Liying Wang

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Vanadium-induced apoptosis and pulmonary inflammation in mice: Role of reactive oxygen species
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Cell Physiol 195:99-107. 2003
  2. ncbi request reprint Potential role of apoptotic macrophages in pulmonary inflammation and fibrosis
    Liying Wang
    National Institute for Occupational Safety and Health, Physiology and Pathology Research Branch, Morgantown, West Virginia 26505, USA
    J Cell Physiol 194:215-24. 2003
  3. ncbi request reprint Role of neutrophil apoptosis in vanadium-induced pulmonary inflammation in mice
    Liying Wang
    National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, Morgantown, WV 26505, USA
    J Environ Pathol Toxicol Oncol 21:343-50. 2002
  4. ncbi request reprint Role of lung surfactant in phagocytic clearance of apoptotic cells by macrophages in rats
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Lab Invest 86:458-66. 2006
  5. doi request reprint Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts
    Liying Wang
    National Institute for Occupational Safety and Health, HELD PPRB, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 73:410-22. 2010
  6. ncbi request reprint Induction of secondary apoptosis, inflammation, and lung fibrosis after intratracheal instillation of apoptotic cells in rats
    Liying Wang
    National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 290:L695-L702. 2006
  7. pmc Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies
    Liying Wang
    National Institute for Occupational Safety and Health, HELD PPRB, Morgantown, WV 26505, USA
    Part Fibre Toxicol 7:31. 2010
  8. ncbi request reprint Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation
    Jirapan Moungjaroen
    West Virginia University, Department of Pharmaceutical Sciences, Morgantown, WV 26506, USA
    J Pharmacol Exp Ther 319:1062-9. 2006
  9. pmc Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production
    Yongju Lu
    West Virginia University, Department of Pharmaceutical Sciences, P O Box 9530, Morgantown, WV 26506, USA
    Am J Respir Cell Mol Biol 42:432-41. 2010
  10. pmc Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells
    Sudjit Luanpitpong
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Mol Biol Cell 24:858-69. 2013

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Vanadium-induced apoptosis and pulmonary inflammation in mice: Role of reactive oxygen species
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Cell Physiol 195:99-107. 2003
    ..These results indicate that multiple oxidative species are involved in V (V)-induced lung inflammation and apoptosis, and that H(2)O(2) plays a major role in this process...
  2. ncbi request reprint Potential role of apoptotic macrophages in pulmonary inflammation and fibrosis
    Liying Wang
    National Institute for Occupational Safety and Health, Physiology and Pathology Research Branch, Morgantown, West Virginia 26505, USA
    J Cell Physiol 194:215-24. 2003
    ..Published 2002 Wiley-Liss, Inc...
  3. ncbi request reprint Role of neutrophil apoptosis in vanadium-induced pulmonary inflammation in mice
    Liying Wang
    National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, Morgantown, WV 26505, USA
    J Environ Pathol Toxicol Oncol 21:343-50. 2002
    ..We conclude that apoptosis of neutrophils and clearance by alveolar macrophages are important mechanisms in the resolution of vanadium-induced lung inflammation...
  4. ncbi request reprint Role of lung surfactant in phagocytic clearance of apoptotic cells by macrophages in rats
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Lab Invest 86:458-66. 2006
    ....
  5. doi request reprint Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts
    Liying Wang
    National Institute for Occupational Safety and Health, HELD PPRB, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 73:410-22. 2010
    ..The results obtained may aid in the development of in vitro models for rapid screening of the potential fibrogenicity of carbon nanotubes, which are lacking and urgently needed...
  6. ncbi request reprint Induction of secondary apoptosis, inflammation, and lung fibrosis after intratracheal instillation of apoptotic cells in rats
    Liying Wang
    National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 290:L695-L702. 2006
    ..Together, our results demonstrate a direct effect of apoptotic cell accumulation on inflammatory and fibrotic pulmonary responses and the continuous induction of lung cell apoptosis by apoptotic cell instillation...
