Paul J Weidle

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Association of Nevirapine Levels with Rash or Hepatotoxicity Among HIV-Infected Thai Women
    Winai Ratanasuwan
    Department of Preventive and Social Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Open AIDS J 6:266-73. 2012
  2. ncbi request reprint HIV/AIDS treatment and HIV vaccines for Africa
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 359:2261-7. 2002
  3. ncbi request reprint Adherence to antiretroviral therapy in a home-based AIDS care programme in rural Uganda
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 368:1587-94. 2006
  4. doi request reprint Liver enzymes improve over twenty-four months of first-line non-nucleoside reverse transcriptase inhibitor-based therapy in rural Uganda
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Patient Care STDS 22:787-95. 2008
  5. pmc Nelfinavir and its active metabolite, hydroxy-t-butylamidenelfinavir (M8), are transferred in small quantities to breast milk and do not reach biologically significant concentrations in breast-feeding infants whose mothers are taking nelfinavir
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 55:5168-71. 2011
  6. doi request reprint HIV drug resistance and mother-to-child transmission of HIV
    Paul J Weidle
    Epidemiology Branch, Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Clin Perinatol 37:825-42, x. 2010
  7. ncbi request reprint A simplified weight-based method for pediatric drug dosing for zidovudine and didanosine in resource-limited settings
    Paul J Weidle
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 25:59-64. 2006
  8. ncbi request reprint Assessment of a pilot antiretroviral drug therapy programme in Uganda: patients' response, survival, and drug resistance
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 360:34-40. 2002
  9. ncbi request reprint Development of phenotypic and genotypic resistance to antiretroviral therapy in the UNAIDS HIV Drug Access Initiative--Uganda
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention NCHSTP, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30333, USA
    AIDS 17:S39-48. 2003
  10. ncbi request reprint Changes in lipid profile over 24 months among adults on first-line highly active antiretroviral therapy in the home-based AIDS care program in rural Uganda
    Kate Buchacz
    Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 47:304-11. 2008

Collaborators

Detail Information

Publications43

  1. pmc Association of Nevirapine Levels with Rash or Hepatotoxicity Among HIV-Infected Thai Women
    Winai Ratanasuwan
    Department of Preventive and Social Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    Open AIDS J 6:266-73. 2012
    ....
  2. ncbi request reprint HIV/AIDS treatment and HIV vaccines for Africa
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 359:2261-7. 2002
    ..In this review, we discuss the prospects for use of treatment and vaccines in resource-poor settings...
  3. ncbi request reprint Adherence to antiretroviral therapy in a home-based AIDS care programme in rural Uganda
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 368:1587-94. 2006
    ..We assessed adherence to antiretroviral therapy in a cohort of HIV-infected people in a home-based AIDS care programme that provides the therapy and other AIDS care, prevention, and support services in rural Uganda...
  4. doi request reprint Liver enzymes improve over twenty-four months of first-line non-nucleoside reverse transcriptase inhibitor-based therapy in rural Uganda
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Patient Care STDS 22:787-95. 2008
    ..The prevalence of hepatic transaminase elevations decreased during non-nucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy in this cohort of HIV-infected persons in rural Uganda...
  5. pmc Nelfinavir and its active metabolite, hydroxy-t-butylamidenelfinavir (M8), are transferred in small quantities to breast milk and do not reach biologically significant concentrations in breast-feeding infants whose mothers are taking nelfinavir
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 55:5168-71. 2011
    ..Nelfinavir-based antiretroviral regimens given to mothers as prevention of mother-to-child HIV transmission (PMTCT) do not expose the breast-feeding infant to biologically significant concentrations of nelfinavir or M8...
  6. doi request reprint HIV drug resistance and mother-to-child transmission of HIV
    Paul J Weidle
    Epidemiology Branch, Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Clin Perinatol 37:825-42, x. 2010
    ..The magnitude and implications of antiretroviral resistance among HIV-infected pregnant women and HIV-infected infants are summarized...
  7. ncbi request reprint A simplified weight-based method for pediatric drug dosing for zidovudine and didanosine in resource-limited settings
    Paul J Weidle
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 25:59-64. 2006
    ..Although weight and height can both be measured, it may be impractical to expect providers in resource-limited settings to estimate accurately body surface area...
  8. ncbi request reprint Assessment of a pilot antiretroviral drug therapy programme in Uganda: patients' response, survival, and drug resistance
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 360:34-40. 2002
    ..We assessed the UNAIDS/Uganda Ministry of Health HIV Drug Access Initiative--one of the first pilot antiretroviral programmes in Africa--in which patients paid for their medications at negotiated reduced prices...
