Weimin Zhong

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications
    Weimin Zhong
    Laboratory of Immunobiology and Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Mol Biol 372:535-48. 2007
  2. pmc Significant impact of sequence variations in the nucleoprotein on CD8 T cell-mediated cross-protection against influenza A virus infections
    Weimin Zhong
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 5:e10583. 2010
  3. doi request reprint Development and evaluation of an M2-293FT cell-based flow cytometric assay for quantification of antibody response to native form of matrix protein 2 of influenza A viruses
    Weimin Zhong
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Immunol Methods 369:115-24. 2011
  4. doi request reprint Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus
    Kathy Hancock
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 361:1945-52. 2009
  5. ncbi request reprint Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance
    Rob Meijers
    Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Mol Biol 345:1099-110. 2005
  6. ncbi request reprint CD8 alpha alpha homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice
    Weimin Zhong
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Eur J Immunol 35:3103-10. 2005
  7. ncbi request reprint In vivo selection of a TCR Vbeta repertoire directed against an immunodominant influenza virus CTL epitope
    Weimin Zhong
    Laboratory of Immunobiology and Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Int Immunol 16:1549-59. 2004
  8. ncbi request reprint Genome-wide characterization of a viral cytotoxic T lymphocyte epitope repertoire
    Weimin Zhong
    Laboratory of Immunobiology and Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 278:45135-44. 2003
  9. ncbi request reprint Vaccines against epidemic and pandemic influenza
    Mary Hoelscher
    National Center for Immunization and Respiratory Diseases, Influenza Division, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Mail Stop G47, 1600 Clifton Road, Atlanta, GA 30333, USA
    Expert Opin Drug Deliv 5:1139-57. 2008

Collaborators

Detail Information

Publications9

  1. ncbi request reprint CTL recognition of a protective immunodominant influenza A virus nucleoprotein epitope utilizes a highly restricted Vbeta but diverse Valpha repertoire: functional and structural implications
    Weimin Zhong
    Laboratory of Immunobiology and Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Mol Biol 372:535-48. 2007
    ..These results provide insight into molecular principles regarding public versus private TCRs linked to immune surveillance after infection with influenza A virus...
  2. pmc Significant impact of sequence variations in the nucleoprotein on CD8 T cell-mediated cross-protection against influenza A virus infections
    Weimin Zhong
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 5:e10583. 2010
    ..However, it is not clear to what extent such pre-existing cellular immunity can provide cross-subtype protection against novel emerging influenza A viruses...
  3. doi request reprint Development and evaluation of an M2-293FT cell-based flow cytometric assay for quantification of antibody response to native form of matrix protein 2 of influenza A viruses
    Weimin Zhong
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Immunol Methods 369:115-24. 2011
    ..These results demonstrate that M2-FCA represents a rapid, simple and sensitive method to quantitatively assess specificity and cross-reactivity of anti-M2 antibodies after infection or vaccination...
  4. doi request reprint Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus
    Kathy Hancock
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 361:1945-52. 2009
    ....
  5. ncbi request reprint Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance
    Rob Meijers
    Laboratory of Immunobiology, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Mol Biol 345:1099-110. 2005
    ....
  6. ncbi request reprint CD8 alpha alpha homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice
    Weimin Zhong
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Eur J Immunol 35:3103-10. 2005
    ..Further studies are needed to define those ligands that induce CD8alphaalpha on T cells during acute viral infections, and the general relevance of this process to memory T cell formation...
  7. ncbi request reprint In vivo selection of a TCR Vbeta repertoire directed against an immunodominant influenza virus CTL epitope
    Weimin Zhong
    Laboratory of Immunobiology and Department of Medical Oncology, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Int Immunol 16:1549-59. 2004
    ....
  8. ncbi request reprint Genome-wide characterization of a viral cytotoxic T lymphocyte epitope repertoire
    Weimin Zhong
    Laboratory of Immunobiology and Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 278:45135-44. 2003
    ..These results have important implications for rationale design of CD8+ T cell vaccines...
  9. ncbi request reprint Vaccines against epidemic and pandemic influenza
    Mary Hoelscher
    National Center for Immunization and Respiratory Diseases, Influenza Division, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Mail Stop G47, 1600 Clifton Road, Atlanta, GA 30333, USA
    Expert Opin Drug Deliv 5:1139-57. 2008
    ..2% only [1] . In addition, H5N1 avian influenza viruses have the potential to cause a pandemic. However, H5N1 vaccines currently licensed in the US are poorly immunogenic in high doses in the absence of an adjuvant even in healthy adults...