005
  10. doi Prepulse inhibition of the startle reflex and response to antipsychotic treatments in two outbred mouse strains in comparison to the inbred DBA/2 mouse
    Dorothy G Flood
    EnVivo Pharmaceuticals, Inc, 480 Aresenal St, Watertown, MA 02472, USA
    Psychopharmacology (Berl) 215:441-54. 2011

Collaborators

Detail Information

Publications16

  1. ncbi FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction
    Dorothy G Flood
    Department of Neurobiology, Cephalon, Inc, West Chester, PA 19380, USA
    Neurobiol Aging 23:335-48. 2002
    ..The APP(NLh/NLh)/PS-1(P264L/P264L) double gene-targeted mouse represents an animal model that exhibits Abeta deposition without overexpression of APP...
  2. doi Mood stabilizers increase prepulse inhibition in DBA/2NCrl mice
    Dorothy G Flood
    CNS Biology, Worldwide Discovery Research, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Psychopharmacology (Berl) 205:369-77. 2009
    ..Lithium and several antiepileptic drugs have mood-stabilizing effects in bipolar disorder and schizophrenia. Both disorders are characterized by deficits in prepulse inhibition (PPI) of the acoustic startle response...
  3. ncbi Variables affecting prepulse inhibition of the startle reflex and the response to antipsychotics in DBA/2NCrl mice
    Dorothy G Flood
    CNS Biology, Worldwide Discovery Research, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Psychopharmacology (Berl) 195:203-11. 2007
    ..Thus, the DBA/2 mouse is increasingly used for testing of novel antipsychotics in PPI; however, the strain has not been fully characterized for relevant variables affecting compound testing...
  4. ncbi A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition
    Dorothy G Flood
    Department of CNS Biology, Discovery Research, Cephalon, Inc, West Chester, PA 19380, USA
    Neurobiol Aging 30:1078-90. 2009
    ..Abeta levels measured by ELISA were comparable to those reported in mouse models, suggesting that substantially greater amounts of soluble Abeta are not required in the rat to generate Abeta deposition...
  5. ncbi Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition
    Mary J Savage
    Department of Neurobiology, Cephalon Inc, West Chester, Pennsylvania 19380, USA
    J Neurosci 22:3376-85. 2002
    ....
  6. ncbi Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease
    Zhi liang Wu
    Cephalon, Inc, Neurobiology, 145 Brandywine Parkway, West Chester, PA 19380 4245, USA
    Neurobiol Aging 27:377-86. 2006
    ....
  7. doi Characterization of pharmacological and wake-promoting properties of the dopaminergic stimulant sydnocarb in rats
    John A Gruner
    CNS Biology, Worldwide Discovery Research, Cephalon, Inc, West Chester, Pennsylvania, USA
    J Pharmacol Exp Ther 337:380-90. 2011
    ..In conclusion, sydnocarb is a selective and potent DAT inhibitor that produces robust increases in the wake state without RHS, and with potential cognitive-enhancing properties...
  8. doi CEP-26401 (irdabisant), a potent and selective histamine H₃ receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting activities
    Rita Raddatz
    Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    J Pharmacol Exp Ther 340:124-33. 2012
    ..CEP-26401 may also have therapeutic utility in treating schizophrenia or as adjunctive therapy to approved antipsychotics...
  9. ncbi CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice
    John R Ciallella
    Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Eur J Pharmacol 515:179-87. 2005
    ..These results suggest that MLK blockade may be useful in inhibiting pro-inflammatory cytokine production in a wide range of diseases...
  10. doi Prepulse inhibition of the startle reflex and response to antipsychotic treatments in two outbred mouse strains in comparison to the inbred DBA/2 mouse
    Dorothy G Flood
    EnVivo Pharmaceuticals, Inc, 480 Aresenal St, Watertown, MA 02472, USA
    Psychopharmacology (Berl) 215:441-54. 2011
    ..Whether other mouse strains with naturally low PPI respond similarly and could be translational models of schizophrenia is unknown...
  11. doi The effects of d-amphetamine, methylphenidate, sydnocarb, and caffeine on prepulse inhibition of the startle reflex in DBA/2 mice
    Dorothy G Flood
    CNS Biology, Worldwide Discovery Research, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Psychopharmacology (Berl) 211:325-36. 2010
    ..DBA/2 mice have naturally low-baseline PPI, which as in the drug-induced translational models, is increased by antipsychotics...
  12. doi Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice
    Karla Kopec
    Cephalon, Inc, West Chester, PA 19380, USA
    Biochem Pharmacol 80:1407-17. 2010
    ..Thus, GlyT1 inhibitors with short residence times demonstrated efficacy without mechanism-based adverse effects...
  13. doi Developing predictive CSF biomarkers-a challenge critical to success in Alzheimer's disease and neuropsychiatric translational medicine
    Dorothy G Flood
    Worldwide Discovery Research, Cephalon, Inc, West Chester, PA 19380, USA
    Biochem Pharmacol 81:1422-34. 2011
    ....
  14. doi Armodafinil promotes wakefulness and activates Fos in rat brain
    Elaine M Fiocchi
    Discovery Research, Cephalon, Inc, 145 Brandywine Parkway, West Chester, PA 19380, USA
    Pharmacol Biochem Behav 92:549-57. 2009
    ..Fos activation of these brainstem arousal centers, as well as of the cortex and striatum, is consistent with the observed arousal effects of armodafinil...
  15. pmc AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice
    Eric H Chang
    Center for Neural Science, New York University, NY 10003, USA
    Proc Natl Acad Sci U S A 103:3410-5. 2006
    ..These results suggest that AMPARs are important synaptic targets for AD and provide evidence that cognitive impairment may involve downscaling of postsynaptic AMPAR function...
  16. ncbi Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome
    Eric E Abrahamson
    Department of Neurology, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Suite 811, 15213, USA
    Exp Neurol 197:437-50. 2006
    ....