  9. ncbi request reprint Development of phenotypic and genotypic resistance to antiretroviral therapy in the UNAIDS HIV Drug Access Initiative--Uganda
    Paul J Weidle
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention NCHSTP, Centers for Disease Control and Prevention CDC, Atlanta, Georgia 30333, USA
    AIDS 17:S39-48. 2003
    ..We describe phenotypic drug resistance, response to therapy, and genotypic mutations among HIV-infected patients in Uganda taking antiretroviral medications for > or = 90 days who had a viral load > or = 1000 copies/ml...
  10. ncbi request reprint Changes in lipid profile over 24 months among adults on first-line highly active antiretroviral therapy in the home-based AIDS care program in rural Uganda
    Kate Buchacz
    Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 47:304-11. 2008
    ..The effects of HAART on lipid metabolism among sub-Saharan Africans, for whom access to antiretroviral therapy is expanding, remain largely unknown...
  11. doi request reprint Hematologic changes associated with Zidovudine following single-drug substitution from stavudine in a home-based AIDS care program in rural Uganda
    Fatu Forna
    Global AIDS Program, National Center for HIV, Hepatitis, STD, and TB Prevention NCHHSTP, CDC, Atlanta, Georgia, USA
    J Int Assoc Physicians AIDS Care (Chic) 8:128-38. 2009
    ..The authors evaluated hematologic changes associated with zidovudine (ZDV) following single-drug substitution from stavudine (D4T) in HIV-infected persons in Uganda...
  12. ncbi request reprint Clinical toxicity of highly active antiretroviral therapy in a home-based AIDS care program in rural Uganda
    Fatu Forna
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 44:456-62. 2007
    ..We evaluated clinical toxicity in HIV-infected persons receiving antiretroviral therapy (ART) in Uganda...
  13. doi request reprint Antiretroviral therapy improves renal function among HIV-infected Ugandans
    Philip J Peters
    Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Kidney Int 74:925-9. 2008
    ..Our study shows that renal dysfunction was common with advanced HIV disease in Uganda but this improved following 2 years of HAART...
  14. doi request reprint Hyponatremia, hypochloremia, and hypoalbuminemia predict an increased risk of mortality during the first year of antiretroviral therapy among HIV-infected Zambian and Kenyan women
    Christine N Dao
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    AIDS Res Hum Retroviruses 27:1149-55. 2011
    ..Assessment of serum sodium, chloride, and albumin can identify HIV-infected patients at highest risk for mortality who may benefit from more intensive medical management during the first year of ART...
  15. doi request reprint Nevirapine-associated hepatotoxicity and rash among HIV-infected pregnant women in Kenya
    Philip J Peters
    1Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Int Assoc Physicians AIDS Care (Chic) 11:142-9. 2012
    ..Few studies have evaluated the risk of nevirapine (NVP)-associated hepatotoxicity among HIV-infected pregnant women with a CD4 count ≥250 cells/mm(3)...
  16. doi request reprint An evaluation of hepatitis B virus diagnostic methods and responses to antiretroviral therapy among HIV-infected women in Thailand
    Philip James Peters
    Centers for Disease Control and Prevention CDC, Atlanta, GA, USA
    J Int Assoc Provid AIDS Care 12:349-53. 2013
    ..Although HBsAg screening did not diagnose 5 occult HBV coinfections, these women achieved HBV suppression on 3TC-containing ART, suggesting that not detecting occult HBV coinfection would have limited clinical impact. ..
  17. ncbi request reprint Systematic review of the safety of trimethoprim-sulfamethoxazole for prophylaxis in HIV-infected pregnant women: implications for resource-limited settings
    Fatu Forna
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, CDC, Atlanta, GA 30333, USA
    AIDS Rev 8:24-36. 2006
    ....
  18. ncbi request reprint HIV antiretroviral drug resistance in Africa
    John N Nkengasong
    Division of HIV AIDS, STD, TB Laboratory Research, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    AIDS Rev 6:4-12. 2004
    ....
  19. doi request reprint Updates of lifetime costs of care and quality-of-life estimates for HIV-infected persons in the United States: late versus early diagnosis and entry into care
    Paul G Farnham
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA Atlanta Veterans Affairs Medical Center, Atlanta, GA Emory University School of Medicine, Atlanta, GA and Emory University Rollins School of Public Health, Atlanta, GA
    J Acquir Immune Defic Syndr 64:183-9. 2013
    ..Updated estimates were used to analyze the effects of late versus early diagnosis/entry on US lifetime care costs, quality-of-life estimates, and HIV transmissions...
