Matthew W Wheeler

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Model uncertainty and risk estimation for experimental studies of quantal responses
    A John Bailer
    Department of Mathematics and Statistics, Miami University, Oxford, OH 45056, USA
    Risk Anal 25:291-9. 2005
  2. doi request reprint An empirical comparison of low-dose extrapolation from points of departure (PoD) compared to extrapolations based upon methods that account for model uncertainty
    Matthew W Wheeler
    Risk Evaluation Branch, National Institute for Occupational Safety and Health, 4626 Columbia Parkway, Cincinnati, OH 45226, USA Electronic address
    Regul Toxicol Pharmacol 67:75-82. 2013
  3. doi request reprint Monotonic Bayesian semiparametric benchmark dose analysis
    Matthew Wheeler
    Risk Evaluation Branch, National Institute for Occupational Safety and Health, Cincinnati, OH, USA
    Risk Anal 32:1207-18. 2012
  4. ncbi request reprint Confidence interval construction for relative toxicity endpoints such as LD50 or LD90 ratios
    Matthew Wheeler
    Risk Education Branch, National Institutional for Occupational Safety and Health, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA
    J Econ Entomol 100:1945-9. 2007
  5. ncbi request reprint Properties of model-averaged BMDLs: a study of model averaging in dichotomous response risk estimation
    Matthew W Wheeler
    National Institute for Occupational Safety and Health, Risk Evaluation Branch, Cincinnati, OH 45226, USA
    Risk Anal 27:659-70. 2007
  6. ncbi request reprint Comparing median lethal concentration values using confidence interval overlap or ratio tests
    Matthew W Wheeler
    National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS 15, Cincinnati, Ohio 45226, USA
    Environ Toxicol Chem 25:1441-4. 2006
  7. doi request reprint Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States
    Eileen D Kuempel
    National Institute for Occupational Safety and Health, Education and Information Division, Risk Evaluation Branch, Cincinnati, Ohio 45226 1998, USA
    Am J Respir Crit Care Med 180:257-64. 2009
  8. ncbi request reprint An approach to risk assessment for TiO2
    David Dankovic
    National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    Inhal Toxicol 19:205-12. 2007
  9. doi request reprint Benchmark dose estimation incorporating multiple data sources
    Matthew W Wheeler
    National Institute for Occupational Safety and Health, Risk Evaluation Branch, Cincinnati, OH, USA
    Risk Anal 29:249-56. 2009
  10. ncbi request reprint A simulation study of methods for constructing confidence intervals for bioaccumulation factors
    Matthew W Wheeler
    Center for Environmental Toxicology and Statistics, Department of Mathematics and Statistics, Miami University, Oxford, Ohio 45056, USA
    Environ Toxicol Chem 22:921-7. 2003

Detail Information

Publications10

  1. ncbi request reprint Model uncertainty and risk estimation for experimental studies of quantal responses
    A John Bailer
    Department of Mathematics and Statistics, Miami University, Oxford, OH 45056, USA
    Risk Anal 25:291-9. 2005
    ..BMA provides excess risk estimates or benchmark dose estimates that reflects model uncertainty...
  2. doi request reprint An empirical comparison of low-dose extrapolation from points of departure (PoD) compared to extrapolations based upon methods that account for model uncertainty
    Matthew W Wheeler
    Risk Evaluation Branch, National Institute for Occupational Safety and Health, 4626 Columbia Parkway, Cincinnati, OH 45226, USA Electronic address
    Regul Toxicol Pharmacol 67:75-82. 2013
    ..This comparison provides empirical support to accompany previous simulation studies that suggest methods that incorporate model uncertainty provide viable, and arguably preferred, alternatives to linear extrapolation from a PoD. ..
  3. doi request reprint Monotonic Bayesian semiparametric benchmark dose analysis
    Matthew Wheeler
    Risk Evaluation Branch, National Institute for Occupational Safety and Health, Cincinnati, OH, USA
    Risk Anal 32:1207-18. 2012
    ....
  4. ncbi request reprint Confidence interval construction for relative toxicity endpoints such as LD50 or LD90 ratios
    Matthew Wheeler
    Risk Education Branch, National Institutional for Occupational Safety and Health, 4676 Columbia Pkwy, Cincinnati, OH 45226, USA
    J Econ Entomol 100:1945-9. 2007
    ..Results of this study provide empirical support for the continued use this technique...
  5. ncbi request reprint Properties of model-averaged BMDLs: a study of model averaging in dichotomous response risk estimation
    Matthew W Wheeler
    National Institute for Occupational Safety and Health, Risk Evaluation Branch, Cincinnati, OH 45226, USA
    Risk Anal 27:659-70. 2007
    ..Although these results show utility of MA for benchmark dose risk estimation, they continue to highlight the importance of choosing an adequate model space as well as proper model fit diagnostics...
  6. ncbi request reprint Comparing median lethal concentration values using confidence interval overlap or ratio tests
    Matthew W Wheeler
    National Institute for Occupational Safety and Health, 4676 Columbia Parkway MS 15, Cincinnati, Ohio 45226, USA
    Environ Toxicol Chem 25:1441-4. 2006
    ..Thus, a ratio-based statistical procedure is preferred to using simple overlap of two independently derived confidence intervals...
  7. doi request reprint Contributions of dust exposure and cigarette smoking to emphysema severity in coal miners in the United States
    Eileen D Kuempel
    National Institute for Occupational Safety and Health, Education and Information Division, Risk Evaluation Branch, Cincinnati, Ohio 45226 1998, USA
    Am J Respir Crit Care Med 180:257-64. 2009
    ..Previous studies have shown associations between dust exposure or lung burden and emphysema in coal miners, although the separate contributions of various predictors have not been clearly demonstrated...
  8. ncbi request reprint An approach to risk assessment for TiO2
    David Dankovic
    National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    Inhal Toxicol 19:205-12. 2007
    ..Bayesian model averaging techniques are now being explored as a method for combining the various estimates into a single estimate, with a confidence interval expressing model uncertainty...
  9. doi request reprint Benchmark dose estimation incorporating multiple data sources
    Matthew W Wheeler
    National Institute for Occupational Safety and Health, Risk Evaluation Branch, Cincinnati, OH, USA
    Risk Anal 29:249-56. 2009
    ..Failing to account for such heterogeneity may result in estimates having confidence intervals that are overly narrow...
  10. ncbi request reprint A simulation study of methods for constructing confidence intervals for bioaccumulation factors
    Matthew W Wheeler
    Center for Environmental Toxicology and Statistics, Department of Mathematics and Statistics, Miami University, Oxford, Ohio 45056, USA
    Environ Toxicol Chem 22:921-7. 2003
    ..Thus, the delta method is preferable when the above sampling time condition is met; however, in all other cases, Fieller's method should be used...