  7. pmc Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies
    Liying Wang
    National Institute for Occupational Safety and Health, HELD PPRB, Morgantown, WV 26505, USA
    Part Fibre Toxicol 7:31. 2010
    ..The aims of this study were to develop a simple and rapid method of nanoparticle dispersion using a natural lung surfactant and to evaluate the effect of dispersion status of SWCNT on cytotoxicity and fibrogenicity in vitro and in vivo...
  8. ncbi request reprint Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation
    Jirapan Moungjaroen
    West Virginia University, Department of Pharmaceutical Sciences, Morgantown, WV 26506, USA
    J Pharmacol Exp Ther 319:1062-9. 2006
    ..Together, our findings indicate a novel pro-oxidant role of LA in apoptosis induction and its regulation by Bcl-2, which may be exploited for the treatment of cancer and related apoptosis disorders...
  9. pmc Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production
    Yongju Lu
    West Virginia University, Department of Pharmaceutical Sciences, P O Box 9530, Morgantown, WV 26506, USA
    Am J Respir Cell Mol Biol 42:432-41. 2010
    ..Together, our results indicate a novel role of PI3K/Akt in fibrogenesis of human lung fibroblasts and its regulation by ROS, which could be exploited for the treatment of pulmonary fibrosis and related disorders...
  10. pmc Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells
    Sudjit Luanpitpong
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Mol Biol Cell 24:858-69. 2013
    ..This new finding reveals crucial redox regulatory mechanisms that control the antiapoptotic function of Bcl-2...
  11. pmc Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis
    Neelam Azad
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Carcinogenesis 29:1538-45. 2008
    ..This study reveals a novel mechanism linking .O(-)(2) with Bcl-2 stability and provides a new dimension to ROS-mediated Bcl-2 downregulation and apoptosis induction...
  12. doi request reprint Dependence of reactive oxygen species and FLICE inhibitory protein on lipofectamine-induced apoptosis in human lung epithelial cells
    Lalana Kongkaneramit
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, USA
    J Pharmacol Exp Ther 325:969-77. 2008
    ..In demonstrating the role of FLIP and ROS in LF death signaling, we document a novel mechanism of apoptosis regulation that may be exploited to decrease cytotoxicity and increase gene transfection efficiency of cationic liposomes...
  13. ncbi request reprint Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells
    Bin Lu
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    J Immunol 176:6785-93. 2006
    ..Together, our results indicate that the PI3K/Akt, in addition to its normal prosurvival role, also plays an apoptotic role in Fas-mediated cell death through a mechanism that involves transcriptional activation of Fas receptor...
  14. pmc Mitochondrial superoxide mediates doxorubicin-induced keratinocyte apoptosis through oxidative modification of ERK and Bcl-2 ubiquitination
    Sudjit Luanpitpong
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Biochem Pharmacol 83:1643-54. 2012
    ....
  15. ncbi request reprint The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunol 180:3072-80. 2008
    ....
  16. ncbi request reprint Peroxide is a key mediator of Bcl-2 down-regulation and apoptosis induction by cisplatin in human lung cancer cells
    Liying Wang
    West Virginia University, Department of Pharmaceutical Sciences, P O Box 9530, Morgantown, WV 26506, USA
    Mol Pharmacol 73:119-27. 2008
    ..Because aberrant expression of Bcl-2 has been associated with death resistance of cancer cells to chemotherapy, the results of this study could be used to aid the design of more effective strategies for cancer treatment...
  17. ncbi request reprint S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis
    Neelam Azad
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, USA
    J Biol Chem 281:34124-34. 2006
    ..These findings indicate a novel function of NO and its regulation of Bcl-2, which provides a key mechanism for the control of apoptotic cell death and cancer development...
  18. ncbi request reprint Matrix metalloproteinase induction in fibrosis and fibrotic nodule formation due to silica inhalation
    James F Scabilloni
    National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 288:L709-17. 2005
    ..In summary, MMP activity was upregulated at 40 days of silica exposure and progressively increased during ensuing fibrotic responses. Early expression of stromelysin was found in fibrosing alveolar walls and fibrotic nodules...