  20. ncbi request reprint A program to provide antiretroviral therapy to residents of an urban slum in nairobi, kenya
    Barbara J Marston
    Global AIDS Program, Centers for Disease Control and Prevention CDC Kenya
    J Int Assoc Physicians AIDS Care (Chic) 6:106-12. 2007
    ..Objective: To evaluate retention in care and response to therapy for patients enrolled in an antiretroviral treatment program in a severely resource-constrained setting...
  21. pmc HIV-1 drug resistance emergence among breastfeeding infants born to HIV-infected mothers during a single-arm trial of triple-antiretroviral prophylaxis for prevention of mother-to-child transmission: a secondary analysis
    Clement Zeh
    Division of HIV AIDS Prevention, US Centers for Disease Control and Prevention, Kisumu, Kenya
    PLoS Med 8:e1000430. 2011
    ..Here, we present findings from a KiBS trial secondary analysis that evaluated the emergence of maternal ARV-associated resistance among 32 HIV-infected breastfed infants...
  22. pmc Retention in an antiretroviral therapy programme during an era of decreasing drug cost in Limbe, Cameroon
    Jembia J Mosoko
    Division of Global HIV AIDS, Centers for Disease Control and Prevention, Mutengene, Cameroon
    J Int AIDS Soc 14:32. 2011
    ....
  23. ncbi request reprint Adverse Events in HIV-Infected Persons Receiving Antiretroviral Drug Regimens in a Large Urban Slum in Nairobi, Kenya, 2003-2005
    Andrea A Kim
    Global AIDS Program, Centers for Disease Control and Prevention CDC, Atlanta, Georgia, USA
    J Int Assoc Physicians AIDS Care (Chic) 6:206-9. 2007
    ..62, 0.42, and 0.21, respectively, and 0.99 at 6, 12, and 18 months. Conclusions: ART toxicities were frequent, but severe toxicities were less common. In resource-limited settings, ART toxicity should not represent a barrier to care...
  24. ncbi request reprint Use of single-dose nevirapine for the prevention of mother-to-child transmission of HIV-1: does development of resistance matter?
    Michelle S McConnell
    Thailand US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand
    Am J Obstet Gynecol 197:S56-63. 2007
    ..Further research in the optimization of perinatal prevention regimens is needed...
  25. doi request reprint The costs of HIV antiretroviral therapy adherence programs and impact on health care utilization
    Stephanie L Sansom
    US Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Patient Care STDS 22:131-8. 2008
    ..IACM was associated with a significant decrease in hospital days compared to SOC and was cost saving when program costs were compared to savings in health care utilization...
  26. doi request reprint Using electronic surveys to gather information on physician practices during a response to a local epidemic--Rhode Island, 2011
    Timothy D Minniear
    Epidemic Intelligence Service, U S Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Ann Epidemiol 23:521-3. 2013
    ..Electronic invitations may improve physician response rates to participate in internet surveys administered by public health agencies...
  27. doi request reprint HIV testing and HIV/AIDS treatment services in rural counties in 10 southern states: service provider perspectives
    Madeline Sutton
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Rural Health 26:240-7. 2010
    ..Data are limited regarding provider perspectives of the accessibility and availability of HIV testing and treatment services in southern rural counties...
  28. doi request reprint How late is too late? Timeliness to scheduled visits as an antiretroviral therapy adherence measure in Nairobi, Kenya and Lusaka, Zambia
    Rachel J Blacher
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    AIDS Care 22:1323-31. 2010
    ..Timeliness to scheduled clinic visits can be used as an objective proxy for self-reported adherence and ultimately for risk of virologic failure...
  29. ncbi request reprint Molecular analysis in support of an investigation of a cluster of HIV-1-infected women
    Kenneth E Robbins
    Center for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 18:1157-61. 2002
    ..In conclusion, phylogenetic analysis of HIV strains in an epidemiologic investigation is highly useful in support of cluster identification, even without sampling from the putative index patient...
  30. ncbi request reprint Antiretroviral therapy in the private sector of Nairobi, Kenya: a review of the experience of five physicians
    Doris K Macharia
    AIDS 17:938-40. 2003
  31. ncbi request reprint The feasibility of a community-based directly administered antiretroviral therapy program
    Amy Rock Wohl
    HIV Epidemiology Program, Los Angeles County Department of Health Services, Los Angeles, CA 90005, USA
    Clin Infect Dis 38:S388-92. 2004
    ..Effective communication between the DAART staff, the medical providers, and the pharmacy is essential for the successful implementation of this program...
