Bao Zhu Yuan

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells
    Bao Zhu Yuan
    Laboratory of Molecular Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, CDC, Morgantown, WV 26505, USA
    Exp Cell Res 313:3868-80. 2007
  2. doi request reprint Proteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavage
    B Z Yuan
    Laboratory of Molecular Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, CDC, Morgantown, WV 26505, USA
    Oncogene 28:3775-86. 2009
  3. pmc Aberrant gene expression in human non small cell lung carcinoma cells exposed to demethylating agent 5-aza-2'-deoxycytidine
    Bao Zhu Yuan
    Laboratory of Cancer Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neoplasia 6:412-9. 2004
  4. ncbi request reprint DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas
    Bao Zhu Yuan
    Laboratory of Genetic Susceptibility, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Oncogene 23:1405-11. 2004
  5. ncbi request reprint Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers
    Bao Zhu Yuan
    Health Effects Laboratory Division, Toxicology and Molecular Biology Branch, National Institute for Occupational Safely and Health, Morgantown, WV 26505, USA
    Cancer Genet Cytogenet 140:113-7. 2003
  6. pmc CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer
    Peilin Zhang
    Department of Pathology, Robert C Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506 9203, USA
    Mol Cancer 3:14. 2004
  7. ncbi request reprint Expression profile of eukaryotic translation factors in human cancer tissues and cell lines
    Pius Joseph
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Mol Carcinog 40:171-9. 2004
  8. pmc Proteasome Inhibitor MG132 Induces Apoptosis and Inhibits Invasion of Human Malignant Pleural Mesothelioma Cells
    Bao Zhu Yuan
    Laboratory of Molecular Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, CDC, Morgantown, WV 26505, USA
    Transl Oncol 1:129-40. 2008
  9. ncbi request reprint DLC-1:a Rho GTPase-activating protein and tumour suppressor
    Marian E Durkin
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Cell Mol Med 11:1185-207. 2007
  10. ncbi request reprint DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity
    Bao Zhu Yuan
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Oncogene 22:445-50. 2003

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells
    Bao Zhu Yuan
    Laboratory of Molecular Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, CDC, Morgantown, WV 26505, USA
    Exp Cell Res 313:3868-80. 2007
    ..Our analyses provide evidence for a possible link between morphological alterations, PNT and proapoptotic and anti-oncogenic activities of DLC1 in lung cancer...
  2. doi request reprint Proteasome inhibitors induce apoptosis in human lung cancer cells through a positive feedback mechanism and the subsequent Mcl-1 protein cleavage
    B Z Yuan
    Laboratory of Molecular Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, CDC, Morgantown, WV 26505, USA
    Oncogene 28:3775-86. 2009
    ..Therefore, this study provides a basis for enhancing the efficacy of PIs in treating NSCLC...
  3. pmc Aberrant gene expression in human non small cell lung carcinoma cells exposed to demethylating agent 5-aza-2'-deoxycytidine
    Bao Zhu Yuan
    Laboratory of Cancer Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neoplasia 6:412-9. 2004
    ..Hint/PKCI-1, which is the only other characterized human histidine triad (HIT) nucleotide-binding protein in addition to tumor-suppressor gene FHIT, might be involved in lung carcinogenesis...
  4. ncbi request reprint DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas
    Bao Zhu Yuan
    Laboratory of Genetic Susceptibility, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Oncogene 23:1405-11. 2004
    ..Furthermore, stable transfer of DLC-1 abolished tumorigenicity in nude mice of two cell lines, suggesting that DLC-1 plays a role in NSCLC by acting as a bona fide new tumor suppressor gene...
  5. ncbi request reprint Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers
    Bao Zhu Yuan
    Health Effects Laboratory Division, Toxicology and Molecular Biology Branch, National Institute for Occupational Safely and Health, Morgantown, WV 26505, USA
    Cancer Genet Cytogenet 140:113-7. 2003
    ..These observations suggest that hypermethylation is responsible for abrogating the function of the DLC-1 gene in a subset of liver, breast, colon, and prostate cancers...
  6. pmc CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer
    Peilin Zhang
    Department of Pathology, Robert C Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506 9203, USA
    Mol Cancer 3:14. 2004
    ..CHK2-/- cells were remarkably resistant to DNA damage induced apoptosis, mimicking the clinical behavior of non-small cell lung cancer to conventional chemo and radiation therapy...
  7. ncbi request reprint Expression profile of eukaryotic translation factors in human cancer tissues and cell lines
    Pius Joseph
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Mol Carcinog 40:171-9. 2004
    ..These results indicate that human carcinogenesis is often associated with alterations in the expression of various translation factors especially the overexpression of eukaryotic translation elongation factor 1A2...
  8. pmc Proteasome Inhibitor MG132 Induces Apoptosis and Inhibits Invasion of Human Malignant Pleural Mesothelioma Cells
    Bao Zhu Yuan
    Laboratory of Molecular Genetics, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, CDC, Morgantown, WV 26505, USA
    Transl Oncol 1:129-40. 2008
    ..These observations demonstrate that MG132 possesses proapoptotic and anti-invasion activities in human MPM cells, therefore encouraging further investigations on the value of PIs for treating MPM...
  9. ncbi request reprint DLC-1:a Rho GTPase-activating protein and tumour suppressor
    Marian E Durkin
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    J Cell Mol Med 11:1185-207. 2007
    ..Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors. This review presents the current status of progress in understanding the biological functions of DLC-1 and its relatives and their roles in neoplasia...
  10. ncbi request reprint DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity
    Bao Zhu Yuan
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Oncogene 22:445-50. 2003
    ..Furthermore, introduction of the DLC-1 cDNA abolished the in vivo tumorigenicity in nude mice, suggesting that the DLC-1 gene plays a role in breast cancer by acting as a bona fide tumor suppressor gene...
  11. ncbi request reprint The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer
    Yadong Zhang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China
    Oncogene 24:4873-82. 2005
    ..These results suggest that the mdig gene may be involved in the regulation of cell growth and possibly the development of cancer...
  12. ncbi request reprint DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development
    Marian E Durkin
    Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA
    FEBS Lett 579:1191-6. 2005
    ..Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions...
  13. pmc Amplification and overexpression of the EMS 1 oncogene, a possible prognostic marker, in human hepatocellular carcinoma
    Bao Zhu Yuan
    Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4258, USA
    J Mol Diagn 5:48-53. 2003
    ..EMS1 amplification and overexpresion is indicative of unfavorable prognosis in several cancers and may have similar prognostic implications in liver cancer...
  14. ncbi request reprint Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7)
    Marian E Durkin
    Laboratory of Experimental Carcinogenesis, Building 37, Room 3C28, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Gene 288:119-27. 2002
    ..A polymorphic microsatellite marker in intron 8 was used for mapping the gene (Arhgap7) to 20 cM on mouse chromosome 8 and for allelotyping of mouse liver tumor DNAs...