  19. ncbi request reprint Essential role of p53 in silica-induced apoptosis
    Liying Wang
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 288:L488-96. 2005
    ..This finding may provide an important link in understanding the molecular mechanisms of silica-induced carcinogenesis and pathogenesis in the lung...
  20. pmc Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells
    Todd A Stueckle
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Toxicol Appl Pharmacol 261:204-16. 2012
    ..In conclusion, transformed B-As cells with their whole genome expression profile provide an in vitro arsenic model for future lung cancer signaling research and data for chronic arsenic exposure risk assessment...
  21. pmc Role of S-nitrosylation in apoptosis resistance and carcinogenesis
    Anand Krishnan V Iyer
    Department of Pharmaceutical Sciences, West Virginia University, P O Box 9530, Morgantown, WV 26506, USA
    Nitric Oxide 19:146-51. 2008
    ..We propose that such post-translational modifications of proteins by NO may be a general mechanism that tumor cells exploit to tilt the scales towards survival and proliferation by evading cell death...
  22. pmc Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes
    Robert R Mercer
    Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Part Fibre Toxicol 7:28. 2010
    ....
  23. pmc Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes
    Robert R Mercer
    Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Part Fibre Toxicol 8:21. 2011
    ..Morphometric measurement of Sirius Red staining was used to assess the connective tissue response...
  24. ncbi request reprint Induction of neutrophil apoptosis and secondary necrosis during endotoxin-induced pulmonary inflammation in mice
    Djordje Medan
    Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
    J Cell Physiol 191:320-6. 2002
    ..Because necrosis is associated with cell damage and release of histotoxic contents, this development is likely to play a role in determining the severity and duration of lung toxicity induced by endotoxin...
  25. ncbi request reprint Regulation of Fas (CD95)-induced apoptotic and necrotic cell death by reactive oxygen species in macrophages
    Djordje Medan
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, USA
    J Cell Physiol 203:78-84. 2005
    ..Because the Fas death pathway is implicated in various inflammatory and immunologic disorders, utilization of antioxidants and apoptosis inhibitors as potential therapeutic agents may be advantageous...
  26. ncbi request reprint Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract
    Min Ding
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 279:10670-6. 2004
    ....
  27. doi request reprint Pulmonary toxicity and fibrogenic response of carbon nanotubes
    Amruta Manke
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Toxicol Mech Methods 23:196-206. 2013
    ..We also discuss the physicochemical properties of CNTs and their effects on pulmonary toxicities as well as various biological factors contributing to the development of fibrosis...
  28. pmc Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States
    Nano Lett 11:2796-803. 2011
    ..This study provides new evidence for carbon nanotube-induced carcinogenesis and indicates the potential role of p53 in the process...
  29. ncbi request reprint Nitric oxide negatively regulates Fas CD95-induced apoptosis through inhibition of ubiquitin-proteasome-mediated degradation of FLICE inhibitory protein
    Pithi Chanvorachote
    Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, USA
    J Biol Chem 280:42044-50. 2005
    ..These findings indicate a novel pathway for NO regulation of FLIP that provides a key mechanism for apoptosis regulation and a potential new target for intervention in death receptor-associated diseases...
  30. pmc Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells
    Hosam A Elbaz
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Toxicol Appl Pharmacol 258:51-60. 2012
    ..In summary, digitoxin and D6-MA exert anti-cancer effects on NCI-H460 cells through apoptosis or cell cycle arrest, with D6-MA showing at least 5-fold greater potency relative to digitoxin...
  31. ncbi request reprint Role of reactive oxygen species and Cr(VI) in Ras-mediated signal transduction
    Suwei Wang
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 255:119-27. 2004
    ..c) Among these reactive species, (.)OH radical is responsible for the further transduction of signals from Ras to the nucleus, leading to various cell responses...