  32. ncbi request reprint Directly administered antiretroviral therapy in an urban methadone maintenance clinic: a nonrandomized comparative study
    Gregory M Lucas
    Johns Hopkins University, Baltimore, MD 21287, USA
    Clin Infect Dis 38:S409-13. 2004
    ..008). The preliminary results of this study both suggest that DAART can be feasible and acceptable to patients in a methadone clinic setting and provide impetus for further study of this treatment strategy in randomized controlled trials...
  33. ncbi request reprint Nevirapine-induced Stevens-Johnson syndrome in a mother and son
    Cheryl A Liechty
    AIDS 19:993-4. 2005
  34. ncbi request reprint Long-term experience providing antiretroviral drugs in a fee-for-service HIV clinic in Uganda: evidence of extended virologic and CD4+ cell count responses
    Charles Kabugo
    St Francis Hospital, Nsambya, Kampala, Uganda
    J Acquir Immune Defic Syndr 38:578-83. 2005
    ..To describe the long-term experience of providing anti-retroviral (ARV) therapy, including CD4 cell count and virologic response, at St. Francis Hospital, Nsambya, Uganda...
  35. ncbi request reprint Combination antiretroviral therapy in african nursing mothers and drug exposure in their infants: new pharmacokinetic and virologic findings
    Marc Bulterys
    J Infect Dis 192:709-12. 2005
  36. ncbi request reprint Short-term safety and tolerability of didanosine combined with high- versus low-dose tenofovir disproxil fumarate in ambulatory HIV-1-infected persons
    Benjamin Young
    Rose Medical Center, Denver, Colorado, USA
    AIDS Patient Care STDS 20:238-44. 2006
    ....
  37. ncbi request reprint A randomized trial of directly administered antiretroviral therapy and adherence case management intervention
    Amy Rock Wohl
    HIV Epidemiology Program, Los Angeles County Department of Health Services, Los Angeles, CA 90005, USA
    Clin Infect Dis 42:1619-27. 2006
    ....
  38. ncbi request reprint Directly administered antiretroviral therapy in methadone clinics is associated with improved HIV treatment outcomes, compared with outcomes among concurrent comparison groups
    Gregory M Lucas
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Clin Infect Dis 42:1628-35. 2006
    ..Directly administered antiretroviral therapy (DAART) in methadone clinics has the potential to improve treatment outcomes for human immunodeficiency virus (HIV)-infected injection drug users (IDUs)...
  39. ncbi request reprint Increased body mass index does not alter response to initial highly active antiretroviral therapy in HIV-1-infected patients
    Ellen M Tedaldi
    Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Acquir Immune Defic Syndr 43:35-41. 2006
    ....
  40. pmc Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine
    Benjamin H Chi
    Centre for Infectious Disease Research in Zambia, Zambia
    AIDS 21:957-64. 2007
    ....
  41. ncbi request reprint Asymptomatic serum cryptococcal antigenemia and early mortality during antiretroviral therapy in rural Uganda
    Cheryl A Liechty
    Centers for Disease Control and Prevention CDC Uganda, Entebbe, Uganda
    Trop Med Int Health 12:929-35. 2007
    ..Cryptococcal meningitis is a leading cause of HIV-related mortality in Africa, but current guidelines do not advocate CRAG testing as a screening tool...
  42. ncbi request reprint Adherence, drug use, and treatment failure in a methadone-clinic-based program of directly administered antiretroviral therapy
    Gregory M Lucas
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    AIDS Patient Care STDS 21:564-74. 2007
    ..Given that a relatively small proportion of the total ART doses were supervised in many patients, future studies should assess how DAART affects adherence with nonsupervised doses and retention to ART...
  43. ncbi request reprint Risk behavior for transmission of human immunodeficiency virus (HIV) among HIV-seropositive individuals in an urban setting
    Joseph P McGowan
    Department of Medicine, Bronx Lebanon Hospital Center, Bronx, New York, USA
    Clin Infect Dis 38:122-7. 2004
    ..2-7.0) and use of highly active antiretroviral therapy (AOR, 1.8; 95% CI, 1.1-3.1). Ongoing risk-reduction counseling and substance abuse treatment for HIV-infected persons are needed to reduce behaviors associated with HIV transmission...